Comparison of Neuropsychological Assessment by Videoconference and Face to Face

Author(s):  
Richard Gnassounou ◽  
Bénédicte Defontaines ◽  
Séverine Denolle ◽  
Stéphanie Brun ◽  
Raphaël Germain ◽  
...  

Abstract Objective: To compare the administration of neuropsychological tests by teleneuropsychology (TeleNP) and face to face (F-F) in order to determine the feasibility and reliability of TeleNP. Method: At the inclusion visit, all participants underwent a traditional F-F neuropsychological assessment as part of their standard care. Four months after inclusion, they were randomized to undergo an additional neuropsychological assessment either by F-F administration or by TeleNP. Results: A total of 150 adults with cognitive complaints, but with no major cognitive or sensorial impairment were included. At 4 months, 69 participants were randomized in the F-F arm and 71 in TeleNP arm (10 lost in the follow-up). The overall satisfaction was high: 87.1% in the TeleNP arm were “very satisfied”, and 82.9% indicated no preference between F-F and TeleNP. In agreement with previous data from the literature, neuropsychological assessments gave similar results across both administration conditions for a large majority of tests [Mini-Mental State Examination (MMSE), Free and Cued Selective Reminding Test (FCSRT) French version, Mahieux gestural praxis battery, Frontal Assessment Battery (FAB), time of completion of the Trail making Test (TMT) A and B, number of errors of the TMT B, Rey complex figure test, categorical et phonological verbal fluency tests] and minor differences for others [80-picture naming test (DO-80), FAB, Digit Span forward and backward and number of errors in the TMT A]. Conclusions: TeleNP is a promising method to be able to test patients as an alternative to F-F condition. Before this procedure can be generalized, it is now necessary to standardize the adaptation of certain tests and to test them in populations with more significant cognitive disorders.

Author(s):  
Eva Calderón-Rubio ◽  
Javier Oltra-Cucarella ◽  
Beatriz Bonete-López ◽  
Clara Iñesta ◽  
Esther Sitges-Maciá

The aim of this work was to develop normative data for neuropsychological tests for the assessment of independent and cognitively active Spanish older adults over 55 years of age. Methods: regression-based normative data were calculated from a sample of 103 nondepressed independent community-dwelling adults aged 55 or older (66% women). The raw data for the Free and Cued Selective Reminding Test (FCSRT), the Rey–Osterrieth Complex Figure Test (ROCF) and the Judgement of Line Orientation Test (JLO) were regressed on age, sex and education. The model predicting the FCSRT delayed-recall (FCSRT-Del) scores also included the FCSRT immediate-recall (FCSRT-Imm) scores. The model predicting the ROCF immediate-recall (ROCF-Imm) scores included the ROCF copy-trial (ROCF-C) scores, and the model predicting the ROCF delayed-recall (ROCF-Del) scores included both the ROCF-C and the ROCF-Imm scores. In order to identify low scores, z-scores were used to determine the discrepancy between the observed and the predicted scores. The base rates of the low scores for both the SABIEX normative data and the published normative data obtained from the general population were compared. Results: the effects of the different sociodemographic variables (age, sex and education) varied throughout the neuropsychological measures. Despite finding similar proportions of low scores between the normative data sets, the agreement was irrelevant or only fair-to-good. Conclusions: the normative data obtained from the general population might not be sensitive enough to identify low scores in cognitively active older adults, incorrectly classifying them as cognitively normal compared to the less active population.


2006 ◽  
Vol 17 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Nina Blaskewitz ◽  
Thomas Merten

