Effectiveness of an outpatient urine screening program.

1977 ◽  
Vol 23 (12) ◽  
pp. 2216-2218 ◽  
Author(s):  
C G Fraser ◽  
B C Smith ◽  
M J Peake
Keyword(s):  
Screening Program ◽  
Hospital Costs ◽  
Significant Benefit ◽  
Sample Population ◽  
Urine Screening ◽  
Positive Action ◽  
Abnormal Test Result ◽  
Laboratory Investigations ◽  
Test Result ◽  
Significant Bearing

Abstract We evaluated the effectiveness of a routine outpatient urinalysis screening program on a sample population of 2600 patients. The 189 abnormal urine results found in 182 patients were followed up by study of any new clinical and laboratory investigations or therapeutic modifications initiated on the basis of any abnormal test result. The urinalysis screening program appeared to have significant bearing on diagnosis or treatment in only 13 patients. Abnormalities found in 150 of the 182 patients were either not noted or no further positive action was taken. Thus we concluded that under the conditions of this study the urine screening program added to hospital costs without significant benefit to the patient.

scholarly journals Neonatal Urine Screening Program in the Province of Quebec: Technological Upgrade from Thin Layer Chromatography to Tandem Mass Spectrometry

2021 ◽  
Vol 7 (1) ◽  
pp. 18
Author(s):  
Christiane Auray-Blais ◽  
Michel Boutin ◽  
Pamela Lavoie ◽  
Bruno Maranda
Keyword(s):  
Mass Spectrometry ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Clinical Symptoms ◽  
Screening Program ◽  
Compliance Rate ◽  
Inborn Errors ◽  
Organic Acidurias ◽  
Urine Screening ◽  
Layer Chromatography

The Quebec Neonatal Urine Screening Program was initiated in 1971 with overall screening inception of newborns in 1973. Forty-seven years later, over 3.5 million babies have been screened for up to 25 inborn errors of metabolism divided into two groups: (1) urea cycle disorders and organic acidurias; and (2) disorders of amino acid metabolism and transport. The main goal of this preventive genetic medicine program is the detection of treatable diseases before the onset of clinical symptoms. Urine specimens from 21-day-old babies are collected and dried on filter paper by parents at home. The participation is voluntary with a high compliance rate over the years (~90%). Specimens are analyzed by thin layer chromatography (TLC). The main objective of this evaluative research project was to assess the feasibility of a technological upgrade towards mass spectrometry. A 2.85-min flow injection method was devised, normal values established, and abnormal profiles confirmed using second-tier tests. The validated assays are sensitive, specific, and suitable for populational screening, as well as for high-risk screening laboratories. Triple H syndrome, which would not be detected in newborns by blood screening at two days of age was found to be positive in the urine of an affected patient.

Frequency of the delta Phe508 mutation and correlation with XV.2c/KM-19 haplotypes in an American population of cystic fibrosis patients: results of a collaborative study

1990 ◽  
Vol 36 (10) ◽  
pp. 1741-1746 ◽  
Author(s):  
W E Highsmith ◽  
G L Chong ◽  
H T Orr ◽  
T R Perry ◽  
D Schald ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Haplotype Analysis ◽  
Screening Program ◽  
Collaborative Study ◽  
Population Based ◽  
Carrier Status ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Phenylalanine Residue ◽  
Test Result

Abstract The cystic fibrosis (CF) gene has been recently cloned, and a deletion of 3 basepairs (bp) of DNA was found on most of the CF chromosomes. This deletion leads to the synthesis of a protein that lacks a phenylalanine residue at position 508. Using two polymerase chain reaction protocols to study the frequency of this mutation in a series of 192 CF patients, we found the mutation on 72% of affected chromosomes. We then used this value to calculate the predictive value of a negative test result in a population-based screening program for CF carrier status. Haplotype analysis with the polymorphic markers XV.2c and KM-19 on 239 CF chromosomes revealed that 90.7% of CF chromosomes with the deletion had a single haplotype. This haplotype was also associated with 60.4% of CF chromosomes with unknown mutations. These values can be used to calculate the probability of whether an individual from the general population is a carrier of any CF mutation.

scholarly journals A Study of the Effect of Parental Education and Occupation on the Study Habits of Class XI Science Students of Aizawl City

2021 ◽  
Vol 5 (2) ◽  
pp. 20-31
Author(s):  
Zairemmawia Renthlei
Keyword(s):  
Parental Education ◽  
Occupational Status ◽  
Educational Status ◽  
Study Habits ◽  
Secondary Science ◽  
Statistical Techniques ◽  
Sample Population ◽  
Science Students ◽  
Study Habit ◽  
Significant Bearing

It has been often said home is the first school and parents the first teachers. A child’s education is greatly affected by his environment including the home. As parents are major figures in the home, their education and occupational status would be expected to have bearing on the educational performance of a child. A study was conducted among secondary science students of Aizawl City Mizoram to examine if parental education and occupational status would have significant bearing on the study habits of the child. A sample population of 512 students from 8 schools was examined and the Study Habit Inventory developed by Dr. M. Mukhopadhyay and Dr. D. N. Sansanwal was used for the purpose of the study. Statistical techniques such as t-test were used to analyse the data and the study found that the study habits of children were affected only by the educational status of the mothers.

