scholarly journals Tetralogy of Fallot in infants less than one year old in the Valencia Region (Spain)

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
C Cavero Carbonell ◽  
L Barrachina Bonet ◽  
T Fernández Rojas ◽  
S Moreno Marro ◽  
L Páramo Rodríguez ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Congenital Anomalies ◽  
Population Based ◽  
Termination Of Pregnancy ◽  
Fetal Anomaly ◽  
Live Births ◽  
Epidemiologic Surveillance ◽  
Increasing Trend ◽  
The Difference ◽  
One Year

Abstract Background Tetralogy of Fallot (TF) is a rare disease characterized by the presence of 4 congenital heart defects (CHD). Objective: to describe the temporal trend and distribution of the TF in the Valencia Region (VR), in less than one year old, during the period 2007-2016. Methods Live births, stillbirths and termination of pregnancy due to fetal anomaly (TOPFA) between 2007-2016 with TF (code Q21.3 of the ICD10-BPA) were selected from the Congenital Anomalies (CA) population-based Registry of VR. The cases were confirmed through the review of clinical documentation. The prevalence of 10000 births with 95% confidence intervals (95%CI) was calculated for the period and for each year, and a descriptive analysis of sociodemographic and clinical variables was made. Results 146 cases were identified (45.2% male, 31.5% female and 23.3% unknown), 89.0% were simple pregnancies and 54.8% were diagnosed prenatally. The overall prevalence of TF was 3.0/10000 births (95%CI: 2.5-3.5), being 2015 the year with the highest prevalence (4.3/10000 births) and 2011 with the lowest (1.8/10000 births). These changes were mainly due to the increase and decrease in the number of TOPFA respectively. 74.7% were live births, 22.6% TOPFA and 2.7% stillbirths. The prevalence in live births was 2.2/10000 births (95%CI: 1.8-2.6) and in TOPFA it was 0.7/10000 births (95%CI: 0.4-0.9), identifying an increasing trend during the period in the last one. 11.0% of live births died during the first year of life. 45.9% of the cases had another CA associated with the TF, being CHD in 52.7% of cases. 66.4% of the mothers were over 30 years of age, being the most frequent those between 30-34 years (30.1%). Conclusions The prevalence obtained in the VR was lower than that of EUROCAT 3.5/10000 births (95%CI: 3.3-3.6) during the same period. EUROCAT has also identified the difference between the prevalence in live births (2.9 (95%CI: 2.8-3.0)) and TOPFA (0.5 (95%CI: 0.5-0.6)), and the increasing trend in the last one. Key messages The prevalence of Tetralogy of Fallot obtained in the VR was lower than that of EUROCAT (European network of population-based registries for the epidemiologic surveillance of congenital anomalies). EUROCAT has also identified the difference between the prevalence of Tetralogy of Fallot in live births and termination of pregnancy due to fetal anomaly, and the increasing trend in the last one.

The Difference in Sibling Birthweight and Neonatal Death: A Population-Based Cohort Study

2018 ◽  
Vol 36 (05) ◽  
pp. 498-504
Author(s):  
Maya Tabet ◽  
Louise Flick ◽  
Hong Xian ◽  
Jen Chang
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Neonatal Death ◽  
Binary Logistic Regression ◽  
Population Based ◽  
Growth Potential ◽  
Live Births ◽  
The Difference ◽  
Second Births ◽  
Half Sibling

Background There has been a call for customized rather than population-based birthweight standards that would classify smallness based on an infant's own growth potential. Thus, this study aimed to examine the association between the difference in sibling birthweight and the likelihood of neonatal death among second births in a U.S. population. Study Design This was a population-based cohort study including 179,300 women who delivered their first two nonanomalous singleton live births in Missouri (1989–2005). We performed binary logistic regression to evaluate the association between being relatively smaller than the elder full- or half-sibling (i.e., smaller by at least 500 g) and neonatal death (i.e., deaths in the first 28 days of life) among second births after controlling for sociodemographic and pregnancy-related variables in the second pregnancy. Results The adjusted odds of neonatal death were 2.54-times higher among second births who were relatively smaller than their elder sibling. Among relatively small second births, every 100-g increase in the difference in sibling birthweight was associated with a 13% increase in the odds of neonatal death. Conclusion The deviation from the elder sibling's birthweight predicts neonatal death. Taking into consideration the elder sibling's birthweight may be warranted in clinical and research settings.

scholarly journals Variation spatiotemporelle de la cryptorchidie et de l’hypospadias au Québec : Une étude exploratoire

