Effect of dietary protein intake on bone mineral density and fracture incidence in older adults in the Health, Aging, and Body Composition study

2021 ◽  
Author(s):  
Ashley A Weaver ◽  
Janet A Tooze ◽  
Jane A Cauley ◽  
Douglas C Bauer ◽  
Frances A Tylavsky ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Body Composition ◽  
Vertebral Fracture ◽  
Protein Intake ◽  
Whole Body ◽  
Mineral Density ◽  
Health Aging ◽  
Lower Protein

Abstract Background Dietary recommendations may underestimate the protein older adults need for optimal bone health. This study sought to determine associations of protein intake with bone mineral density (BMD) and fracture among community-dwelling white and black older adults. Methods Protein as a percentage of total energy intake (TEI) was assessed with a food frequency questionnaire in 2,160 older adults (73.5±2.8 years; 51.5% women; 35.8% black) in the Health, Aging, and Body Composition prospective cohort. Hip, femoral neck, and whole body BMD was assessed by dual-energy x-ray absorptiometry at baseline and 4 years, and lumbar trabecular, cortical, and integral BMD was assessed by computed tomography at baseline and 5 years. Fragility fractures over 5 years were adjudicated from self-report data collected every 6 months. Associations with tertiles of protein intake were assessed using analysis of covariance for BMD and multivariate Cox regression for fracture, adjusting for confounders. Results Participants in the upper protein tertile (≥15% TEI) had 1.8-6.0% higher mean hip and lumbar spine BMD compared to the lower protein tertile (<13% TEI; p<0.05). Protein intake did not affect change in BMD at any site over the follow-up period. Participants in the upper protein tertile had a reduced risk of clinical vertebral fracture over five years of follow-up (Hazard Ratio: 0.36 [95% Confidence Intervals (CI), 0.14, 0.97] vs. lower protein tertile, p=0.04). Conclusions Older adults with higher protein intake (≥15% TEI) had higher BMD at the hip, whole body, and lumbar spine, and a lower risk of vertebral fracture.

Hearing sensitivity and bone mineral density in older adults: the Health, Aging and Body Composition Study

2005 ◽  
Vol 16 (12) ◽  
pp. 1675-1682 ◽  
Author(s):  
Elizabeth P. Helzner ◽  
Jane A. Cauley ◽  
Sheila R. Pratt ◽  
Steven R. Wisniewski ◽  
Evelyn O. Talbott ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Body Composition ◽  
Bone Mineral ◽  
Mineral Density ◽  
Hearing Sensitivity ◽  
Body Composition Study ◽  
Health Aging ◽  
Composition Study

scholarly journals The Effects of a High-Protein Diet on Bone Mineral Density in Exercise-Trained Women: A 1-Year Investigation

2018 ◽  
Vol 3 (4) ◽  
pp. 62
Author(s):  
Jose Antonio ◽  
Anya Ellerbroek ◽  
Cassandra Carson
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Mineral Content ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Whole Body ◽  
Mineral Density ◽  
One Year

The effects of long-term high-protein consumption (i.e., >2.2 g/kg/day) are unclear as it relates to bone mineral content. Thus, the primary endpoint of this investigation was to determine if consuming a high-protein diet for one year affected various parameters of body composition in exercise-trained women. This investigation is a follow-up to a prior 6-month study. Subjects were instructed to consume a high-protein diet (>2.2 g/kg/day) for one year. Body composition was assessed via dual-energy X-ray absorptiometry (DXA). Subjects were instructed to keep a food diary (i.e., log their food ~three days per week for a year) via the mobile app MyFitnessPal®. Furthermore, a subset of subjects had their blood analyzed (i.e., basic metabolic panel). Subjects consumed a high-protein diet for one year (mean ± SD: 2.3 ± 1.1 grams per kilogram body weight daily [g/kg/day]). There were no significant changes for any measure of body composition over the course of the year (i.e., body weight, fat mass, lean body mass, percent fat, whole body bone mineral content, whole body T-score, whole body bone mineral density, lumbar bone mineral content, lumbar bone mineral density and lumbar T-score). In addition, we found no adverse effects on kidney function. Based on this 1-year within-subjects investigation, it is evident that a diet high in protein has no adverse effects on bone mineral density or kidney function.

