scholarly journals A Familial Cluster of Infection Associated With the 2019 Novel Coronavirus Indicating Possible Person-to-Person Transmission During the Incubation Period

2020 ◽  
Vol 221 (11) ◽  
pp. 1757-1761 ◽  
Author(s):  
Ping Yu ◽  
Jiang Zhu ◽  
Zhengdong Zhang ◽  
Yingjun Han

Abstract An ongoing outbreak of pneumonia associated with 2019 novel coronavirus was reported in China. It is unclear whether the virus is infective exists during the incubation period, although person-to-person transmission has been reported elsewhere. We report the epidemiological features of a familial cluster of 4 patients in Shanghai, including an 88-year-old man with limited mobility who was exposed only to asymptomatic family members whose symptoms developed later. The epidemiological evidence has shown possible transmission of 2019 novel coronavirus during the incubation period.

2020 ◽  
Author(s):  
Miao Liu ◽  
Leijie Liu ◽  
Ping Li ◽  
Yibo Ding ◽  
Ting Wu ◽  
...  

Abstract Background Novel coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused emerging infectious disease, firstly identified in Wuhan (Hubei, China), is pandemic. However, data concerning presymptomatic SARS-CoV-2 transmission and disease diversity among family members are limited. Herein, We investigated the epidemiological and clinical characteristics of presymptomatic transmission-caused familial clustering cases of SARS-CoV-2 infection in Zhoushan island, China. Methods All family members were tested for SARS-CoV-2 genomic RNA by quantitative reverse transcription PCR in 3 different samples and serum antibody immunoglobin M (IgM) and IgG against SARS-CoV-2. Exposure identification, laboratory test, and imaging were performed according to the national guideline of COVID-19 (7th edition, China). Results Of the 6 cases, index case who ever met his relative with COVID-19 from Xianning, Hubei on January 26–31, 2020, transmitted SARS-CoV-2 to his family members in Zhoushan via visiting family during January 31 and February 3, 2020. The index was identified as common-type COVID-19 on February 6, 2020. All 5 family members were infected with SARS-CoV-2. Of those, a 7-year-old girl was an asymptomatic carrier whereas her grandparents, especially her grandfather, were very sick. Case 6 (grandfather) remained positive for SARS-CoV-2 RNA in his sputum specimen in subsequent 2 months. Case 2 (mother) tested negative for SARS-CoV-2 RNA in all samples but positive for IgM and IgG to SARS-CoV-2 since February 9, 2020. Conclusions Presymptomatic transmission of SARS-CoV-2 causes familial cluster of COVID-19. Exposed to the same source of infection, family members present their differences in disease severity and viral clearance.


2020 ◽  
Author(s):  
Miao Liu ◽  
Leijie Liu ◽  
Ping Li ◽  
Yibo Ding ◽  
Ting Wu ◽  
...  

Abstract Background Novel coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused emerging infectious disease, firstly identified in Wuhan (Hubei, China), is pandemic. However, data concerning presymptomatic SARS-CoV-2 transmission and disease diversity among family members are limited. Objectives To investigate the epidemiological and clinical characteristics of presymptomatic transmission-caused familial clustering cases of SARS-CoV-2 infection in Zhoushan island, China. Methods All family members were tested for SARS-CoV-2 genomic RNA by quantitative reverse transcription PCR in 3 different samples and serum antibody immunoglobin M (IgM) and IgG against SARS-CoV-2. Exposure identification, laboratory test, and imaging were performed according to the national guideline of COVID-19 (7th edition, China). Results Of the 6 cases, index case who ever met his relative with COVID-19 from Xianning, Hubei on January 26–31, 2020, transmitted SARS-CoV-2 to his family members in Zhoushan via visiting family during January 31 and February 3, 2020. The index was identified as common-type COVID-19 on February 6, 2020. All 5 family members were infected with SARS-CoV-2. Of those, a 7-year-old girl was an asymptomatic carrier whereas her grandparents, especially her grandfather, were very sick. Case 6 (grandfather) remained positive for SARS-CoV-2 RNA in his sputum specimen in subsequent 2 months. Case 2 (mother) tested negative for SARS-CoV-2 RNA in all samples but positive for IgM and IgG to SARS-CoV-2 since February 9, 2020. Conclusions Presymptomatic transmission of SARS-CoV-2 causes familial cluster of COVID-19. Exposed to the same source of infection, family members present their differences in disease severity and viral clearance.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yi-Ning Dai ◽  
Wei Zheng ◽  
Qing-Qing Wu ◽  
Tian-Chen Hui ◽  
Nan-Nan Sun ◽  
...  

