scholarly journals Cholesterogenic Effects of Whey Protein Isolate Supplementation in Women with Polycystic Ovary Syndrome

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 581-581
Author(s):  
Shenavia Balcom-Luker ◽  
Kayleigh Kaiser ◽  
Irene Low ◽  
Emily Zumbro ◽  
K Shane Broughton ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Total Cholesterol ◽  
Whey Protein ◽  
Polycystic Ovary ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Long Term Effects ◽  
Ovary Syndrome ◽  
Short And Long Term

Abstract Objectives The current study examined the short- and long-term effects of whey protein isolate ingestion on circulating Low-Density Lipoprotein (LDL) and total cholesterol (TC) concentrations in women with polycystic ovary syndrome (PCOS). PCOS is a disorder characterized by reproductive, metabolic and endocrine disruption in women of reproductive age. Nutritional management options are limited. Whey protein isolate (WPI) improves metabolic parameters in patients with type 2 diabetes, but its therapeutic potential in polycystic women has yet to be realized. Women with PCOS have altered metabolic profiles and are more likely to develop liver disorders such as non-alcoholic fatty liver disease (NAFLD). Given the association between PCOS and NAFLD, we hypothesized that supplementation with WPI may attenuate circulating LDL and TC in a polycystic population. Methods Fifteen premenopausal women with PCOS and fourteen healthy, regularly menstruating women underwent three 150-min oral glucose tolerance tests (OGTT): (i) OGTT without protein preload, (ii) OGTT on 20th, and (iii) 40th day of protein preload. Participants consumed 35g protein daily with protein intake 30 min before carbohydrate load on test days. Plasma levels of LDL and total cholesterol were assessed at baseline, day 20 and day 40 to determine short- and long-term effects using a Biolis 24i chemistry analyzer. (Participant recruitment, data collection and analyses in progress.) Results Preliminary data indicates that time and condition (PCOS vs control) did not have a significant effect on LDL or TC levels within and between groups (P > .05). However, disease condition had a significant impact on LDL (P < .001) and TC (P = .001) concentrations. Changes in LDL and TC levels after 40 days of protein preload are currently being analyzed. Conclusions Women with PCOS have higher levels of LDL and TC than those without this condition. While short-term effects of 35g WPI ingestion do not seem to alter these levels, a longer duration of supplementation may induce more beneficial effects (currently being conducted). Findings from this study may provide foundational support for WPI as a nutritional treatment for women with PCOS. Funding Sources Glanbia Nutritionals, INC and Human Nutrition Research Funds, Texas Woman's University.

Metabolic Effects of Whey Protein Isolate Supplementation on Cholesterol and Triglycerides in Women with Polycystic Ovary Syndrome

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Shenavia Balcom-Luker ◽  
Kayleigh Kaiser ◽  
Emily L. Zumbro ◽  
Manisha Rao ◽  
Irene Low ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Whey Protein ◽  
Polycystic Ovary ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Metabolic Effects ◽  
Ovary Syndrome

scholarly journals Influence of Whey Protein Isolate Supplementation on ALT and AST in Women with Polycystic Ovary Syndrome (P08-067-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Shenavia Balcom-Luker ◽  
Manisha Rao ◽  
K Shane Broughton ◽  
Monique LeMieux
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Whey Protein ◽  
Polycystic Ovary ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Short Term ◽  
Management Options ◽  
Ovary Syndrome ◽  
Alcoholic Fatty Liver ◽  
Short Term Effects

Abstract Objectives The current study examined the short- and long-term effects of whey protein isolate ingestion on plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in women with polycystic ovary syndrome (PCOS). PCOS, an endocrine abnormality in women of reproductive age, is characterized by menstrual cycle disturbance, hyperandrogenism and obesity. Nutritional management options are limited. Whey protein isolate (WPI) improves metabolic parameters in patients with type 2 diabetes, but its therapeutic potential in polycystic women has yet to be realized. Women with PCOS have altered metabolic profiles and are more likely to develop liver disorders such as non-alcoholic fatty liver disease (NAFLD). Given the association between PCOS and NAFLD, we hypothesized that supplementation with WPI may attenuate circulating ALT and AST in a polycystic population. Methods Eleven premenopausal women with PCOS and ten healthy, regularly menstruating women underwent four 150-min oral glucose tolerance tests (OGTT): (i) OGTT without protein preload, (ii) OGTT on 1st, (iii) 7th, and (iv) 60th day of protein preload. Participants consumed 35 g protein daily with protein intake 30 min before carbohydrate load on test days. Plasma levels of ALT and AST were assessed at baseline, day 1 and day 7 to determine short-term effects on liver stress using a Biolis 24i chemistry analyzer. (Participant recruitment, data collection and analyses in progress.) Results Mixed Model Repeated Measure ANOVA indicates that time and condition (PCOS vs control) did not have a significant effect on ALT or AST levels within and between groups (P > .05). However, preliminary data indicate that condition had a significant impact on ALT (P < .001) and AST (P = .001) concentrations. Changes in ALT and AST levels after 60 days of protein preload are currently being analyzed. Conclusions Women with PCOS have higher levels of AST and ALT than those without this condition. While short-term effects of 35 g WPI ingestion do not seem to alter these levels, a longer duration of supplementation may induce more beneficial effects (currently being conducted). Findings from this study may provide foundational support for WPI as a nutritional treatment for PCOS and possible alleviation of liver stress. Funding Sources Glanbia Nutritionals, INC, and TWU Human Nutrition Research Funds.

