Effects of estrogen on mineral metabolism in postmenopausal women as evaluated by multiple assays measuring parathyrin bioactivity.

Abstract Data on the effect of estrogen on immunoreactive parathyrin (iPTH) in postmenopausal women are conflicting. We administered estrogen or placebo to 21 postmenopausal women for 12 weeks and measured PTH bioactivity (bioPTH), using the renal cytochemical bioassay. Before treatment, there was a negative correlation between nephrogenous cAMP and the tubular maximum for urinary phosphate excretion and a positive correlation between values measured by a mid-region-specific PTH RIA and those measured in an immunoradiometric assay for intact PTH. Values measured by the midregion-specific RIA were also positively correlated with nephrogenous cAMP. BioPTH values were not correlated with other indices of PTH activity but were increased compared with values for younger subjects. After estrogen treatment there was no change in bioPTH activity despite an early decrease in serum osteocalcin and a later increase in nephrogenous cAMP. PTH concentrations measured by mid-region-specific or intact RIAs were unchanged, but sample size may have been insufficient to exclude the possibility of significant changes in these values. The effects of estrogen on mineral metabolism in postmenopausal women are time-dependent. Early effects are independent of PTH, and later effects are variably associated with increased PTH activity.

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Intact parathyrin in postmenopausal women.

Clinical Chemistry ◽

10.1093/clinchem/34.2.407 ◽

1988 ◽

Vol 34 (2) ◽

pp. 407-410 ◽

Cited By ~ 23

Author(s):

L J Sokoll ◽

F D Morrow ◽

D M Quirbach ◽

B Dawson-Hughes

Keyword(s):

Parathyroid Hormone ◽

Confidence Interval ◽

Postmenopausal Women ◽

Calcium Homeostasis ◽

Negative Correlation ◽

Reference Range ◽

Normal Population ◽

Significant Negative Correlation ◽

Intact Pth ◽

The Mean

Abstract To establish a reference range, we measured intact parathyrin (parathyroid hormone, PTH) in 245 healthy postmenopausal women, ages 42-75 years, with use of the Allegro Intact PTH Kit from Nichols Institute Diagnostics. We also assayed serum from a subset of 120 of the women with kits specific for mid-molecule PTH. The mean intact PTH concentration for the 245 women was 32 ng/L (95% confidence interval 14-60 ng/L). Intact PTH values in these subjects were not normally distributed, although calcium concentrations in the same samples were. There was positive, but not significant (r = 0.12, P = 0.06), correlation between intact PTH and age, and a significant negative correlation between serum calcium and intact PTH that was not observed between calcium and mid-molecule PTH. The improved sensitivity of the intact PTH assay makes it useful in studies of calcium homeostasis in the normal population.

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Mapping Urban Environmental Performance with Emerging Data Sources: A Case of Urban Greenery and Traffic Noise in Sydney, Australia

Sustainability ◽

10.3390/su13020605 ◽

2021 ◽

Vol 13 (2) ◽

pp. 605

Author(s):

Zahra Nourmohammadi ◽

Tanapon Lilasathapornkit ◽

Mudabber Ashfaq ◽

Ziyuan Gu ◽

Meead Saberi

Keyword(s):

Negative Correlation ◽

Seasonal Variations ◽

Environmental Performance ◽

Traffic Noise ◽

Time Dependent ◽

Data Sources ◽

Street Level ◽

Urban Greenery ◽

Key Aspects ◽

Sydney Australia

Measuring urban environmental performance supports understanding and improving the livability and sustainability of a city. Creating a more livable and attractive environment facilitates a greater shift to active and greener transport modes. Two key aspects, among many others, that determine the environmental performance of an urban area are greenery and noise. This study aims to map street-level greenery and traffic noise using emerging data sources including crowd-sourced mobile phone-based data and street-level imagery data in Sydney, Australia. Results demonstrate the applicability of emerging data sources and the presented advanced techniques in capturing the seasonal variations in urban greenery and time-dependent nature of traffic noise. Results also confirm the presence of a negative correlation between urban greenery and traffic noise.

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Time-Dependent Effects of Vitamin K2 (Menatetrenone) on Bone Metabolism in Postmenopausal Women.

Endocrine Journal ◽

10.1507/endocrj.49.363 ◽

2002 ◽

Vol 49 (3) ◽

pp. 363-370 ◽

Cited By ~ 32

Author(s):

RIEKO OZURU ◽

TOSHITSUGU SUGIMOTO ◽

TOHRU YAMAGUCHI ◽

KAZUO CHIHARA

Keyword(s):

Bone Metabolism ◽

Postmenopausal Women ◽

Vitamin K2 ◽

Time Dependent

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Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

Acta Endocrinologica ◽

10.1530/eje-09-0585 ◽

2009 ◽

Vol 161 (5) ◽

pp. 723-729 ◽

Cited By ~ 128

Author(s):

Mi Zhou ◽

Xiaojing Ma ◽

Huating Li ◽

Xiaoping Pan ◽

Junling Tang ◽

...

Keyword(s):

Regression Analysis ◽

Lipid Metabolism ◽

Glucose Tolerance ◽

Lipid Profile ◽

Postmenopausal Women ◽

Multiple Logistic Regression Analysis ◽

Premenopausal Women ◽

Diabetic Patients ◽

Model Assessment ◽

Serum Osteocalcin

ObjectivesOsteocalcin, a bone-derived protein, has recently been reported to affect energy metabolism. We investigated the relationship between serum osteocalcin and parameters of adiposity, glucose tolerance, and lipid profile in Chinese subjects.MethodsSerum osteocalcin was measured by electrochemiluminescence immunoassay in 254 men (128 with newly diagnosed type 2 diabetes mellitus (T2DM) and 126 with normal glucose tolerance (NGT)), 66 premenopausal women (33 with T2DM and 33 with NGT) as well as 180 postmenopausal women (92 with T2DM and 88 with NGT). Their associations with parameters of adiposity, glucose tolerance, and lipid profile were examined.ResultsSerum osteocalcin concentrations in diabetic patients were significantly lower than those in NGT subjects after adjusted for age, gender, and body mass index (P=0.003). Postmenopausal women had higher osteocalcin concentrations than premenopausal women and men (both P<0.001). Multiple stepwise regression analysis showed that age, %fat, high-density lipoprotein cholesterol, fasting plasma glucose, and fasting serum insulin were independently associated with osteocalcin in men (P<0.05). Age and HbA1c were independently correlated with osteocalcin in postmenopausal women. Besides age and HbA1c, serum triglyceride was also an independent factor influencing osteocalcin in premenopausal women. In addition, osteocalcin was also positively associated with homeostasis model assessment of β-cell function. Furthermore, multiple logistic regression analysis demonstrated that osteocalcin was independently associated with T2DM.ConclusionsSerum osteocalcin was closely associated with not only fat and glucose metabolism but also with lipid metabolism.

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