Zusammenfassung: Beschwerdenvalidierungstests (BVT) dienen zur Überprüfung der Gültigkeit erhaltener Testprofile. Im Rahmen eines Analogdesigns wurden drei BVT (Medical Symptom Validity Test MSVT, Amsterdamer Kurzzeitgedächtnistest AKGT, One-in-Five Test) sowie eine Reihe von Beschwerdenvaliditätsindikatoren anderer Tests auf ihre Güte überprüft. 24 jüngere Erwachsene mit dem Mindestbildungsabschluss Abitur zeigten in der Untersuchung entweder ihre volle Leistung oder waren instruiert, entsprechend einem detaillierten Szenario überzeugend kognitive Störungen vorzutäuschen. Neben den drei BVT wurden folgende neuropsychologische Tests durchgeführt: der Trail Making Test (TMT), der Rey Complex Figure Test and Recognition Trial (RCFT), der Test d2, der Judgment of Line Orientation Test (JLO) und das Zahlennachsprechen des HAWIE-R, woraus auch die Reliable Digit Span (RDS) bestimmt wurde. Für den MSVT, den AKGT und die RDS konnten durch Testwiederholung nach zwei bis drei Tagen bzw. Einsatz einer Äquivalenzform des MSVT Reliabilitätsangaben erhalten werden. Für den AKGT und den MSVT-Durchgang Verzögerte Wiedererkennung ergaben sich zufrieden stellende Reliabilitätskoeffizienten (mit Phi-Koeffizienten von je 0.92), die für die RDS niedriger ausfielen (0.74). Die Ergebnisse zeigen auch eine gute Klassifikationsgüte für die BVT und die RDS, die zwischen 100 % (AKGT) und 79 % (One-in-Five Test) lag. Andere Validitätsindikatoren, die aus TMT, d2 und JLO ermittelt werden, schnitten schlechter ab. Während BVT gegenwärtig die best entwickelte Methodenklasse zur Diagnostik suboptimalen Leistungsverhaltens darstellen, sollte die Güte von Beschwerdenvaliditätsindikatoren, die aus Standardtests abgeleitet werden, deutlich besser überprüft werden, bevor ihr Einsatz in der Einzelfalldiagnostik in Frage kommt.


2004 ◽  
Vol 15 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Thomas Merten ◽  
Matthias Henry ◽  
Robin Hilsabeck

Zusammenfassung: In der neuropsychologischen Diagnostik, mehr noch aber in der Begutachtung gewinnen Symptomvalidierungstests (SVT) zur Untersuchung der Leistungsmotivation zunehmend an Bedeutung. In einer Analogstudie wurde die Güte zweier international bekannter Verfahren (Word Memory Test; Amsterdam Short Term Memory Test) sowie einer Neuentwicklung (Word Completion Memory Test) untersucht. Zusätzlich wurden Leistungstests eingesetzt: der Trail Making Test (TMT), der Complex Figure Test sowie die Standard Progressive Matrices (SPM). Eine Gruppe von 10 experimentellen Simulanten wurde spezifisch auf die Vortäuschung von Gedächtnisstörungen vorbereitet, während eine Kontrollgruppe (n = 10) optimale Testanstrengung zeigen sollte. Alle SVT führten im Gegensatz zu den Simulationsmarkern des TMT und der SPM zu einer ausgezeichneten Klassifikationsgüte (95-100 %). Die neuropsychologischen Leistungsmaße wiesen zwar signifikante Gruppenunterschiede aus, zeigten aber auch eine nicht unbedeutende Überlappung der Verteilungen. Mehr Studien sind notwendig, um den SVT in den deutschsprachigen Ländern den Platz zu sichern, den sie international aktuell in der klinisch-neuropsychologischen Forschung und Praxis einnehmen.


2020 ◽  
Vol 10 (2) ◽  
pp. 25 ◽  
Author(s):  
Agostino Chiaravalloti ◽  
Maria Ricci ◽  
Daniele Di Biagio ◽  
Luca Filippi ◽  
Alessandro Martorana ◽  
...  

Background: The study aimed to investigate the relationships between F-18 fluorodeoxyglucose (18F)FDG uptake and neuropsychological assessment in Alzheimer’s disease (AD). Methods: We evaluated 116 subjects with AD according to the NINCDS-ADRDA criteria. All the subjects underwent a brain PET/CT with (18F)FDG, cerebrospinal fluid (CSF) assay, mini-mental state examination (MMSE) and further neuropsychological tests: Rey auditory verbal learning test, immediate recall (RAVLT immediate); Rey auditory verbal learning test, delayed recall (RAVLT, delayed); Rey complex figure test, copy (RCFT, copy); Rey complex figure test, delayed recall (RCFT, delayed); Raven’s colored progressive matrices (RCPM); phonological word fluency test (PWF) and Stroop test. We performed the statistical analysis by using statistical parametric mapping (SPM12; Wellcome Department of Cognitive Neurology, London, UK). Results: A significant relationship has been reported between (18F)FDG uptake and RAVLT immediate test in Brodmann area (BA)37 and BA22 and with RCFT, copy in BA40, and BA7. We did not find any significant relationships with other tests. Conclusion: In the AD population, brain (18F)FDG uptake is moderately related to the neuropsychological assessment, suggesting a limited impact on statistical data analysis of glucose brain metabolism.