scholarly journals Association of total protein intake with bone mineral density and bone loss in men and women from the Framingham Offspring Study

2013 ◽  
Vol 17 (11) ◽  
pp. 2570-2576 ◽  
Author(s):  
Shivani Sahni ◽  
Kerry E Broe ◽  
Katherine L Tucker ◽  
Robert R McLean ◽  
Douglas P Kiel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Protein Intake ◽  
Mineral Density ◽  
Cross Sectional ◽  
Total Protein Intake ◽  
Multivariable Regression ◽  
The Impact

AbstractObjectiveTo examine (i) the association of percentage of total energy intake from protein (protein intake %) with bone mineral density (BMD, g/cm2) and bone loss at the femoral neck, trochanter and lumbar spine (L2–L4) and (ii) Ca as an effect modifier.SettingThe Framingham Offspring Study.SubjectsMen (n 1280) and women (n 1639) completed an FFQ in 1992–1995 or 1995–1998 and underwent baseline BMD measurement by dual-energy X-ray absorptiometry in 1996–2000. Men (n 495) and women (n 680) had follow-up BMD measured in 2002–2005.DesignCohort study using multivariable regression to examine the association of protein intake % with each BMD, adjusting for covariates. Statistical interaction between protein intake % and Ca (total, dietary, supplemental) intake was examined.ResultsThe mean age at baseline was 61 (sd 9) years. In the cross-sectional analyses, protein intake % was positively associated with all BMD sites (P range: 0·02–0·04) in women but not in men. Significant interactions were observed with total Ca intake (<800 mg/d v. ≥800 mg/d) in women at all bone sites (P range: 0·002–0·02). Upon stratification, protein intake % was positively associated with all BMD sites (P range: 0·04–0·10) in women with low Ca intakes but not in those with high Ca intakes. In the longitudinal analyses, in men, higher protein intake % was associated with more bone loss at the trochanter (P = 0·01) while no associations were seen in women, regardless of Ca intake.ConclusionsThis suggests that greater protein intake benefits women especially those with lower Ca intakes. However, protein effects are not significant for short-term changes in bone density. Contrastingly, in men, higher protein intakes lead to greater bone loss at the trochanter. Longer follow-up is required to examine the impact of protein on bone loss.

Bone Mineral Density and Body Composition in Ulcerative Colitis: A Six-Year Follow-up

2001 ◽  
Vol 12 (5) ◽  
pp. 343-348 ◽  
Author(s):  
F. M. Ulivieri ◽  
L. P. Piodi ◽  
E. Taioli ◽  
D. Lisciandrano ◽  
T. Ranzi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Ulcerative Colitis ◽  
Body Composition ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Effect of 6-12 Weeks of Systemic Glucocorticoids on Bone Mineral Density in Children

2021 ◽  
Author(s):  
Kalpana Panda ◽  
Soumya Dey ◽  
Namrita Sachdev ◽  
Tribhuvan Pal Yadav
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Whole Body ◽  
Categorical Variables ◽  
Care Hospital ◽  
Mineral Density ◽  
Systemic Steroids ◽  
Systemic Glucocorticoids ◽  
Age And Sex

