Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor

Abstract T cells originate from early T lineage precursors that have entered the thymus and differentiate through well-defined steps. Mice deficient for the BTB/POZ domain of zinc finger protein-1 (Miz-1) almost entirely lack early T lineage precursors and have a CD4−CD8− to CD4+CD8+ block causing a strong reduction in thymic cellularity. Miz-1ΔPOZ pro-T cells cannot differentiate in vitro and are unable to relay signals from the interleukin-7R (IL-7R). Both STAT5 phosphorylation and Bcl-2 up-regulation are perturbed. The high expression levels of SOCS1 found in Miz-1ΔPOZ cells probably cause these alterations. Moreover, Miz-1 can bind to the SOCS1 promoter, suggesting that Miz-1 deficiency causes a deregulation of SOCS1. Transgenic overexpression of Bcl-2 or inhibition of SOCS1 restored pro-T cell numbers and their ability to differentiate, supporting the hypothesis that Miz-1 is required for the regulation of the IL-7/IL-7R/STAT5/Bcl-2 signaling pathway by monitoring the expression levels of SOCS1.

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A role of zinc-finger protein 143 for cancer cell migration and invasion through ZEB1 and E-cadherin in colon cancer cells

Molecular Carcinogenesis ◽

10.1002/mc.22083 ◽

2013 ◽

Vol 53 (S1) ◽

pp. E161-E168 ◽

Cited By ~ 18

Author(s):

A Rome Paek ◽

Chang-Hoon Lee ◽

Hye Jin You

Keyword(s):

Colon Cancer ◽

Cell Migration ◽

Cancer Cells ◽

Zinc Finger ◽

Zinc Finger Protein ◽

Migration And Invasion ◽

Cancer Cell Migration ◽

Colon Cancer Cells ◽

Finger Protein

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The Krüppel-associated Box (KRAB)-Zinc Finger Protein Kid-1 and the Wilms’ Tumor Protein WT1, Two Transcriptional Repressor Proteins, Bind to Heteroduplex DNA

Journal of Biological Chemistry ◽

10.1074/jbc.272.44.27908 ◽

1997 ◽

Vol 272 (44) ◽

pp. 27908-27912 ◽

Cited By ~ 15

Author(s):

Bernd Elser ◽

Wilhelm Kriz ◽

Joseph V. Bonventre ◽

Christoph Englert ◽

Ralph Witzgall

Keyword(s):

Zinc Finger ◽

Zinc Finger Protein ◽

Wilms Tumor ◽

Transcriptional Repressor ◽

Heteroduplex Dna ◽

Finger Protein ◽

Repressor Proteins

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A Cys2/His2 Zinc Finger Protein Acts as a Repressor of the Green Revolution Gene SD1/OsGA20ox2 in Rice (Oryza sativa L.)

Plant and Cell Physiology ◽

10.1093/pcp/pcaa120 ◽

2020 ◽

Author(s):

Min Duan ◽

Xiao-Juan Ke ◽

Hong-Xia Lan ◽

Xi Yuan ◽

Peng Huang ◽

...

Keyword(s):

Plant Growth ◽

Zinc Finger ◽

Growth And Development ◽

Zinc Finger Protein ◽

Green Revolution ◽

Critical Role ◽

Transcriptional Repressor ◽

Fine Tuning ◽

Plant Growth And Development ◽

Finger Protein

Abstract Gibberellins (GAs) play important roles in the regulation of plant growth and development. The green revolution gene SD1 encoding gibberellin 20-oxidase 2 (GA20ox2) has been widely used in modern rice breeding. However, the molecular mechanism of how SD1/OsGA20ox2 expression is regulated remains unclear. Here, we report a Cys2/His2 zinc finger protein ZFP207 acting as a transcriptional repressor of OsGA20ox2. ZFP207 was mainly accumulated in young tissues and more specifically in culm nodes. ZFP207-overexpression (ZFP207OE) plants displayed semidwarfism phenotype and small grains by modulating cell length. RNA interference of ZFP207 caused increased plant height and grain length. The application of exogenous GA3 could rescue the semidwarf phenotype of ZFP207OE rice seedlings. Moreover, ZFP207 repressed the expression of OsGA20ox2 via binding to its promoter region. Taken together, ZFP207 acts as a transcriptional repressor of SD1/OsGA20ox2 and it may play a critical role in plant growth and development in rice through the fine-tuning of GA biosynthesis .

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