AbstractNovel coronavirus pneumonia (NCP) has been widely spread in China and several other countries. Early finding of this pneumonia from huge numbers of suspects gives clinicians a big challenge. The aim of the study was to develop a rapid screening model for early predicting NCP in a Zhejiang population, as well as its utility in other areas. A total of 880 participants who were initially suspected of NCP from January 17 to February 19 were included. Potential predictors were selected via stepwise logistic regression analysis. The model was established based on epidemiological features, clinical manifestations, white blood cell count, and pulmonary imaging changes, with the area under receiver operating characteristic (AUROC) curve of 0.920. At a cut-off value of 1.0, the model could determine NCP with a sensitivity of 85% and a specificity of 82.3%. We further developed a simplified model by combining the geographical regions and rounding the coefficients, with the AUROC of 0.909, as well as a model without epidemiological factors with the AUROC of 0.859. The study demonstrated that the screening model was a helpful and cost-effective tool for early predicting NCP and had great clinical significance given the high activity of NCP.


2022 ◽  
Vol 1 (1) ◽  
pp. 207-213
Author(s):  
Indra Karana

ABSTRAKCOVID-19 adalah penyakit yang disebabkan Novel Coronavirus 2019. Gejalanya bergejala mirip dengan flu biasa, namun COVID-19 sampai saat ini memiliki fatalitas lebih tinggi dan virus ini juga menyebar dengan sangat cepat karena bisa pindah dari orang ke orang bahkan sebelum orang tersebut menunjukkan gejala. Cara isolasi mandiri dirumah yaitu selalu memakai masker dan membuang masker bekas ditempat yang ditentukan,  jika sakit (ada gejala demam, flu dan batuk) maka tetap di rumah. Jangan pergi bekerja, sekolah, ke pasar atau ke ruang publik untuk mencegah penularan masyarakat, manfaatkan fasilitas telemedicine atau sosial media kesehatan dan hindari transportasi publik. Beritahu dokter dan perawat tentang keluhan dan gejala, serta riwayat bekerja ke daerah terjangkit atau kontak dengan pasien COVID-19, selama dirumah, bisa bekerja di rumah. Gunakan kamar terpisah dari anggota keluarga lainya, dan jaga jarak 1 meter dari anggota keluarga, tentukan pengecekan suhu harian, amati batuk dan sesak nafas. Hindari pemakaian bersama peralatan makan dan mandi dan tempat tidur, terapkan perilaku hidup sehat dan bersih, serta konsumsi makanan bergizi, mencuci tangan dengan sabun dan air mengalir dan lakukan etika batuk dan bersin, jaga kebersihan dan kesehatan rumah dengan cairan desinfektan. Selalu berada di ruang terbuka dan berjemur di bawah sinar matahari setiap pagi (±15-30 menit), Hubungi segera fasilitas pelayanan kesehatan jika sakit berlanjut seperti sesak nafas dan demam tinggi, untuk mendapatkan perawatan lebih lanjut. Tujuan pengabdian masyarakat ini adalah untuk melakukan pemantauan kasus covid 19 di Kota Bandung. Kegiatan pengabdian masyarakat ini memberikan pelayanan dengan melakukan pemantauan agar mengetahui keadaan, kondisi dan perkembangan yang dialami oleh warga yang terpapar covid 19 di Kota Bandung. Hasil pengabdian masyarakat diperoleh seluruh warga yang terpapar covid 19 sudah dalam keadaan sehat dan pulih seperti sedia kala. Kata Kunci: Pemantauan kasus covid 19. ABSTRACT COVID-19 is a disease caused by the 2019 Novel Coronavirus. The symptoms are similar to the common cold, but COVID-19 has so far had a higher fatality and this virus also spreads very quickly because it can move from person to person even before the person shows symptoms. . The way to self-isolate at home is to always wear a mask and throw away used masks in the designated place, if you are sick (symptoms of fever, flu and cough) then stay at home. Do not go to work, school, to the market or to public spaces to prevent community transmission, take advantage of telemedicine facilities or health social media and avoid public transportation. Tell doctors and nurses about complaints and symptoms, as well as a history of working in infected areas or in contact with COVID-19 patients, while at home, you can work at home. Use a separate room from other family members, and keep a distance of 1 meter from family members, determine daily temperature checks, observe coughs and shortness of breath. Avoid sharing eating and bathing utensils and bedding, apply healthy and clean living habits, and consume nutritious food, wash hands with soap and running water and practice coughing and sneezing etiquette, keep your home clean and healthy with disinfectant liquid. Always be in an open space and bask in the sun every morning (±15-30 minutes), Contact the health care facility immediately if the illness persists such as shortness of breath and high fever, to get further treatment. The purpose of this community service is to monitor COVID-19 cases in the city of Bandung. This community service activity provides services by monitoring to find out the conditions, conditions, and developments experienced by residents exposed to COVID-19 in the city of Bandung. The results of community service were obtained that all residents who were exposed to COVID-19 were in good health and recovered as usual. Keywords: Monitoring cases of covid 19.


