scholarly journals Endothelial cell proliferation follows the mid-cycle luteinizing hormone surge, but not human chorionic gonadotrophin rescue, in the human corpus luteum

1997 ◽  
Vol 12 (8) ◽  
pp. 1723-1729 ◽  
Author(s):  
F. E. Rodger ◽  
F. M. Young ◽  
H. M. Fraser ◽  
P. J. Illingworth
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Luteinizing Hormone ◽  
Corpus Luteum ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Endothelial Cell Proliferation ◽  
Luteinizing Hormone Surge ◽  
Human Corpus Luteum

Oxytocin may play a role in the control of the human corpus luteum

1982 ◽  
Vol 95 (1) ◽  
pp. 65-70 ◽  
Author(s):  
G. J. S. Tan ◽  
R. Tweedale ◽  
J. S. G. Biggs
Keyword(s):  
Menstrual Cycle ◽  
Corpus Luteum ◽  
Inhibitory Action ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Corpora Lutea ◽  
Luteal Cells ◽  
Progesterone Production ◽  
Human Corpus Luteum

The effects of oxytocin on dispersed luteal cells from human corpora lutea of the menstrual cycle were studied. Oxytocin at a concentration of 4 mi.u./ml produced a slight increase in basal progesterone production. However, higher oxytocin concentrations (400 and 800 mi.u./ml) markedly inhibited both basal and human chorionic gonadotrophin-induced progesterone production. These data provide evidence for an effect of oxytocin on the human corpus luteum. In view of the inhibitory action of oxytocin, increased secretion of this hormone may be important in the demise of the corpus luteum at the end of the menstrual cycle.

Inhibitory action of chemically deglycosylated human chorionic gonadotrophin on hormone-induced steroid production by dispersed cells from human corpus luteum

1984 ◽  
Vol 101 (3) ◽  
pp. 327-332 ◽  
Author(s):  
M. C. Richardson ◽  
G. M. Masson ◽  
M. R. Sairam
Keyword(s):  
Corpus Luteum ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Maximum Response ◽  
Luteal Cells ◽  
Progesterone Production ◽  
Anhydrous Hydrogen Fluoride ◽  
Tenfold Excess ◽  
Human Corpus Luteum ◽  
Dispersed Cells

ABSTRACT The biological activity of deglycosylated human chorionic gonadotrophin (hCG) prepared by treatment of the native hormone with anhydrous hydrogen fluoride was evaluated using suspensions of dispersed cells from biopsies of human corpus luteum obtained during the luteal phase of normal menstrual cycles. A reproducible pattern of response to hCG in terms of progesterone production by luteal cells was established for a range of luteal ages. Deglycosylation of hCG led to a diminished level of maximum response to the hormone. Co-incubation of luteal cells with a level of hCG just sufficient to elicit a maximum response and increasing concentrations of deglycosylated hCG led to a progressive inhibition of the hormonal response; at a concentration of 103 ng deglycosylated hCG/ml (a tenfold excess of deglycosylated hCG over the native hormone), hCG-induced progesterone production was reduced by about 50%. Deglycosylated hCG therefore acts as a partial antagonist for the action of hCG on human luteal cells. J. Endocr. (1984) 101, 327–332

Prolactin stimulates steroidogenesis by human luteal tissue in vitro

1984 ◽  
Vol 103 (1) ◽  
pp. 107-110 ◽  
Author(s):  
M. G. Hunter
Keyword(s):  
Corpus Luteum ◽  
Luteal Phase ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Corpora Lutea ◽  
Progesterone Production ◽  
Luteal Tissue ◽  
Oestradiol Production ◽  
Human Corpus Luteum

ABSTRACT Human luteal tissue recovered from varying stages of the luteal phase was minced and incubated for 3 h and the effect of human chorionic gonadotrophin (hCG), prolactin and hCG + prolactin on progesterone and oestradiol production measured. While hCG generally enhanced both progesterone and oestradiol synthesis, prolactin alone at either 20 or 200 μg/l had no significant effect on steroidogenesis. When prolactin was added along with hCG in four of six corpora lutea, however, progesterone production significantly increased and in three of six corpora lutea oestradiol production was increased above that induced by hCG alone. It is concluded that prolactin may play some role in the control of steroidogenesis by the human corpus luteum. J. Endocr. (1984) 103, 107–110

