scholarly journals Isoflavone Stability Quality Control Assessment of Q-CAN® Plus, a Novel Fermented Soy Beverage (P12-034-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Wajahat Mehal ◽  
Eric Secor ◽  
Theresa Weiss ◽  
Maxine Fields ◽  
Michael Leapman ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Quality Control ◽  
Microbial Contamination ◽  
Soy Isoflavones ◽  
Third Party ◽  
Biological Research ◽  
Residual Solvents ◽  
Funding Sources ◽  
Relevant Dose ◽  
Mold And Yeast

Abstract Objectives The purpose of this investigation is to validate the soy isoflavone content, 24 months stability and quality control of “Q-CAN® Plus,” a novel fermented soy beverage imported from China. Methods Q-CAN® Plus was independently tested through third-party laboratories for: Soy isoflavones, microbial contamination, herbicides, pesticides, fungicides, heavy metals and residual solvents. To evaluate the potency or stability, total soy isoflavones were measured over 24 months through accelerated (40 degrees Celsius 75% relative humidity) and shelf (ambient temperature) and microbial contamination evaluated. Results Upon initial analysis Q-CAN® Plus contained 290.12 mg of total soy isoflavones. Microbial contamination, mold and yeast were absent or WNLs. Product was free of herbicides, pesticides, fungicides, heavy metals and residual solvents. The mean total isoflavones was 303.23 mg +/− 11.5 mg (SD). The 24-month stability testing in both the accelerated chamber (12 mo = 294 mg, 24 mo = 318 mg) and shelf (12 mo = 304 mg, 24 mo = 310 mg) determined that total soy isoflavones did not significantly change in potency, and microbiology analysis at each time point revealed no contamination. Conclusions In this first independent evaluation of Q-CAN® Plus it was determined that the manufacturer's Certificate of Analysis was validated, soy isoflavones remained stable over 24 months, and microbial contamination was absent. Q-CAN® Plus is a functional beverage that provides a high quality, clinically relevant dose of soy isoflavones. Future investigations will determine the clinical benefit of this natural fermented soy beverage. Funding Sources Beso Biological Research, Inc.

scholarly journals Infant Formula: An Analysis of the Contents of Plant-Based vs. Whey-Based Formulas (P11-056-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jaclyn Bowen MPH
Keyword(s):  
Analytical Chemistry ◽  
Heavy Metals ◽  
Antioxidant Activity ◽  
Infant Formula ◽  
Third Party ◽  
Chemistry Laboratory ◽  
Infant Formulas ◽  
Nutritional Content ◽  
Funding Sources ◽  
Nutritional Benefits

Abstract Objectives Assess the nutritional and environmental consistencies and differences between plant-based (soy) infant formulas and whey-based infant formulas While the nutritional contents are similar, there is significant variability in the levels of heavy metal in soy-based infant formulas than whey-based infant formulas Methods • Clean Label Project utilized the Amazon.com best sellers list to identify and purchase the top selling infant formulas in America from national and local grocers and e-retailers. • Clean Label Project had the products analyzed by an accredited analytical chemistry laboratory for antioxidant activity, nutritional content, and over 130 industrial and environmental contaminants and toxins including heavy metals (lead, cadmium, arsenic, and mercury) and endocrine disruptors (BPA, BPS). • The samples were blinded prior to testing by the laboratory to avoid any real or perceived perception of bias • Analytical chemistry instrumentation including ICP-MS, LCMS-MS, and GCMS • A variety of statistical applications were used to identify data trends Results • The nutritional content was largely consistent • Infant Formulas consistently yielded high test results for antioxidant activity (a product trait not typically marketed in the category) • Soy-based infant formulas had higher quantities of heavy metals than whey-based infant formulas Conclusions • Additional studies are needed to assess the health outcomes from children raised on plant-based vs. dairy-based infant formulas to assess any correlations to the higher quantity of heavy metals • The nutritional benefits of antioxidants in infant formula should be highlighted as a beneficial product attribute by brands Funding Sources Clean Label Project is a 501c3 which gets its funding from donations, it's Amazon.com affiliate and Smiles beneficiary status, it's third party certification service offering, and private grants.

