scholarly journals P-P06 Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: a feasibility randomised controlled trial [ISRCTN 36077283]

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Farid Froghi ◽  
Fiammetta Soggiu ◽  
Federico Ricciardi ◽  
Cecilia Vindrola-Padros ◽  
Lefteris Floros ◽  
...  

Abstract Background Goal directed fluid therapy (GDFT) based on cardiac output assessment has been shown to reduce complications and improve survival for people undergoing major general surgery. There are no reports of cardiac output evaluation being used to optimise the fluid administration for patients with acute pancreatitis who are in a general surgery admission ward. Methods The trial protocol has been published. 50 patients with acute pancreatitis were recruited, consented and randomly allocated to either ward-based GDFT with intravenous (IV) fluids administered based on stroke volume optimisation or standard ward care but with blinded cardiac output evaluation for 48 hours following hospital admission. Results Over a period of 20 months 50 of 142 screened patients were recruited demonstrating that it was feasible to recruit into a randomised trial of this nature in ward patients with acute pancreatitis. 36 (72%) completed the allocated 48 hours of goal directed fluids with 10 (20%) discharged within 48 hours and 4 withdrawals (3 GDFT and 1 SC).  Baseline characteristics of the groups were similar with only 3 participants having severe disease (6%, 1 GDFT, 2 SC). Similar volumes of IV fluids were administered in both groups (GDFT 5465 (1839) ml, SC 5211 (1745) ml). GDFT group had a lower heart rate, blood pressure and respiratory rate and improved oxygen saturations. GDFT was not associated with any harms. Complications of AP appear to be similar as was duration of stay in intensive care. Length of hospital stay was 5 (2.9) in GDFT and 6.3 (7.6) in SC groups. Conclusions Ward GDFT is feasible and shows a signal of possible efficacy in acute pancreatitis in this early-stage study. A larger multi-site RCT is required to confirm clinical and cost effectiveness.

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e028783 ◽  
Author(s):  
Farid Froghi ◽  
Fiammetta Soggiu ◽  
Federico Ricciardi ◽  
Kurinchi Gurusamy ◽  
Daniel S Martin ◽  
...  

IntroductionAcute pancreatitis is an inflammatory disease of the pancreas with high risk of developing multiorgan failure and death. There are no effective pharmacological interventions used in current clinical practice. Maintaining fluid and electrolyte balance is the mainstay of supportive management. Goal-directed fluid therapy (GDFT) has been shown to decrease morbidity and mortality in surgical conditions with systemic inflammatory response. There is currently no randomised controlled trial (RCT) investigating the role of GDFT based on cardiac output parameters in patients with acute pancreatitis in the ward setting. A feasibility trial was designed to determine patient and clinician support for recruitment into an RCT of ward-based GDFT in acute pancreatitis, adherence to a GDFT protocol, safety, participant withdrawal, and to determine appropriate endpoints for a subsequent larger trial to evaluate efficacy.Methods and analysisThe GDFT in Acute Pancreatitis trial is a prospective two-centre feasibility RCT. Eligible adults admitted with new onset of acute pancreatitis will be enrolled and randomised into ward-based GDFT (n=25) or standard fluid therapy (n=25) within 6 hours from the diagnosis and continuing for the following 48 hours. Cardiac output parameters will be monitored with a non-invasive device (Cheetah NICOM; Cheetah Medical). The intervention group will consist of a protocolised GDFT approach consisting of stroke volume optimisation with crystalloid fluid boluses, while the control group will receive standard care fluid therapy as advised by the clinical team. The primary endpoint is feasibility. Secondary endpoints will include safety of the intervention, complications, mortality, admission to intensive care unit, cost and quality of life.Ethics and disseminationEthics approval was granted by the London Central Research Ethics Committee (17/LO/1235, project ID: 221872). The results of this trial will be presented to international conference with interest in general surgery and acute care and published in a peer-reviewed journal.Trial registration numberISRCTN36077283.


2008 ◽  
Vol 6 (2) ◽  
pp. 0-0
Author(s):  
Audrius Andrijauskas ◽  
Juozas Ivaškevičius ◽  
Manvilius Kocius ◽  
Narūnas Porvaneckas

