Type 2 diabetes and a history of coronary heart disease are additive cardiovascular risks in high-risk hypertensive patients: a subanalysis of the CASE-J Ex

Abstract Objective: In the diabetes treatment policy after the Kumamoto Declaration 2013, it is difficult to accurately predict the incidence of complications in patients using the JJ risk engine. This study was conducted to develop a prediction equation suitable for the current diabetes treatment policy using patient data from Kitasato Institute Hospital (Hospital A) and to externally validate the developed equation using patient data from Kitasato University Hospital (Hospital B). Outlier tests were performed on the patient data from Hospital A to exclude the outliers. Prediction equation was developed using the patient data excluding the outliers and was subjected to external validation.Results: By excluding outlier data, we were able to develop a new prediction equation for the incidence of coronary heart disease (CHD) as a complication of type 2 diabetes, incorporating the use of antidiabetic drugs with a high risk of hypoglycemia. This is the first prediction equation in Japan that incorporates the use of antidiabetic drugs. We believe that it will be useful in preventive medicine for treatment for people at high risk of CHD as a complication of diabetes or other diseases. In the future, we would like to confirm the accuracy of this equation at other facilities.

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Development and validation of an equation to predict the incidence of coronary heart disease in patients with type 2 diabetes in Japan

BMC Research Notes ◽

10.1186/s13104-021-05844-w ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Yasunari Yamashita ◽

Gaku Inoue ◽

Yoichi Nozaki ◽

Rina Kitajima ◽

Kiyoshi Matsubara ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

High Risk ◽

Prediction Equation ◽

Patient Data ◽

Antidiabetic Drugs ◽

Diabetes Treatment ◽

Treatment Policy

Abstract Objective In the diabetes treatment policy after the Kumamoto Declaration 2013, it is difficult to accurately predict the incidence of complications in patients using the JJ risk engine. This study was conducted to develop a prediction equation suitable for the current diabetes treatment policy using patient data from Kitasato University Kitasato Institute Hospital (Hospital A) and to externally validate the developed equation using patient data from Kitasato University Hospital (Hospital B). Outlier tests were performed on the patient data from Hospital A to exclude the outliers. Prediction equation was developed using the patient data excluding the outliers and was subjected to external validation. Results By excluding outlier data, we could develop a new prediction equation for the incidence of coronary heart disease (CHD) as a complication of type 2 diabetes, incorporating the use of antidiabetic drugs with a high risk of hypoglycemia. This is the first prediction equation in Japan that incorporates the use of antidiabetic drugs. We believe that it will be useful in preventive medicine for treatment for people at high risk of CHD as a complication of diabetes or other diseases. In the future, we would like to confirm the accuracy of this equation at other facilities.

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RISK FACTORS OF CORONARY HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Majalah Biomorfologi ◽

10.20473/mbiom.v32i1.2022.13-17 ◽

2022 ◽

Vol 32 (1) ◽

pp. 13

Author(s):

Elisabeth Sekaringtyas Medistya Putri ◽

Soebagijo Adi S ◽

Mohammad Budiarto

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

High Risk ◽

Academic Hospital ◽

Male Sex

Highlight:1. One of the major causes of morbidity and mortality in diabetes mellitus patients is coronary heart disease (CHD).2. The risk factors for coronary heart disease in type 2 diabetes mellitus patients were observed.3. The risk factors of CHD more commonly found in T2DM patients were high-risk age, male sex, hypertension and dyslipidemia.Abstract:Background: Diabetes mellitus is a metabolic syndrome that becomes a concern in almost all countries in the world, particularly developing countries. Changes in lifestyle and genetic factors are causing the incidence of this disease to continue to increase every year. Nowadays, type 2 diabetes mellitus (T2DM) caused by insulin resistance is the most common kind. One of its complications known as a major cause of morbidity and mortality in patients with diabetes is coronary heart disease (CHD). Insulin resistance can lead to the atherosclerosis process that is the basis of coronary heart disease. It is said that conditions of hyperglycemia, hypercoagulable state, and high cholesterol can induce the process of atherosclerosis. Besides diabetes mellitus, the other risk factors that increase the incidence of CHD are sex, age, family history, dyslipidemia, smoking, hypertension, and obesity. Objective: The purpose of this study was to describe the risk factors for coronary heart disease in patients with type 2 diabetes mellitus in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: A cross-sectional study of diabetes mellitus patients with coronary heart disease was conducted in Dr. Soetomo General Academic Hospital from 1 January 2014 to 31 December 2014. Data were taken from medical records at the Department of Internal Medicine. Incomplete medical records were not included in this study. Risk factors analyzed were age, sex, history of hypertension and dyslipidemia. Results of this study were presented in a frequency distribution table. Results: Based on the data of 70 samples, risk factors of CHD in T2DM patients are found as follows: 44 (62.9%) samples were male, 56 (80%) high-risk aged group, 48 (68.6%) with dyslipidemia, and 50 (71.4%) with hypertension, while 24 (34.3%) samples had three risk factors at once. Conclusion: High-risk aged, male sex, hypertension, and dyslipidemia are more commonly found in T2DM patients with CHD. The more risk factors that one may have will increase the occurrence of cardiovascular disease within 10 years forward.

