Correction to: Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study

Abstract Background Peripheral artery disease (PAD) is recognized as a significant predictor of mortality and adverse cardiovascular outcomes in patients with coronary heart disease (CHD). In fact, coexisting PAD and CHD is strongly associated with a greater coronary event recurrence compared with either one of them alone. High-density lipoprotein (HDL)-mediated cholesterol efflux capacity (CEC) is found to be inversely associated with an increased risk of incident CHD. However, this association is not established in patients with PAD in the context of secondary prevention. In this sense, our main aim was to evaluate the association between CEC and PAD in patients with CHD and whether the concurrent presence of PAD and T2DM influences this association. Methods CHD patients (n = 1002) from the CORDIOPREV study were classified according to the presence or absence of PAD (ankle-brachial index, ABI ≤ 0.9 and ABI > 0.9 and < 1.4, respectively) and T2DM status. CEC was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma was performed. Results The presence of PAD determined low CEC in non-T2DM and newly-diagnosed T2DM patients. Coexisting PAD and newly-diagnosed T2DM provided and additive effect providing an impaired CEC compared to non-T2DM patients with PAD. In established T2DM patients, the presence of PAD did not determine differences in CEC, compared to those without PAD, which may be restored by glucose-lowering treatment. Conclusions Our findings suggest an inverse relationship between CEC and PAD in CHD patients. These results support the importance of identifying underlying mechanisms of PAD, in the context of secondary prevention, that provide potential therapeutic targets, that is the case of CEC, and establishing strategies to prevent or reduce the high risk of cardiovascular events of these patients. Trial registrationhttps://clinicaltrials.gov/ct2/show/NCT00924937. Unique Identifier: NCT00924937

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High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with diabetic nephropathy and the role of netrin-1 levels

Endocrine Abstracts ◽

10.1530/endoabs.49.gp96 ◽

2017 ◽

Author(s):

Ahmet Kor ◽

Suleyman Baldane ◽

Suleyman Hilmi Ipekci ◽

Kamile Marakoglu ◽

Ali Altinok ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Lower Extremity ◽

Peripheral Artery Disease ◽

Peripheral Artery ◽

High Prevalence ◽

Artery Disease ◽

Diabetes Patients

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2217-PUB: Type 2 Diabetes Is a Strong Predictor for LDL Cholesterol Target Achievement in Patients with Peripheral Artery Disease

Diabetes ◽

10.2337/db19-2217-pub ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2217-PUB

Author(s):

SIMON STERNBAUER ◽

ALEXANDER VONBANK ◽

CHRISTINE HEINZLE ◽

DANIELA ZANOLIN-PURIN ◽

JÖRN F. DOPHEIDE ◽

...

Keyword(s):

Type 2 Diabetes ◽

Peripheral Artery Disease ◽

Ldl Cholesterol ◽

Strong Predictor ◽

Peripheral Artery ◽

Artery Disease

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Plasma concentrations of lipoproteins and risk of lower-limb peripheral artery disease in people with type 2 diabetes: the SURDIAGENE study

Diabetologia ◽

10.1007/s00125-020-05326-x ◽

2021 ◽

Vol 64 (3) ◽

pp. 668-680

Author(s):

Capucine Bertrand ◽

◽

Pierre-Jean Saulnier ◽

Louis Potier ◽

Mikaël Croyal ◽

...

Keyword(s):

Type 2 Diabetes ◽

Peripheral Artery Disease ◽

Lower Limb ◽

Plasma Concentrations ◽

Peripheral Artery ◽

Artery Disease

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Cholesterol Efflux Capacity Associates with the Ankle-Brachial Index but Not All-Cause Mortality in Patients with Peripheral Artery Disease

Diagnostics ◽

10.3390/diagnostics11081407 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1407

Author(s):

Robert K. Clemens ◽

Monika Hunjadi ◽

Andreas Ritsch ◽

Lucia Rohrer ◽

Thomas O. Meier ◽

...

