scholarly journals Dairy Consumption and Risk of Cancer: An 11 Year Prospective Cohort Study of the China Kadoorie Biobank

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1046-1046
Author(s):  
Maria Kakkoura ◽  
Huaidong Du ◽  
Timothy Key ◽  
Zhengming Chen
Keyword(s):  
Breast Cancer ◽  
Liver Cancer ◽  
Dairy Products ◽  
Smoking Status ◽  
Female Breast Cancer ◽  
Chinese Adults ◽  
Dairy Intake ◽  
Dairy Consumption ◽  
Female Breast ◽  
Risk Of Cancer

Abstract Objectives Consumption of dairy products has been associated with possible higher or lower risks of some types of cancer. However, results are often inconsistent and evidence from China, particularly for prospective data, is very limited. We therefore investigated the associations between intake of dairy products and incidence of 17 common cancers in Chinese adults. Methods The prospective China Kadoorie Biobank study recruited slightly over 0.5 million adults, aged 30–79 years, from ten diverse regions (five urban and five rural) in China during 2004–2008. Information on the consumption frequency of major food groups, including total dairy products, was collected at baseline and periodic resurveys, using a validated interviewer-administered laptop-based questionnaire. Over a mean follow-up of 10.8 years, 29,177 incident malignant cancer cases were recorded among the 510,146 study participants, who did not have a prior history of cancer at baseline. Cox regression analyses were performed to estimate hazard ratios (HRs) for incident cancers associated with dairy intake. Analyses were stratified by age-at-risk, sex and region, and adjusted for cancer family history, education, income, alcohol intake, smoking status, physical activity, fresh fruit intake and BMI. Analyses for liver cancer was additionally adjusted for status of hepatitis B surface antigen. Results Overall at baseline, 68.5% of participants reported never or rare dairy consumption and 20.4% reported weekly dairy consumption (≥1 day/week), with milk accounting largely for the total dairy consumption. The multivariable-adjusted HRs per 50 g/day increase in usual dairy consumption were 1.07 (95% CI 1.04–1.10), 1.12 (1.02–1.22), 1.19 (1.01–1.41) and 1.17 (1.07–1.29) for total cancer, liver cancer, lymphoma and female breast cancer, respectively. These associations were similar across subgroups defined by baseline sociodemographic and lifestyle characteristics (e.g., sex and smoking status) and across the ten survey regions. No significant associations were observed between dairy intake and risk of the other 14 common cancer sites. Conclusions In this large study of Chinese adults, higher consumption of dairy products was associated with higher risks of liver cancer, lymphoma and female breast cancer. Funding Sources Wellcome Trust.

scholarly journals Type 2 Diabetes and Risk of Incident Cancer in China: A Prospective Study Among 0.5 Million Chinese Adults

2018 ◽  
Vol 187 (7) ◽  
pp. 1380-1391 ◽  
Author(s):  
Xiong-Fei Pan ◽  
Meian He ◽  
Canqing Yu ◽  
Jun Lv ◽  
Yu Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Type 2 Diabetes ◽  
Liver Cancer ◽  
Female Breast Cancer ◽  
Chinese Adults ◽  
Female Breast ◽  
Incident Cancer ◽  
Increased Risk ◽  
Total Cancer

Abstract Using data from the China Kadoorie Biobank Study, we conducted a prospective investigation on the association between type 2 diabetes mellitus (T2DM) and cancer risk in Chinese adults. A total of 508,892 participants (mean age = 51.5 (standard deviation, 10.7) years) without prior cancer diagnosis at baseline (2004–2008) were included. We documented 17,463 incident cancer cases during follow-up through December 31, 2013. Participants with T2DM had increased risks of total and certain site-specific cancers; hazard ratios were 1.13 (95% confidence interval (CI): 1.07, 1.19) for total cancer, 1.51 (95% CI: 1.29, 1.76) for liver cancer, 1.86 (95% CI: 1.43, 2.41) for pancreatic cancer, and 1.21 (95% CI: 1.01, 1.47) for female breast cancer. The associations were largely consistent when physician-diagnosed and screen-detected T2DM were analyzed separately, except for colorectal cancer (for physician-diagnosed T2DM, HR = 0.91 (95% CI: 0.73, 1.13), and for screen-detected T2DM, HR = 1.44 (95% CI: 1.18, 1.77)). In participants without a prior diagnosis of T2DM, higher random blood glucose levels were positively associated with risks of total cancer, liver cancer, and female breast cancer (all P’s for trend ≤ 0.02). In conclusion, T2DM is associated with an increased risk of new-onset cancer in China, particularly cancers of the liver, pancreas, and female breast.