Audrius Andrijauskas1,  Juozas Ivaškevičius1, Manvilius Kocius2,  Narūnas Porvaneckas21 Vilniaus universiteto Anesteziologijos ir reanimatologijos klinika, Šiltnamių g. 29, LT-04130 Vilnius2 Vilniaus universiteto Reumatologijos, ortopedijos, traumatologijos, plastinės ir rekonstrukcinėschirurgijos klinika, Šiltnamių g. 29, LT-04130 VilniusEl paštas: [email protected] Perioperacinis skysčių ir kraujo komponentų skyrimas yra labai svarbi chirurginio paciento perioperacinio gydymo dalis, neatskiriama anestezijos ir intensyviosios terapijos priemonė. Tai turi daug reikšmės širdies, inkstų ir plaučių funkcijai, audinių oksigenacijai ir žaizdų gijimui, pooperacinei žarnyno motorikai ir kraujo krešėjimui, komplikacijų dažniui ir hospitalizacijos laikui, paciento savijautai ir optimaliam gydymo išteklių naudojimui. Nors žinios apie skysčių terapijos ypatumus perioperaciniu laikotarpiu pastaraisiais metais reikšmingai išsiplėtė, klinikinėje praktikoje vis dar lieka daugiau klausimų negu atsakymų. Dar dažnai atliekama per daug intensyvi skysčių terapija, dėl to per didelis krūvis tenka širdies ir kraujagyslių sistemai, skatinama organų disfunkcija. Neapakankamai skiriant skysčių, skatinama žarnyno išemija, taigi ir sepsis, dauginės organų disfunkcijos vystymasis. Daug vilčių teikia naujas metodas – į tikslą nukreipta skysčių terapija (angl. goal-directed fluid therapy). Šiuo metodu stebimas minutinio širdies tūrio atsakas į pakartotinius bandomuosius infuzijos tūrius. Kai atsakas tampa nereikšmingas, toliau skirti skysčių yra netikslinga ir net pavojinga. Šioje apžvalgoje aprašoma, kaip panašiai gali būti stebimas arterinio kraujospūdžio atsakas į skysčių infuziją, kai gydoma perioperacinė hipotenzija. Priimant perioperacinės eritrocitų transfuzijos sprendimą, irgi išlieka daug neapibrėžtumo. Dėl to gydytojų pasirenkamos individualios taktikos įvairovė yra didelė. Taigi instituciniai standartai ir algoritmai yra veiksmingiausia darnios kolektyvinės klinikinės praktikos priemonė. Pastaruoju metu skatinama kurti į chirurginę intervenciją ir individą nukreiptus skysčių terapijos metodus ir kraujo transfuzijos algoritmus. Šioje apžvalgoje ne tik apibendrinami perioperacinės skysčių terapijos ypatumai atliekant planinį kelio ir klubo endoprotezavimą, bet ir pateikiami autorių sukurti nauji algoritmai, kuriuose skysčių terapija susieta su sprendimais perpilti kraujo. Pagrindiniai žodžiai: anemija, kraujas, transfuzija, algoritmas Issues of perioperative transfusion and fluid therapy in elective total hip and knee arthroplasty surgery Audrius Andrijauskas1,  Juozas Ivaškevičius1, Manvilius Kocius2,  Narūnas Porvaneckas21 Vilnius University Clinic of Anaesthesiology and Intensive Care, Vilnius UniversityClinic of Anaesthesiology and Intensive Care, Šiltnamių 29 LT-04130 Vilnius-43, Lithuania2 Vilnius University Clinic of Rheumatology, Orthopaedics, Traumatology, Plastic andReconstructive Surgery, Šiltnamių 29, LT-04130 Vilnius-43, LithuaniaE-mail: [email protected] Fluid and red cell administration is a critical component of perioperative treatment in major surgery. It is apparent from the literature that operating a normohydrated patient is associated with fewer complications and a shorter hospital stay. However, numerous patients receive excessive fluid therapy with the resulting volume overload and organ dysfunction. Oedema contributes to tissue hypoxia, delayed wound healing and an increased risk of infection. On the other hand, inadequate fluid resuscitation promotes gut ischaemia which is one of the initiating causes of sepsis and multi-organ failure. Therefore, optimizing the patients’ perioperative hydration may improve the clinical outcome. However, traditionally used haemodynamic parameters, such as arterial blood pressure, central venous or pulmonary arthery wedge pressures, are unreliable for optimizing fluid therapy. The most promising method, the “goal-directed fluid therapy”, implies that cardiac output is measured before and after consequitive intravenous test-fluid loads. The procedure is repeated until no further increase in cardiac output is achieved. In such a way the circualting blood volume is optimized so that cardiac output is maximized. Similarly, in the treatment of perioperative hypotension, the blood pressure response to the test-fluid load can be monitored, suggesting that the patient will not benefit from the further fluid infusion when the haemodynamic response becomes inadequate. The transfusion decission-making continues being a never-ending debate. Acknowledging the need for surgery and patient specific strategies in perioperative fluid management and transfusion decision-making, as well as the existing variability in individual practices, in this review the authors introduced their new algorithms applicable to patients who undergo elective total hip and knee arthroplasty. Keywords: anemia, blood, fluid, transfusion, algorithm


2019 ◽  
Vol 45 ◽  
pp. 45-53 ◽  
Author(s):  
Laurence Weinberg ◽  
Damian Ianno ◽  
Leonid Churilov ◽  
Steven Mcguigan ◽  
Lois Mackley ◽  
...  

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