Adult Male All-Cause, Cardiovascular and Cerebrovascular Mortality in Relation to Ethnic Group, Systolic Blood Pressure and Blood Glucose Concentration in Trinidad, West Indies

1988 ◽  
Vol 17 (1) ◽  
pp. 62-69 ◽  
Author(s):  
G J MILLER ◽  
B R KIRKWOOD ◽  
G L A BECKLES ◽  
S D ALEXIS ◽  
D C CARSON ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Systolic Blood Pressure ◽  
Ethnic Group ◽  
Adult Male ◽  
Glucose Concentration ◽  
West Indies ◽  
Blood Glucose Concentration

The effect of insulin-induced hypoglycaemia on gastrointestinal motility in man

1987 ◽  
Vol 72 (6) ◽  
pp. 743-748 ◽  
Author(s):  
I. W. Fellows ◽  
D. F. Evans ◽  
T. Bennett ◽  
I. A. Macdonald ◽  
A. G. Clark ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Glucose ◽  
Motor Activity ◽  
Arterial Blood Pressure ◽  
Pancreatic Polypeptide ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Arterial Blood ◽  
Median Interval

1. The effect of insulin-induced hypoglycaemia on gastro-jejunal motility was studied in five, healthy, male subjects using tethered, pressure sensitive, radiotelemetry capsules. 2. Thirty minutes after the intravenous injection of soluble insulin (0.15 unit/kg body weight), a significant reduction in blood glucose concentration (control: 5.26 ± 0.19 sem mmol/l; insulin: 1.48 ± 0.44 mmol/l; P < 0.001) was associated with a rise in heart rate (mean peak rise 29 ± 8 beats/min, P < 0.05), systolic arterial blood pressure (mean peak rise 28 ± 4 mmHg, P < 0.01) and plasma pancreatic polypeptide concentration (control: 20 ± 7 pmol/l; insulin: 287 ± 66 pmol/l; P < 0.01). These events coincided with a short period of jejunal motor activity, which was not associated with gastric motor activity nor with raised plasma motilin concentrations. 3. During the control study, there were no changes in blood glucose concentration, heart rate, arterial blood pressure or plasma pancreatic polypeptide concentrations, and there was no jejunal motor activity. 4. The interval between successive gastric migrating motor complexes (MMC) was not significantly different in the insulin and control studies (control: median interval 110 min, range 108–148 min; insulin: median interval 124 min, range 115–125 min), suggesting that the fasting gastro-jejunal MMC and jejunal motor activity arose independently. 5. Insulin-induced hypoglycaemia is accompanied by jejunal motor activity, which may underlie the abdominal symptoms associated with hypoglycaemia.

Changes in Level of Consciousness and Association with Hyperglycemia as Tool for Predicting and Preventing Re-bleeding after Spontaneous Subarachnoid Hemorrhage

2006 ◽  
Vol 21 (3) ◽  
pp. 190-195 ◽  
Author(s):  
Yoichi Kitsuta ◽  
Noriyuki Suzuki ◽  
Mitsugi Sugiyama ◽  
Isao Yamamoto
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Subarachnoid Hemorrhage ◽  
Serum Potassium ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Bleeding Rate ◽  
Level Of Consciousness ◽  
Gcs Score ◽  
Spontaneous Subarachnoid Hemorrhage

AbstractIntroduction:It is crucial to predict and prevent re-bleeding from ruptured intracranial aneurysms in patients with subarachnoid hemorrhage (SAH). During the prehospital period and on arrival to the hospital, blood glucose and serum potassium levels, as well as changes in levels of consciousness were assessed in patients in the acute stage of spontaneous subarachnoid hemorrhage. These assessments were analyzed as possible risk factors for re-bleeding and as potential contributors to the prevention of re-bleeding, both in prehospital care and after hospital admission.Methods:Upon the arrival of 202 patients with spontaneous subarachnoid hemorrhage, the following indications were examined retrospectively: (1) presence/absence of re-bleeding; (2) time interval between the onset of SAH and re-bleeding; (3) level of consciousness using the Glasgow Coma Scale (GCS) score before and on arrival; (4) amount and distribution of subarachnoid blood using Fisher's Computerized Tomography Classification; (5) blood pressure; (6) blood glucose concentration; and (7) serum potassium concentration. The patients were hospitalized in the Yokohama City University Critical Care and Emergency Center (Yokohama, Japan) between January 1991 and December 2000. The re-bleeding rate was analyzed using the chi-square ([X]2 test, and the averages and standard deviations of hematological data were compared using the Mann-Whitney U-test. The level of statistical significance was set at p <0.05.Results:The overall re-bleeding rate was 20.8%. Among 119 patients with a GCS score of 3–7 before arrival, 42 (35.3%) had re-bleeding, but none of the 83 patients with a GCS score of 8–15 before arrival had re-bleeding. Of 105 patients with a GCS score of 13–15 on arrival, 14 (51.8%) of 27 patients whose consciousness level was a GCS score of 3–7 before arrival experienced re-bleeding. The re-bleeding rate of this group was high. Moreover, this rebleeding group had a significantly higher blood glucose concentration than did the patients whose GCS score was 13–15 both before and on arrival. Between the patients with or without re-bleeding, there was no significant difference in the blood pressure on arrival or in distribution according to Fisher's Computerized Tomography ClassificationConclusion:Since the re-bleeding rate is high in patients who have hyperglycemia and a history of a level of consciousness as low as a GCS score of 3–7, a detailed assessment of level of consciousness and blood glucose tests performed on arrival provide important information that will contribute to predicting and preventing re-bleeding. This may be extended to the prehospital phase, because blood glucose tests are simple and safe when performed by paramedics.

scholarly journals Associations of Variability in Metabolic Parameters with Lung Cancer: A Nationwide Population-Based Study

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1982
Author(s):  
In Young Cho ◽  
Kyungdo Han ◽  
Dong Wook Shin ◽  
Mi Hee Cho ◽  
Jung Eun Yoo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Blood Pressure ◽  
Blood Glucose ◽  
Cancer Risk ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Lung Cancer Risk ◽  
Fasting Blood Glucose ◽  
High Variability ◽  
Metabolic Parameters

We investigated whether visit-to-visit variability in metabolic parameters is associated with lung cancer risk. We used nationally representative data from the Korean National Health Insurance System, and 8,011,209 lung-cancer-free subjects who underwent over three health examinations from 2005 to 2010 were followed until 2017. Variability of fasting blood glucose, total cholesterol, systolic blood pressure, and body weight were measured by the variability independent of the mean, assessed by quartiles. There were 44,982 lung cancer events. The hazard ratio (HR) and 95% confidence interval (CI) for lung cancer risk was 1.07 (1.04, 1.10) for fasting blood glucose in the highest quartile, 1.08 (1.05, 1.10) for systolic blood pressure, 1.04 (1.01, 1.07) for weight, and 1.11 (1.08, 1.14) for total cholesterol. When comparing ≥3 vs. 0 high-variability metabolic parameters, the HR for lung cancer was 1.18 (95% CI, 1.14, 1.22). However, while ≥3 high-variability parameters showed an increased lung cancer risk in men (HR 1.26, 95% CI 1.21, 1.31), women did not show increased risk (HR 0.99, 95% CI 0.92, 1.06). High variability in each metabolic parameter, and a higher number of high-variability parameters, were associated with increased lung cancer risk.

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