PSVII-25 Amount of colostrum feeding impacts performance and potential colostrum biomarkers at arrival at the rearing facility in unweaned male dairy beef calves

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 450-451
Author(s):  
Lucía Pisoni ◽  
Anna Bassols ◽  
Yolanda Saco ◽  
Nestor Gomez ◽  
Joan Pujols ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Mixed Models ◽  
Gamma Glutamyl Transferase ◽  
Beef Calves ◽  
Weight Losses ◽  
Holstein Bull ◽  
Bull Calves ◽  
Colostrum Feeding ◽  
The Difference ◽  
Glutamyl Transferase

Abstract Eighty-two newborn unweaned Holstein bull calves (43.3 ± 0.86 kg) were used to evaluate the effect of the amount of colostrum feeding on performance and potential colostrum feeding on serum biomarkers. Immediately after calves were born, calves were randomly distributed to well colostrated treatment (WC; n = 49) where calves were fed 4 L of colostrum in less than 2 h after birth and 2 L of colostrum in each of the following 3 feedings; or poor colostrated (PC; n = 33) where calves were fed 2 L of colostrum only once in less than 2 h after birth. At d 14 of age calves were submitted to an assembly center situation for 4 d and transported for 19 h to the rearing farm. Forty-eight hours and 18 d after birth a blood sample was collected to analyze alkaline phosphatase (ALP), cholesterol (CHO), and gamma-glutamyl transferase (GGT). Calves were weighed (BW) after birth, before transport and at arrival. Data were analyzed using mixed models. At 48 h, serum concentration of ALP, GGT were greater (P < 0.05) for WC compared with PC calves, showing that the difference in the amount of colostrum applied as a treatment was successful. The BW losses from birth to arrival were greater for PC calves (-2.3 ± 0.41 kg) compared with WC calves (-0.02 ± 0.41 kg). Shrink during transport did not differ between treatments. At arrival (d 18) no differences on serum ALP or CHO were observed. However, serum concentration of GGT was greater (P < 0.01) for WC calves compared with PC calves (127.2 ± 9.09 U/L and 55.7 ± 8.95 U/L, respectively). Increasing the amount of colostrum fed to the calves reduces the postnatal weight losses and GGT might be an indicator of colostrum feeding at arrival in calves of 18 d of age.

Blood mercury and liver enzymes: A pan-India retrospective correlation study

2020 ◽  
Vol 36 (12) ◽  
pp. 1019-1023
Author(s):  
Krishnakumar Sivapandi ◽  
Amruta Velumani ◽  
Kallathikumar Kallathiyan ◽  
Sandhya Iyer ◽  
Prachi Sinkar
Keyword(s):  
Inductively Coupled Plasma ◽  
Liver Enzymes ◽  
National Laboratory ◽  
Linear Regression Analysis ◽  
Correlation Study ◽  
Gamma Glutamyl Transferase ◽  
Toxic Heavy Metal ◽  
Elevated Liver Enzymes ◽  
The Difference ◽  
Glutamyl Transferase

Mercury (Hg) is a toxic heavy metal, and the reported effects of exposure on liver function continue to be inconsistent. The objective of our study was to identify correlations between high blood Hg levels and liver enzymes in a pan-India population including adults ≥19 years of age. This retrospective study analyzed the data from 95,398 individuals tested for blood Hg levels and liver enzymes in our national laboratory. Testing for blood Hg was done by inductively coupled plasma-mass spectrometry, while testing for liver enzymes—aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT), and gamma-glutamyl transferase—was done by automated photometry systems. Data from all the individuals inclusive of 52,497 males and 42,901 females were studied. The frequency of high blood Hg levels (>5 µg/L) was found to be 0.6%, and the difference between males and females was not found to be significant. Further correlation by linear regression analysis found no relationship between high blood Hg levels and liver enzymes among females. However, among males, there was a significant correlation between high blood Hg levels, and increased AST as well as ALT. Our report suggested that for males but not females, Hg exposure may be one of the differentials for elevated liver enzymes.

