Increased Risk of Type 2 Diabetes From a Family History of Coronary Heart Disease and Type 2 Diabetes

IntroductionWe sought to investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and the risk of type 2 diabetes mellitus (T2DM) in adults who participated in the Trøndelag Health Study (HUNT), and the possible effect modification by family history and genetic predisposition.Research design and methodsThis prospective study included 3574 diabetes-free adults at baseline who participated in the HUNT2 (1995–1997) and HUNT3 (2006–2008) surveys. Serum 25(OH)D levels were determined at baseline and classified as <50 and ≥50 nmol/L. Family history of diabetes was defined as self-reported diabetes among parents and siblings. A Polygenic Risk Score (PRS) for T2DM based on 166 single-nucleotide polymorphisms was generated. Incident T2DM was defined by self-report and/or non-fasting glucose levels greater than 11 mmol/L and serum glutamic acid decarboxylase antibody level of <0.08 antibody index at the follow-up. Multivariable logistic regression models were applied to calculate adjusted ORs with 95% CIs. Effect modification by family history or PRS was assessed by likelihood ratio test (LRT).ResultsOver 11 years of follow-up, 92 (2.6%) participants developed T2DM. A higher risk of incident T2DM was observed in participants with serum 25(OH)D level of<50 nmol/L compared with those of ≥50 nmol/L (OR 1.72, 95% CI 1.03 to 2.86). Level of 25(OH)D<50 nmol/L was associated with an increased risk of T2DM in adults without family history of diabetes (OR 3.87, 95% CI 1.62 to 9.24) but not in those with a family history (OR 0.72, 95% CI 0.32 to 1.62, p value for LRT=0.003). There was no effect modification by PRS (p value for LRT>0.23).ConclusionSerum 25(OH)D<50 nmol/L was associated with an increased risk of T2DM in Norwegian adults. The inverse association was modified by family history of diabetes but not by genetic predisposition to T2DM.

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Abstract 054: Diet Beverage Intake is Positively Associated With Incident Coronary Heart Disease in People With Type 2 Diabetes

Circulation ◽

10.1161/circ.137.suppl_1.054 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Andrew O Odegaard ◽

Lyn M Steffen ◽

David R Jacobs ◽

Katherine L Tucker ◽

Kenneth J Mukamal ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Meta Analysis ◽

Health Concern ◽

Cardiovascular Health Study ◽

High Risk Population ◽

Incident Coronary Heart Disease ◽

Increased Risk

Introduction: Diet beverages are calorie free beverages sweetened with non-nutritive sweeteners. People with diabetes are the highest per-capita consumers of diet beverages, tending to consume them as a replacement for dietary sources of sugar, especially in place of sugar sweetened beverages. This behavior is endorsed by dietetic and scientific organizations and diet beverages are marketed synonymously with better health, weight loss, and thus, are considered advantageous for diabetes control. The underlying public health concern is the lack of data to support or refute this concept. Hypothesis: Higher diet beverage intake is positively associated with incident Coronary Heart Disease (CHD) Methods: We pooled the data sets of the Atherosclerosis Risk in Communities (ARIC) study (1987-2014), Cardiovascular Health Study (CHS) (1989-2014), Framingham Offspring Study (FOS) (1995-2014), Jackson Heart Study (JHS) (2000-2012), and Multi-Ethnic Study of Atherosclerosis (MESA (2000-2013) to conduct a prospective examination of the association of diet beverage intake with the incidence of CHD among participants with clinically ascertained type 2 diabetes (T2D) without prevalent CHD and with valid dietary data (N=3,947). We carried out a 2-step meta-analysis using individual level, cohort-specific Cox regression analyses with identical adjustment for demographic, lifestyle, overall diet quality and clinical risk factors to generate effect estimates that were pooled together using fixed and random effects meta-analysis. Results: 1,046 participants developed adjudicated CHD during follow-up. There was a positive, graded association between diet beverage intake and risk of incident CHD (Table). Results were consistent by sex, race and age. Conclusions: Diet beverage intake is associated with increased risk of developing CHD in a population with T2D. These results suggest the need to further evaluate dietary recommendations related to diet beverages and consider their role in this high risk population.

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Two-hour postload glycemia is associated to an increased risk of NAFLD in healthy subjects with family history of type 2 diabetes: a case control study

Endocrine ◽

10.1007/s12020-016-1008-4 ◽

2016 ◽

Vol 57 (2) ◽

pp. 352-355

Author(s):

Nadia Pallotta ◽

Tiziana Filardi ◽

Anna Carnovale ◽

Luciano Nieddu ◽

Paola Mariani ◽

...

Keyword(s):

Type 2 Diabetes ◽

Family History ◽

Healthy Subjects ◽

Case Control Study ◽

Case Control ◽

Increased Risk ◽

History Of ◽

Control Study

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Family history of non-communicable diseases and associations with weight and movement behaviours in Australian school-aged children: a prospective study

BMJ Open ◽

10.1136/bmjopen-2020-038789 ◽

2020 ◽

Vol 10 (11) ◽

pp. e038789

Author(s):

Katherine L Downing ◽

Kylie D Hesketh ◽

Anna Timperio ◽

Jo Salmon ◽

Katrina Moss ◽

...