2013 ◽  
Vol 5 (3) ◽  
pp. 167
Author(s):  
Sophie Guertin ◽  
Karine-Sylvie Lemieux ◽  
Natalie Makhoulian ◽  
Sébastien Michaud ◽  
Rose-Marie Patry ◽  
...  
Keyword(s):  
Epidemiological Study ◽  
Congenital Anomalies ◽  
Environmental Contaminants ◽  
Live Births ◽  
Statistical Institute ◽  
Anomalies Congénitales ◽  
Increasing Trend ◽  
Potential Link ◽  
Système De Surveillance

Objectifs : La majorité des études effectuées au cours des dernièresdécennies ont mis en évidence une augmentation du nombre decas de cryptorchidie et d’hypospadias entre 1970 et 1990. De plus,l’importante variabilité géographique de ces anomalies est biendécrite. Cette étude vise à mesurer la prévalence à la naissancede la cryptorchidie et de l’hypospadias au Québec, à vérifier sices anomalies sont en augmentation et à en évaluer la répartitioninterrégionale.Méthode : Une étude épidémiologique descriptive a été réalisée àpartir du nombre de garçons de cinq ans et moins hospitalisés pourune cryptorchidie ou un hypospadias au Québec de 1989 à 2004selon les données du fichier administratif d’hospitalisation MEDÉCHO.Les données sur les naissances provenaient de l’Institut dela statistique du Québec.Résultats : La prévalence annuelle moyenne pour 1000 naissancesvivantes de sexe masculin est de 19,1 (IC à 95 % : 18,8-19,4) pourla cryptorchidie et 11,4 (IC à 95 % 11,1-11,6) pour l’hypospadiasau Québec. Au cours de la période étudiée, la prévalence de cryptorchidiea légèrement diminué, alors que celle de l’hypospadiasest demeurée stable. Comparativement à la province du Québec,des régions présentent une prévalence significativement différentede cryptorchidie et/ou d’hypospadias. .Conclusion : Au Québec, la prévalence de cryptorchidie est enlégère diminution alors que celle de l’hypospadias est stable.Des variations régionales significatives sont observables. D’autresétudes sont nécessaires afin d’évaluer l’hypothèse d’un lien avecles contaminants environnementaux en émergence. L’implantationd’un système de surveillance des anomalies congénitales permettraitune représentation plus valide de la situation.Objectives: Previous research has shown evidence of an increasein the number of cases of cryptorchidism and hypospadias between1970 and 1990. Geographical disparities of these anomalies arewidely described. This study aims to measure the prevalence ofcryptorchidism and hypospadias at birth in the province of Quebec,to investigate if there is an increasing trend and to assess the interregionaldistribution of these anomalies. Method: A descriptive epidemiological study was undertaken toinvestigate the number of newborn males up to five years of age,hospitalized for cryptorchidism or hypospadias in Quebec between1989 and 2004 based on data collected from MED-ECHO, a databasecompiling hospitalizations and used for administrative purposes.Birth rates were provided by the Statistical Institute of Quebec. Results: Mean yearly prevalence per 1000 male live births was19.1 (95% CI 18.8-19.4) for cryptorchidism and 11.4 (95% CI11.1-11.6) for hypospadias for the province of Quebec. Within theperiod of study, the prevalence of cryptorchidism decreased slightlywhile that of hypospadias remained stable. Significant variationsin prevalence were observed in some regions compared to theprovince, for both pathologies. Conclusion: In Quebec, the prevalence of cryptorchidism isdecreasing while that of hypospadias is stable. There is significantregional variation among the province. More studies are neededto assess the potential link with environmental contaminants asan emerging explanation. The implementation of an adequate surveillancesystem for congenital anomalies would allow for a moreaccurate representation of the situation.

scholarly journals Serosurveillance among COVID-19 Cases in Ahmedabad Using SARS-COV2 IgG Antibodies

2021 ◽  
Vol 33 (2) ◽  
pp. 351-356
Author(s):  
Om Prakash ◽  
Bhavin Solanki ◽  
Jay Sheth ◽  
Daxa Maitrak ◽  
Mina Kadam ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Close Correlation ◽  
Population Based ◽  
Age Group ◽  
Igg Antibodies ◽  
Factors Affecting ◽  
Increasing Trend ◽  
Duration Of Hospitalization ◽  
The Difference ◽  
Clinical Illness

