Association Between Arterial Stiffness and Fatigability in Well-Functioning Older Adults

Abstract The association between vascular health measured by arterial stiffness and fatigability, a marker of future mobility decline, is unknown. We examined 1210 men (47.7%) and women from the Baltimore Longitudinal Study of Aging, mean age 66.6 ± 13.9 years. Perceived fatigability was assessed after a 5-minute, treadmill walk using Borg rating (range 6-20). Arterial stiffness was determined by carotid femoral pulse wave velocity (PWV). In linear regression analyses fatigability and PWV were associated in men (Beta/P-value) (0.160/0.001) and women (0.136/0.008). Adjustment for mean arterial and pulse pressure attenuated the association in women (0.104/0.050) but not men (0.160/0.001). The association was significant among those with slower usual and rapid gait speeds, longer 400m walk time and slower repeated chair stands pace (all p<0.05). Arterial stiffness is associated with a greater proneness to fatigue especially in older adults exhibiting poorer mobility. The underlying mechanisms appear to differ between men and women.

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Sex-Specific Gait Patterns of Older Adults with Knee Osteoarthritis: Results from the Baltimore Longitudinal Study of Aging

Current Gerontology and Geriatrics Research ◽

10.1155/2011/175763 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Seung-uk Ko ◽

Eleanor M. Simonsick ◽

Liz M. Husson ◽

Luigi Ferrucci

Keyword(s):

Older Adults ◽

Longitudinal Study ◽

Early Detection ◽

Frontal Plane ◽

Joint Diseases ◽

Gait Patterns ◽

Men And Women ◽

Gait Adaptation ◽

Knee Oa ◽

Baltimore Longitudinal Study

Men and women exhibit different gait patterns during customary walking and may respond differently to joint diseases. The present paper aims to identify gait patterns associated with knee-OA separately in men and women. Participants included 144 men and 124 women aged 60 years and older enrolled in the Baltimore Longitudinal Study of Aging (BLSA) who underwent gait testing at a self-selected speed. Both men and women with knee-OA had lower ankle propulsion mechanical work expenditure (MWE;P<.001for both) and higher hip generative MWE (P<.001) compared to non-OA controls. Women with knee-OA had a higher BMI (P=.008), slower gait speed (P=.049), and higher knee frontal-plane absorbing MWE (P=.007) than women without knee-OA. These differences were not observed in men. Understanding sex-specific differences in gait adaptation to knee-OA may inform the development of appropriate strategies for early detection and intervention for knee-OA in men and women.

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Personality and Insomnia Symptoms in Older Adults: The Baltimore Longitudinal Study of Aging

Innovation in Aging ◽

10.1093/geroni/igaa057.1925 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 578-579

Author(s):

Darlynn Rojo-Wissar ◽

Amal Wanigatunga ◽

Eleanor Simonsick ◽

Antonio Terracciano ◽

Jennifer Schrack ◽

...

Keyword(s):

Older Adults ◽

Longitudinal Study ◽

Sleep Disturbances ◽

Positive Emotions ◽

Rating Scale ◽

Factor Model ◽

Five Factor Model ◽

Baltimore Longitudinal Study ◽

Insomnia Symptoms ◽

Insomnia Severity

Abstract Personality and disturbed sleep are tied to medical morbidity in older adults. We examined associations of personality dimensions and facets from the five-factor model with reports of insomnia symptoms in 1,069 well-functioning older adults 60-97 (SD=8.64) years (51% women) from the Baltimore Longitudinal Study of Aging. Personality was assessed by the Revised NEO Personality Inventory, and insomnia symptoms measured by the Women’s Health Initiative Insomnia Rating Scale. Adjusting for demographics and depressive symptoms, higher neuroticism (B=0.05, SE=-0.01, p<.001) and lower conscientiousness (B=-0.03, SE=-0.01, p<.05) were associated with greater insomnia severity. Although openness, extraversion and agreeableness were not associated with insomnia, a facet of each was. Higher scores on the “positive emotions” facet of extraversion (B =-0.03, SE=-0.01, p<.05) “ideas” facet of openness (B=-0.03, SE=-0.01, p<.05) and altruism facet of agreeableness (B=-0.03, SE=-0.01, p<.05) were associated with lower insomnia severity. Sleep disturbances may partially mediate personality’s influence on health. Part of a symposium sponsored by the Sleep, Circadian Rhythms and Aging Interest Group.

