Higher Dietary Intake of Resveratrol Was Associated with Lower Risk of Hip Fracture- a 1:1 Matched Case-control Study in Chinese Elderly (OR18-07-19)

Abstract Objectives In vitro and animal experiments suggest that resveratrol (RVS) could improve bone health by alleviation of bone mineral and strength loss. However, there has been no epidemiologic evidence linking habitual resveratrol consumption with fracture risk. The aim of the study was to testify the association of habitual RSV consumption with hip fracture risk in Chinese elderly. Methods This was a 1:1 age- and gender- matched case–control study among Chinese elderly. Eligible cases were newly diagnosed (within 2-week). Dietary survey was conducted by a 79-item validated food frequency questionnaire. The habitual intake of RSV was estimated as the sum of trans-and cis-resveratrol and trans- and cis-piceid based on the available database of Phenol Explorer. Multivariate conditional logistic regression was applied to examine the relationship of dietary RSV and RSV rich foods with the risk of hip fracture. Results A total of 1070 pairs of hip fracture incident cases and controls were included in the analysis, with an average age of 70.6 y and body mass index (BMI) of 22.5 kg/m2. The controls were recruited from both community (82.3%) and hospital (17.7%). The average total RSV intake was 178.6 μg/d and 96.6% participants had no habitual red wine consumption. After adjustment of a range of potential confounders, comparing with the lowest quartile, the highest quartile group had a reduced hip fracture risk by 80.2% (OR: 0.198, 0.099∼0.394) for total RSV, and 46.7% (OR: 0.533, 0.319∼0.890) for grapes intake in a significant dose-response manner across the quartiles (all P for trend < 0.001). Similar findings were observed for cis- and trans-RSV, as well as cis- and trans-Piceid. Sensitivity analysis with exclusion of patients with chronic disorders made little change in the results. Subgroup analyses indicated that the findings were consistent across gender (men and women), BMI (below or above median), physical activities (below or above median), supplementation of calcium (yes or no), as well as habitual tea drinking (yes or no). Conclusions Our findings indicated that higher dietary RSV was associated with a reduced risk of hip fracture in Chinese elderly. As dietary intake of RSV is modifiable, this finding would be of public health importance with respect to fracture prevention in elderly. Funding Sources This work was jointly supported by the National Natural Science Foundation of China (Grants 81773416, 30872100 and 81072299).

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A 1:1 matched case-control study on dietary protein intakes and hip fracture risk in Chinese elderly men and women

Osteoporosis International ◽

10.1007/s00198-021-05960-0 ◽

2021 ◽

Author(s):

Z.-m. Liu ◽

Q. Huang ◽

S.-y. Li ◽

Y.-p. Liu ◽

Y. Wu ◽

...

Keyword(s):

Hip Fracture ◽

Fracture Risk ◽

Dietary Protein ◽

Case Control Study ◽

Case Control ◽

Elderly Men ◽

Men And Women ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

British Journal Of Nutrition ◽

10.1017/s0007114521002956 ◽

2021 ◽

pp. 1-26

Author(s):

Xue-min Huang ◽

Yan-hua Liu ◽

Han Zhang ◽

Yuan Cao ◽

Wei-feng Dou ◽

...

Keyword(s):

Vitamin D ◽

Dietary Intake ◽

Pregnant Women ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Serum Concentrations ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

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Risk factors for second hip fracture in elderly patients: an age, sex, and fracture type matched case–control study

European Journal of Orthopaedic Surgery & Traumatology ◽

10.1007/s00590-021-02996-0 ◽

2021 ◽

Author(s):

Tomoki Fujita ◽

Yasuhiko Takegami ◽

Kei Ando ◽

Yasuomi Sakai ◽

Hiroatsu Nakashima ◽

...

Keyword(s):

Risk Factors ◽

Hip Fracture ◽

Elderly Patients ◽

Case Control Study ◽

Case Control ◽

Fracture Type ◽

Second Hip Fracture ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Low 25(OH) D serum levels are related with hip fracture in postmenopausal women: a matched case–control study

Journal of Translational Medicine ◽

10.1186/s12967-015-0756-x ◽

2015 ◽

Vol 13 (1) ◽

Cited By ~ 3

Author(s):

Xing-Mao Fu ◽

Shao-Guang Fan ◽

Shu-Liang Li ◽

Yi-Sheng Chen ◽

Hai Wu ◽

...

Keyword(s):

Hip Fracture ◽

Postmenopausal Women ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Dietary Protein Intakes Were Associated with Lowered Hip Fracture Risk -A 1:1 Age- and Gender- Matched Case-Control Study Among Chinese Elderly Men and Women

Current Developments in Nutrition ◽

10.1093/cdn/nzaa061_071 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1443-1443

Author(s):

Zhao-min Liu ◽

Qi Huang ◽

Shuyi Li ◽

Yu-Ming Chen

Keyword(s):

Hip Fracture ◽

Fracture Risk ◽

Protein Intake ◽

Case Control Study ◽

Case Control ◽

Elderly Men ◽

Chinese Elderly ◽

Men And Women ◽

Hip Fracture Risk ◽

Control Study

Abstract Objectives Protein has been identified as being both detrimental and beneficial to bone health, depending on a variety of factors such as the amount of dietary protein intake, the protein sources, calcium intake and supplementation, weight change, and the acid/base balance of the diet. Studies examining the relationship between dietary protein and bone health have reported conflicting findings. Thus, the aim of current study was to investigate the association of protein in diet with hip fracture risk among Chinese elderly. Methods This was an age- and sex-matched 1:1 case-control study among 1070 pairs of Chinese elderly men and women aged 55 to 80 years. Dietary intakes were evaluated by a validated food frequency questionnaire for estimation of dietary total protein, protein from different sources, dietary amino acids profile, estimated renal acid load in diet and other nutrients intake. Multivariable conditional logistic regression models were used to examine the relationship of protein intake with hip fracture risk in elderly. Results Multivariable regression models in both men and women indicated that, compared with the lowest quartile, the highest energy adjusted total protein [OR: 0.360(0.206∼0.630) for women and 0.381(0.153∼0.949) for men] and animal protein [0.326(0.183, 0.560) for women and 0.335(0.136∼0.828) for men] were significantly associated with the lowered risk of hip fracture in a notable dose-response manner (all p for trend < 0.05). A significant hip fracture risk reduction was observed in women but not in men with higher intakes of dietary sulfur amino acids [OR: 0.464 (0.286∼0.753)] and aromatic amino acids [0.537(0.326∼0.884)]. Subgroup analysis suggested that these associations remained similar for different sources of controls and regular calcium supplementation (yes and no), while more evident in elderly with lower body mass index and lower dietary source of calcium intakes. Conclusions This case-control study among Chinese elderly men and women suggest that a higher level of protein intake is associated with lowered hip fracture risk. Given the prevalence of osteoporosis and sarcopenia, increase of total protein intakes should be recommended in Chinese elderly. Funding Sources This work was jointly supported by the National Natural Science Foundation of China (Grants 81,773,416, 30,872,100 and 81,072,299).

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