Metabolic comorbidities among patients with peripheral artery disease: a national population-based study

Abstract Peripheral artery disease (PAD) is a chronic disease which is associated with old age. PAD was known as an age-related chronic condition. Metabolic comorbid conditions which include hypertension, diabetes, and hyperlipidemia can have negative impacts on blood vessels aggravating PAD in elderly patients. Therefore, metabolic comorbidities need be considered in order to develop intervention for patients with PAD. The aim of this study is to find the characteristics of PAD patients with metabolic comorbidities. This is a retrospective study that used the national claim data of South Korea from 2009 to 2018. The inclusion criteria were adults (20+) and patients diagnosed with PAD as a primary or secondary diagnosis from 2011 to 2017. The frequency of hypertension, hyperlipidemia, diabetes, and metabolic comorbidities in PAD patients was examined. In addition, the difference in the number of metabolic comorbidities according to sex was identified using the chi-squared test. Among the total PAD adult patients(n=8,478,876), the number of elderly patients over 60 years old was 4,124,592(48.7%). Among the total patients, PAD patients with hypertension were the most common at 958,329 (11.30%). Sex was significantly related to having metabolic comorbidities and women showed higher proportion of metabolic comorbidities compared to men (χ2 =5.02, p<.001). As the frequency of PAD patients with hypertension were the highest, it is necessary to develop a health management program that considers metabolic comorbidities, especially hypertension, in order to manage PAD disease. In addition, there is a need for special interest in intervening metabolic conditions of female patients with PAD.

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Peripheral artery disease in Germany (2009–2018): Prevalence, frequency of specialized ambulatory care and use of guideline-recommended therapy – A population-based study

The Lancet Regional Health - Europe ◽

10.1016/j.lanepe.2021.100113 ◽

2021 ◽

Vol 5 ◽

pp. 100113

Author(s):

Christos Rammos ◽

Martin Steinmetz ◽

Julia Lortz ◽

Amir A. Mahabadi ◽

Olga Petrikhovich ◽

...

Keyword(s):

Ambulatory Care ◽

Peripheral Artery Disease ◽

Population Based ◽

Peripheral Artery ◽

Population Based Study ◽

Artery Disease ◽

Recommended Therapy

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The Association between Earlobe Crease (Frank’s Sign) and Abnormal Ankle-Brachial Index Determination Is Related to Age: A Population-Based Study

International Journal of Vascular Medicine ◽

10.1155/2018/4735731 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Oscar H. Del Brutto ◽

Robertino M. Mera ◽

Aldo F. Costa ◽

Mauricio Zambrano ◽

Mark J. Sedler

Keyword(s):

Logistic Regression ◽

Peripheral Artery Disease ◽

Ankle Brachial Index ◽

Heart Association ◽

Population Based ◽

Community Dwelling ◽

Peripheral Artery ◽

Probability Models ◽

High Prevalence ◽

Artery Disease

Background. Information on the association between earlobe crease (ELC) and peripheral artery disease is limited. We assessed this association in community-dwelling older adults. Study Design. A total of 294 Atahualpa residents aged ≥60 years were enrolled. ELC were visually identified by two raters. The ankle-brachial index (ABI), used as a surrogate of peripheral artery disease, was categorized using American Heart Association criteria. Using logistic regression and probability models, adjusted for demographics and cardiovascular risk factors, we assessed the relationship between ELC and abnormal ABI determinations, as well as the influence of age on this association. Results. ELC was identified in 141 (48%) individuals, and abnormal ABI determination was carried out in 56 (19%). The association between ELC and abnormal ABI was nonsignificant in logistic regression and probability models with individuals stratified according to their median age. Conclusions. The association between ELC and abnormal ABI determinations is probably attenuated by the high prevalence of both conditions in older persons. ELC might not be useful for identifying candidates for ABI determination.

