scholarly journals Comparative Genomic Analysis of Rapid Evolution of an Extreme-Drug-Resistant Acinetobacter baumannii Clone

2013 ◽  
Vol 5 (5) ◽  
pp. 807-818 ◽  
Author(s):  
Sean Yang-Yi Tan ◽  
Song Lin Chua ◽  
Yang Liu ◽  
Niels Høiby ◽  
Leif Percival Andersen ◽  
...  
2020 ◽  
Vol 21 ◽  
pp. 363-368
Author(s):  
Jason Farlow ◽  
Maia Nozadze ◽  
Nino Mitaishvili ◽  
Adam Kotorashvili ◽  
Nato Kotoria ◽  
...  

2014 ◽  
Vol 59 (2) ◽  
pp. 1168-1176 ◽  
Author(s):  
Henan Li ◽  
Fei Liu ◽  
Yawei Zhang ◽  
Xiaojuan Wang ◽  
Chunjiang Zhao ◽  
...  

ABSTRACTAcinetobacter baumanniiis a globally important nosocomial pathogen characterized by an evolving multidrug resistance. A total of 35 representative clinicalA. baumanniistrains isolated from 13 hospitals in nine cities in China from 1999 to 2011, including 32 carbapenem-resistant and 3 carbapenem-susceptibleA. baumanniistrains, were selected for whole-genome sequencing and comparative genomic analysis. Phylogenetic analysis revealed that the earliest strain, strain 1999BJAB11, and two strains isolated in Zhejiang Province in 2004 were the founder strains of carbapenem-resistantA. baumannii. Ten types of AbaR resistance islands were identified, and a previously unreported AbaR island, which comprised a two-component response regulator, resistance-related proteins, and RND efflux system proteins, was identified in two strains isolated in Zhejiang in 2004. Multiple transposons or insertion sequences (ISs) existed in each strain, and these gradually tended to diversify with evolution. Some of these IS elements or transposons were the first to be reported, and most of them were mainly found in strains from two provinces. Genome feature analysis illustrated diversified resistance genes, surface polysaccharides, and a restriction-modification system, even in strains that were phylogenetically and epidemiologically very closely related. IS-mediated deletions were identified in the type VI secretion system region, thecsuEregion, and core lipooligosaccharide (LOS) loci. Recombination occurred in the heme utilization region, and intrinsic resistance genes (blaADCandblaOXA-51-likevariants) and three novelblaOXA-51-likevariants (blaOXA-424,blaOXA-425, andblaOXA-426) were identified. Our results could improve the understanding of the evolutionary processes that contribute to the emergence of carbapenem-resistantA. baumanniistrains and help elucidate the molecular evolutionary mechanism inA. baumannii.


PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56577 ◽  
Author(s):  
Elena N. Ilina ◽  
Egor A. Shitikov ◽  
Larisa N. Ikryannikova ◽  
Dmitry G. Alekseev ◽  
Dmitri E. Kamashev ◽  
...  

Viruses ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 188 ◽  
Author(s):  
Anastasia Popova ◽  
Daria Lavysh ◽  
Evgeniy Klimuk ◽  
Mikhail Edelstein ◽  
Alexander Bogun ◽  
...  

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