Prediction of Serum IgG1Concentration in Beef Calves Based on Age and Serum Gamma-Glutamyl-Transferase Activity

1999 ◽  
Vol 13 (2) ◽  
pp. 123-125 ◽  
Author(s):  
Leilani K. Wilson ◽  
Jeff W. Tyler ◽  
Thomas E. Besser ◽  
Steven M. Parish ◽  
Roderick Gant
Keyword(s):  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Beef Calves ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Growth and Blood Parameters of Weaned Crossbred Beef Calves Fed Forage Kale (Brassica oleraceaspp.acephala)

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Y. Chorfi ◽  
Y. Couture ◽  
G. F. Tremblay ◽  
R. Berthiaume ◽  
D. Cinq-Mars
Keyword(s):  
Nutritive Value ◽  
Liver Enzymes ◽  
Blood Parameters ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Total Proteins ◽  
Pasture Management ◽  
Blood Samples ◽  
Beef Calves ◽  
Glutamyl Transferase

Forty lightweight calves (206.4±3.2 kg) were randomly distributed to four treatments: (Control) low nutritive value pasture and hay plus 1 kg d−1of rolled barley; (Pasture) management intensive pasture; (Haylage) timothy haylage; and (Kale) 50% timothy haylage −50% kale pasture. Blood samples were analysed for thyroid hormones, liver enzymes, glucose, cholesterol, total proteins (TP), albumin, globulins, and urea-N. At the end of the trial, the Pasture group was the heaviest with323.6±4.2 kg BW and 1.54 kg ADG. Final BW and ADG were similar for the Kale and Haylage groups. Blood T3was higher for Kale than for the other groups. The T3/T4ratio was greater for Control at the end of the experiment. There were no treatment differences for T4, aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), glutamate dehydrogenase (GLDH), cholesterol, and glucose. Blood urea-N was lower for Kale and higher for Pasture; however albumin concentrations were greater for Pasture and similar for other treatments. Except for the Control group, calves had a lower concentration of circulating globulins at the end than at the beginning of the experiment. This study showed that Kale could be fed to backgrounding calves without detrimental effects on performance.

A note on the influence of climatic variables and age on the response of beef calves to different housing types

1991 ◽  
Vol 52 (2) ◽  
pp. 400-403 ◽  
Author(s):  
H.-M. Kubisch ◽  
M. Makarechian ◽  
P. F. Arthur
Keyword(s):  
Growth Temperature ◽  
Significant Interaction ◽  
Temperature Fluctuations ◽  
Climatic Variables ◽  
Regression Analyses ◽  
Housing Type ◽  
Beef Calves ◽  
Average Daily Temperature ◽  
Bull Calves ◽  
The Difference

ABSTRACTThe response of 376 weaned bull calves to two different housing types was studied in a 2-year feedlot trial. Overall, animals with shelter had a higher rate of gain than animals with no shelter. The difference in the rate of gain between the housing types was, however, restricted to the coldest periods. No significant interaction between housing type and age of calf was observed. Regression analyses showed that whilst average daily temperature appeared to have a negligible effect on growth, temperature fluctuations between weighing days appeared to affect growth of calves in both housing types. Overall, climatic variables contributed more to the variance in gain of calves with shelter than of calves with no shelter.

scholarly journals A donorspecifikus antitestek szerepének vizsgálata a gyermekkori májtranszplantációk hosszú távú kimenetelében

2021 ◽  
Vol 162 (47) ◽  
pp. 1897-1901
Keyword(s):  
Solid Organ Transplantation ◽  
Human Leukocyte ◽  
Gamma Glutamyl Transferase ◽  
Solid Organ ◽  
Term Survival ◽  
Leukocyte Antigen ◽  
Immunological Mechanisms ◽  
Significant Difference ◽  
The Difference ◽  
Glutamyl Transferase