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Changes in leisure time physical activity and risk of all-cause mortality in men and women: The Baltimore Longitudinal Study of Aging

Preventive Medicine ◽

10.1016/j.ypmed.2007.05.014 ◽

2007 ◽

Vol 45 (2-3) ◽

pp. 169-176 ◽

Cited By ~ 68

Author(s):

Laura A. Talbot ◽

Christopher H. Morrell ◽

Jerome L. Fleg ◽

E. Jeffrey Metter

Keyword(s):

Physical Activity ◽

Longitudinal Study ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Men And Women ◽

All Cause Mortality ◽

Baltimore Longitudinal Study

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Longitudinal change in forced expiratory volume in healthy, non-smoking men and women: The Baltimore Longitudinal Study of Aging

American Journal of Human Biology ◽

10.1002/(sici)1520-6300(1998)10:4<471::aid-ajhb7>3.0.co;2-j ◽

1998 ◽

Vol 10 (4) ◽

pp. 471-481 ◽

Cited By ~ 3

Author(s):

Jay D. Pearson ◽

Stephanie Y. Kao ◽

Larry J. Brant ◽

E. Jeffrey Metter ◽

Melvyn S. Tockman ◽

...

Keyword(s):

Longitudinal Study ◽

Forced Expiratory Volume ◽

Longitudinal Change ◽

Men And Women ◽

Baltimore Longitudinal Study

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Abstract 3077: Cross-Sectional Associations of Arterial Stiffness Measures and Ankle-Brachial Index: The Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽

10.1161/circ.118.suppl_18.s_810-b ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

John T Wilkins ◽

Mary M McDermott ◽

Kiang Liu ◽

Cheeling Chan ◽

Michael Criqui ◽

...

Keyword(s):

Arterial Stiffness ◽

Mechanical Characteristics ◽

Pulse Wave ◽

Ankle Brachial Index ◽

Arterial Disease ◽

Cross Sectional ◽

Men And Women ◽

Independent Variables ◽

Vascular Impedance ◽

Peripheral Arterial

The association between tonometry-derived measures of arterial stiffness and peripheral arterial disease (PAD) is unclear. Using baseline data from 2847 female and 2614 male participants of the NHLBI-funded MESA study, we conducted linear regression analyses adjusted for age, demographics and risk factors. Ankle-brachial index (ABI) was the dependent variable and measures of large (C1) and small artery elasticity (C2) and total vascular impedance (TVI), all measured from radial artery tonometry, were the independent variables in separate models. In men and women, lower C1 and C2 values were associated with lower ABI. Higher TVI was associated with lower ABI in men and women [P<0.001]. Significant trends for C1, C2 and TVI were observed across clinical strata of ABI (Table ). In pairwise analyses, compared with participants with a normal ABI (1.1 to <1.3), those with ABI <1.1 tended to have significantly lower C2. Additionally, women with high ABI (1.3–1.5) tended to have significantly higher C2 values. Pairwise comparisons of lower and higher ABI groups compared with normal groups did not yield consistent findings for C1. Significantly higher TVI levels with lower ABI group were noted mostly in women (Table ). We observed a continuum of arterial mechanical characteristics across clinical ABI values, indicating that measures of arterial stiffness are significantly associated with ABI and severity of PAD. These results suggest that changes in C2 occur in patients with advanced lower extremity large-vessel atherosclerotic disease. Of note, female participants with high ABI between 1.3–1.5 had a significantly higher C2, arguing against the accepted “non-compressible” or “calcified arterial disease” explanation for high ABI in women. Associations Between ABI and Pulse Wave Analysis Measurements when adjusted for age, cigarette smoking, diabetes, hypertension, and creatinine level

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Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

10.21203/rs.3.rs-31909/v2 ◽

2020 ◽

Author(s):

Minghui Li ◽

Aihua Zhan ◽

Xiao Huang ◽

Lihua Hu ◽

Wei Zhou ◽

...

