scholarly journals Serosurveillance among COVID-19 Cases in Ahmedabad Using SARS-COV2 IgG Antibodies

2021 ◽  
Vol 33 (2) ◽  
pp. 351-356
Author(s):  
Om Prakash ◽  
Bhavin Solanki ◽  
Jay Sheth ◽  
Daxa Maitrak ◽  
Mina Kadam ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Close Correlation ◽  
Population Based ◽  
Age Group ◽  
Igg Antibodies ◽  
Factors Affecting ◽  
Increasing Trend ◽  
Duration Of Hospitalization ◽  
The Difference ◽  
Clinical Illness

Background: Serosurveillance study focusing on antibodies against SARS-CoV2 among the Covid19 cases can add value in the scientific knowledge & help in formulating valid predictions regarding immunity status in the post-covid period. Objectives: To estimate seropositivity among covid19 cases and to identify various factors affecting seropositivity. Methods: During second half of October 2020, a population based serosurvey on Covid19 cases was carried out in Ahmedabad. Covid-Kavach test kits were used and estimated seroprevalence was compared with available demographic and covid19 case related parameters to identify factors affecting seropositivity in the post-covid period. Simple proportions and Z-test were used as appropriate. Results: As on October 2020, the sero-positivity among Covid19 cases in Ahmedabad was 54.51% [95% Confidence Interval (CI) 52.14-56.86%]. Females have higher positivity (54.78%) as compared to males (54.30%) but the difference was statistically not significant (Z=0.19, P=0.84). Among children and elderly, the positivity is high and from young adults to elderly the seropositivity has an increasing trend. Severity of clinical illness and longer duration of hospitalization are associated with higher seropositivity. Conclusion: With 54.51% seropositivity among covid19 cases, it is clear that all the covid19 cases may not have developed IgG antibodies, have undetectable level or might have disappeared during the post-covid period. Comparison of seropositivity with age group and clinical case details clearly suggest close correlation with the severity of clinical symptoms. The seronegative cases indicate the need for further in-depth scientific research to identify the factors affecting immunity and to uncover the reasons behind the same.

scholarly journals Tetralogy of Fallot in infants less than one year old in the Valencia Region (Spain)

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
C Cavero Carbonell ◽  
L Barrachina Bonet ◽  
T Fernández Rojas ◽  
S Moreno Marro ◽  
L Páramo Rodríguez ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Congenital Anomalies ◽  
Population Based ◽  
Termination Of Pregnancy ◽  
Fetal Anomaly ◽  
Live Births ◽  
Epidemiologic Surveillance ◽  
Increasing Trend ◽  
The Difference ◽  
One Year

Abstract Background Tetralogy of Fallot (TF) is a rare disease characterized by the presence of 4 congenital heart defects (CHD). Objective: to describe the temporal trend and distribution of the TF in the Valencia Region (VR), in less than one year old, during the period 2007-2016. Methods Live births, stillbirths and termination of pregnancy due to fetal anomaly (TOPFA) between 2007-2016 with TF (code Q21.3 of the ICD10-BPA) were selected from the Congenital Anomalies (CA) population-based Registry of VR. The cases were confirmed through the review of clinical documentation. The prevalence of 10000 births with 95% confidence intervals (95%CI) was calculated for the period and for each year, and a descriptive analysis of sociodemographic and clinical variables was made. Results 146 cases were identified (45.2% male, 31.5% female and 23.3% unknown), 89.0% were simple pregnancies and 54.8% were diagnosed prenatally. The overall prevalence of TF was 3.0/10000 births (95%CI: 2.5-3.5), being 2015 the year with the highest prevalence (4.3/10000 births) and 2011 with the lowest (1.8/10000 births). These changes were mainly due to the increase and decrease in the number of TOPFA respectively. 74.7% were live births, 22.6% TOPFA and 2.7% stillbirths. The prevalence in live births was 2.2/10000 births (95%CI: 1.8-2.6) and in TOPFA it was 0.7/10000 births (95%CI: 0.4-0.9), identifying an increasing trend during the period in the last one. 11.0% of live births died during the first year of life. 45.9% of the cases had another CA associated with the TF, being CHD in 52.7% of cases. 66.4% of the mothers were over 30 years of age, being the most frequent those between 30-34 years (30.1%). Conclusions The prevalence obtained in the VR was lower than that of EUROCAT 3.5/10000 births (95%CI: 3.3-3.6) during the same period. EUROCAT has also identified the difference between the prevalence in live births (2.9 (95%CI: 2.8-3.0)) and TOPFA (0.5 (95%CI: 0.5-0.6)), and the increasing trend in the last one. Key messages The prevalence of Tetralogy of Fallot obtained in the VR was lower than that of EUROCAT (European network of population-based registries for the epidemiologic surveillance of congenital anomalies). EUROCAT has also identified the difference between the prevalence of Tetralogy of Fallot in live births and termination of pregnancy due to fetal anomaly, and the increasing trend in the last one.