Összefoglaló. Bevezetés: A gyermekkori májtranszplantációk hosszú távú kimenetelének javítása érdekében az immunológiai mechanizmusok kerültek a kutatások középpontjába. A donorspecifikus antitesteknek (DSA-k) fontos szerepük van a graft túlélésében a szervtranszplantációk után, a májtranszplantáció esetén azonban ez még vitatott. Célkitűzés: Tanulmányunk célja májtranszplantált gyermekeknél a DSA-k meghatározása, valamint a DSA-k jelenléte és a graft állapota közötti összefüggés vizsgálata volt. Módszer: A Semmelweis Egyetem I. Sz. Gyermekgyógyászati Klinikáján gondozott 54 májtranszplantált gyermek vérmintájából történt a humán leukocytaantigén (HLA) elleni antitestek meghatározása. Vizsgáltuk, hogy a laboratóriumi vérvizsgálat eredményei – szérumbilirubin (összes, direkt), alkalikus foszfatáz (ALP), transzaminázok, gamma-glutamil-transzferáz (GGT), immunglobulin-G (IgG) –, az aszpartát-aminotranszferáz/thrombocyta hányadosindex (APRI) és a 4 tényezőn alapuló fibrosisindex (FIB4) tekintetében van-e eltérés a DSA-pozitív, illetve a HLA-immunizált betegek esetén a nem immunizált csoporthoz képest. Eredmények: A vizsgált paraméterekben nem találtunk szignifikáns különbségeket a DSA-pozitív, a HLA-immunizált és a nem immunizált betegek csoportjai között. Következtetés: Bár a jelen vizsgálatban nem volt szignifikáns különbség a vizsgált paraméterek esetén, de ez a kis esetszámból is adódhat. A DSA-knak a graftfibrosis kialakulásában való szerepe tisztázására több páciens vizsgálata szükséges, ezért megkezdtük az összes páciensnél a DSA- és HLA- (donor, recipiens) meghatározást, valamint ennek a klinikai gyakorlatunkba való beépítését. Orv Hetil. 2021; 162(47): 1897–1901. Summary. Introduction: To improve the long-term survival of liver-transplanted children, immunological mechanisms became the main interest of researchers. Donor-specific antibodies (DSAs) play a significant role in graft survival after solid organ transplantation, although their role in liver transplantation is controversial. Objective: The aim of our study was to determine the presence of DSAs in liver-transplanted children and to examine their effect on graft’s condition. Method: The determination of anti-human leukocyte antigen (HLA) antibodies was performed using the blood samples of 54 liver-transplanted children. We analysed the difference between the results of the laboratory blood examination – serum bilirubin (all, direct), alkaline-phosphatase (ALP), transaminases, gamma-glutamyl transferase (GGT), immunoglobulin-G (IgG) –, aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 index (FIB4) according to DSA and HLA immunization. Results: We did not find any significant difference in the examined parameters regarding DSA and HLA immunization. Conclusion: Although this study was not able to provide significant difference in the examined parameters, this can be explained with the low number of cases. To clarify the significance of DSA in graft fibrosis, we need a larger dataset. We started regular DSA and HLA (donor and recipient) determination during follow-up in liver-transplanted children. Orv Hetil. 2021; 162(47): 1897–1901.

Evaluation of the effect of phenobarbital administration on the biochemistry profile, with a focus on serum liver values, in epileptic cats

2021 ◽  
pp. 1098612X2110374
Author(s):  
Michelle Hermans ◽  
Marios Charalambous ◽  
Akos Pakozdy ◽  
Ursula Eisl-Glantschnigg ◽  
Jasmin Neßler ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Liver Enzyme ◽  
Enzyme Induction ◽  
Serum Biochemistry ◽  
Idiopathic Epilepsy ◽  
Gamma Glutamyl Transferase ◽  
Baseline Serum ◽  
Structural Epilepsy ◽  
Glutamyl Transferase

