scholarly journals THE IMPORTANCE OF HSP-25 IN CAENORHABDITIS ELEGANS LONGEVITY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S865-S865
Author(s):  
Niaya James ◽  
Jessica L Scheirer ◽  
Karl Rodriguez
Keyword(s):  
Heat Stress ◽  
Caenorhabditis Elegans ◽  
Heat Shock ◽  
Model Organism ◽  
Small Heat Shock Protein ◽  
Health Science ◽  
Science Center ◽  
Knock Out ◽  
University Of Texas

Abstract Karl A. Rodriguez’s laboratory at the University of Texas Health Science Center, San Antonio, Texas, is interested in the role of small heat shock proteins in the proteostasis network and aging using the model organism, Caenorhabditis elegans. Molecular chaperones facilitate protein folding and improve the degradation activity of the proteasome and autolysosome hence decreasing disease-associated aggregates. Previous work in rodents have shown an increase in expression levels of the small heat shock protein 25 (HSP-25) correlates with maximum lifespan potential. To further explore the role of HSP-25 in C. elegans, two HSP-25 knock-out strains were exposed to a one-hour heat stress, heat shock, and two non-heat stress conditions.

Pulmonary Hypertension Roundtable: COPD, IPF, and Pulmonary Hypertension: A Clinician's Dilemma

2013 ◽  
Vol 12 (3) ◽  
pp. 145-151
Keyword(s):  
Pulmonary Hypertension ◽  
Rhode Island ◽  
Medical Center ◽  
Puget Sound ◽  
Health Science ◽  
Pulmonary Vascular Disease ◽  
University Hospitals ◽  
Science Center ◽  
University Of Texas ◽  
Transplant Program

On October 9, 2013, a group of experts met by telephone to discuss PH in the setting of COPD and IPF. The group consisting of guest editor of this issue Jeffrey Edelman, MD, Head, Lung Transplant Program VA Puget Sound Health System, University of Washington; Deborah J. Levine, MD, Director, Pulmonary Hypertension Center, University of Texas Health Science Center at San Antonio; James Klinger, MD, Director, Rhode Island Hospital Pulmonary Hypertension Center; and Robert Schilz, DO, PhD, Director of Pulmonary Vascular Disease and Lung Transplantation, University Hospitals, Case Medical Center; provided perspective and insight into how clinicians can approach these patients most effectively.

scholarly journals Role of the Conserved SRLFDQFFG Region of α-Crystallin, a Small Heat Shock Protein

2003 ◽  
Vol 278 (51) ◽  
pp. 51159-51166 ◽  
Author(s):  
Saloni Yatin Pasta ◽  
Bakthisaran Raman ◽  
Tangirala Ramakrishna ◽  
Ch. Mohan Rao
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Small Heat Shock Protein

scholarly journals Research Hot Spots and Trends on Melatonin From 2000 to 2019

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Meng ◽  
Zhengbo Tao ◽  
Siming Zhou ◽  
Wacili Da ◽  
Lin Tao
Keyword(s):  
Hot Spots ◽  
Hot Spot ◽  
Health Science ◽  
Science Center ◽  
Main Research ◽  
University Of Texas ◽  
Texas Health ◽  
The University ◽  
Number Of Citations ◽  
Analysis Platform

Research on melatonin remains one of the major hot spots in the field of disease treatment, but relevant data are numerous. The purpose of this study was to quantitatively and qualitatively analyze the progress of melatonin research through the method of bibliometrics and to predict hot spots and trends in melatonin research. This study retrieved all the studies on melatonin from 2000 to 2019 in the Web of Science and PubMed and analysed the publishing trends in the literature on a bibliometric online analysis platform and CiteSpace software. The research results were also visually analysed to summarize melatonin research hot spots through gCLUTO and pubMR. The study retrieved a total of 20,351 publications, of which the number of US publications ranked first, accounting for 21.46%, with the greatest impact (centrality = 0.31). The University of Texas Health Science Center at San Antonio and Harvard University had the highest average number of citations at 43.19 and 33.96, respectively. Journal of Pineal Research had the highest average number of citations in 2,993 journals. Professor Reiter made the largest contribution to this area. We further analysed 100 highly cited articles for clinical applications and ongoing related clinical drug trials based on the first hot spot. We systematically analysed melatonin for nearly 20 years while predicting the main research trends in the future, which may provide new directions and ideas for melatonin research. The structure and normal physiological functions of melatonin have been intensively studied in the past few years. And clinical application research and target of melatonin treatment for different diseases and target-based drug design will certainly become the focus of melatonin research.

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