Predictors of Serum Levels of 25 Hydroxyvitamin D in a National Bi-Racial Population

Background:The association between hyperuricemia and psoriatic arthritis (PsA) is actually generally accepted. Previous studies have demonstrated that uric acid suppress 25(OH)D metabolism [1]. More evidence is required to demonstrate the immune modulatory effects in psoriasis, psoriatic arthritis and other autoimmune diseases. In particular, the potential association between 25-hydroxyvitamin D serum levels and PsA still remains unknown.Objectives:To assess a clinical association between uric acid/25(OH)D serum levels ratio related to PASI, BASDAI and DAPSA, if any, in patients with psoriatic arthritis.Methods:We retrospectively observed 61 patients with psoriatic arthritis referred to our outpatients clinic, independently from already being on therapy or naïve. All selected patients underwent only conventional non-biological therapy at baseline and none received vitamin D supplementation and either allopurinol or febuxostat previously. Blood samples were drawn from all participants for assessment of 25-hydroxyvitamin D and uric acid serum levels. Disease activity of psoriasis and psoriatic arthritis were assessed by the Psoriasis Area and Severity Index (PASI), the Disease Activity Index for Psoriatic Arthritis (DAPSA) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). We assessed the covariates of interest by the Wilcoxon non parametric test, through the SPSS 24 Software.Results:We observed 61 patients, mainly females (83.6%). At the univariate analysis, the uric acid/25(OH)D serum levels ratio revealed significantly associated with DAPSA and BASDAI indexes (p<0.001 and p<0.001, respectively), whilst no significant association emerged with the PASI index (p=0.462).Conclusion:Data in the literature about these associations in the context of psoriatic arthritis are really poor. As a consequence, our findings, though preliminary, suggest us to hypothesize a potential role of uric acid/25(OH)D serum levels ratio as potential inflammation marker in order to better assess the disease activity. However, future larger studies are needed to investigate more in depth this association.[1]Charoenngam N, Ponvilawan B, Ungprasert P. Vitamin D insufficiency and deficiency are associated with a higher level of serum uric acid: A systematic review and meta-analysis. Mod Rheumatol. 2019 Mar 4:1-6.Disclosure of Interests:None declared

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Serum 25-hydroxyvitamin D serum levels in a large German cohort of patients with melanoma

British Journal of Dermatology ◽

10.1111/j.1365-2133.2012.11212.x ◽

2012 ◽

Vol 168 (3) ◽

pp. 625-628 ◽

Cited By ~ 28

Author(s):

T. Gambichler ◽

M. Bindsteiner ◽

S. Höxtermann ◽

A. Kreuter

Keyword(s):

Serum Levels ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Seasonal variations of serum 1,25-dihydroxyvitamin D3 and alkaline phosphatase in relation to the antler formation in the fallow deer (Dama dama L.)

Acta Endocrinologica ◽

10.1530/acta.0.1070141 ◽

1984 ◽

Vol 107 (1) ◽

pp. 141-144 ◽

Cited By ~ 11

Author(s):

B. Eiben ◽

St. Scharla ◽

K. Fischer ◽

H. Schmidt-Gayk

Keyword(s):

Alkaline Phosphatase ◽

Seasonal Variation ◽

Serum Alkaline Phosphatase ◽

Serum Levels ◽

Fallow Deer ◽

Dama Dama ◽

Dihydroxyvitamin D3 ◽

Hydroxyvitamin D ◽

1,25 Dihydroxyvitamin D3 ◽

25 Hydroxyvitamin D

Abstract. Serum 1,25-dihydroxyvitamin D3 and serum alkaline phosphatase increased several fold during the antler formation period in July. Both maxima were observed in the second half of the antler formation period, where the mineralization of the antler takes place. In contrast serum levels of calcium and 25-hydroxyvitamin D3 showed no alternation or seasonal variation.

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Analysis of Suicidal Behavior and Chronicity of Depressive Symptoms in the Presence of Hypovitaminosis D

Current Psychiatry Research and Reviews ◽

10.2174/2666082217666211122155401 ◽

2021 ◽

Vol 17 ◽

Author(s):

Catarina Magalhães Porto ◽

Natalia Santos Barbosa da Silva ◽

Cecília Magalhães Porto Lira ◽

Rayana Porpino Magalhães ◽

José Luiz Oliveira Magalhães ◽

...