Introduction: Prolonged use of systemic steroids in children is associated with many side-effects including effect on Bone Mineral Density (BMD). Effect of more than three months of systemic steroids on BMD has been studied in children but not the effect of 6-12 weeks duration of steroid. Aim: To evaluate the effect of 6-12 weeks of systemic glucocorticoids on BMD in children. Materials and Methods: A longitudinal observational study was conducted at a Tertiary Care Hospital. Dual Energy X-ray Absorptiometry (DEXA) of Whole Body (WB), Lumbar Spine (LS) and Distal Radius (DR) were done at baseline, end of steroid therapy or third month whichever was earlier and end of six months, on 30 patients receiving systemic steroid (Nephrotic Syndrome (NS)-7, Systemic Onset Juvenile Idiopathic Arthritis (SOJIA)-12, Tubercular Meningitis-11). Age and sex adjusted values of Bone Mineral Content (BMC), BMD and Z scores were analysed. Bone densitometric parameters of Total Body Less the Head (TBLH) were derived from WB values. X-rays of whole spine (antero-posterior and lateral view) were done at baseline and follow-up. Equal number of age and sex matched healthy controls were subjected to biochemical and DEXA scans at baseline. Continuous and categorical variables were compared using Student’s t-test and Fisher-exact test, respectively. Pairwise comparison over period of time was done using Bonferroni correction. Results: Bone densitometric parameters of cases and controls were comparable at baseline. At follow-up statistically significant decrease in BMD was found at all three sites. A statistically significant negative correlation was found between cumulative dose of steroid and duration of steroid treatment with Z score of TBLH. No vertebral fractures were detected at baseline or follow-up. Conclusion: Use of systemic glucocorticoids for 6-12 weeks negatively affects bone mineralisation, not only during therapy but even three months after stopping it.

scholarly journals Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study

2019 ◽  
Vol 109 (3) ◽  
pp. 535-543 ◽  
Author(s):  
Amely M Verreijen ◽  
Mariëlle F Engberink ◽  
Denise K Houston ◽  
Ingeborg A Brouwer ◽  
Peggy M Cawthon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Older Adults ◽  
Body Composition ◽  
Protein Intake ◽  
Vegetable Protein ◽  
Thigh Muscle ◽  
Sectional Area ◽  
Cross Sectional ◽  
Health Aging ◽  
Muscle Cross Sectional Area

ABSTRACTBackgroundA higher protein intake is suggested to preserve muscle mass during aging and may therefore reduce the risk of sarcopenia.ObjectivesWe explored whether the amount and type (animal or vegetable) of protein intake were associated with 5-y change in mid-thigh muscle cross-sectional area (CSA) in older adults (n = 1561).MethodsProtein intake was assessed at year 2 by a Block food-frequency questionnaire in participants (aged 70–79 y) of the Health, Aging, and Body Composition (Health ABC) Study, a prospective cohort study. At year 1 and year 6 mid-thigh muscle CSA in square centimeters was measured by computed tomography. Multiple linear regression analysis was used to examine the association between energy-adjusted protein residuals in grams per day (total, animal, and vegetable protein) and muscle CSA at year 6, adjusted for muscle CSA at year 1 and potential confounders including prevalent health conditions, physical activity, and 5-y change in fat mass.ResultsMean (95% CI) protein intake was 0.90 (0.88, 0.92) g · kg–1 · d–1 and mean (95% CI) 5-y change in muscle CSA was −9.8 (−10.6, −8.9) cm2. No association was observed between energy-adjusted total (β = −0.00; 95% CI: −0.06, 0.06 cm2; P = 0.982), animal (β = −0.00; 95% CI: −0.06, 0.05 cm2; P = 0.923), or plant (β = +0.07; 95% CI: −0.06, 0.21 cm2; P = 0.276) protein intake and muscle CSA at year 6, adjusted for baseline mid-thigh muscle CSA and potential confounders.ConclusionsThis study suggests that a higher total, animal, or vegetable protein intake is not associated with 5-y change in mid-thigh muscle CSA in older adults. This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.

Primary hyperparathyroidism: whole-body bone mineral density in surgically treated Danish patients: a three-year follow-up study

Bone ◽  
1999 ◽  
Vol 25 (5) ◽  
pp. 597-602 ◽  
Author(s):  
P Christiansen ◽  
T Steiniche ◽  
K Brixen ◽  
I Hessov ◽  
F Melsen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Follow Up Study ◽  
Body Bone
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