APOE- 4, Depressive Symptoms, and Cognitive Decline in Chinese Older Adults: Singapore Longitudinal Aging Studies

Abstract Background Social isolation and loneliness have each been associated with cognitive decline, but most previous research is limited to Western populations. This study examined the relationships of social isolation and loneliness on cognitive function among Chinese older adults. Methods This study used two waves of data (2011 and 2015) from the China Health and Retirement Longitudinal Study and analyses were restricted to those respondents aged 50 and older. Social isolation, loneliness, and cognitive function were measured at baseline. Follow-up measures on cognitive function were obtained for 7761 participants (mean age = 60.97, s.d. = 7.31; male, 50.8%). Lagged dependent variable models adjusted for confounding factors were used to evaluate the association between baseline isolation, loneliness, and cognitive function at follow-up. Results Loneliness was significantly associated with the cognitive decline at follow-up (episodic memory: β = −0.03, p < 0.01; mental status: β = −0.03, p < 0.01) in the partially adjusted models. These associations became insignificant after additional confounding variables (chronic diseases, health behaviors, disabilities, and depressive symptoms) were taken into account (all p > 0.05). By contrast, social isolation was significantly associated with decreases in all cognitive function measures at follow-up (episodic memory: β = −0.05, p < 0.001; mental status: β = −0.03, p < 0.01) even after controlling for loneliness and all confounding variables. Conclusions Social isolation is associated with cognitive decline in Chinese older adults, and the relationships are independent of loneliness. These findings expand our knowledge about the links between social relationships and the cognitive function in non-Western populations.

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Adult Children’s Support and Trajectory of Depressive Symptoms Among Disabled Chinese Older Adults

Innovation in Aging ◽

10.1093/geroni/igaa057.2705 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 751-751

Author(s):

Jianyun Wang ◽

Renyao Zhong ◽

Yaolin Pei ◽

Bei Wu

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Lower Risk ◽

Risk Group ◽

Policy Implications ◽

Instrumental Support ◽

Growth Mixture Model ◽

Chinese Older Adults ◽

Growth Mixture

Abstract This study aimed to examine the trajectory of depressive symptoms among Chinese older adults with disabilities and the role of adult children’s support in predicting trajectory classes of depressive symptoms. Data were drawn from three waves of the China Health and Retirement Longitudinal Study (2011-2015). The sample included 1420 disabled older adults age 60+ at the baseline and completed all three waves of the data. Growth mixture model shows two-class depressive symptoms trajectories: the higher risk group (25.49%) and the lower risk group (74.51%). Logistic regression results showed that respondents who received a longer term of adult children’s instrumental support were more likely to be classified in a higher risk group after controlling the covariates (OR=1.184, p<0.05), while financial support and the frequency of contacts were not associated with the increased level of depressive symptoms. The policy implications were also discussed in this study.

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P2-607: DEPRESSIVE SYMPTOMS PREDICT COGNITIVE DECLINE IN OLDER ADULTS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.1303 ◽

2006 ◽

Vol 14 (7S_Part_18) ◽

pp. P972-P972

Author(s):

Elizabeth Guerrero-Berroa ◽

James Schmeidler ◽

Vahram Haroutunian ◽

Joshua Arneson ◽

Rebecca West ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Cognitive Decline

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LOW LEVELS OF PHYSICAL ACTIVITY ARE ASSOCIATED WITH COGNITIVE DECLINE, DEPRESSIVE SYMPTOMS AND MOBILITY IMPAIRMENTS IN OLDER ADULTS ENROLLED IN A HEALTH INSURANCE PLAN

Geriatrics Gerontology and Aging ◽

10.5327/z2447-211520191900053 ◽

2019 ◽

Vol 13 (4) ◽

pp. 205-210

Author(s):

Henrique Souza Barros de Oliveira ◽

◽

Helena Cristina Buffalo ◽

Isabella Ferlini Cieri ◽

Laura Nicolau Nassif ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Health Insurance ◽

Depressive Symptoms ◽

Cognitive Decline ◽

Insurance Plan ◽

Health Insurance Plan ◽

Mobility Impairments ◽

Low Levels

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Longitudinal Relationships Between Subjective Cognitive Decline and Objective Memory: Depressive Symptoms Mediate Between-Person Associations

Journal of Alzheimer s Disease ◽

10.3233/jad-210230 ◽

2021 ◽

pp. 1-14

Author(s):

Nikki L. Hill ◽

Sakshi Bhargava ◽

Emily Bratlee-Whitaker ◽

Jennifer R. Turner ◽

Monique J. Brown ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Cognitive Decline ◽