Parental Response to Repeat Testing of Infants with `False-Positive' Results in a Newborn Screening Program

PEDIATRICS ◽  
1984 ◽  
Vol 73 (2) ◽  
pp. 183-187
Author(s):  
James R. Sorenson ◽  
Harvey L. Levy ◽  
Thomas W. Mangione ◽  
Stephen J. Sepe
Keyword(s):  
Newborn Screening ◽  
Screening Program ◽  
Testing Procedure ◽  
Sufficient Information ◽  
Test Results ◽  
Initial Test ◽  
Newborn Screening Program ◽  
Repeat Testing ◽  
Repeat Test ◽  
Test Result

Forty-five percent of the parents of 60 infants being retested in a newborn screening program for metabolic disorders understood that their infant was undergoing retesting because the first test result was abnormal. Fifty-five percent had incorrect or incomplete information, believing that retesting was routine, or that mistakes had been made in the original testing procedure, or they report being told nothing specific about the testing. Parents who were aware that the initial test was abnormal were no more anxious or depressed while waiting for the repeat test results than other parents. At a second interview after learning the normal results of the repeat test, both those parents informed of the initial abnormal result as well as those not informed were less anxious and depressed. However, 36% of the parents of these normal infants reported concern about the health of their infant because of the repeat testing. This concern was not related to a parent's knowledge that the initial test result was abnormal, but was greater in parents reporting that they had not received sufficient information about the screening/testing process and its significance for the health of their infant.

scholarly journals Routine Screening of Blood and Urine for Severe Anticonvulsant Reactions in Asymptomatic Patients is of Doubtful Value

1989 ◽  
Vol 16 (3) ◽  
pp. 361-363 ◽  
Author(s):  
Peter Camfield ◽  
Carol Camfield ◽  
Joseph Dooley ◽  
Kevin Farrell ◽  
Pierre Langevin ◽  
...  
Keyword(s):  
Screening Program ◽  
Child Neurology ◽  
Urine Screening ◽  
Basic Assumptions ◽  
Routine Blood ◽  
Canadian Association ◽  
Asymptomatic Patients ◽  
Anticonvulsant Medication ◽  
Toxic Reactions ◽  
Special Risk

ABSTRACT:On rare occasions anticonvulsant medication may cause severe or fatal toxic reactions. This position paper, approved by the Canadian Association for Child Neurology, examines the value of routine blood and urine screening to prevent catastrophic reactions in asymptomatic patients. The basic assumptions of such a screening program are faulty or unproven. Although not definitive, available studies of screening do not appear to support its value. It is recommended that routine blood and urine screening be discontinued in asymptomatic patients. Until such time as further research is able to identify patients at special risk, it is suggested that patients be carefully informed of the early symptoms of severe toxic reactions and report these immediately to a physician.

Levels of anxiety and distress following receipt of positive screening tests in Australia’s HPV-based cervical screening programme: a cross-sectional survey

2020 ◽  
Vol 96 (3) ◽  
pp. 166-172 ◽  
Author(s):  
Rachael Helen Dodd ◽  
Olivia Mac ◽  
Julia M L Brotherton ◽  
Erin Cvejic ◽  
Kirsten J McCaffery
Keyword(s):  
Online Survey ◽  
Screening Program ◽  
Cervical Screening ◽  
Screening Tests ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
General Distress ◽  
Hpv Test ◽  
Hpv Screening ◽  
Test Result

ObjectiveFrom December 2017, the Australian National Cervical Screening Program commenced 5 yearly primary human papillomavirus (HPV) screening; one of the first high-income countries to implement primary HPV screening. This study aimed to examine the psychosocial impact of self-reporting testing HPV positive in a sample of women screened since the renewal of the programme.MethodsWomen in Australia aged 25–74 years who reported participating in cervical screening since December 2017 were recruited through an online market research company to complete a cross-sectional survey. The primary outcomes were anxiety and general distress.Results1004 women completed the online survey; 80.9% reported testing HPV negative (HPV−), 6.5% reported testing HPV positive (HPV+) and 12.9% did not know/remember their test result. Women who reported testing HPV+ had significantly poorer psychological outcomes on a range of measures. Those who reported testing HPV+ had higher anxiety scores (53.03 vs 43.58 out of 80, p<0.001), showed more general distress (3.94 vs 2.52 out of 12, p=0.004), concern about their test result (5.02 vs 2.37, p<0.001), expressed greater distress about their test result (7.06 vs 4.74, p<0.001) and cancer worry (quite or very worried 35.4% vs 11.6%, p<0.001) than women who reported testing HPV−. Concern regarding test results was also significantly higher in women who did not know/remember their test result (3.20 vs 2.37, p<0.001) compared with women who reported testing HPV−. Women who reported testing HPV+ had greater knowledge of HPV (9.25 vs 6.62, p<0.001) and HPV testing (2.44 vs 1.30, p<0.001) than women who reported testing HPV−.ConclusionsReceipt of an HPV+ test result was associated with high levels of anxiety and distress, which reached clinical significance. Further work is needed to understand whether distress and concern could be reduced by ensuring all women receive high-quality standardised information with their results or by other interventions.