Objectives Phenobarbital (PB) is the most common antiseizure drug (ASD) used for the management of feline epilepsy. In dogs, PB is known to cause serum liver enzyme induction and hepatotoxicity, especially after administration long term or in high concentrations. In cats, insufficient evidence is available to draw similar conclusions. The aim of this study was to evaluate the effect of PB administration on the serum biochemistry profile of epileptic cats. As an additional objective, other adverse effects arising, related to PB treatment, were recorded. Methods Medical records of four veterinary centres were retrospectively reviewed for epileptic cats receiving PB treatment. Cats were included if they had a diagnosis of idiopathic epilepsy or structural epilepsy; a normal baseline serum biochemistry profile; at least one follow-up serum biochemistry profile; no concurrent disease or had not received medication that could possibly influence liver function or lead to serum liver enzyme induction. Alkaline phosphatase, alanine aminotransferase (ALT), aspartate transaminase and gamma-glutamyl transferase activities, and total bilirubin, bile acids, glucose, albumin, total protein, urea and creatinine concentrations before and during PB administration were recorded. PB serum concentration was also recorded, when available. Results Thirty-three cats (24 males, nine females) with a median age of 3 years (range 2 months to 12 years) met the inclusion criteria. Idiopathic or structural epilepsy was diagnosed in 25 (76%) and eight (24%) cats, respectively. The follow-up period ranged from 9 to 62 months. This study found an increase in ALT in three cats, possibly related to a PB serum concentration >30 µg/ml. No statistically significant increase in serum liver enzymes or other evaluated biochemistry parameters was found by comparing pre- and post-treatment parameters. Conclusions and relevance PB administration did not result in hepatic enzyme induction or other biochemical abnormalities in cats. This strengthens the safety profile of PB as an ASD in cats.

Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review

2016 ◽  
Vol 25 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Benoit Brilland ◽  
Johnny Sayegh ◽  
Anne Croue ◽  
Frank Bridoux ◽  
Jean-François Subra ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Intrahepatic Cholestasis ◽  
Relevant Literature ◽  
Gamma Glutamyl Transferase ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Uncommon Presentation ◽  
Light Chain Deposition ◽  
Glutamyl Transferase

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic and exceptionally manifests with severe cholestatic hepatitis. We report the case of a 66-year-old female with κ-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver κ-light chain deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the liver histology and exclusion of possible diagnoses. Chemotherapy was maintained and resulted in progressive resolution of cholestasis. We report here an uncommon presentation of LCDD, with prominent liver involvement that fully recovered with bortezomib-based chemotherapy, and briefly review the relevant literature. Abbreviations: AKI: Acute kidney injury; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CMV: Cytomegalovirus; EBV: Epstein–Barr virus; GGT: gamma-glutamyl transferase; HSV: Herpes simplex virus; LC: light chain; LCDD: Light chain deposition disease; MIDD: Monoclonal immunoglobulin deposition disease; MM: Multiple myeloma.

Evaluation of Hematological and Biochemical Changes in Dromedary Camel during the Different Stages of Lactation

2020 ◽  
Vol 21 (3) ◽  
pp. 121-124
Author(s):  
Ahmed El-Sayed
Keyword(s):  
Organic Phosphorus ◽  
Hemoglobin Concentration ◽  
Controlled Study ◽  
Mean Corpuscular Hemoglobin ◽  
Dromedary Camel ◽  
Gamma Glutamyl Transferase ◽  
Corpuscular Hemoglobin ◽  
Stage Of Lactation ◽  
Group 2 ◽  
Glutamyl Transferase

Objective: To assess the potential hematobiochemical alterations in healthy dromedary camel during the different stages of lactation. Design: Randomized controlled study. Animals: Fifteen healthy female dromedary camels, with mean body weight of 499.6 kg and mean age of 20 years. Procedures: Camels were categorized into 3 groups' according to their stage of lactation: group 1, early lactation (1-3 months), group 2, mid-lactation (four-6 months) and group3, late lactation (≥ 7 months). Blood samples were collected from every animals for hematological and biochemical evaluation. Results: Total erythrocyte count (TEC), hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), total leukocytes (TLC), lymphocytes, neutrophils, monocytes, Calcium, glucose, aspartate aminotransferase (AST), alanine transaminase (ALT), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) confirmed significant (p < 0.05) variation between different stages of lactation. However, non-notable (p > 0.05) dissimilarity were located in packed cell volume (PCV), mean corpuscular hemoglobin concentration (MCHC), in organic phosphorus (P), magnesium (Mg), cholesterol, total protein (TP), albumen, globulin, blood urea nitrogen (BUN) and creatinine kinase (CK) in the course of different ranges of lactation, Conclusion and clinical relevance: The results of this investigation may be useful as reference guide for dromedary camel to evaluate the metabolic health status at different stages of lactation.

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