Development of a centralized approach to conducting interlaboratory proficiency tests

2021 ◽  
pp. 428-434
Author(s):  
Светлана Владимировна Габова ◽  
Анастасия Александровна Трусагина ◽  
Михаил Евгеньевич Артёмов
Keyword(s):  
Quality Control ◽  
Control System ◽  
Oil Quality ◽  
Third Party ◽  
Quality Control System ◽  
Proficiency Tests ◽  
Testing Program ◽  
Testing Laboratories ◽  
Measurement Results ◽  
Reliability Of Measurement Results

Важнейшим звеном системы контроля качества нефти являются испытательные лаборатории, от компетентности которых зависит достоверность результатов измерений и эффективность управленческих решений, принимаемых с учетом полученных данных. Одним из способов подтверждения достоверности результатов измерений является проверка квалификации лаборатории посредством ее участия в межлабораторных сличительных (сравнительных) испытаниях (МСИ). В настоящей статье рассмотрены вопросы проведения таких испытаний для лабораторий организаций системы «Транснефть». Описан действующий порядок, предполагающий участие лабораторий в МСИ в регионах своего местонахождения, при этом разработкой и реализацией программы проверки квалификации занимаются сторонние организации - провайдеры МСИ. Такая практика имеет существенные недостатки, не позволяя, в том числе, систематизировать и обобщить результаты МСИ для общей оценки деятельности испытательных лабораторий ПАО «Транснефть». В статье представлен централизованный подход к проведению МСИ в ПАО «Транснефть», устанавливающий единый порядок участия лабораторий в испытаниях с целью осуществления общей оценки квалификации лабораторий, своевременной разработки и реализации предупреждающих и корректирующих мероприятий по улучшению деятельности лабораторий, усовершенствования системы контроля качества нефти на объектах ПАО «Транснефть». The most important link in the oil quality control system are testing laboratories, the competence of which determines the reliability of measurement results and the effectiveness of management decisions based on the data obtained. One way to confirm the validity of measurement results is to verify the laboratory qualifications through its participation in interlaboratory proficiency (comparative) tests (IPT). This article considers the issues of such tests for the laboratories of Transneft system entities. The current procedure is described, which involves the participation of laboratories in the IPT in the regions of their location, while the development and implementation of the proficiency testing program is carried out by third-party IPT provider organizations. This practice has significant drawbacks, not allowing, among other things, to systematize and summarize the results of IPT for an overall assessment of the activities of Transneft PJSC’s testing laboratories. The article presents a centralized approach to conducting IPT in Transneft PJSC, which establishes a unified procedure for the participation of laboratories in tests in order to implement an overall assessment of laboratory qualification, timely development and implementation of preventive and corrective measures to improve the performance of laboratories and improve the oil quality control system at the Transneft PJSC facilities.

scholarly journals Intake of Commercially Produced Fermented Soy Powder Q CAN PLUS® Favorably Changes Cholesterol and Isoflavone Intake in Individuals at High Risk of Cardiovascular Disease

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 408-408
Author(s):  
Sarah Jung ◽  
Rawiwan Sirirat ◽  
Alice Kim ◽  
Ella Haddad ◽  
Joan Sabaté
Keyword(s):  
Cardiovascular Diseases ◽  
High Risk ◽  
Food Product ◽  
Placebo Treatment ◽  
Soy Isoflavones ◽  
Biological Research ◽  
Cvd Risk ◽  
Total Carbohydrate ◽  
Placebo Phase ◽  
Soy Powder

Abstract Objectives Q CAN PLUS® is a fermented soy powder currently marketed in the US as a food product. We conducted a feeding trial to examine the effects of Q CAN PLUS® on the nutrient composition of the habitual diets of individuals at high risk of cardiovascular diseases. We hypothesized that the nutrient profile, particularly nutrients associated with CVD risk, differs among individuals in the Q CAN PLUS® phase compared to the placebo phase. Methods Study design was a randomized, controlled crossover intervention with twenty-four free living adults (29–75 years old; 80% female; 8% normal BMI, 45% overweight, 47% obese) at high risk of cardiovascular diseases. Subjects were randomized to receive either Q CAN PLUS® (fermented soy) powder or placebo powder for twelve weeks and switched over to the placebo treatment after two weeks of wash out period. Two 24-hour dietary recalls were collected during each phase which included one weekday and one weekend dietary recall. The nutrient consumption per day (mean ± SD) were based on a synthetic week by using the following formula: ((weekday * 5) +(weekday * 2))/7. Results On average, intake of cholesterol (211 ± 169 mg) was 13% lower (P = 0.05) in the Q CAN PLUS® phase compared to placebo (243 ± 179 mg). Total soy isoflavones (444 ± 210 mg) was 12 times higher (P < 0.0001) during Q CAN PLUS® phase than the placebo phase (33 ± 93 mg). Dietary total carbohydrate, total protein, vegetable protein, animal protein during Q CAN PLUS® phase were not statistically different from placebo phase. Conclusions The differences in the intake of cholesterol and total soy isoflavones may have implications on risk of cardiovascular diseases. Funding Sources BESO Biological Research Inc Diamond Bar, CA, USA.