scholarly journals Seroepidemiological Study of Novel Corona Virus (CoVID-19) in Tehran, Iran

2021 ◽  
Author(s):  
Zeinab Tabanejad ◽  
Sorena Darvish ◽  
Zeinab Borjian Boroujeni ◽  
Seyed Saeed Asadi ◽  
Morteza Mesri ◽  
...  
Keyword(s):  
False Negative ◽  
Underlying Disease ◽  
Population Based ◽  
Immunological Methods ◽  
Age Group ◽  
Igg Antibodies ◽  
Rt Pcr ◽  
Igg Antibody ◽  
Cross Sectional ◽  
Exposed Population

AbstractA novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread to all countries of the world, including Iran. Although new anti-coronavirus antibodies in patients may be identified by immunological methods with sufficient sensitivity and specificity, the conclusive diagnosis of the disease is by the molecular RT-PCR process. We used a population-based seroepidemiological survey to quantify the proportion of the exposed population with SARS-CoV-2 antibodies and evaluated whether the antibodies are a marker of total or partial immunity to the proportion of the population that remains susceptible to the virus. This cross-sectional study was conducted to investigate the seroprevalence of CoVID-19 in Tehran, the capital of Iran, between April and end of October 2020. Specimens of clotted and heparinized blood (2ml) were collected from the patients. The serum and plasma were separated and stored at − 80LJ°C until use. We examined serum anti-SARS-CoV-2 IgG and IgM antibodies from 1375 in-patients admitted to our hospitals using ELISA kits. In total, 1375 participants were enrolled in this study, and SARS-CoV-2 antibodies were detected using IgM-IgG antibody assay in 291 patients. Among the seropositive patients studied, 187 were men (64.3%), and 104 were women (35.7%) (P<0.05). The mean age of the patients was 49±8.4 years; the majority (27%) were in age group 31-40 years. Also, the lowest frequency of cases was reported in the age group of 1-10 years (P <0.05). We determined the seroprevalence of SARS-CoV-2 for IgM or IgG antibodies to be 21.2%. Diabetes mellitus was the most common underlying disease among SARS-CoV-2 patients [P=0.05; Odd Ratio=1.61(0.90-2.91)]. Conventional serological assays in SARS-CoV-2 cases, such as the enzyme-linked immunoassay (ELISA) for specific IgM and IgG antibodies, have a high-throughput advantage and minimize false-negative rates that occur with the RT-PCR method. This study determined the seroprevalence of SARS-CoV-2 antibodies to be 21%. Control of diabetes among other cases factors shall play important role in management and control of COVID-19.

scholarly journals Increased Risk of Central Serous Chorioretinopathy among Patients with Nonorganic Sleep Disturbance

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Peng-Tai Tien ◽  
Chien-Yu Lai ◽  
Chun-Ju Lin ◽  
Wen-Lu Chen ◽  
Po-Kang Lin ◽  
...  
Keyword(s):  
Sleep Disturbance ◽  
Psychological Stress ◽  
Central Serous Chorioretinopathy ◽  
Population Based ◽  
Sensitivity Analyses ◽  
Rank Test ◽  
Age Group ◽  
Frequency Matching ◽  
Increased Risk ◽  
The Difference