Keyword(s):

Type 2 Diabetes ◽

Heart Disease ◽

Health Insurance ◽

Family History ◽

Screen Time ◽

Communicable Diseases ◽

Non Communicable Diseases ◽

Lower Odds ◽

History Of

ObjectiveTo assess differences in weight status and movement behaviour guideline compliance among children aged 5–12 years with and without a family history of non-communicable diseases (NCDs).DesignProspective.Setting and participantsWomen born between 1973 and 1978 were recruited to the Australian Longitudinal Study on Women’s Health (ALSWH) via the database of the Health Insurance Commission (now Medicare; Australia’s universal health insurance scheme). In 2016–2017, women in that cohort were invited to participate in the Mothers and their Children’s Health Study and reported on their three youngest children (aged <13 years). Data from children aged 5–12 years (n=4416) were analysed.MeasuresMothers reported their children’s height and weight, used to calculate body mass index (kg/m2), physical activity, screen time and sleep. In the 2015 ALSWH Survey, women reported diagnoses and family history of type 2 diabetes, heart disease and hypertension. Logistic regression models determined differences between outcomes for children with and without a family history of NCDs.ResultsBoys with a family history of type 2 diabetes had 30% (95% CI: 0.51%–0.97%) and 43% lower odds (95% CI: 0.37%–0.88%) of meeting the sleep and combined guidelines, respectively, and 40% higher odds (95% CI: 1.01%– 1.95%) of being overweight/obese. Girls with a family history of hypertension had 27% lower odds (95% CI: 0.57%–0.93%) of meeting the screen time guidelines. No associations were observed for family history of heart disease.ConclusionsChildren who have a family history of type 2 diabetes and hypertension may be at risk of poorer health behaviours from a young age. Mothers with a diagnosis or a family history of these NCDs may need additional support to help their children develop healthy movement behaviours and maintain healthy weight.

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GRB10 rs1800504 Polymorphism Is Associated With the Risk of Coronary Heart Disease in Patients With Type 2 Diabetes Mellitus

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.728976 ◽

2021 ◽

Vol 8 ◽

Author(s):

Yang Yang ◽

Wentao Qiu ◽

Qian Meng ◽

Mouze Liu ◽

Weijie Lin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Vascular Complications ◽

Nucleotide Polymorphisms ◽

Diabetic Vascular Complications ◽

Increased Risk

Diabetic vascular complications are one of the main causes of death and disability. Previous studies have reported that genetic variation is associated with diabetic vascular complications. In this study, we aimed to investigate the association between GRB10 polymorphisms and susceptibility to type 2 diabetes mellitus (T2DM) vascular complications. Eight single nucleotide polymorphisms (SNPs) in the GRB10 gene were genotyped by MassARRAY system and 934 patients with type 2 diabetes mellitus (T2DM) were included for investigation. We found that GRB10 rs1800504 CC+CT genotypes were significantly associated with increased risk of coronary heart disease (CHD) compared with TT genotype (OR = 2.24; 95%CI: 1.36–3.70, p = 0.002). Consistently, levels of cholesterol (CHOL) (CC+CT vs. TT, 4.44 ± 1.25 vs. 4.10 ± 1.00 mmol/L; p = 0.009) and low density lipoprotein cholesterin (LDL-CH) (CC+CT vs. TT, 2.81 ± 1.07 vs. 2.53 ± 0.82 mmol/L; p = 0.01) in T2DM patients with TT genotype were significant lower than those of CC+CT genotypes. We further validated in MIHA cell that the total cholesterol (TC) level in GRB10-Mut was significantly reduced compared with GRB10-WT; p = 0.0005. Likewise, the reversed palmitic acid (PA) induced lipid droplet formation in GRB10-Mut was more effective than in GRB10-WT. These results suggest that rs1800504 of GRB10 variant may be associated with the blood lipids and then may also related to the risk of CHD in patients with T2DM.

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Type 2 diabetes and a history of coronary heart disease are additive cardiovascular risks in high-risk hypertensive patients: a subanalysis of the CASE-J Ex

European Heart Journal ◽

10.1093/eurheartj/eht308.p1559 ◽

2013 ◽

Vol 34 (suppl 1) ◽

pp. P1559-P1559

Author(s):

S. Yasuno ◽

K. Ueshima ◽

S. Tanaka ◽

A. Fujimoto ◽

M. Kasahara ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

High Risk ◽

Cardiovascular Risks ◽

Hypertensive Patients ◽

History Of

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Type 2 diabetes as a potential risk marker for early onset colorectal cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.e15005 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. e15005-e15005 ◽

Cited By ~ 1

Author(s):

Joanne Young ◽

Timothy Jay Price ◽

Jenny Hardingham ◽

Erin Symonds ◽

Eric Smith ◽

...