Keyword(s):

Vitamin D ◽

Depressive Symptoms ◽

Suicidal Ideation ◽

Depressive Disorder ◽

Suicidal Behavior ◽

Suicide Risk ◽

Hypovitaminosis D ◽

Serum Levels ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

Background: One of the risk factors for suicide includes the presence of depressive disorder and symptoms, which may be related to the reduction of 25-hydroxyvitamin D serum levels. In this scenario, evidence shows vitamin D deficiency as an important aspect, directly related to depressive disorder chronicity. Objective: To assess the association between Vitamin D serum levels and the intensity of depressive symptoms and suicidal behavior in a clinical sample of depressed patients. Methods: A cross-sectional study with 146 patients aged between 18 and 59, seen in two psychiatry ambulatories. Data collection involved measurement of serum 25-hydroxyvitamin D levels and assessment of the intensity of depressive symptoms and suicide risk. Results: In the sample, 35% presented low Vitamin D serum levels and, in these individuals, the incidence of family history of Depressive Disorder (95.2%) and chronicity of severe depressive symptoms (47.8%) was higher. As to suicidal behavior, both groups presented high active suicide risk, with higher rates in the group with hypovitaminosis D. Only suicidal ideation was linked to lower Vitamin D levels (67.4% p= 0,005). Conclusion: In this study, hypovitaminosis D was associated with negative mental health outcomes, such as more severe chronicity of depressive symptoms and suicidal behavior, characterized by active suicidal ideation.

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Low serum levels of 25-hydroxyvitamin D (25-OHD) among psychiatric out-patients in Sweden: Relations with season, age, ethnic origin and psychiatric diagnosis

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2010.03.013 ◽

2010 ◽

Vol 121 (1-2) ◽

pp. 467-470 ◽

Cited By ~ 79

Author(s):

Mats B. Humble ◽

Sven Gustafsson ◽

Susanne Bejerot

Keyword(s):

Psychiatric Diagnosis ◽

Serum Levels ◽

Ethnic Origin ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Low Serum

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25-Hydroxyvitamin D: Serum Levels and Oral Administration of Calcifediol in Neonates

Archives of Internal Medicine ◽

10.1001/archinte.138.suppl_5.869 ◽

1978 ◽

Vol 138 (Suppl_5) ◽

pp. 869-873 ◽

Cited By ~ 1

Author(s):

A. R. Fleischman ◽

J. F. Rosen ◽

G. Nathenson

Keyword(s):

Oral Administration ◽

Serum Levels ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Serum levels of the bone turnover markers dickkopf-1, sclerostin, osteoprotegerin, osteopontin, osteocalcin and 25-hydroxyvitamin D in Swedish geriatric patients aged 75 years or older with a fresh hip fracture and in healthy controls

Journal of Endocrinological Investigation ◽

10.1007/s40618-015-0421-5 ◽

2016 ◽

Vol 39 (8) ◽

pp. 855-863 ◽

Cited By ~ 10

Author(s):

P. Wanby ◽

R. Nobin ◽

S.-P. Von ◽

L. Brudin ◽

M. Carlsson

Keyword(s):

Hip Fracture ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Geriatric Patients ◽

Serum Levels ◽

Healthy Controls ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Turnover Markers ◽

Dickkopf 1

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25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis

Multiple Sclerosis Journal ◽

10.1191/1352458505ms1157oa ◽

2005 ◽

Vol 11 (3) ◽

pp. 266-271 ◽

Cited By ~ 157

Author(s):

M Soilu-Hänninen ◽

L Airas ◽

I Mononen ◽

A Heikkilä ◽

M Viljanen ◽

...

Keyword(s):

Vitamin D ◽

Bone Metabolism ◽

Sun Exposure ◽

Serum Levels ◽

Vitamin D Supplementation ◽

Hydroxyvitamin D ◽

Normal Bone ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

Lower Vitamin

Past sun exposure and vitamin D supplementation have been associated with a reduction in the risk of MS. We measured the serum concentration of 25-hydroxyvitamin D (25[OH]D) at the time of MS diagnosis in 40 MS patients and 40 controls. We found no difference in the serum levels of 25(OH)D between MS patients and controls when all samples or samples obtained during winter months were compared, but MS patients had significantly lower serum 25(OH)D concentrations in June to September than the controls. The vitamin D stores were adequate for bone metabolism (> 37 nmol/L) in 70% of MS patients throughout the year and within the hypovitaminosis level (< 37 nmol/L) in 30% of MS patients at some time of the year. During MS-relapses, 25(OH)D levels were lower than in remission, but mostly within the reference range observed in relation with normal bone metabolism. We conclude that the vitamin D stores in most MS patients are adequate for their normal bone metabolism. However, lower vitamin D levels during MS relapses than in remission suggest that vitamin D could be involved in the regulation of the clinical disease activity of MS. The optimal serum levels of vitamin D for the regulation of immune responses remain to be determined.

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