Abstract P178: Dairy Consumption and Risk of Becoming Overweight or Obese in Middle-Aged and Older Women.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Susanne Rautiainen ◽  
Lu Wang ◽  
I-Min Lee ◽  
JoAnn E Manson ◽  
Julie E Buring ◽  
...  
Keyword(s):  
Body Weight ◽  
Dairy Products ◽  
Smoking Status ◽  
Health Study ◽  
High Fat ◽  
Low Fat ◽  
Dairy Intake ◽  
Dairy Consumption ◽  
History Of

Background: Dairy products have been positively associated with weight loss and inversely associated with weight gain. However, limited number of studies has investigated the role of dairy consumption in the prevention of becoming overweight or obese. The aim of this study was to prospectively investigate how consumption of dairy products was associated with the risk of becoming overweight or obese among initially normal-weight women. Methods: We studied 19,180 women aged ≥45y from the Women’s Health Study free of cardiovascular disease (CVD), cancer, and diabetes with an initial body mass index (BMI) of 18.5-<25 kg/m 2 . Dairy intake was assessed through a 131-item food-frequency questionnaire. Total dairy intake was defined as the sum of servings per day of low-fat dairy products (skim/low-fat milk, sherbet, yogurt, and cottage/ricotta cheese) and high-fat dairy products (whole milk, cream, sour cream, ice cream, cream cheese, other cheese, and butter). Women self-reported body weight along with obesity-related risk factors on baseline and annual follow-up questionnaires. In multivariable-adjusted analyses, we included the following covariates: baseline age, randomization treatment, BMI, smoking status, vigorous exercise, postmenopausal status, postmenopausal hormone use, history of hypercholesterolemia, history of hypertension, multivitamin use, alcohol intake, total energy intake, and fruit and vegetable intake. Results: During a mean follow-up of 11.2y (216,979 person-years), 8,582 women became overweight or obese (BMI ≥25 kg/m 2 ). The multivariable-adjusted mean changes in body weight (95% confidence interval (CI)) during the follow-up were 3.9 (3.5-4.3), 3.9 (3.5-4.2), 3.8 (3.5-4.2), 3.7 (3.4-4.1), and 3.4 (3.0-3.7) lbs in quintiles 1-5 of total dairy consumption (P-trend: 0.01), respectively. In multivariable-adjusted analyses (Table 1) , women in the highest versus lowest quintile of had a rate ratio (RR) of 0.91 (0.84-0.98, P-trend: 0.16) of becoming overweight or obese. No associations were observed in highest quintiles of low-fat dairy and high-fat dairy intakes. Conclusion: Greater consumption of dairy products may be inversely ssociated with risk of becoming overweight or obese in women.

Treatment disparities in female breast cancer patients according to race, ethnicity and socioeconomic status

2013 ◽  
Author(s):  
Christopher S. Bartlett ◽  
Tulay Koru-Sengul ◽  
Feng Miao ◽  
Stacey L. Tannenbaum ◽  
David J. Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Socioeconomic Status ◽  
Cancer Patients ◽  
Female Breast Cancer ◽  
Breast Cancer Patients ◽  
Female Breast ◽  
Treatment Disparities ◽  
Race Ethnicity

scholarly journals 165P Comparison of male and female breast cancer in reference hospital in Mexico

2021 ◽  
Vol 32 ◽  
pp. S90-S91
Author(s):  
G. Sanchez ◽  
A. Gutierrez ◽  
J.C. Jímenez ◽  
R. Correa ◽  
J.A. Alegría Baños ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Female Breast Cancer ◽  
Male And Female ◽  
Female Breast ◽  
Reference Hospital

scholarly journals Socio-Economic Position, Cancer Incidence and Stage at Diagnosis: A Nationwide Cohort Study in Belgium

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 933
Author(s):  
Michael Rosskamp ◽  
Julie Verbeeck ◽  
Sylvie Gadeyne ◽  
Freija Verdoodt ◽  
Harlinde De Schutter
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Cohort Study ◽  
Cancer Incidence ◽  
Regression Models ◽  
Female Breast Cancer ◽  
Stage At Diagnosis ◽  
Female Breast ◽  
Economic Parameters ◽  
Economic Position

Background: Socio-economic position is associated with cancer incidence, but the direction and magnitude of this relationship differs across cancer types, geographical regions, and socio-economic parameters. In this nationwide cohort study, we evaluated the association between different individual-level socio-economic and -demographic factors, cancer incidence, and stage at diagnosis in Belgium. Methods: The 2001 census was linked to the nationwide Belgian Cancer Registry for cancer diagnoses between 2004 and 2013. Socio-economic parameters included education level, household composition, and housing conditions. Incidence rate ratios were assessed through Poisson regression models. Stage-specific analyses were conducted through logistic regression models. Results: Deprived groups showed higher risks for lung cancer and head and neck cancers, whereas an inverse relation was observed for malignant melanoma and female breast cancer. Typically, associations were more pronounced in men than in women. A lower socio-economic position was associated with reduced chances of being diagnosed with known or early stage at diagnosis; the strongest disparities were found for male lung cancer and female breast cancer. Conclusions: This study identified population groups at increased risk of cancer and unknown or advanced stage at diagnosis in Belgium. Further investigation is needed to build a comprehensive picture of socio-economic inequality in cancer incidence.

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