Follow-up on the diagnostic level of children covered by the Universal Neonatal Hearing Screening Program in Poland, divided into voivodships

2019 ◽  
Vol 73 (3) ◽  
pp. 1-5
Author(s):  
Grażyna Greczka ◽  
Monika Zych ◽  
Piotr Dąbrowski ◽  
Anna Gasińska ◽  
Anna Król ◽  
...  
Keyword(s):  
Telephone Survey ◽  
Screening Program ◽  
Hearing Screening ◽  
Actual Number ◽  
Number Of Children ◽  
Neonatal Hearing Screening ◽  
Central Database ◽  
Universal Neonatal Hearing Screening ◽  
Test Result

Introduction: Thanks to the Polish Universal Neonatal Hearing Screening Program (PUNHSP), All newborns in Poland undergo a free, screening hearing examination. Between 2006 and 2015, the average number of tested children per year was 373,477. According to the analysis of The Central Database(CDB), only 55.8% of the children attended the detailed hearing examinations at the second level of the Program. Aim: The aim of this study is to analyze the dates concerning the attendance of the children at the diagnostic level of PUNHSP in different regions of Poland. Materials and methods: To conduct an analysis of this fact and find out the reasons for the low attendance at the second level in 2015, a telephone survey questionnaire was developed for parents whose children had not registered for further consultation - 3,239 randomly selected parents. Results: The analysis revealed that the number of children examined at the second diagnostic level of the program is in fact much higher than the results of The Central Database show. The actual number is 83.6% as opposed to 55,8%. As a result of the telephone questionnaire, some inaccuracies in the input data to the CDB were detected. The main errors involved in the gathering of information for the CDB was the incorrect OAE test result and the lack of performed examination. Conclusion: In Poland, the worst results for the attendance to the diagnostic level (the results were a comparison of the questionnaire results compared to the CDB) was shown in Pomorskie, Lubelskie, Mazowieckie, and Podlaskie regions. In many cases, there was a large difference in reality to what the information in the CDB claimed. The improvement of clarity concerning the CDB application is important in order to minimize the possibility of malformation in the CDB.

scholarly journals International practice variation in perioperative laboratory testing in glioblastoma patients—a retrospective cohort study

2022 ◽  
Author(s):  
Joeky T. Senders ◽  
Sybren L. N. Maas ◽  
Kaspar Draaisma ◽  
John J. McNulty ◽  
Joanna L. Ashby ◽  
...  
Keyword(s):  
Laboratory Testing ◽  
Laboratory Tests ◽  
Medical Center ◽  
Standard Of Care ◽  
Perioperative Period ◽  
Practice Variation ◽  
Survival Status ◽  
Clinical Consequences ◽  
Abnormal Test Result ◽  
Test Result

Abstract Purpose Although standard-of-care has been defined for the treatment of glioblastoma patients, substantial practice variation exists in the day-to-day clinical management. This study aims to compare the use of laboratory tests in the perioperative care of glioblastoma patients between two tertiary academic centers—Brigham and Women’s Hospital (BWH), Boston, USA, and University Medical Center Utrecht (UMCU), Utrecht, the Netherlands. Methods All glioblastoma patients treated according to standard-of-care between 2005 and 2013 were included. We compared the number of blood drawings and laboratory tests performed during the 70-day perioperative period using a Poisson regression model, as well as the estimated laboratory costs per patient. Additionally, we compared the likelihood of an abnormal test result using a generalized linear mixed effects model. Results After correction for age, sex, IDH1 status, postoperative KPS score, length of stay, and survival status, the number of blood drawings and laboratory tests during the perioperative period were 3.7-fold (p < 0.001) and 4.7-fold (p < 0.001) higher, respectively, in BWH compared to UMCU patients. The estimated median laboratory costs per patient were 82 euros in UMCU and 256 euros in BWH. Furthermore, the likelihood of an abnormal test result was lower in BWH (odds ratio [OR] 0.75, p < 0.001), except when the prior test result was abnormal as well (OR 2.09, p < 0.001). Conclusions Our results suggest a substantially lower clinical threshold for ordering laboratory tests in BWH compared to UMCU. Further investigating the clinical consequences of laboratory testing could identify over and underuse, decrease healthcare costs, and reduce unnecessary discomfort that patients are exposed to.

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