scholarly journals A-187 Is Once Enough? First Trial Performance on the Free and Cued Selective Reminding Test in a Clinical Sample of Older Adults with Neurocognitive Disorders

2020 ◽  
Vol 35 (6) ◽  
pp. 982-982
Author(s):  
Gettens K ◽  
Daly M ◽  
Chaudhry T ◽  
Duncanson H ◽  
Sherman J ◽  
...  

Abstract Objective There is urgent need for tools that quickly identify neurocognitive disorders (NCD). The Free and Cued Selective Reminding Test (FCSRT) has high sensitivity for detecting NCD severity (Mild vs. Major) and type (amnestic vs. non-amnestic). However, full administration of three learning trials makes it relatively lengthy. We examined whether first trial performance detects NCD type and severity. Method 187 patients (Mage = 74.7 ± 6.9, Medu = 16 ± 3.1; 58% male) were clinically evaluated. Diagnoses were Mild NCD—amnestic (N = 55), Mild NCD—non-amnestic (N = 67), Major NCD -amnestic (N = 23), and Major NCD –non-amnestic (N = 42). Free recall accuracy (FRA) [number freely recalled/16 *100] and cued recall accuracy (CRA) [(number of cues provided—number recalled with cues)/16 *100] were calculated for each of 3 learning trials. Results First trial performance predicted NCD severity (2 (2) = 7.84, p < .03) and type (2 (1) = 59.0, p < .001). First trial FRA predicted NCD severity (B = −3.29, p < .01). First trial FRA and CRA predicted NCD type (CRA better than FRA, (B = −4.54, p < .001). Third trial accuracy did not predict NCD severity [2 (2) = 5.75, p = .06). Third trial accuracy predicted NCD type [2 (2) = 56.6, p < .001]; third trial FRA performed similarly to first trial FRA. Conclusions Our results suggest that first trial FCSRT performance may be enough to screen for neurocognitive disorders. Findings identify free recall accuracy as a better predictor of type and cued recall accuracy a better predictor of NCD severity.

Neurology ◽  
2020 ◽  
Vol 95 (10) ◽  
pp. e1312-e1321
Author(s):  
Edmarie Guzmán-Vélez ◽  
Jairo Martínez ◽  
Kate Papp ◽  
Ana Baena ◽  
Clara Vila-Castelar ◽  
...  

ObjectiveTo determine whether performance on the Free and Cued Selective Reminding Test (FCSRT) is associated with PET in vivo markers of brain pathology and whether it can distinguish those who will develop dementia later in life due to autosomal-dominant Alzheimer disease (AD) from age-matched controls.MethodsTwenty-four cognitively unimpaired Presenilin-1 E280A carriers (mean age 36 years) and 28 noncarriers (mean age 37 years) underwent Pittsburg compound B-PET (amyloid), flortaucipir-PET (tau), and cognitive testing, including the FCSRT (immediate and delayed free and cued recall scores). Linear regressions were used to examine the relationships among FCSRT scores, age, mean cortical amyloid, and regional tau burden.ResultsFree and total recall scores did not differ between cognitively unimpaired mutation carriers and noncarriers. Greater age predicted lower free recall and delayed free and total recall scores in carriers. In cognitively impaired carriers, delayed free recall predicted greater amyloid burden and entorhinal tau, while worse immediate free recall scores predicted greater tau in the inferior temporal and entorhinal cortices. In turn, in all carriers, lower free and total recall scores predicted greater amyloid and regional tau pathology.ConclusionsFCSRT scores were associated with in vivo markers of AD–related pathology in cognitively unimpaired individuals genetically determined to develop dementia. Difficulties on free recall, particularly delayed recall, were evident earlier in the disease trajectory, while difficulties on cued recall were seen only as carriers neared the onset of dementia, consistent with the pathologic progression of the disease. Findings suggest that the FCSRT can be a useful measure to track disease progression in AD.


2021 ◽  
Author(s):  
Elisa Resende ◽  
Vivian Lara ◽  
Ana Luisa Santiago ◽  
Clarisse Friedlaender ◽  
Howard Rosen ◽  
...  

Background: The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Objectives: To determine whether the hippocampal connectivity correlate with episodic memory in illiterate adults. Methods: Thirty-nine illiterate adults underwent resting state functional MRI and an episodic memory test (Free and Cued Selective Reminding Test). We correlated the hippocampal connectivity at rest with the free recall scores. Analyzes were corrected for head motion and physiological BOLD signal. Results: Participants were most female (66%) and black (79%) and the mean age was 49 years-old (±13.9). The mean score on free recall was 27.2 (±10.7) out of 48 points. We found a significant correlation between both hippocampi and the posterior cingulate and ventral medial prefrontal cortex. However, we did not find an association between the hippocampal connectivity and the memory scores. Conclusions: The lack of association with memory scores might be associated with low brain reserve in this group of individuals.


Author(s):  
Ellen Grober ◽  
Cuiling Wang ◽  
Melissa Kitner-Triolo ◽  
Richard B. Lipton ◽  
Claudia Kawas ◽  
...  