scholarly journals Content of heavy metals in Gentiana lutea L. roots and galenic forms

2007 ◽  
Vol 72 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Dragoja Radanovic ◽  
Svetlana Antic-Mladenovic ◽  
Miodrag Jakovljevic ◽  
Mirjana Kresovic
Keyword(s):  
Heavy Metals ◽  
Quality Control ◽  
Soil Analysis ◽  
Root Tissue ◽  
Raw Material ◽  
Potential Hazard ◽  
Gentiana Lutea ◽  
Liquid Extract ◽  
Very High

An experimental field for the cultivated production of Gentiana lutea L. was established five years ago at the Suvobor Mountain, Serbia. Soil analysis of this area revealed the occurrence of high pseudo-total (Ni - 1270 mg/kg, Cr - 423 mg/kg, Co - 385 mg/kg) and available (especially Ni - 133 mg/kg) heavy metals contents in the soil. Hence, the aim of this research was to evaluate the quality of Gentiana lutea L. - roots and galenic forms (liquid extract in 70 % ethanol, spissum and siccum) produced from the roots, because, for most plants, heavy metals accumulate in the root tissue. The amounts of Ni and Cr found in the analyzed roots were very high (54 mg/kg and 14 mg/kg, respectively). The efficiency of ethanol in extracting heavy metals from the roots varied depending on the particular element. The highest efficiency was obtained for Ni (41.3 %), then for Cd (39.5 %), Pb (37.0%) and Co (30.4 %). According to this, a potential hazard exists for humans, if gentian's galenic forms are produced from the raw material with high heavy metals contents. It is concluded that quality control of the raw material must be carried out before further utilization of gentian. .

Lactobacillus plantarum ZJ316 improves the quality of Stachys sieboldii Miq. pickle by inhibiting harmful bacteria growth and degrading nitrite, promoting the gut microbiota health in vitro

2022 ◽  
Author(s):  
Shu Ting Hang ◽  
Ling zhou Zeng ◽  
Jia run Han ◽  
Zhong qin Zhang ◽  
Qingqing Zhou ◽  
...  
Keyword(s):  
Quality Control ◽  
Lactic Acid ◽  
Lactobacillus Plantarum ◽  
Microbial Contamination ◽  
Nitrite Accumulation ◽  
Bacteria Growth ◽  
Lactobacillus Plantarum Zj316 ◽  
Stachys Sieboldii

Microbial contamination and nitrite accumulation are two major concerns on the quality control of fermented vegetables. In the present study, a lactic acid bacteria strain Lactobacillus plantarum ZJ316 (ZJ316) was...

AssesINS;s/INS;ment of the performance of two quality control materials, in-kit and a new third party control, for anti-Müllerian hormone in cobas e411 analyzer

2019 ◽  
Vol 493 ◽  
pp. S511-S512
Author(s):  
M. Simón Velasco ◽  
N. Rodríguez Roca ◽  
M.J. González Villalba ◽  
P. Fernández-Calle ◽  
A.L. Qasem Moreno ◽  
...  
Keyword(s):  
Quality Control ◽  
Third Party ◽  
Party Control ◽  
Quality Control Materials

scholarly journals Assessment of heavy metals and microbial contamination of gari from Liberia

2017 ◽  
Vol 6 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Wasiu Awoyale ◽  
Robert Asiedu ◽  
William K. C. Kawalawu ◽  
Busie Maziya-Dixon ◽  
Adebayo Abass ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Microbial Contamination

scholarly journals Automated glycan assembly using the Glyconeer 2.1 synthesizer

2017 ◽  
Vol 114 (17) ◽  
pp. E3385-E3389 ◽  
Author(s):  
Heung Sik Hahm ◽  
Mark K. Schlegel ◽  
Mattan Hurevich ◽  
Steffen Eller ◽  
Frank Schuhmacher ◽  
...  
Keyword(s):  
Quality Control ◽  
Peptide Synthesis ◽  
Medical Practice ◽  
Building Blocks ◽  
Solid Support ◽  
Biological Research ◽  
Structure Activity Relationships ◽  
Rapid Access ◽  
Structure Activity ◽  
Control Protocols

Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure–activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosaccharides using the commercially available Glyconeer 2.1 automated glycan synthesizer, monosaccharide building blocks, and a linker-functionalized polystyrene solid support. Purification and quality-control protocols for the oligosaccharide products have been standardized. Synthetic glycans prepared in this way are useful reagents as the basis for glycan arrays, diagnostics, and carbohydrate-based vaccines.

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