Keyword(s):

Peripheral Artery Disease ◽

Cholesterol Efflux ◽

Ankle Brachial Index ◽

Mortality Rates ◽

High Density Lipoproteins ◽

Peripheral Artery ◽

Cholesterol Efflux Capacity ◽

Hdl Function ◽

All Cause Mortality ◽

Artery Disease

Background: Cholesterol efflux is an important mechanism by which high-density lipoproteins (HDLs) protect against cardiovascular disease. As peripheral artery disease (PAD) is associated with high mortality rates, mainly due to cardiovascular causes, we investigated whether cholesterol efflux capacity (CEC) of apolipoprotein B (apoB)-depleted plasma, a widely used surrogate of HDL function, may serve as a predictive marker for mortality in this patient population. Methods: In this prospective single-center study (median follow-up time: 9.3 years), apoB-containing lipoproteins were precipitated from plasma of 95 patients with PAD and incubated with J744-macrophages, which were loaded with radiolabeled cholesterol. CEC was defined as the fractional radiolabel released during 4 h of incubation. Results: Baseline CEC was lower in PAD patients that currently smoked (p = 0.015) and had a history of myocardial infarction (p = 0.011). Moreover, CEC showed a significant correlation with HDL-cholesterol (p = 0.003) and apolipoprotein A-I levels (p = 0.001) as well as the ankle-brachial index (ABI, p = 0.018). However, CEC did not differ between survivors and non-survivors. Neither revealed Kaplan–Meier and Cox regression analyses any significant association of CEC with all-cause mortality rates. Conclusion: Taken together, CEC is associated with ABI but does not predict all-cause mortality in patients with PAD.

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Type 2 diabetes and risk of cardiovascular events in peripheral artery disease versus coronary artery disease patients

Atherosclerosis ◽

10.1016/j.atherosclerosis.2021.06.609 ◽

2021 ◽

Vol 331 ◽

pp. e199

Author(s):

L. Sprenger ◽

A. Vonbank ◽

B. Larcher ◽

A. Mader ◽

M. Maechler ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Peripheral Artery Disease ◽

Cardiovascular Events ◽

Peripheral Artery ◽

Artery Disease

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Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus

BioFactors ◽

10.1002/biof.1800 ◽

2021 ◽

Author(s):

Gabriela M. Sanda ◽

Laura Toma ◽

Teodora Barbalata ◽

Oriana E. Moraru ◽

Loredan S. Niculescu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Peripheral Artery Disease ◽

High Density ◽

Paraoxonase 1 ◽

High Density Lipoproteins ◽

Peripheral Artery ◽

Artery Disease

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Impact of diabetes type on treatment and outcome of patients with peripheral artery disease

Diabetes and Vascular Disease Research ◽

10.1177/1479164118793986 ◽

2018 ◽

Vol 15 (6) ◽

pp. 504-510 ◽

Cited By ~ 8

Author(s):

Lars Richter ◽

Eva Freisinger ◽

Florian Lüders ◽

Katrin Gebauer ◽

Matthias Meyborg ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Type 1 Diabetes Mellitus ◽

Peripheral Artery Disease ◽

Peripheral Artery ◽

Artery Disease

Background: The prevalence of diabetes mellitus and its associated complications such as peripheral artery disease is increasing worldwide. We aimed to explore the distinct impact of type 1 diabetes mellitus and type 2 diabetes mellitus on treatment and on short- and long-term outcome in patients with peripheral artery disease. Methods: Retrospective analysis of anonymized data of hospitalized patients covered by a large German health insurance. Assessment of patient’s characteristics (comorbidities, complications, etc.) and outcome using multivariable Cox regression and Kaplan–Meier curves. Results: Among 41,702 patients with peripheral artery disease, 339 (0.8%) had type 1 diabetes mellitus and 13,151 (31.5%) had type 2 diabetes mellitus. Patients with diabetes mellitus had more comorbidities and complications than patients without diabetes mellitus ( p < 0.001). Type 1 diabetes mellitus patients exhibited the highest risk for limb amputation at 4-year follow-up (44.6% vs 35.1%, p < 0.001), while type 2 diabetes mellitus patients had higher mortality than type 1 diabetes mellitus (43.6% vs 31.0%, p < 0.001). Conclusion: Although the fraction of type 1 diabetes mellitus among patients with peripheral artery disease and diabetes mellitus is low, it represents a subset of patients being at particular high risk for limb amputation. Research focused on elaborating the determinants of limb amputation and mortality in peripheral artery disease patients with diabetes mellitus is warranted to improve the poor prognosis of these patients.

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