scholarly journals P122 Longitudinal follow-up of body mass index as a predictor for severe disease course in children with inflammatory bowel disease

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S148-S149
Author(s):  
A Yerushalmy-Feler ◽  
S Cohen
Keyword(s):  
Body Mass Index ◽  
Inflammatory Bowel Disease ◽  
Body Mass ◽  
Bowel Disease ◽  
Severe Disease ◽  
Disease Course ◽  
Inflammatory Bowel

High and low body mass index may predict severe disease course in children with inflammatory bowel disease

2018 ◽  
Vol 53 (6) ◽  
pp. 708-713 ◽  
Author(s):  
Anat Yerushalmy-Feler ◽  
Amir Ben-Tov ◽  
Yael Weintraub ◽  
Achiya Amir ◽  
Tut Galai ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Inflammatory Bowel Disease ◽  
Body Mass ◽  
Bowel Disease ◽  
Severe Disease ◽  
Disease Course ◽  
Low Body Mass Index ◽  
Inflammatory Bowel

scholarly journals The Unique Disease Course of Children with Very Early onset-Inflammatory Bowel Disease

2019 ◽  
Author(s):  
Judith R Kelsen ◽  
Maire A Conrad ◽  
Noor Dawany ◽  
Trusha Patel ◽  
Rawan Shraim ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Targeted Therapy ◽  
Bowel Disease ◽  
Early Onset ◽  
Severe Disease ◽  
Disease Course ◽  
Poor Growth ◽  
Study Objective ◽  
Inflammatory Bowel

Abstract Background Insight into the pathogenesis of very early onset-inflammatory bowel disease (VEO-IBD) has expanded through the identification of causative monogenic defects detected in a subset of patients. However, the clinical course of this population remains uncertain. The study objective is to determine whether VEO-IBD is associated with more severe disease, defined as increased surgical intervention and growth failure, than older pediatric IBD. Secondary outcomes included therapeutic response and hospitalizations. Methods Subjects with IBD diagnosed younger than 6 years old (VEO-IBD) were compared with children diagnosed 6 to 10 (intermediate-onset) and older than 10 years of age (older-onset IBD). Metadata obtained from the medical record included age of onset, disease phenotype and location, surgeries, medical therapy, and comorbid conditions. Length of follow-up was at least 1 year from diagnosis. Results There were 229, 221, and 521 subjects with VEO, intermediate-onset, and older-onset IBD, respectively. Very early onset-inflammatory bowel disease subjects underwent more diverting ileostomies (P < 0.001) and colectomies (P < 0.001) than the older children. There was less improvement in weight- and height-for-age Z scores during the follow-up period in subjects with VEO-IBD. Additionally, subjects with VEO-IBD had higher rates of medication failure at 1 year and were more frequently readmitted to the hospital. Targeted therapy was successfully used almost exclusively in VEO-IBD. Conclusion Patients with VEO-IBD can have a more severe disease course with increased surgical interventions and poor growth as compared with older-onset IBD patients. Further, VEO-IBD patients are more likely to be refractory to conventional therapies. Strategies using targeted therapy in these children can improve outcome and, in some cases, be curative.

scholarly journals Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144872 ◽  
Author(s):  
Jie Dong ◽  
Yi Chen ◽  
Yuchen Tang ◽  
Fei Xu ◽  
Chaohui Yu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Inflammatory Bowel Disease ◽  
Body Mass ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel

Relation of Body Mass Index to Risk of Developing Inflammatory Bowel Disease: Evidence for two Types of Crohn's Disease

2017 ◽  
Vol 152 (5) ◽  
pp. S972
Author(s):  
Michael A. Mendall ◽  
Maria C. Harpsoe ◽  
Devinder Kumar ◽  
Mikael Andersson ◽  
Tine Jess
Keyword(s):  
Body Mass Index ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Body Mass ◽  
Bowel Disease ◽  
Inflammatory Bowel

Risk Factors for Low Bone Density in Inflammatory Bowel Disease: Use of Glucocorticoids, Low Body Mass Index, and Smoking

2019 ◽  
Vol 37 (4) ◽  
pp. 284-290 ◽  
Author(s):  
Razi Even Dar ◽  
Yoav Mazor ◽  
Amir Karban ◽  
Sofia Ish-Shalom ◽  
Elena Segal
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Inflammatory Bowel Disease ◽  
Bone Density ◽  
Body Mass ◽  
Bowel Disease ◽  
Mineral Density ◽  
Low Bone Density ◽  
Low Body Mass Index ◽  
Inflammatory Bowel