2020 ◽  
Vol 12 (2) ◽  
pp. 156-157
Author(s):  
Mohammad Mostafa Ansari Ramandi ◽  
Mohammadreza Baay ◽  
Nasim Naderi

The disaster due to the novel coronavirus disease 2019 (COVID-19) around the world has made investigators enthusiastic about working on different aspects of COVID-19. However, although the pandemic of COVID-19 has not yet ended, it seems that COVID-19 compared to the other coronavirus infections (the Middle East Respiratory Syndrome [MERS] and Severe Acute Respiratory Syndrome [SARS]) is more likely to target the heart. Comparing the previous presentations of the coronavirus family and the recent cardiovascular manifestations of COVID-19 can also help in predicting possible future challenges and taking measures to tackle these issues.


Background: Novel coronavirus outbreak that originated in Wuhan, province of China has now been declared as one of the deadliest pandemics inflicting humankind in last hundred years. Method: In the present study, we have inferred the clinical, laboratory, radiological, and microbiological findings of five patients in a family cluster who presented with unexplained pneumonia after coming back from overseas and touchdown right here in India on 1st March 2020 earlier than lockdown and another member of the family who didn’tvisit thiscountry. Results: From March 10, 2020, we enrolled a family of six patients who travelled to SingaporeonJanuary 10th 2020and returned on March 1st 2020. Of six family members who travelled to Singapore, five were recognised as affected with the radical coronavirus (COVID 19). Additionally, one family member, who did not travel to overseas also became infected with the virus post14 days of staying with four of the family members. Five family members (aged 30–55 years) presented with symptoms like fever, upper or lower respiratory tract symptoms, or diarrhoea, or a combination of these 3–6 days after exposure. Phylogenetic evaluation of these five subjects’ RT-PCR amplicons and two full genomes by nextgeneration sequencing presented that this is a novel coronavirus, which is closest to the severe acute respiratory syndrome (SARS)-related coronaviruses. Conclusion: Our findings are steady with person-to-person transmission of this novel coronavirus in hospital (nosocomial) and family settings, and the reports of infected travellers in other geographical regions.


The Lancet ◽  
2020 ◽  
Vol 395 (10223) ◽  
pp. 514-523 ◽  
Author(s):  
Jasper Fuk-Woo Chan ◽  
Shuofeng Yuan ◽  
Kin-Hang Kok ◽  
Kelvin Kai-Wang To ◽  
Hin Chu ◽  
...  

1984 ◽  
Vol 150 (2) ◽  
pp. 263-266 ◽  
Author(s):  
J. P. Hanrahan ◽  
G. P. Wormser ◽  
A. A. Reilly ◽  
D. H. Maguire ◽  
G. Gavis ◽  
...  

2020 ◽  
Vol 9 (2) ◽  
pp. 538 ◽  
Author(s):  
Natalie Linton ◽  
Tetsuro Kobayashi ◽  
Yichi Yang ◽  
Katsuma Hayashi ◽  
Andrei Akhmetzhanov ◽  
...  

The geographic spread of 2019 novel coronavirus (COVID-19) infections from the epicenter of Wuhan, China, has provided an opportunity to study the natural history of the recently emerged virus. Using publicly available event-date data from the ongoing epidemic, the present study investigated the incubation period and other time intervals that govern the epidemiological dynamics of COVID-19 infections. Our results show that the incubation period falls within the range of 2–14 days with 95% confidence and has a mean of around 5 days when approximated using the best-fit lognormal distribution. The mean time from illness onset to hospital admission (for treatment and/or isolation) was estimated at 3–4 days without truncation and at 5–9 days when right truncated. Based on the 95th percentile estimate of the incubation period, we recommend that the length of quarantine should be at least 14 days. The median time delay of 13 days from illness onset to death (17 days with right truncation) should be considered when estimating the COVID-19 case fatality risk.


2020 ◽  
Vol 32 (8) ◽  
pp. 458-460
Author(s):  
Seema Rajesh Patrikar ◽  
Atul Kotwal ◽  
Vijay K. Bhatti ◽  
Amitav Banerjee ◽  
Kunal Chatterjee ◽  
...  

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