1994 ◽  
Vol 24 (3) ◽  
pp. 152-162 ◽  
Author(s):  
Brad C. Shannon ◽  
Shirley G. Tollman

In view of the debate regarding the behavioural sequelae accompanying multiple sclerosis (MS), this study aimed to identify the deficits underlying observed behavioural performance difficulties in 24 MS sufferers. Qualitative and quantitative assessment instruments were employed, that is, Christensen's formalization of Luria's Neuropsychological Investigation, the Trail Making Test and Rey's Complex Figure Test. Results were analysed using syndrome analysis, which proceeded according to a hypothetico-deductive process, based on the principle of double dissociation of function. Five underlying factors were identified, namely: fatigability; information overload; disturbed fine control and integration of skilled motor movements; disturbed attention, concentration and tracking; and, disturbed executive control. Subjects divided into two subgroups. Those in subgroup 1 displayed fatigability, information overload and disturbed fine control and integration of skilled motor movement. In addition to these, subjects in subgroup 2 displayed disturbed attention, concentration and tracking, and disturbed executive skills. The identification of two subgroups may assist in explaining why controversy still surrounds the question of cognitive deficits in MS. It was concluded that the five underlying factors gave rise to a specific pattern of neuropsychological dysfunctioning in subjects consistent with a subcortical syndrome.


2017 ◽  
Vol 87 (2) ◽  
pp. 124-140 ◽  
Author(s):  
Małgorzata T. Piskunowicz ◽  
Katarzyna Linkowska ◽  
Szymon Gołota ◽  
Tomasz Grzybowski ◽  
Kornelia Kędziora-Kornatowska ◽  
...  

The ε4 allele of the apolipoprotein E (APOE) gene is known as a risk factor for dementia. How APOE ε polymorphism affects cognitive performance in nondemented aging subjects remains less clear. In this study, the relationship between APOE status and cognitive performance across various cognitive domains in adults aged 55 to 75 years ( n = 74) without dementia was investigated. E4 carriers ( n = 11) performed worse versus noncarriers on forward Digit Span and delayed recall of the Rey-Osterrieth complex figure. General linear model analysis revealed a small but significant main effect of ε4 on Rey-Osterrieth complex figure delayed recall. Comparing ε2 carriers, ε3 homozygotes, and ε4 carriers, ε3/ε3 performed significantly better on Trail Making Test part B and derived score Trail Making Test B-A. The findings support the relation between the APOE ε polymorphism and visual memory, short-term auditory memory, visuospatial attention, and executive functions in an aging sample without dementia.


1999 ◽  
Vol 84 (10) ◽  
pp. 3681-3685 ◽  
Author(s):  
Elizabeth Barrett-Connor ◽  
Deborah Goodman-Gruen ◽  
Brad Patay

Abstract The objective of this study was to determine whether endogenous sex hormone levels predict cognitive function in older men. Our study design was an exploratory analysis in a population-based cohort in Rancho Bernardo, California. The study participants were 547 community-dwelling men 59–89 yr of age at baseline who were not using testosterone or estrogen therapy. Between 1984 and 1987, sera were collected for measurement of endogenous total and bioavailable testosterone and estradiol levels. Between 1988 and 1991, 12 standard neuropsychological instruments were administered, including two items from the Blessed Information-Memory-Concentration (BIMC) Test, three measures of retrieval from the Buschke-Fuld Selective Reminding Test, a category fluency test, immediate and delayed recall from the Visual Reproduction Test, the Mini-Mental State Examination with individual analysis of the Serial Sevens and the “World” Backwards components, and the Trail-Making Test Part B. In age- and education-adjusted analyses, men with higher levels of total and bioavailable estradiol had poorer scores on the BIMC Test and Mini-Mental State Examination. Men with higher levels of bioavailable testosterone had better scores on the BIMC Test and the Selective Reminding Test (long-term storage). Five associations were U-shaped: total testosterone and total and bioavailable estradiol with the BIMC Test; bioavailable testosterone with the “World” test; and total estradiol with the Trail-Making Test. All associations were relatively weak but independent of age, education, body mass index, alcohol use, cigarette smoking and depression. In these older men, low estradiol and high testosterone levels predicted better performance on several tests of cognitive function. Linear and nonlinear associations were also found, suggesting that an optimal level of sex hormones may exist for some cognitive functions.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Simona Lattanzi ◽  
Michela Coccia ◽  
Alessandra Pulcini ◽  
Claudia Cagnetti ◽  
Federica Lucia Galli ◽  
...  