Purpose. Patients with central serous chorioretinopathy (CSC) typically present with acute visual impairment and metamorphopsia. The disease previously has been associated with psychological stress. Population-based cohort studies on the risk of CSC among patients with nonorganic sleep disturbance (NOSD) are limited. An early sign of psychiatric disorder was probably sleep disturbance. Furthermore, psychological stress may be caused by sleep disturbance. We investigated the relationship between NOSD and the incidence of CSC. Design. Longitudinal cohort study. Participants. We used the Longitudinal Health Insurance Database and collected the data of 53,743 NOSD patients without CSC between 2000 and 2005 as the study group. Four-fold controls were selected randomly from those without neither sleep disturbance nor a CSC history with frequency matching of age, sex, and index-year. Methods. The difference in sex, age group, comorbidities, and steroid use between the two groups was analyzed by the χ2 test. Cox-proportional hazard regression was utilized to estimate the hazard ratio (HR) and 95% confidence intervals (95% CI) for comparison of the two groups. Kaplan–Meier analysis was applied to measure the cumulative incidence of CSC. Furthermore, the log-rank test was used to test the incidence difference between the two groups. Main Outcome Measures. The incidence rate of CSC in the following years until 2011 was detected. Results. During a mean follow-up of 7.36 ± 2.88 years, NOSD patients had a higher incidence of CSC than the controls (3.10 vs. 1.86 per 10,000 person-years; adjusted HR, 1.65; 95% CI, 1.34–2.02). Men had a higher risk of CSC than women. Sensitivity analyses stratified by sex, age group, or comorbidity condition showed consistently that NOSD patients had a higher risk of CSC than their controls. Dose-response showed that higher NOSD severity had even higher CSC risk. Conclusions. NOSD is an independent indicator for the increased risk of subsequent CSC development.

scholarly journals COVID-19 Vaccination Uptake among individuals with Immune-Mediated Inflammatory Diseases in Ontario, Canada between December 2020 and October 2021: A population-based analysis

2022 ◽  
pp. jrheum.211148
Author(s):  
Jessica Widdifield ◽  
Lihi Eder ◽  
Simon Chen ◽  
Jeffrey C. Kwong ◽  
Carol Hitchon ◽  
...  
Keyword(s):  
General Population ◽  
Inflammatory Diseases ◽  
Population Based ◽  
Vaccine Uptake ◽  
Age Group ◽  
Case Definitions ◽  
Vaccination Programs ◽  
Cumulative Percentage ◽  
Immune Mediated ◽  
The Difference

Objective We assessed COVID-19 vaccine uptake among individuals with immune-mediated inflammatory diseases (IMID) and the Ontario general population. Methods We studied all residents 16 years and older who were alive and enrolled in Ontario's universal health insurance plan as of December 14, 2020 when vaccination commenced (n=12,435,914). Individuals with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), psoriasis (PsO), and inflammatory bowel disease (IBD) were identified using established disease-specific case definitions applied to health administrative data. Vaccination status was extracted from the provincial COVaxON registry. Weekly cumulative proportions of first and second doses up until October 3, 2021 were expressed as the vaccinated percentage of each disease group, and compared to the general Ontario population, and stratified by age. Results By October 3, 2021, the cumulative percentage with at least one dose was 82.1% for the general population, 88.9% for RA, 87.4% for AS, 90.6% for PsA, 87.3% for PsO, and 87.0% for IBD. There was also a higher total cumulative percentage with two doses among IMIDs (83.8-88.2%) vs the general population (78.0%). The difference was also evident when stratifying by age. Individuals with IMIDs in the youngest age group initially had earlier uptake than the general population but remain the lowest age group with two doses (70.6% in the general population vs. 73.7-79.2% across IMID groups). Conclusion While implementation of COVID-19 vaccination programs has differed globally, these Canadian estimates are the first to reassuringly show higher COVID-19 vaccine uptake among individuals with IMIDs.

scholarly journals Reassessing the population based Seroprevalence for IgG antibodies against SARS COV2 in Ahmedabad

2021 ◽  
Vol 12 (5) ◽  
pp. 1-6
Author(s):  
Om Prakash ◽  
Bhavin Solanki ◽  
Jay Sheth ◽  
Ashwin Kharadi ◽  
Mina Kadam ◽  
...  
Keyword(s):  
Public Health ◽  
General Population ◽  
Population Based ◽  
Effective Vaccine ◽  
Igg Antibodies ◽  
The Public ◽  
Health Measures ◽  
The People ◽  
Care Workers ◽  
Increasing Trend