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Multiple Peri-Operative Complications are Associated with Reduced Long Term Amputation Free Survival Following Revascularisation for Lower Limb Peripheral Artery Disease: A Population Based Linked Data Study

Journal of Vascular Surgery ◽

10.1016/j.jvs.2020.01.070 ◽

2020 ◽

Vol 71 (4) ◽

pp. 1452

Author(s):

S.J. Aitken ◽

D.A. Randall ◽

N. Noguchi ◽

F.M. Blyth ◽

V. Naganathan

Keyword(s):

Peripheral Artery Disease ◽

Lower Limb ◽

Linked Data ◽

Population Based ◽

Peripheral Artery ◽

Free Survival ◽

Operative Complications ◽

Artery Disease

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Prevalence, Correlates, and Prognosis of Peripheral Artery Disease in Rural Ecuador—Rationale, Protocol, andPhase IResults of a Population-Based Survey: An Atahualpa Project-Ancillary Study

International Journal of Vascular Medicine ◽

10.1155/2014/643589 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Oscar H. Del Brutto ◽

Mark J. Sedler ◽

Robertino M. Mera ◽

Pablo R. Castillo ◽

Elizabeth H. Cusick ◽

...

Keyword(s):

Phase I ◽

Peripheral Artery Disease ◽

Cardiovascular Health ◽

Ankle Brachial Index ◽

Vascular Diseases ◽

Population Based ◽

Test Reliability ◽

Phase Iii ◽

Peripheral Artery ◽

Artery Disease

Background. Little is known on the prevalence of peripheral artery disease (PAD) in developing countries.Study design. Population-based study in Atahualpa. InPhase I, the Edinburgh claudication questionnaire (ECQ) was used for detection of suspected symptomatic PAD; persons with a negative ECQ but a pulse pressure ≥65 mmHg were suspected of asymptomatic PAD. InPhase II, the ankle-brachial index will be used to test reliability of screening instruments and to determine PAD prevalence. InPhase III, participants will be followed up to estimate the relevance of PAD as a predictor of vascular outcomes.Results. DuringPhase I, 665 Atahualpa residents aged ≥40 years were enrolled (mean age: 59.5 ± 12.6 years, 58% women). A poor cardiovascular health status was noticed in 464 (70%) persons of which 27 (4%) had a stroke and 14 (2%) had ischemic heart disease. Forty-four subjects (7%) had suspected symptomatic PAD and 170 (26%) had suspected asymptomatic PAD. Individuals with suspected PAD were older, more often women, and had a worse cardiovascular profile than those with nonsuspected PAD.Conclusions. Prevalence of suspected PAD in this underserved population is high. Subsequent phases of this study will determine whether prompt detection of PAD is useful to reduce the incidence of catastrophic vascular diseases in the region.

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Validation of Diagnosis and Procedure Codes for Revascularization for Peripheral Artery Disease in Ontario Administrative Databases

Clinical & Investigative Medicine ◽

10.25011/cim.v44i2.36354 ◽

2021 ◽

Vol 44 (2) ◽

pp. E36-43

Author(s):

Jean Jacob-Brassard ◽

Mohammed Al-Omran ◽

Thérèse A. Stukel ◽

Muhammad Mamdani ◽

Douglas S. Lee ◽

...

Keyword(s):

Positive Predictive Value ◽

Peripheral Artery Disease ◽

Predictive Value ◽

Population Based ◽

Administrative Databases ◽

Peripheral Artery ◽

Predictive Values ◽

Diagnosis Codes ◽

Artery Disease ◽

Procedure Codes

Purpose: To estimate the positive predictive value of diagnosis and procedure codes for open and endovascular revascularization for peripheral artery disease (PAD) in Ontario administrative databases. Methods: We conducted a retrospective validation study using population-based Ontario administrative databases (2005-2019) to identify a random sample of 600 patients who underwent revascularization for PAD at two academic centres, based on ICD-10 diagnosis codes and Canada Classification of Health Intervention procedure codes. Administrative data coding was compared to the gold standard diagnosis (PAD vs. non-PAD) and revascularization approach (open vs. endovascular) extracted through blinded hospital chart re-abstraction. Positive predictive values and 95% confidence intervals were calculated. Combinations of procedure codes with or without supplemental physician claims codes were evaluated to optimize the positive predictive value. Results: The overall positive predictive value of PAD diagnosis codes was 87.5% (84.6%-90.0%). The overall positive predictive value of revascularization procedure codes was 94.3% (92.2%-96.0%), which improved through supplementation with physician fee claim codes to 98.1% (96.6%-99.0%). Algorithms to identify individuals revascularized for PAD had combined positive predictive values ranging from 82.8% (79.6%-85.8%) to 95.7% (93.5%-97.3%). Conclusion: Diagnosis and procedure codes with or without physician claims codes allow for accurate identifi-cation of individuals revascularized for PAD in Ontario administrative databases.

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