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Increased Risk of Type 2 Diabetes From a Family History of Coronary Heart Disease and Type 2 Diabetes

Diabetes Care ◽

10.2337/dc06-1463 ◽

2006 ◽

Vol 30 (1) ◽

pp. 154-156 ◽

Cited By ~ 11

Author(s):

E. H. Yeung ◽

J. S. Pankow ◽

B. C. Astor ◽

N. R. Powe ◽

C. D. Saudek ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Family History ◽

Increased Risk ◽

History Of

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The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population

PLoS ONE ◽

10.1371/journal.pone.0128627 ◽

2015 ◽

Vol 10 (6) ◽

pp. e0128627 ◽

Cited By ~ 4

Author(s):

Chang Hee Jung ◽

Gi Hyeon Seo ◽

Sunghwan Suh ◽

Ji Cheol Bae ◽

Mee Kyoung Kim ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Coronary Revascularization ◽

Population Based ◽

Korean Population ◽

History Of

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Joint effects of history of hypertension at baseline and type 2 diabetes at baseline and during follow-up on the risk of coronary heart disease

European Heart Journal ◽

10.1093/eurheartj/ehm501 ◽

2007 ◽

Vol 28 (24) ◽

pp. 3059-3066 ◽

Cited By ~ 55

Author(s):

G. Hu ◽

P. Jousilahti ◽

J. Tuomilehto

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Joint Effects ◽

History Of

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Family history of diabetes and the risk of coronary heart disease in people with or without type 2 diabetes

Diabetes & Metabolism ◽

10.1016/j.diabet.2016.07.032 ◽

2017 ◽

Vol 43 (2) ◽

pp. 180-183 ◽

Cited By ~ 4

Author(s):

M. Afarideh ◽

S. Noshad ◽

A. Ghajar ◽

Z. Aryan ◽

E. Khajeh ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Family History ◽

Family History Of Diabetes ◽

History Of

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2436-PUB: Predicting Risk for New-Onset Type 2 Diabetes in Chinese People with Coronary Heart Disease and Impaired Glucose Tolerance

Diabetes ◽

10.2337/db19-2436-pub ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2436-PUB

Author(s):

SHISHI XU ◽

CHARLES A. SCOTT ◽

RUTH L. COLEMAN ◽

JAAKKO TUOMILEHTO ◽

RURY R. HOLMAN

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Chinese People ◽

Onset Type ◽

New Onset

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Mutations of mtDNA in some vascular and metabolic diseases

Current Pharmaceutical Design ◽

10.2174/1381612826999200820162154 ◽

2020 ◽

Vol 26 ◽

Author(s):

Margarita A. Sazonova ◽

Anastasia I. Ryzhkova ◽

Vasily V. Sinyov ◽

Marina D. Sazonova ◽

Tatiana V. Kirichenko ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Chronic Diseases ◽

Metabolic Diseases ◽

Present Review ◽

Mtdna Mutations

Background: The present review article considers some chronic diseases of vascular and metabolic genesis, the causes of which may be mitochondrial dysfunction. Very often, in the long course of the disease, complications may occur, leading to myocardial infarction or ischemic stroke and as a result, death.In particular, a large percentage of human deaths nowadays belongs to cardiovascular diseases such as coronary heart disease (CHD), arterial hypertension, cardiomyopathies and type 2 diabetes mellitus. Objective: The aim of the present review was the analysis of literature sources, devoted to an investigation of a link of mitochondrial DNA mutations with chronic diseases of vascular and metabolic genesis, Results: The analysis of literature indicates the association of the mitochondrial genome mutations with coronary heart disease, type 2 diabetes mellitus, hypertension and various types of cardiomyopathies. Conclusion: The detected mutations can be used to analyze the predisposition to chronic diseases of vascular and metabolic genesis. They can also be used to create molecular-cell models necessary to evaluate the effectiveness of drugs developed for treatment of these pathologies. MtDNA mutations associated withthe absence of diseases of vascular and metabolic genesis could be potential candidates for gene therapy of diseases of vascular and metabolic genesis.

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