Background: Inflammatory bowel disease (IBD) patients are reported to have lower bone density compared to healthy controls. There is limited consensus regarding factors affecting bone density among these patients. Our aim, therefore, was to determine clinical and genetic variables that contribute to lower bone mineral density (BMD) in IBD patients. Methods: A cross-sectional study of IBD patients treated in a tertiary referral center was performed. Epidemiological and clinical data were collected, and genetic testing for the common mutations in Nucleotide-binding Oligomerization Domain-containing protein (NOD)2 was performed. We examined correlations between the different variables and BMD in the total hip, femoral neck, and lumbar spine. Results: Eighty-nine patients (49% males, 67 Crohn’s disease [CD]) participated in the study. 42Forty-two (63%) of the CD and 13 (59%) of the ulcerative colitis patients met the criteria for osteoporosis/osteopenia. Factors associated with lower Z scores were low body mass index (BMI; r = –0.307, p = 0.005), use of glucocorticoids (likelihood ratio [LR] 5.1, p = 0.028), and a trend for male gender (LR = 3.4, p = 0.079). Among CD patients, low bone density showed borderline significance for association with gastrointestinal surgery (LR = 4.1, p = 0.07) and smoking (LR = 3.58, p = 0.06). Low levels of 25OHD were not associated with low BMD, nor were mutations in NOD2. No increased rate of fractures was seen among patients with osteopenia or osteoporosis. Conclusion: In addition to the generally accepted risk factors for osteoporosis (glucocorticoids, low BMI, smoking), male IBD patients had a trend toward lower BMD. Carrying a mutaticon in NOD2 did not confer a risk for bone loss.

scholarly journals The Risk of Later Diagnosis of Inflammatory Bowel Disease in Patients With Dermatological Disorders Associated With Inflammatory Bowel Disease

2021 ◽  
Author(s):  
Dominic King ◽  
Joht Singh Chandan ◽  
Tom Thomas ◽  
Krishnarajah Nirantharakumar ◽  
Raoul C Reulen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Inflammatory Bowel Disease ◽  
Prediction Model ◽  
Body Mass ◽  
Bowel Disease ◽  
Gastrointestinal Symptoms ◽  
C Statistic ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Inflammatory Bowel

Abstract Background Dermatological conditions such as erythema nodosum (EN), pyoderma gangrenosum, Sweet’s syndrome, and aphthous stomatitis can occur with inflammatory bowel disease (IBD) and are considered dermatological extraintestinal manifestations (D-EIMs). Rarely, they may precede IBD. Other common conditions such as psoriasis have also been associated with IBD. This study examined the risk of a subsequent IBD diagnosis in patients presenting with a D-EIM. Methods A retrospective cohort study compared patients with D-EIMs and age-/sex-matched patients without D-EIMs. Hazard ratios (HRs) were adjusted for age, sex, body mass index, deprivation, comorbidity, smoking, loperamide use, anemia, and lower gastrointestinal symptoms. Logistic regression was used to produce a prediction model for the diagnosis of IBD within 3 years of EN diagnosis. Results We matched 7447 patients with D-EIMs (74% female; median age 38 years (interquartile ratio [IQR], 24-65 years) to 29,297 patients without D-EIMs. We observed 131 (1.8%) subsequent IBD diagnoses in patients with D-EIMs compared with 65 (0.2%) in those without D-EIMs. Median time to IBD diagnosis was 205 days (IQR, 44-661 days) in those with D-EIMs and 1594 days (IQR, 693-2841 days) in those without D-EIMs. The adjusted HR for a later diagnosis of IBD was 6.16 (95% confidence interval [CI], 4.53-8.37; P &lt; 0.001), for ulcerative colitis the HR was 3.30 (95% CI, 1.98-5.53; P &lt; 0.001), and for Crohn’s disease the HR was 8.54 (95% CI, 5.74-12.70; P &lt; 0.001). Patients with psoriasis had a 34% increased risk of a subsequent IBD diagnosis compared with the matched control patients (HR, 1.34; 95% CI, 1.20-1.51; P &lt; 0.001). We included 4043 patients with an incident EN diagnosis in the prediction model cohort, with 87 patients (2.2%) diagnosed with IBD within 3 years. The model had a bias-corrected c-statistic of 0.82 (95% CI, 0.78-0.86). Conclusions Patients with D-EIMs have a 6-fold increased risk of a later diagnosis of IBD. Younger age, smoking, low body mass index, anemia, and lower gastrointestinal symptoms were associated with an increased risk of diagnosis of IBD within 3 years in patients with EN.

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