Keyword(s):

Arterial Stiffness ◽

Pulse Wave ◽

Fasting Glucose ◽

Independent Predictor ◽

Positive Association ◽

Regression Analyses ◽

Registry Study ◽

Hypertensive Patients ◽

Tyg Index ◽

Triglyceride Glucose Index

Abstract Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

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Energy Metabolism and the Burden of Multimorbidity in Older Adults: Results From the Baltimore Longitudinal Study of Aging

The Journals of Gerontology Series A ◽

10.1093/gerona/glu209 ◽

2014 ◽

Vol 70 (11) ◽

pp. 1297-1303 ◽

Cited By ~ 37

Author(s):

Elisa Fabbri ◽

Yang An ◽

Jennifer A. Schrack ◽

Marta Gonzalez-Freire ◽

Marco Zoli ◽

...

Keyword(s):

Older Adults ◽

Longitudinal Study ◽

Energy Metabolism ◽

Baltimore Longitudinal Study

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Differential associations between dual-task walking abilities and usual gait patterns in healthy older adults—Results from the Baltimore Longitudinal Study of Aging

Gait & Posture ◽

10.1016/j.gaitpost.2018.04.039 ◽

2018 ◽

Vol 63 ◽

pp. 63-67 ◽

Cited By ~ 4

Author(s):

Seung-uk Ko ◽

Gerald J. Jerome ◽

Eleanor M. Simonsick ◽

Stephanie Studenski ◽

Jeffrey M. Hausdorff ◽

...

Keyword(s):

Older Adults ◽

Longitudinal Study ◽

Dual Task ◽

Gait Patterns ◽

Healthy Older Adults ◽

Baltimore Longitudinal Study

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Abstract P048: Segment-Specific Pulse Wave Velocity and Subclinical Cardiac Overload and Damage in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽

10.1161/circ.137.suppl_1.p048 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Shuiqing Liu ◽

Esther Kim ◽

Aozhou Wu ◽

Michelle L Meyer ◽

Susan Cheng ◽

...

Keyword(s):

Older Adults ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Cardiac Disease ◽

Pulse Wave ◽

Troponin T ◽

High Sensitivity ◽

Clinical History ◽

Cardiac Biomarkers

Background: Pulse wave velocity (PWV) independently predicts cardiovascular disease. However, few studies simultaneously explored the associations of segment-specific PWV measures with markers of both cardiac overload (natriuretic peptide [NT-proBNP]) and damage (high-sensitivity cardiac troponin T [hs-cTnT]) among adults without cardiac disease. Methods: We examined 2,845 whites and blacks (67-90 years) without clinical history of cardiac disease during ARIC visit 5 (2011-13). The association of PWV quartiles (cf [carotid-femoral], hc [heart-carotid], hf [heart-femoral], ha [heart-ankle], ba [brachial-ankle], and fa [femoral-ankle]) with log-transformed NT-proBNP and hs-cTnT was evaluated using linear and logistic regression models to adjust for potential confounders. Results: Most PWV measures demonstrated J- or U-shaped associations with NTpro-BNP and hs-cTnT [Figure]. The highest vs. the second lowest quartile of central PWV measures (cfPWV, hfPWV, and hcPWV) was associated with higher levels of NT-proBNP independently of demographic characteristics. The associations were weaker for hs-cTnT. These associations were attenuated after further adjustment, but hcPWV and NT-proBNP remained borderline significant (p=0.069). haPWV, baPWV, and faPWV including peripheral elements had less evident positive associations after adjusting for traditional risk. Conclusion: The positive associations between PWV and cardiac biomarkers were stronger for central vs. peripheral arterial stiffness and for NT-proBNP vs. hs-cTnT among older adults without prevalent cardiac disease. Our findings indicate the relative importance of central arterial stiffness behind subclinical cardiac overload.

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