scholarly journals EARLY-LIFE SOCIOECONOMIC POSITION AND ACCUMULATION OF HEALTH-RELATED DEFICITS IN MIDLIFE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S226-S226
Author(s):  
Nina Rogers ◽  
Chris Power ◽  
Snehal P Pereira
Keyword(s):  
Linear Regression ◽  
Birth Cohort ◽  
Socioeconomic Position ◽  
Early Life ◽  
Frailty Index ◽  
Later Life ◽  
Health Related ◽  
Managerial Class

Abstract Improved understanding of predictors of frailty is key to delaying its onset. Yet, few studies have examined whether early-life socioeconomic position (SEP) predicts frailty in midlife. In the 1958 British Birth Cohort (n=7601), we examined (i) associations between early-life SEP and frailty at 50y and (ii) whether associations were due to continuities in disadvantage into mid-adulthood. Frailty was measured using an index composed of 37 health-deficits. Associations between early-life SEP and frailty were examined using linear regression. Lower early-life SEP was associated with higher frailty, e.g. compared to professional/managerial class, the frailty index was higher by 3.09% (95% CI:-0.65%, 6.84%) for skilled non-manual, 10.8% (8.20%, 13.4%) for skilled manual and 14.2% (11.1%, 17.2%) for partly skilled/unskilled. After adjustment for adult disadvantage, the trend remained, albeit weaker. Findings suggest that interventions in mid-adulthood targeted to those exposed to early-life disadvantage could reduce the risk of developing frailty when entering later life.

scholarly journals Early-life socioeconomic position and the accumulation of health-related deficits by midlife in the 1958 British birth cohort study

2020 ◽  
Author(s):  
Nina Trivedy Rogers ◽  
Joanna M Blodgett ◽  
Samuel D Searle ◽  
Rachel Cooper ◽  
Daniel HJ Davis ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Socioeconomic Position ◽  
Early Life ◽  
Frailty Index ◽  
Birth Cohort Study ◽  
Adult Health ◽  
Occupational Class ◽  
Hazard Ratios ◽  
Health Related ◽  
The Life Course

Reducing population levels of frailty is an important goal and preventing its development in mid-adulthood could be pivotal. Childhood socioeconomic position (SEP) is associated with a myriad of adult health outcomes but evidence is limited on associations with frailty. Using 1958 British birth cohort data (N=8711), we aimed to: (i) establish the utility of measuring frailty in mid-life, by examining associations between a 34-item frailty index at 50y (FI50y) and mortality over an eight-year follow-up period and (ii) examine associations between early-life SEP and FI50y and investigate whether these associations were explained by adult SEP. Hazard ratios (HRs) for mortality increased with increasing levels of frailty, e.g., HRsex-adjusted was 4.07(95% CI:2.64,6.25) for highest vs. lowest fifth of FI50y. Lower early-life SEP was associated with higher FI50y: per unit decrease in early-life SEP (on a 4-point scale), FI50y increased by 12.7%(10.85%,14.6%) in a model adjusted for early-life covariates. After additional adjustment for adult occupational class and education, the association attenuated to 5.71%(3.71%,7.70%). Findings suggest that early-life SEP is associated with frailty and that adult SEP only partially explains this association. Results highlight the importance of improving socioeconomic circumstances across the life course to reduce inequalities in frailty from mid-adulthood.

scholarly journals Early-life Socioeconomic Position and the Accumulation of Health-related Deficits by Midlife in the 1958 British Birth Cohort Study

2021 ◽  
Author(s):  
Nina T Rogers ◽  
Joanna M Blodgett ◽  
Samuel D Searle ◽  
Rachel Cooper ◽  
Daniel H J Davis ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Socioeconomic Position ◽  
Early Life ◽  
Frailty Index ◽  
Birth Cohort Study ◽  
Limited Evidence ◽  
Important Goal ◽  
Hazard Ratios ◽  
Health Related ◽  
The Life Course

Abstract Reducing population levels of frailty is an important goal and preventing its development in mid-adulthood could be pivotal. There is limited evidence on associations between childhood socioeconomic position (SEP) and frailty. Using 1958 British birth cohort data (followed from 1958 to 2016; N=8711), we aimed to: (i) establish the utility of measuring frailty in mid-life, by examining associations between a 34-item frailty index at 50y (FI50y) and mortality (50-58y) and, (ii) examine associations between early-life SEP and FI50y, and investigate whether these associations were explained by adult SEP. Hazard ratios (HRs) for mortality increased with increasing frailty, e.g., HRsex-adjusted was 4.07(95% CI:2.64,6.25) for highest vs. lowest fifth of FI50y. Lower early-life SEP was associated with higher FI50y. Compared with participants born in the highest social class, the estimated total effect on FI50y was 42.0%(35.5%,48.4%) for participants born in the lowest class, with the proportion mediated by adult SEP being 0.45(0.35,0.55). Mediation by adult SEP was negligible, for other early-life SEP classes. Findings suggest that early-life SEP is associated with frailty and that adult SEP only partially explains this association. Results highlight the importance of improving socioeconomic circumstances across the life course to reduce inequalities in mid-life frailty.

