Low Skeletal Muscle Index Adjusted for Body Mass Index Is an Independent Risk Factor for Inflammatory Bowel Disease Surgical Complications

Abstract Background This study aims to evaluate sarcopenia defined by skeletal muscle index (SMI) with cutoffs adjusted for sex and body mass index as a predictive marker for postoperative outcomes among individuals with inflammatory bowel disease. Methods The SMI was measured using the cross-sectional computed tomography images at the lumbar spine. Multivariate logistic regression was performed to identify independent risk factors of postoperative complications. Results Ninety-one patients were included in the study. In multivariate analysis, sarcopenia (odds ratio = 5.37; confidence interval: 1.04–27.6) was predictive of infectious postoperative complications. Conclusions Sarcopenia as defined by the SMI is a predictor for 30-day postoperative infection complications in inflammatory bowel disease surgeries.

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Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0144872 ◽

2015 ◽

Vol 10 (12) ◽

pp. e0144872 ◽

Cited By ~ 28

Author(s):

Jie Dong ◽

Yi Chen ◽

Yuchen Tang ◽

Fei Xu ◽

Chaohui Yu ◽

...

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Inflammatory Bowel Disease ◽

Body Mass ◽

Bowel Disease ◽

Meta Analysis ◽

Inflammatory Bowel

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P159 Body mass index in the lower or upper quartile is a marker of severe disease course in children with inflammatory bowel disease

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjx180.286 ◽

2018 ◽

Vol 12 (supplement_1) ◽

pp. S177-S177

Author(s):

A Yerushalmy-Feler ◽

S Cohen

Keyword(s):

Body Mass Index ◽

Inflammatory Bowel Disease ◽

Body Mass ◽

Bowel Disease ◽

Severe Disease ◽

Disease Course ◽

Inflammatory Bowel

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Relation of Body Mass Index to Risk of Developing Inflammatory Bowel Disease: Evidence for two Types of Crohn's Disease

Gastroenterology ◽

10.1016/s0016-5085(17)33295-x ◽

2017 ◽

Vol 152 (5) ◽

pp. S972

Author(s):

Michael A. Mendall ◽

Maria C. Harpsoe ◽

Devinder Kumar ◽

Mikael Andersson ◽

Tine Jess

Keyword(s):

Body Mass Index ◽

Inflammatory Bowel Disease ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Body Mass ◽

Bowel Disease ◽

Inflammatory Bowel

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High and low body mass index may predict severe disease course in children with inflammatory bowel disease

Scandinavian Journal of Gastroenterology ◽

10.1080/00365521.2018.1464595 ◽

2018 ◽

Vol 53 (6) ◽

pp. 708-713 ◽

Cited By ~ 9

Author(s):

Anat Yerushalmy-Feler ◽

Amir Ben-Tov ◽

Yael Weintraub ◽

Achiya Amir ◽

Tut Galai ◽

...

Keyword(s):

Body Mass Index ◽

Inflammatory Bowel Disease ◽

Body Mass ◽

Bowel Disease ◽

Severe Disease ◽

Disease Course ◽

Low Body Mass Index ◽

Inflammatory Bowel

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Risk Factors for Low Bone Density in Inflammatory Bowel Disease: Use of Glucocorticoids, Low Body Mass Index, and Smoking

Digestive Diseases ◽

10.1159/000496935 ◽

2019 ◽

Vol 37 (4) ◽

pp. 284-290 ◽

Cited By ~ 7

Author(s):

Razi Even Dar ◽

Yoav Mazor ◽

Amir Karban ◽

Sofia Ish-Shalom ◽

Elena Segal

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Inflammatory Bowel Disease ◽

Bone Density ◽

Body Mass ◽

Bowel Disease ◽

Mineral Density ◽

Low Bone Density ◽

Low Body Mass Index ◽

Inflammatory Bowel

Background: Inflammatory bowel disease (IBD) patients are reported to have lower bone density compared to healthy controls. There is limited consensus regarding factors affecting bone density among these patients. Our aim, therefore, was to determine clinical and genetic variables that contribute to lower bone mineral density (BMD) in IBD patients. Methods: A cross-sectional study of IBD patients treated in a tertiary referral center was performed. Epidemiological and clinical data were collected, and genetic testing for the common mutations in Nucleotide-binding Oligomerization Domain-containing protein (NOD)2 was performed. We examined correlations between the different variables and BMD in the total hip, femoral neck, and lumbar spine. Results: Eighty-nine patients (49% males, 67 Crohn’s disease [CD]) participated in the study. 42Forty-two (63%) of the CD and 13 (59%) of the ulcerative colitis patients met the criteria for osteoporosis/osteopenia. Factors associated with lower Z scores were low body mass index (BMI; r = –0.307, p = 0.005), use of glucocorticoids (likelihood ratio [LR] 5.1, p = 0.028), and a trend for male gender (LR = 3.4, p = 0.079). Among CD patients, low bone density showed borderline significance for association with gastrointestinal surgery (LR = 4.1, p = 0.07) and smoking (LR = 3.58, p = 0.06). Low levels of 25OHD were not associated with low BMD, nor were mutations in NOD2. No increased rate of fractures was seen among patients with osteopenia or osteoporosis. Conclusion: In addition to the generally accepted risk factors for osteoporosis (glucocorticoids, low BMI, smoking), male IBD patients had a trend toward lower BMD. Carrying a mutaticon in NOD2 did not confer a risk for bone loss.

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