Background: Assessing population based seroprevalence can help in monitor the pandemic, and suggest appropriate corrective public health measures. Aims and Objectives: To study seroprevalence of IgG antibodies against SARS-CoV2 to understand the pandemic status and deriving valid conclusions for guiding the public health measures for managing the covid19 pandemic. Materials and Methods: A serosurveillance study was carried out using population based stratified sampling for the general population of Ahmedabad city. Seroprevalence for Cases, Contacts and Health Care Workers (HCWs) was also estimated as separate additional categories. The seroprevalence was compared with various demographic factors for valid and precise predictions regarding the immunity status of the population. Results: As on October 2020, the seroprevalence for IgG antibodies against SARS-CoV2 in the general population of Ahmedabad is 24.20% (95% Confidence Interval 23.57%–24.85%) The sero-positivity has increasing trend with age and is higher among females (24.83%) than males (23.72%) but is statistically not significant. The zone wise positivity ranged from 18.70% to 33.52%. The seropositivity among HCWs, contacts and cases are 20.84%, 26.05% and 54.51% respectively and it closely correlate with the risk. Conclusion: As on October 2020, general population demonstrate a seropositivity of 24.20%. The seropositivity among various groups is according to the risk of contracting the disease. Results also indicate the possibility of undetectable level or disappearing IgG during the post-covid period. Results also indicate that the preventive measures must be strongly followed for continued control of the pandemic situation till an effective vaccine is provided to the people at large.

scholarly journals Carriers of a Classic CYP21A2 Mutation Have Reduced Mortality: A Population-Based National Cohort Study

2019 ◽  
Vol 104 (12) ◽  
pp. 6148-6154
Author(s):  
Anna Nordenström ◽  
Johan Svensson ◽  
Svetlana Lajic ◽  
Louise Frisén ◽  
Agneta Nordenskjöld ◽  
...  
Keyword(s):  
General Population ◽  
Cause Of Death ◽  
Clinical Symptoms ◽  
Population Based ◽  
Hazard Ratios ◽  
Severe Mutation ◽  
National Cohort ◽  
The Difference ◽  
Population Controls ◽  
Overall Mortality

Abstract Context Congenital adrenal hyperplasia (CAH) is a common monogenic recessive disorder. It has been suggested that CYP21A2 deficiency is common because carriers may have a survival advantage, 1 in 15,000 in most populations. Carriers of CYP21A2 mutations typically do not have clinical symptoms but have a defined phenotype with a more prompt cortisol response to ACTH. Objective We investigated whether the mortality was lower, and determined the cause of death in carriers and population controls. Design A total of 1143 obligate carriers of a CYP21A2 mutation (561 men) were identified from the Swedish National CAH Registry, encompassing >700 patients and the Multi-Generation Registry to identify their parents. The mortality and cause of death were identified through the Swedish Cause of Death Registry. The hazard ratios (HRs) and 95% CIs were calculated. The results were compared with controls from the general population, matched for sex and age. Results The overall mortality was lower in carriers of a CYP21A2 mutation compared with the controls (HR 0.79; 95% CI, 0.678 to 0.917; P = 0.002). The difference was more marked among carriers of a more severe mutation. Infection as the cause of death was significantly lower (HR 0.65; 95% CI, 0.48 to 0.87; P < 0.01), particularly for death in pneumonia (HR 0.22; 95% CI, 0.06 to 0.88; P = 0.03). The lower overall mortality among women compared with men in the general population was confirmed among both carriers and controls. Conclusion Obligate CYP21A2 carriers of a classic mutation had a reduced mortality. Specifically, a possible reduced mortality due to pneumonia was seen.

scholarly journals A new customised placental weight standard redefines the relationship between maternal obesity and extremes of placental size and is more closely associated with pregnancy complications than an existing population standard

2019 ◽  
Vol 11 (4) ◽  
pp. 350-359
Author(s):  
Jacqueline M. Wallace ◽  
Joeleita P. Agard ◽  
Graham W. Horgan
Keyword(s):  
Pregnancy Complications ◽  
Maternal Obesity ◽  
Population Based ◽  
Multiple Regression Model ◽  
Placental Weight ◽  
Morbidly Obese ◽  
Obese Women ◽  
Entire Cohort ◽  
Multiparous Women ◽  
The Difference