Associations between life-course frailty and later-life heart size and function in the 1946 NSHD British birth cohort-an epidemiological study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C.C Topriceanu ◽  
J.C Moon ◽  
R Hardy ◽  
A.D Hughes ◽  
N Chaturvedi ◽  
...  
Keyword(s):  
Life Course ◽  
Birth Cohort ◽  
Frailty Index ◽  
Later Life ◽  
Left Ventricular ◽  
Step Change ◽  
Deficit Accumulation ◽  
Heart Size ◽  
And Function ◽  
The Life Course

Abstract Background Cardiovascular diseases are an important component of the multi-morbidity syndrome which is associated with negative health outcomes resulting in a major societal economic burden. An objective way to assess multi-morbidity is to calculate a frailty index based on medical deficit accumulation. Late-life frailty has been validated to predict mortality, but little is known about the association between life-course frailty and cardiovascular health in later-life. Purpose To study the association between life-course frailty and later-life heart size and function using data from the world's longest running birth cohort with continuous follow-up. Methods A 45-deficit frailty index (FI) was calculated at 4 age-intervals across the life-course (0 to 16 years old, 19 to 44 years old, 45 to 54 years old and 60 to 64 years old) in participants from the UK 1946 Medical Research Council (MRC) National Survey of Heath and Development (NSHD) birth cohort. The life-course frailty indices (FI0_16, FI19_44, FI45_54 and FI60_64) reflect the cumulative medical deficits at the corresponding age-intervals. They were used to derive FImean and FIsum reflecting overall-life frailty. The step change in deficit accumulation between age-intervals was also calculated (FI2-1, FI3-1, FI4-1, FI3-2, FI4-2, FI4-3). Echocardiographic data at 60–64 years provided: E/e' ratio, ejection fraction (EF), myocardial contraction fraction index (MCFi) and left ventricular mass index (LVmassi). Generalized linear mixed models with gamma distribution and log link assessed the association between FIs and echo parameters after adjustment for sex, socio-economic position and body mass index. Results 1.805 NSHD participants were included (834 male). Accumulation of a single deficit had a significant impact (p<0.0001 to p<0.049) on LVmassi and MCFi in all the life-course FIs and overall FIs. LVmassi increased by 0.89% to 1.42% for the life-course FIs and by 0.36%/1.82% for FIsum and FImean respectively. MCFi decreased by 0.62% to 1.02% for the life-course FIs and by 0.33%/ 1.04%. for FIsum and FImean respectively. One accumulated deficit translated into higher multiplicative odds (13.2 for FI60-64, 2.1 for FI4-1, 75.4 for FI4-2 and 78.5 for FI4-3) of elevated filling pressure (defined as E/e' ratio >13, p<0.0.005 to p<0.02).A unit increase in frailty decreased LV EF (%) by 11%/12% for FI45-54 and FI60-64 respectively, by 10% to 12% for FI2-1, FI3-1, FI4-1 and FI4-2, and 4%/15% for FIsum and FImean respectively (p<0.0014 to p<0.044). Conclusion Frailty during the life-course, overall life-frailty and the step change in deficit accumulation is associated with later-life cardiac dysfunction. Frailty strain appears to have its greatest impact on pathological myocardial hypertrophy (high LVmassi and low MCFi) potentially paving the way to later-life systolic or diastolic dysfunction in susceptible individuals. Funding Acknowledgement Type of funding source: None

The Controlled Direct Effect of Early-Life Socioeconomic Position on Periodontitis in a Birth Cohort

2019 ◽  
Vol 188 (6) ◽  
pp. 1101-1108 ◽  
Author(s):  
Helena Silveira Schuch ◽  
Gustavo G Nascimento ◽  
Karen Glazer Peres ◽  
Murthy N Mittinty ◽  
Flavio Fernando Demarco ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Direct Effect ◽  
Socioeconomic Position ◽  
Early Life

scholarly journals Parental socioeconomic position and chronic inflammation during adolescence

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
S Fraga ◽  
M Severo ◽  
E Ramos ◽  
M Kelly-Irving ◽  
S Silva ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Socioeconomic Position ◽  
Early Life ◽  
High Sensitivity ◽  
Early Life Adversity ◽  
Socioeconomic Environment ◽  
Reactive Protein ◽  
Increased Risk ◽  
Health Related ◽  
Inflammatory Processes