Abstract Objective: To compare the predictive validity of learning and retention measures from the picture version of the Free and Cued Selective Reminding Test with Immediate Recall (pFCSRT + IR) for identifying incident mild cognitive impairment (MCI). Methods: Learning was defined by the sum of free recall (FR) and retention by delayed free recall (DFR) tested 15–20 min later. Totally, 1422 Baltimore Longitudinal Study of Aging (BLSA) participants (mean age 69.6 years, 54% male, mean 16.7 years of education) without dementia or MCI received the pFCSRT + IR at baseline and were followed longitudinally. Cox proportional hazards models were used to evaluate the effect of baseline learning and retention on risk of MCI. Results: In total, 187 participants developed MCI over a median of 8.1 years of follow-up. FR and DFR each predicted incident MCI adjusting for age, sex, and education. Also, each independently predicted incident MCI in the presence of the other with similar effect sizes: around 20% decrease in the hazard of MCI corresponding to one standard deviation increase in FR or DFR. Conclusion: The practice of preferring retention over learning to predict incident MCI should be reconsidered. The decision to include retention should be guided by time constraints and patient burden.


2021 ◽  
pp. 1-9
Author(s):  
Ellen Grober ◽  
Qi Qi ◽  
Lynn Kuo ◽  
Jason Hassenstab ◽  
Richard J. Perrin ◽  
...  

Background: The ultimate validation of a clinical marker for Alzheimer’s disease (AD) is its association with AD neuropathology. Objective: To identify clinical measures that predict pathology, we evaluated the relationships of the picture version of the Free and Cued Selective Reminding Test (pFCSRT + IR), the Mini-Mental State Exam (MMSE), and the Clinical Dementia Rating scale Sum of Boxes (CDR-SB) to Braak stage. Methods: 315 cases from the clinicopathologic series at the Knight Alzheimer’s Disease Research Center were classified according to Braak stage. Boxplots of each predictor were compared to identify the earliest stage at which decline was observed and ordinal logistic regression was used to predict Braak stage. Results: Looking at the assessment closest to death, free recall scores were lower in individuals at Braak stage III versus Braak stages 0 and I (combined) while MMSE and CDR scores for individuals did not differ from Braak stages 0/I until Braak stage IV. The sum of free recall and total recall scores independently predicted Braak stage and had higher predictive validity than MMSE and CDR-SB in models including all three. Conclusion: pFCSRT + IR + IR scores may be more sensitive to early pathological changes than either the CDR-SB or the MMSE.


1991 ◽  
Author(s):  
David G. Payne ◽  
Jeffrey S. Anastasi
Keyword(s):  

Author(s):  
Richard Gnassounou ◽  
Bénédicte Defontaines ◽  
Séverine Denolle ◽  
Stéphanie Brun ◽  
Raphaël Germain ◽  
...  

Abstract Objective: To compare the administration of neuropsychological tests by teleneuropsychology (TeleNP) and face to face (F-F) in order to determine the feasibility and reliability of TeleNP. Method: At the inclusion visit, all participants underwent a traditional F-F neuropsychological assessment as part of their standard care. Four months after inclusion, they were randomized to undergo an additional neuropsychological assessment either by F-F administration or by TeleNP. Results: A total of 150 adults with cognitive complaints, but with no major cognitive or sensorial impairment were included. At 4 months, 69 participants were randomized in the F-F arm and 71 in TeleNP arm (10 lost in the follow-up). The overall satisfaction was high: 87.1% in the TeleNP arm were “very satisfied”, and 82.9% indicated no preference between F-F and TeleNP. In agreement with previous data from the literature, neuropsychological assessments gave similar results across both administration conditions for a large majority of tests [Mini-Mental State Examination (MMSE), Free and Cued Selective Reminding Test (FCSRT) French version, Mahieux gestural praxis battery, Frontal Assessment Battery (FAB), time of completion of the Trail making Test (TMT) A and B, number of errors of the TMT B, Rey complex figure test, categorical et phonological verbal fluency tests] and minor differences for others [80-picture naming test (DO-80), FAB, Digit Span forward and backward and number of errors in the TMT A]. Conclusions: TeleNP is a promising method to be able to test patients as an alternative to F-F condition. Before this procedure can be generalized, it is now necessary to standardize the adaptation of certain tests and to test them in populations with more significant cognitive disorders.


2011 ◽  
Vol 17 (6) ◽  
pp. 1006-1013 ◽  
Author(s):  
Jagan A. Pillai ◽  
Charles B. Hall ◽  
Dennis W. Dickson ◽  
Herman Buschke ◽  
Richard B. Lipton ◽  
...  

AbstractParticipation in cognitively stimulating leisure activities such as crossword puzzles may delay onset of the memory decline in the preclinical stages of dementia, possibly via its effect on improving cognitive reserve. We followed 488 initially cognitively intact community residing individuals with clinical and cognitive assessments every 12–18 months in the Bronx Aging Study. We assessed the influence of crossword puzzle participation on the onset of accelerated memory decline as measured by the Buschke Selective Reminding Test in 101 individuals who developed incident dementia using a change point model. Crossword puzzle participation at baseline delayed onset of accelerated memory decline by 2.54 years. Inclusion of education or participation in other cognitively stimulating activities did not significantly add to the fit of the model beyond the effect of puzzles. Our findings show that late life crossword puzzle participation, independent of education, was associated with delayed onset of memory decline in persons who developed dementia. Given the wide availability and accessibility of crossword puzzles, their role in preventing cognitive decline should be validated in future clinical trials. (JINS, 2011, 17, 1006–1013)


Author(s):  
Kate D. Randall ◽  
Kimberly A. Kerns

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