Keyword(s):

Colorectal Cancer ◽

Type 2 Diabetes ◽

Young Adults ◽

Family History ◽

Potential Risk ◽

Personal History ◽

Risk Marker ◽

Increased Risk ◽

History Of

e15005 Background: Colorectal cancer (CRC) is rising in incidence in young adults. Because they are not included in population screening, and are more likely to present at an advanced stage, there is a need to identify young adults at increased risk for CRC. An association has been reported between type 2 diabetes (T2D) and CRC in the general population. Though lifestyle risk factors may be involved, the early occurrence of CRC in young adults suggests that there may also be a role for inherited predispositions. We therefore investigated whether having a personal and/or first-degree family history of T2D was a potential risk marker for early onset CRC. Methods: The South Australian Young Onset (SAYO) CRC study is an unselected series of young adults with CRC up to age 55. Fifty unrelated young adults (31/50 or 62% female) diagnosed with CRC were recruited to the study. Personal history of T2D was confirmed. Detailed family history of T2D was recorded. 253 patients with clear colonoscopies and no known CRC predisposition served as controls for personal history studies of T2D. Diabetes status was recorded on admission for colonoscopy controls. Associations were explored using a chi-squared statistic. Results: CRC patients ranged in age from 23-54 years (median age 42) and controls from 18-54 (median age 45). Six patients (12%) met the WHO clinical criteria for serrated polyposis, and two (4%) carried a Lynch syndrome mutation. CRC was present in the distal colon in 15/19 males (79%) and 17/31 females (55%) (p = 0.12). A personal history of T2D was confirmed in 12/50 (24%) CRC patients compared with clear colonoscopy controls under 55 years (13/258 or 5% P < 0.001; OR = 5.9; 95%CI 2.5-13.8). T2D was seen in 7/31 or 23% females and 5/19 or 26% males. Young adults with CRC frequently reported at least one first-degree relative with T2D (24/47 or 51%). All patients with personal history of T2D also had first-degree relatives with T2D. A first-degree family history of T2D was observed in 12/27 (44%) CRC patients aged under 45 yrs and 12/20 (60%) of CRC patients aged between 45 and 54 yrs having this characteristic (p = 0.29), and was present in both males and females (10/17 or 58% and 13/30 or 43% respectively; p = 0.37). Conclusions: Though the mechanism remains unclear, given the prevalence of T2D in those aged < 55yrs is 5% in Australia, our observations suggest that there is a striking enrichment for personal and first-degree family history of T2D in young adults with CRC. These features could potentially identify a subset of young adults at increased risk for CRC and in whom early screening might be appropriate.

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Low soluble thrombomodulin activity and antigen is associated with a family history of heart disease while a high level is associated with a personal history of heart disease in type 2 diabetes

Thrombosis and Haemostasis ◽

10.1160/th06-03-0160 ◽

2007 ◽

Vol 97 (01) ◽

pp. 161-164 ◽

Cited By ~ 1

Author(s):

Constantine Konstantoulas ◽

Jackie Cooper ◽

Ann-Kristin Ohlin ◽

Stephen Humphries ◽

Alison Goodall ◽

...

Keyword(s):

Type 2 Diabetes ◽

Heart Disease ◽

Family History ◽

Personal History ◽

Soluble Thrombomodulin ◽

History Of ◽

High Level

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Long-term use of antibiotics and risk of type 2 diabetes in women: a prospective cohort study

International Journal of Epidemiology ◽

10.1093/ije/dyaa122 ◽

2020 ◽

Vol 49 (5) ◽

pp. 1572-1581

Author(s):

Jinqiu Yuan ◽

Yanhong Jessika Hu ◽

Jie Zheng ◽

Jean Hee Kim ◽

Tim Sumerlin ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cohort Study ◽

Family History ◽

Antibiotic Use ◽

Family History Of Diabetes ◽

The Past ◽

Increased Risk ◽

History Of

Abstract Background Accumulating evidence suggested that long-term antibiotic use may alter the gut microbiome, which has, in turn, been linked to type 2 diabetes. We undertook this study to investigate whether antibiotic use was associated with increased risk of type 2 diabetes. Methods This prospective cohort study included women free of diabetes, cardiovascular disease and cancer in the Nurses’ Health Study (NHS 2008–2014) and NHS II (2009–2017). We evaluated the overall duration of antibiotics use in the past 4 years and subsequent diabetes risk with Cox proportional-hazards regression adjusting for demography, family history of diabetes and lifestyle factors. Results Pooled analyses of NHS and NHS II (2837 cases, 703 934 person-years) revealed that a longer duration of antibiotic use in the past 4 years was associated with higher risk of diabetes [Trend-coefficient = 0.09, 95% confidence interval (CI) 0.04 to 0.13]. Participants who received antibiotics treatment for a medium duration of 15 days to 2 months [hazard ratio (HR) 1.23, 95% CI 1.10 to 1.39] or long duration of >2 months (HR 1.20, 95% CI 1.02 to 1.38) had higher risk of type 2 diabetes as compared with non-users. Subgroup analyses suggested that the associations were unlikely to be modified by age, family history of diabetes, obesity, smoking, alcohol drinking, physical activity and overall diet quality. Conclusions A longer duration of antibiotic use in recent years was associated with increased risk of type 2 diabetes in women. Physicians should exercise caution when prescribing antibiotics, particularly for long-term use.

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