OVULATION AND CORPUS LUTEUM FUNCTION IN THE LLAMA (LAMA GLAMA)

1969 ◽  
Vol 45 (4) ◽  
pp. 505-513 ◽  
Author(s):  
B. G. ENGLAND ◽  
W. C. FOOTE ◽  
D. H. MATTHEWS ◽  
ARMANDO G. CARDOZO ◽  
S. RIERA
Keyword(s):  
Luteinizing Hormone ◽  
Corpus Luteum ◽  
Breeding Season ◽  
Luteal Phase ◽  
Maximum Size ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Corpora Lutea ◽  
Lama Glama

SUMMARY Results in 53 llamas (33 mated animals and 20 controls) showed that ovulation is copulation-induced in this species. Ovulation without copulation occasionally occurred during the height of the recognized breeding season in Bolivia. The first mating during the luteal phase (12–24 days after the preceding ovulation) resulted in ovulation in four out of ten llamas. Determination of pituitary luteinizing hormone (LH) content showed the highest level on the day before mating (9·00 μg./mg.) and the lowest level on day 4 (6·25 μg./mg.). LH level on day 8 was significantly higher than on day 4 (7·62 μg./mg.). Corpora lutea (c.l.) were well formed on day 4 after mating (408 mg.), reached a maximum size by day 8 (1920 mg.) and rapidly decreased in size to day 16 (136 mg.). The corpus albicans remained as an entity but decreased in size to 21 mg. on day 120. Similar changes were found in c.l. histology and progesterone content. The combined results indicate that the functional life of the c.l. in a non-pregnant llama is 16 days or less. Treatment with 25 i.u. human chorionic gonadotrophin was sufficient to cause ovulation in 50% of the animals treated. A large (150 mg.) dose of norethandrolone did not cause morphological regression of the c.l. when measured 5 days after treatment. Treatment with 5 mg. daily for 14 days caused regression of c.l. as compared with untreated controls and animals treated with oestradiol valerate.

Analysis of urinary human chorionic gonadotrophin concentrations in normal and failing pregnancies using longitudinal, Cox proportional hazards and two-stage modelling

2016 ◽  
Vol 54 (5) ◽  
pp. 548-557
Author(s):  
Lorrae Marriott ◽  
Michael Zinaman ◽  
Keith R Abrams ◽  
Michael J Crowther ◽  
Sarah Johnson
Keyword(s):  
Luteinizing Hormone ◽  
Early Pregnancy ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Cox Proportional Hazards Model ◽  
Stage Model ◽  
Two Stage ◽  
Luteinizing Hormone Surge

Background Human chorionic gonadotrophin is a marker of early pregnancy. This study sought to determine the possibility of being able to distinguish between healthy and failing pregnancies by utilizing patient-associated risk factors and daily urinary human chorionic gonadotrophin concentrations. Methods Data were from a study that collected daily early morning urine samples from women trying to conceive (n = 1505); 250 of whom became pregnant. Data from 129 women who became pregnant (including 44 miscarriages) were included in these analyses. A longitudinal model was used to profile human chorionic gonadotrophin, a Cox proportional hazards model to assess demographic/menstrual history data on the time to failed pregnancy, and a two-stage model to combine these two models. Results The profile for log human chorionic gonadotrophin concentrations in women suffering miscarriage differs to that of viable pregnancies; rate of human chorionic gonadotrophin rise is slower in those suffering a biochemical loss (loss before six weeks, recognized by a rise and fall of human chorionic gonadotrophin) and tends to plateau at a lower log human chorionic gonadotrophin in women suffering an early miscarriage (loss six weeks or later), compared with viable pregnancies. Maternal age, longest cycle length and time from luteinizing hormone surge to human chorionic gonadotrophin reaching 25 mIU/mL were found to be significantly associated with miscarriage risk. The two-stage model found that for an increase of one day in the time from luteinizing hormone surge to human chorionic gonadotrophin reaching 25 mIU/mL, there is a 30% increase in miscarriage risk (hazard ratio: 1.30; 95% confidence interval: 1.04, 1.62). Conclusion Rise of human chorionic gonadotrophin in early pregnancy could be useful to predict pregnancy viability. Daily tracking of urinary human chorionic gonadotrophin may enable early identification of some pregnancies at risk of miscarriage.

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