Structural Equation ◽

Disease Risk ◽

Well Being ◽

Equation Modeling ◽

Subjective Cognitive Decline ◽

Future Research ◽

Over Time

Background: Subjective cognitive decline (SCD) may be an early indicator of cognitive impairment, but depressive symptoms can confound this relationship. Associations may be influenced by differences between individuals (i.e., between-persons) or how each individual changes in their experiences over time (i.e., within-persons). Objective: We examined depressive symptoms as a mediator of the between- and within-person associations of SCD and objective memory in older adults. Methods: Coordinated analyses were conducted across four datasets drawn from large longitudinal studies. Samples (range: n = 1,889 to n = 15,841) included participants 65 years of age or older with no dementia at baseline. We used multilevel structural equation modeling to examine the mediation of SCD and objective memory through depressive symptoms, as well as direct relationships among SCD, objective memory, and depressive symptoms. Results: Older adults who were more likely to report SCD had lower objective memory on average (between-person associations), and depressive symptoms partially mediated this relationship in three of four datasets. However, changes in depressive symptoms did not mediate the relationship between reports of SCD and declines in objective memory in three of four datasets (within-person associations). Conclusion: Individual differences in depressive symptoms, and not changes in an individual’s depressive symptoms over time, partially explain the link between SCD and objective memory. Older adults with SCD and depressive symptoms may be at greater risk for poor cognitive outcomes. Future research should explore how perceived changes in memory affect other aspects of psychological well-being, and how these relationships influence cognitive decline and Alzheimer’s disease risk.

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IC-P-139: LONGITUDINAL DEPRESSIVE SYMPTOMS AND CORTICAL AMYLOID ARE ASSOCIATED WITH COGNITIVE DECLINE IN OLDER ADULTS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.2205 ◽

2006 ◽

Vol 14 (7S_Part_2) ◽

pp. P116-P117

Author(s):

Jennifer R. Gatchel ◽

Jennifer S. Rabin ◽

Rachel F. Buckley ◽

Joseph J. Locascio ◽

Yakeel T. Quiroz ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Cognitive Decline

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ELDER MISTREATMENT AND DEPRESSIVE SYMPTOMS AMONG OLDER CHINESE AMERICANS

Innovation in Aging ◽

10.1093/geroni/igz038.2797 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S761-S761

Author(s):

Ying-Yu Chao ◽

Yu-Ping Chang ◽

XinQi Dong

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Chinese Americans ◽

Comprehensive Understanding ◽

Elder Mistreatment ◽

Chinese Older Adults ◽

Financial Exploitation ◽

Different Types ◽

Older Chinese ◽

Older Chinese Americans

Abstract This study aimed to examine the association between different types of elder mistreatment and depressive symptoms among U.S. Chinese older adults. Data were from the Population Study of Chinese Elderly in Chicago (PINE). Participants were 3,157 Chinese older adults who were 60 years and over (mean age = 72.8). Logistic regression analyses were performed. The results showed that participants with overall mistreatment (OR, 2.11; 95% CI, 1.83-2.43), psychological mistreatment (OR, 2.12; 95% CI, 1.78-2.51), physical mistreatment (OR, 1.82; 95% CI, 1.10-2.99), and financial exploitation (OR, 1.33; 95% CI, 1.11 – 1.60) were more likely to report more depressive symptoms. There was no significant association between sexual mistreatment and depressive symptoms (p = 0.07). Longitudinal studies are needed to obtain a more comprehensive understanding of the pathways between elder mistreatment and depressive symptoms.

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Intergenerational Coresidence and Depressive Symptoms of Rural and Urban Older Adults in China

Journal of Family Issues ◽

10.1177/0192513x19888256 ◽

2019 ◽

Vol 41 (8) ◽

pp. 1282-1306

Author(s):

Jinyu Liu ◽

Lydia Li ◽

Zhenmei Zhang ◽

Hongwei Xu

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Marital Status ◽

Linear Regression Analysis ◽

Later Life ◽

Well Being ◽

Chinese Older Adults ◽

Rural And Urban ◽

Intergenerational Coresidence

Objectives: This study aimed to examine whether gender and marital status of coresiding adult children are associated with depressive symptoms of Chinese older adults. Methods: Using data from the China Health and Retirement Longitudinal Study, linear regression analysis was conducted to identify longitudinal associations of intergenerational coresidence with depressive symptoms in rural and urban older Chinese. Results: Both rural and urban older adults living with unmarried sons had significantly higher depressive symptoms at four-year follow-up than those who did not live with children. Living with married sons was significantly associated with higher levels of depressive symptoms at four-year follow-up among rural elders only. Discussion: This study sheds light on the heterogeneity in the relationship between intergenerational coresidence and Chinese older adults’ psychological well-being by the gender and marital status of coresiding children. Further research is needed to understand the complex and dynamic household structures and health outcomes in later life.

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