A novel route for aspartame production by combining enzymatic and chemical reactions for industrial use
Keyword(s):
ABSTRACT Here, we report a novel industrial aspartame production route, involving the enzymatic production of α-l-aspartyl-l-phenylalanine β-methylester from l-aspartic acid dimethylester and l-phenylalanine by α-amino acid ester acyl transferase. The route also involves the chemical transformation of α-l-aspartyl-l-phenylalanine β-methylester to α-l-aspartyl-l-phenylalanine methylester hydrochloride (aspartame hydrochloride) in an aqueous solution with methanol and HCl, followed by HCl removal to form aspartame.
2013 ◽
Vol 77
(3)
◽
pp. 618-623
◽
2011 ◽
Vol 75
(11)
◽
pp. 2087-2092
◽
Keyword(s):
Keyword(s):
Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir
2001 ◽
Vol 90
(5)
◽
pp. 615
◽
Keyword(s):
2012 ◽
Vol 40
(1)
◽
pp. 413-424
◽
2016 ◽
Vol 302
(2)
◽
pp. 1600318
◽