Background: Serosurveillance study focusing on antibodies against SARS-CoV2 among the Covid19 cases can add value in the scientific knowledge & help in formulating valid predictions regarding immunity status in the post-covid period. Objectives: To estimate seropositivity among covid19 cases and to identify various factors affecting seropositivity. Methods: During second half of October 2020, a population based serosurvey on Covid19 cases was carried out in Ahmedabad. Covid-Kavach test kits were used and estimated seroprevalence was compared with available demographic and covid19 case related parameters to identify factors affecting seropositivity in the post-covid period. Simple proportions and Z-test were used as appropriate. Results: As on October 2020, the sero-positivity among Covid19 cases in Ahmedabad was 54.51% [95% Confidence Interval (CI) 52.14-56.86%]. Females have higher positivity (54.78%) as compared to males (54.30%) but the difference was statistically not significant (Z=0.19, P=0.84). Among children and elderly, the positivity is high and from young adults to elderly the seropositivity has an increasing trend. Severity of clinical illness and longer duration of hospitalization are associated with higher seropositivity. Conclusion: With 54.51% seropositivity among covid19 cases, it is clear that all the covid19 cases may not have developed IgG antibodies, have undetectable level or might have disappeared during the post-covid period. Comparison of seropositivity with age group and clinical case details clearly suggest close correlation with the severity of clinical symptoms. The seronegative cases indicate the need for further in-depth scientific research to identify the factors affecting immunity and to uncover the reasons behind the same.

Racial/ethnic differences in the birth prevalence of congenital anomalies in the United States

2015 ◽  
Vol 43 (1) ◽  
Author(s):  
Alexander Egbe ◽  
Simon Lee ◽  
Deborah Ho ◽  
Santosh Uppu ◽  
Shubhika Srivastava
Keyword(s):  
African Americans ◽  
Ethnic Differences ◽  
Congenital Anomalies ◽  
Lower Risk ◽  
The United States ◽  
Population Based ◽  
Social Differences ◽  
Birth Prevalence ◽  
Live Births ◽  
Racial Ethnic

AbstractThis work aimed to analyze a single large representative population to determine racial/ethnic differences in the prevalence of congenital anomalies (CA).This is a population-based comprehensive analysis of racial/ethnic differences in the prevalence of CA diagnoses. We reviewed all live births in the 2008 Nationwide Inpatient Sample (NIS) database and determined the birth prevalence of 55 selected CA diagnoses in Caucasians. We then calculated the relative risk of these CA diagnoses in African American, Hispanics, and Asians relative to Caucasians.Overall CA prevalence was 29.2 per 1000 in a cohort of 1,048,252 live births, of which 51% were Caucasians. Compared with Caucasians, risk of overall CA was lower in African Americans (RR=0.9, CI: 0.8–0.9) and Hispanics (RR=0.9, CI: 0.8–0.9). Risk of overall CA was similar in Caucasians and Asians. Relative to the Caucasians, African Americans had lower risk of cardiac, genitourinary, and craniofacial CA but higher risk of musculoskeletal anomalies. Hispanics had lower risk of genitourinary and gastrointestinal CA. Asians had higher risk of craniofacial and musculoskeletal CA.Observed racial/ethnic differences in risk of CA may be related to genetic susceptibilities, cultural or social differences that could modify exposures, or many potential combinations between susceptibilities and exposures.

scholarly journals Hospital Based Birth Defect Surveillance in a Tertiary Care Centre

2017 ◽  
Vol 6 (3) ◽  
pp. 81
Author(s):  
MK Mohan Kumar ◽  
M.S. Vinodkumar ◽  
, Indu
Keyword(s):  
Congenital Anomalies ◽  
Tertiary Care ◽  
Care Centre ◽  
Timely Manner ◽  
Tertiary Care Centre ◽  
Live Births ◽  
Medical College ◽  
Still Births ◽  
One Year ◽  
And Child Health

<div><p><em>According to WHO in 2010, an estimated 270000 deaths globally were attributable to congenital anomalies during first 28 days of life. In an effort to decrease the number of congenital anomalies worldwide, 63<sup>rd</sup> the WHO adopted a birth defects resolution. The aim was to prevent congenital anomalies and raise awareness about their effects. Hospital based surveillance was implemented in India in collaboration with WHO. Institute of Maternal and Child Health (IMCH), Govt. Medical College Kozhikode was selected from the state of Kerala. Aim of this study includes, monitor and detect clusters (outbreaks) of congenital anomalies among a defined population and refer affected infants to appropriate services in a timely manner. Out of 15519 live births and 409 still births during the period of one year from November 2015 to 2016, there were 123 newborns with selected external congenital anomalies. </em><em></em></p></div>

scholarly journals Earnings among people with multiple sclerosis in Sweden, by education and occupation