Abstract Background Early life adversity has been associated with increased risk of inflammation and inflammation-related diseases in adulthood. This study aimed to examine the association of parental socioeconomic position with chronic inflammation over adolescence. Methods We used information on 2942 members (1507 girls and 1435 boys) of the EPITeen cohort that was established in 2003 in Porto, Portugal, and included 13 years old adolescents that were further evaluated at 17 and 21 years. Mother’ and father’s education and occupation were used as indicators of parental socioeconomic position. High-sensitivity C-reactive protein (CRP) was measured at three points in time (13, 17 and 21 years). CRP levels were categorized in tertiles separately for each wave; chronic inflammation in adolescence was defined as having CRP levels in the highest tertile in at least 2 waves and never in the lowest tertile. Results Over adolescence, the prevalence of chronic inflammation was significantly higher among participants with low parental socioeconomic position. Low parental socioeconomic position was associated with chronic inflammation in adolescence, after adjustment for sex, perinatal and physical environment factors, health-related behaviours and health status in adolescence OR = 1.63; 95%CI: 1.11, 2.40 for lowest vs. highest mother’s education and OR = 1.61; 95%CI: 1.12, 2.30 for lowest vs. highest father’s education. Conclusions Low parental socioeconomic position is associated with chronic inflammation during adolescence. Our results suggest that the early life socioeconomic environment has an impact on inflammatory processes over adolescence.

scholarly journals EARLY-LIFE ADVERSITY, LATER-LIFE MENTAL HEALTH, AND RESILIENCE RESOURCES: A LONGITUDINAL BIRTH COHORT ANALYSIS

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 511-511 ◽  
Author(s):  
T Cosco ◽  
M Richards ◽  
R Hardy ◽  
D Kuh ◽  
L Howe ◽  
...  
Keyword(s):  
Mental Health ◽  
Birth Cohort ◽  
Early Life ◽  
Cohort Analysis ◽  
Later Life ◽  
Early Life Adversity ◽  
Birth Cohort Analysis

scholarly journals Socioeconomic position during pregnancy and DNA methylation signatures at three stages across early life: epigenome-wide association studies in the ALSPAC birth cohort

2018 ◽  
Vol 48 (1) ◽  
pp. 30-44 ◽  
Author(s):  
Rossella Alfano ◽  
Florence Guida ◽  
Bruna Galobardes ◽  
Marc Chadeau-Hyam ◽  
Cyrille Delpierre ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Birth Cohort ◽  
Socioeconomic Position ◽  
Early Life ◽  
Association Studies ◽  
Three Stages

Childhood socioeconomic conditions are associated with increased chronic low-grade inflammation over adolescence: findings from the EPITeen cohort study

2020 ◽  
Vol 105 (7) ◽  
pp. 677-683 ◽  
Author(s):  
Sílvia Fraga ◽  
Milton Severo ◽  
Elisabete Ramos ◽  
Michelle Kelly-Irving ◽  
Susana Silva ◽  
...  
Keyword(s):  
Socioeconomic Position ◽  
Early Life ◽  
High Sensitivity ◽  
Low Grade ◽  
Socioeconomic Conditions ◽  
Early Life Adversity ◽  
Increased Risk ◽  
Health Related ◽  
Hs Crp ◽  
Low Grade Inflammation

ObjectiveEarly life adversity has been associated with increased risk of inflammation and inflammation-related diseases in adulthood. This study aimed to examine the association of childhood socioeconomic conditions with chronic low-grade inflammation over adolescence.MethodsWe used information on 2942 members (1507 girls and 1435 boys) of the EPITeen (Epidemiological Health Investigation of Teenagers in Porto) cohort that was established in 2003 in Porto, Portugal, and included 13-year-old adolescents were further evaluated at 17 and 21 years. Mother’ and father’s education and occupation were used as indicators of childhood socioeconomic conditions. High-sensitivity C reactive protein (hs-CRP) was measured at three points in time (13, 17 and 21 years). hs-CRP levels were categorised in tertiles separately for each wave; chronic low-grade inflammation in adolescence was defined as having hs-CRP levels in the highest tertile in at least two waves and never in the lowest tertile.ResultsPrevalence of chronic low-grade inflammation during adolescence was significantly higher among participants with low parental socioeconomic position. Low parental socioeconomic position was associated with chronic low-grade inflammation in adolescence, after adjustment for sex, perinatal and physical environment factors, health-related behaviours and health status in adolescence OR=1.6; 95% CI: 1.1 to 2.4 for lowest versus highest mother’s education and OR=1.6; 95% CI: 1.1 to 2.3 for lowest versus highest father’s occupation.ConclusionLow childhood socioeconomic conditions are associated with chronic low-grade inflammation during adolescence. Our results suggest that the early life socioeconomic environment has an impact on inflammatory processes over adolescence.

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