scholarly journals Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome

2016 ◽  
Vol 29 (7-8) ◽  
pp. 441 ◽  
Author(s):  
Rita Luz ◽  
Joana Barros ◽  
Ana Aguiar ◽  
Cátia Rodrigues ◽  
Ana Paula Soares ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Predictive Factors ◽  
Polycystic Ovary ◽  
University Hospital ◽  
Ovary Syndrome ◽  
Short And Long Term ◽  
Ovarian Diathermy ◽  
Anovulatory Infertility ◽  
Laparoscopic Ovarian Diathermy

Introduction: Polycystic ovary syndrome is the most frequent cause of anovulatory infertility and management involves a multistep approach. Laparoscopic ovarian diathermy is accepted as a second-line treatment of patients who failed to respond to clomiphene citrate. The aims of this study were to determine the efficacy of this technique at short and long-term and to perform an analysis of predictive factors of spontaneous pregnancy.Material and Methods: This retrospective study involved 76 women who underwent laparoscopic ovarian diathermy between 2004 and 2013 in a university hospital. Main outcomes were cycle regularity and pregnancy. Short-term outcomes recorded during followup in our centre were reviewed and long-term outcomes were evaluated by a telephone interview to all women whose surgery was undertaken more than three years ago. Clinical and biochemical data were analysed as predictive factors of spontaneous conceptionin patients without other infertility factors.Results: Menstrual cycle regularity was initially achieved in 53 (70%) women and in the long-term follow-up subgroup, 52% (12/23) had regular periods. In general, 53 (70%) women conceived and 77 pregnancies were achieved, 60% of which were spontaneous. The only prognostic factor found to be significantly associated with spontaneous conception was a shorter duration of infertility (< 3 years) (p < 0.05).Discussion: Laparoscopic ovarian diathermy showed pregnancy rates comparable to other ovulation induction treatments with the advantage of having a long lasting beneficial effect in menstrual regularity and fertility.Conclusion: Laparoscopic ovarian diathermy is a safe and effective treatment option for anovulatory infertility in women with polycystic ovary syndrome.

Pharmacologic Treatment of Polycystic Ovary Syndrome: Alternate and Future Paths

2017 ◽  
Vol 35 (04) ◽  
pp. 326-343
Author(s):  
Richard Legro ◽  
Luciana Duguech
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Metabolic Dysfunction ◽  
Long Term Effects ◽  
Ovary Syndrome ◽  
Gonadotropin Secretion ◽  
Regulatory Pathways ◽  
Recent Developments ◽  
Genetic And Environmental Factors

AbstractPolycystic ovary syndrome (PCOS) is a complex disorder which interacts with other genetic and environmental factors to cause dysregulation of steroidogenesis and anovulation as well as insulin resistance. Treatments which address the long-term effects of this unique combination of reproductive and metabolic dysfunction are needed. Over the past decade, new insights into the genetic factors of PCOS and biotechnological advances have led to potential treatments for women with PCOS. These treatments include both new potent pharmaceutical compounds and repurposed drugs which target different steps in metabolic-reproductive pathways to improve long-term health of women with PCOS. These new therapies target key enzymes involved in steroidogenesis, regulatory pathways of gonadotropin secretion, or lower oxidative stress. We review in this article the current common treatments of PCOS, recent developments in the field, and current information on the mode of action, efficacy, and safety of emerging therapeutic compounds.

Polycystic Ovary Syndrome: Long-term Effects

1993 ◽  
Vol 25 (4) ◽  
pp. 307-308 ◽  
Author(s):  
Eva Dahlgren ◽  
Per Olof Janson
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Long Term Effects ◽  
Ovary Syndrome
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