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
C Murley ◽  
M Wiberg ◽  
P Tinghög ◽  
K Alexanderson ◽  
E Palmer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Educational Level ◽  
Population Based ◽  
Individual Characteristics ◽  
University Education ◽  
P Value ◽  
Aged People ◽  
Before And After ◽  
The Difference ◽  
One Year

Abstract Background Multiple sclerosis (MS) may affect the individual’s working life. We aimed to 1) investigate the mean levels and distributions of earnings among people with MS (PwMS) before and after MS diagnosis compared to people without an MS diagnosis, and whether such differences in earnings were associated with educational level or occupation and 2) assess the prevalence of sickness absence (SA) and disability pension (DP). Methods Population-based cohort study (10 years prior to 5 years after MS diagnosis) using microdata linked from nationwide Swedish registers of all individuals aged 30-54 with MS diagnosed in 2003-2006 (n = 2553) and references without MS (n = 7584) randomly selected by stratified matching (sex and age). Annual mean earnings, by educational level and type of occupation, were compared with t-tests. Tobit regressions investigated the associations of earnings with individual characteristics. Lastly, the proportions on SA and DP, stratified by educational level and type of occupation, were examined in the diagnosis year and 5 years later. Results Differences in earnings between PwMS and references were observed beginning one year prior to diagnosis and increased with time. PwMS had lower mean earnings for the diagnosis year (difference=SEK 28,000, p-value&lt;0.05), and the difference had more than doubled (p-value&lt;0.05) 5 years later. These differences remained after taking educational level and type of occupation into account. PwMS with university education and/or more qualified occupations had mean earnings most like their respective references’. PwMS had higher prevalence of SA and DP than the references, in both the diagnosis year and 5 years later. Conclusions Earnings of people with MS were lower than references’ already one year before diagnosis, and the gap increased thereafter. Results indicate that educational level and type of occupation are of importance for earnings. Moreover, SA and DP were more common among people with MS. Key messages Our results indicate that working-aged people with MS have less earnings than references already one year before diagnosis and that thereafter this gap in earnings increases with time. Education and occupation were influential in explaining the people with MS’ heterogeneous earnings, with a hierarchal ordering of who maintained similar earnings to their respective peers.

scholarly journals Impact of pre-pregnancy diabetes mellitus on congenital anomalies, Canada, 2002–2012

2015 ◽  
Vol 35 (5) ◽  
pp. 79-84 ◽  
Author(s):  
S Liu ◽  
J Rouleau ◽  
JA León ◽  
R Sauve ◽  
KS Joseph ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Anomaly ◽  
Congenital Anomalies ◽  
Population Attributable Risk ◽  
Population Based ◽  
Birth Prevalence ◽  
Live Births ◽  
Diagnostic Codes ◽  
Cardiovascular Defects ◽  
The Impact

Objective To examine the impact of pre-pregnancy diabetes mellitus (DM) on the population birth prevalence of congenital anomalies in Canada. Methods We carried out a population-based study of all women who delivered in Canadian hospitals (except those in the province of Quebec) between April 2002 and March 2013 and their live-born infants with a birth weight of 500 grams or more and/or a gestational age of 22 weeks or more. Pre-pregnancy type 1 or type 2 DM was identified using ICD-10 diagnostic codes. The association between DM and all congenital anomalies as well as specific congenital anomaly categories was estimated using adjusted odds ratios; the impact was calculated as a population attributable risk percent (PAR%). Results There were 118 892 infants with a congenital anomaly among 2 839 680 live births (41.9 per 1000). While the prevalence of any congenital anomaly declined from 50.7 per 1000 live births in 2002/03 to 41.5 per 1000 in 2012/13, the corresponding PAR% for a congenital anomaly related to pre-pregnancy DM rose from 0.6% (95% confidence interval [CI]: 0.4–0.8) to 1.2% (95% CI: 0.9–1.4). Specifically, the PAR% for congenital cardiovascular defects increased from 2.3% (95% CI: 1.7–2.9) to 4.2% (95% CI: 3.5–4.9) and for gastrointestinal defects from 0.8% (95% CI: 0.2–1.9) to 1.4% (95% CI: 0.7–2.6) over the study period. Conclusion Although there has been a relative decline in the prevalence of congenital anomalies in Canada, the proportion of congenital anomalies due to maternal prepregnancy DM has increased. Enhancement of preconception care initiatives for women with DM is recommended.

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