scholarly journals Management of asymptomatic arrhythmias: a European Heart Rhythm Association (EHRA) consensus document, endorsed by the Heart Failure Association (HFA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin America Heart Rhythm Society (LAHRS)

EP Europace ◽  
2019 ◽  
Author(s):  
David O Arnar ◽  
Georges H Mairesse ◽  
Giuseppe Boriani ◽  
Hugh Calkins ◽  
Ashley Chin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Latin America ◽  
Clinical Practice ◽  
Sudden Cardiac Death ◽  
Southern Africa ◽  
Cardiac Death ◽  
Heart Rhythm ◽  
Asia Pacific ◽  
Prognostic Evaluation ◽  
Consensus Document

AbstractAsymptomatic arrhythmias are frequently encountered in clinical practice. Although studies specifically dedicated to these asymptomatic arrhythmias are lacking, many arrhythmias still require proper diagnostic and prognostic evaluation and treatment to avoid severe consequences, such as stroke or systemic emboli, heart failure, or sudden cardiac death. The present document reviews the evidence, where available, and attempts to reach a consensus, where evidence is insufficient or conflicting.

Abstract 395: A Synonymous Coding SNP Alters SCN5A Regulation by miR-24 and Associates With Non-Arrhythmic Death in Heart Failure

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Xiaoming Zhang ◽  
Jin-Young Yoon ◽  
Michael Morley ◽  
Patrick Breheny ◽  
Heather Bloom ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Clinical Signs ◽  
Heart Rhythm ◽  
Coding Sequence ◽  
Reduced Ejection Fraction ◽  
Arrhythmic Death ◽  
And Function ◽  
Myocardial Gene Expression

Mutations disrupting SCN5A coding sequence cause inherited arrhythmias and cardiomyopathy, and SNPs linked to SCN5A splicing, localization and function associate with heart failure-related sudden cardiac death. However, the clinical relevance of SNPs that modulate SCN5A expression levels remains understudied. Recently, we generated a transcriptome-wide map of microRNA (miR) binding sites in human heart and evaluated their interface with polymorphisms. Among >500 common SNPs residing within miR target regions, we identified a synonymous SNP (rs1805126) adjacent to a miR-24 site within SCN5A coding sequence. This SNP is known to reproducibly associate with heart rhythm measurements, but is not considered to be “causal”. Here, we show that miR-24 potently suppresses SCN5A and that rs1805126 modulates this regulation. In further exploring the clinical significance of this, we found that rs1805126 minor allele homozygosity associates with decreased cardiac SCN5A expression and increased mortality in heart failure patients. Unexpectedly, this risk was not linked with arrhythmic sudden cardiac death, but rather, with clinical signs of worsening heart failure (e.g. reduced ejection fraction) and myocardial gene expression changes related to bioenergetics, inflammation and extracellular remodeling. Together, these data attribute a molecular mechanism to this firmly-established GWAS SNP and highlight a novel and surprising link between common variations in SCN5A expression and non-arrhythmic death in heart failure.

scholarly journals Cardiovascular Pathology in Patients With COVID-19

Kardiologiia ◽  
2020 ◽  
Vol 60 (8) ◽  
pp. 23-26
Author(s):  
E. K. Serezhina ◽  
A. G. Obrezan
Keyword(s):  
Heart Failure ◽  
Chest Pain ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Myocardial Injury ◽  
Heart Rhythm ◽  
Hospitalized Patients ◽  
Cardiovascular Pathology ◽  
Heart Rhythm Disorders ◽  
Coronavirus Infection

In the recent months of the COVID-19 pandemics, the cardiological society has faced a new challenge, myocardial injury by the coronavirus infection. According to statistics, 20-40% of hospitalized patients have chest pain, heart rhythm disorders, heart failure, and sudden cardiac death syndrome. This review focuses on recent studies and clinical cases related with this issue.

scholarly journals European Heart Rhythm Association/Heart Failure Association joint consensus document on arrhythmias in heart failure, endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society

2015 ◽  
Vol 17 (9) ◽  
pp. 848-874 ◽  
Author(s):  
Gregory Y.H. Lip ◽  
Frank R. Heinzel ◽  
Fiorenzo Gaita ◽  
Jose Rámon Gonzalez Juanatey ◽  
Jean Yves Le Heuzey ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rhythm ◽  
Asia Pacific ◽  
Consensus Document

Heart failure patients at high risk of sudden cardiac death in clinical practice

2003 ◽  
Vol 9 (5) ◽  
pp. S76
Author(s):  
Eugene S. Chung ◽  
Thomas G. Bartlett ◽  
Steven S. Gubin ◽  
Roger K. Muse ◽  
Maureen McGuire
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
High Risk ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Heart Failure Patients

scholarly journals European Heart Rhythm Association/Heart Failure Association joint consensus document on arrhythmias in heart failure, endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society

EP Europace ◽  
2015 ◽  
Vol 18 (1) ◽  
pp. 12-36 ◽  
Author(s):  
Gregory Y.H. Lip ◽  
Frank R. Heinzel ◽  
Fiorenzo Gaita ◽  
Jose Rámon Gonzalez Juanatey ◽  
Jean Yves Le Heuzey ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rhythm ◽  
Asia Pacific ◽  
Consensus Document

scholarly journals THE MECHANISMS AND CAUSES OF SUDDEN CARDIAC DEATH.FACTORS AND RISK STRATIFICATION IN CLINICAL PRACTICE. DEFINITIONS AND TERMS

2014 ◽  
Vol 5 (4) ◽  
pp. 3-12
Author(s):  
A V Ardashev ◽  
G P Arutyunov ◽  
E G Zhelyakov ◽  
Yu N Belenkov
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Cardiovascular Disease ◽  
Clinical Practice ◽  
Sudden Cardiac Death ◽  
Risk Stratification ◽  
Cardiac Death ◽  
Calculated Data ◽  
Growing Up ◽  
The World

Cardiovascular mortality in Russia is one of the highest in the world and is 1462 deaths per 100,000 per year. The main mechanisms dramatic outcomes of cardiovascular disease are death due to heart failure and sudden cardiac death (SCD). According to the calculated data 200,000-250,000 patients died suddenly in Russia per year.The problem of the SCD is one of the urgent problems of healthcare because prevalence of it is growing up and there is obvious possibility of effective preventive measures.In the present article presents definitions associated with SCD, mechanisms, primary and secondary risk factors for SCD.

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