Abstract The impact of reperfusion therapies on cognition has been poorly explored and little knowledge exists. We explored the influence of endovascular treatment (EVT) on cognitive outcome in patients with anterior circulation ischemic stroke. Patients presenting with ischemic stroke due to anterior large vessel occlusion who underwent intravenous thrombolysis (IVT) alone or EVT plus IVT were recruited. Cognitive abilities were evaluated at 6 months from stroke through a neuropsychological test battery. A total of 88 patients with a mean age of 66.3 ± 12.9 years were included, of which 38 treated with IVT alone and 50 with IVT plus EVT. Compared to patients treated with IVT alone, patients who received EVT plus IVT performed significantly better at the neuropsychological tests exploring executive functions, attention, abstract reasoning, visuospatial ability, visual and verbal and memory. At multivariable regression analysis, the EVT was independently associated with the 6-month cognitive performance after the adjustment for age, sex, admission National Institutes of Health Stroke Scale score, systolic blood pressure, glucose level, Alberta Stroke Program Early CT score, side of stroke, site of occlusion, and Back Depression Inventory score [Stroop Test Word Reading: adjβ = 13.99, 95% confidence interval (CI) 8.47–19.50, p < 0.001; Stroop Test Colour Naming: adjβ = 6.63, 95% CI 2.46–10.81, p = 0.002; Trail Making Test-A: adjβ = − 92.98, 95% CI − 153.76 to − 32.20, p = 0.003; Trail Making Test-B: adjβ = − 181.12, 95% CI − 266.09 to − 96.15; p < 0.001; Digit Span Test Forward: adjβ = 1.44, 95% CI 0.77–2.10, p < 0.001; Digit Span Test Backward: adjβ = 1.10, 95% CI 0.42–1.77, p = 0.002; Coloured Progressive Matrices: adjβ = 5.82, 95% CI 2.71–8.93, p < 0.001; Rey Complex Figure Test-Copy: adjβ = 6.02, 95% CI 2.74–9.30, p < 0.001; Rey Complex Figure Test-Immediate recall: adjβ = 6.00, 95% CI 2.34–9.66, p = 0.002; Rey Complex Figure Test-Delayed recall: adjβ = 5.73, 95% CI 1.95–9.51, p = 0.003; Rey Auditory Verbal Learning Test-Immediate recall: adjβ = 12.60, 95% CI 6.69–18.52, p < 0.001; Rey Auditory Verbal Learning Test-Delayed recall: adjβ = 1.85, 95% CI 0.24–3.45, p = 0.025]. Patients treated with EVT plus IVT had better cognitive performance than patients treated with IVT alone at 6 months from anterior circulation ischemic stroke.


2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Pukovisa Prawiroharjo ◽  
Hainah Ellydar ◽  
Peter Pratama ◽  
Rizki Edmi Edison ◽  
Sitti Evangeline Imelda Suaidy ◽  
...  

We aimed to find the differences in memory capabilities between pornography-addicted and nonaddicted juveniles. We enrolled 30 juveniles (12–16 y) consisting of 15 pornography addiction and 15 nonaddiction subjects. We used Rey Auditory Verbal Learning Test (RAVLT) to measure verbal memory, Rey–Osterrieth Complex Figure Test (ROCFT) for visual memory, along with Trail Making Test A and B (TMT-A and TMT-B) for attention. We found a significant reduction in the RAVLT A6 result of the addiction group (nonaddiction vs addiction: 13.47 ± 2.00 vs 11.67 ± 2.44, MD = −1.80, p=0.04), but not in ROCFT or attention tests. Analysis in sex subgroups yielded no sex-specific difference. We concluded that pornography addiction may be associated with impaired recent verbal memory in juveniles, regardless of sex and without association to attention.


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