AbstractPlacental weight is a valuable indicator of its function, predicting both pregnancy outcome and lifelong health. Population-based centile charts of weight-for-gestational-age and parity are useful for identifying extremes of placental weight but fail to consider maternal size. To address this deficit, a multiple regression model was fitted to derive coefficients for predicting normal placental weight using records from healthy pregnancies of nulliparous/multiparous women of differing height and weight (n = 107,170 deliveries, 37–43 weeks gestation). The difference between actual and predicted placental weight generated a z-score/individual centile for the entire cohort including women with pregnancy complications (n = 121,591). The association between maternal BMI and placental weight extremes defined by the new customised versus population-based standard was investigated by logistic regression, as was the association between low placental weight and pregnancy complications. Underweight women had a greater risk of low placental weight [<10thcentile, OR 1.84 (95% CI 1.66, 2.05)] and obese women had a greater risk of high placental weight [>90th centile, OR 1.98 (95% CI 1.88, 2.10)] using a population standard. After customisation, the risk of high placental weight in obese/morbidly obese women was attenuated [OR 1.17 (95% CI 1.09, 1.25)]/no longer significant, while their risk of low placental weight was 59%–129% higher (P < 0.001). The customised placental weight standard was more closely associated with stillbirth, hypertensive disease, placental abruption and neonatal death than the population standard. Our customised placental weight standard reveals higher risk of relative placental growth restriction leading to lower than expected birthweights in obese women, and a stronger association between low placental weight and pregnancy complications generally. Further, it provides an alternative tool for defining placental weight extremes with implications for the placental programming of chronic disease.

A quantitative evaluation of some factors affecting the non-fatty solids of cow's milk

1960 ◽  
Vol 27 (1) ◽  
pp. 19-32 ◽  
Author(s):  
W. H. Alexander ◽  
F. B. Leech
Keyword(s):  
Cell Count ◽  
Residual Effect ◽  
Clinical Mastitis ◽  
High Cell ◽  
Factors Affecting ◽  
Stage Of Lactation ◽  
Cell Counts ◽  
Satisfactory Analysis ◽  
The Difference ◽  
Image Position

SummaryTen farms in the county of Durham took part in a field study of the effects of feeding and of udder disease on the level of non-fatty solids (s.n.f.) in milk. Statistical analysis of the resulting data showed that age, pregnancy, season of the year, and total cell count affected the percentage of s.n.f. and that these effects were additive and independent of each other. No effect associated with nutritional changes could be demonstrated.The principal effects of the factors, each one freed from effects of other factors, were as follows:Herds in which s.n.f. had been consistently low over a period of years were compared with herds in which s.n.f. had been satisfactory. Analysis of the data showed that about 70% of the difference in s.n.f. between these groups could be accounted for by differences in age of cow, stage of lactation, cell count and breed.There was some evidence of a residual effect following clinical mastitis that could not be accounted for by residual high cell counts.The within-cow regression of s.n.f. on log cell count calculated from the Durham data and from van Rensburg's data was on both occasions negative.The implications of these findings are discussed, particularly in relation to advisory work.

scholarly journals Tower Running—Participation, Performance Trends, and Sex Difference

2020 ◽  
Vol 17 (6) ◽  
pp. 1902 ◽  
Author(s):  
Daniel Stark ◽  
Stefania Di Gangi ◽  
Caio Victor Sousa ◽  
Pantelis Nikolaidis ◽  
Beat Knechtle
Keyword(s):  
Sex Differences ◽  
Statistical Model ◽  
Sex Difference ◽  
Random Effects ◽  
Age Groups ◽  
Repeated Measurements ◽  
Stair Climbing ◽  
Age Group ◽  
Performance Trends ◽  
The Difference

Though there are exhaustive data about participation, performance trends, and sex differences in performance in different running disciplines and races, no study has analyzed these trends in stair climbing and tower running. The aim of the present study was therefore to investigate these trends in tower running. The data, consisting of 28,203 observations from 24,007 climbers between 2014 and 2019, were analyzed. The effects of sex and age, together with the tower characteristics (i.e., stairs and floors), were examined through a multivariable statistical model with random effects on intercept, at climber’s level, accounting for repeated measurements. Men were faster than women in each age group (p < 0.001 for ages ≤69 years, p = 0.003 for ages > 69 years), and the difference in performance stayed around 0.20 km/h, with a minimum of 0.17 at the oldest age. However, women were able to outperform men in specific situations: (i) in smaller buildings (<600 stairs), for ages between 30 and 59 years and >69 years; (ii) in higher buildings (>2200 stairs), for age groups <20 years and 60–69 years; and (iii) in buildings with 1600–2200 stairs, for ages >69 years. In summary, men were faster than women in this specific running discipline; however, women were able to outperform men in very specific situations (i.e., specific age groups and specific numbers of stairs).

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