scholarly journals Purity of Synthetic Cannabinoids Sold Online for Recreational Use

2012 ◽  
Vol 36 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Brett C. Ginsburg ◽  
Lance R. McMahon ◽  
Jesus J. Sanchez ◽  
Martin A. Javors
Keyword(s):  
Synthetic Cannabinoids ◽  
Recreational Use

scholarly journals A New Differential Diagnosis: Synthetic Cannabinoid-Associated Gross Hematuria

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Osamah Hasan ◽  
Ankit A. Patel ◽  
James J. Siegert
Keyword(s):  
Unusual Case ◽  
Synthetic Cannabinoids ◽  
Fresh Frozen Plasma ◽  
Health Concern ◽  
Clinical Effects ◽  
Gross Hematuria ◽  
Fresh Frozen ◽  
History Of ◽  
Recreational Use ◽  
Frozen Plasma

Recreational use of synthetic cannabinoids (SCs), also known as “K2” or “Spice,” is becoming a major public-health concern due to their potential for abuse and harmful consequences. New substances are constantly being added to the content of SCs. The dearth of information on these newly added contents as they are introduced into the black market hinders risk assessments of these compounds. We report a highly unusual case of gross hematuria in a 28-year-old male patient after SC use. He was found to have a supratherapeutic INR with no history of prior anticoagulation. His hematuria resolved after four units of fresh-frozen plasma were administered. We include a literature review of the clinical effects of SCs and their possible mechanism of gross hematuria and management.

scholarly journals The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB1 Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations

2020 ◽  
Vol 21 (17) ◽  
pp. 6277
Author(s):  
João Alexandre ◽  
Rui Malheiro ◽  
Diana Dias da Silva ◽  
Helena Carmo ◽  
Félix Carvalho ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Synthetic Cannabinoids ◽  
In Vitro Differentiation ◽  
Neurite Length ◽  
Neuronal Marker ◽  
Biologically Relevant ◽  
Specific Antagonist ◽  
Recreational Use ◽  
Potential Onset

Recreational use of synthetic cannabinoids (SCs) before and during pregnancy poses a major public health risk, due to the potential onset of neurodevelopmental disorders in the offspring. Herein, we report the assessment of the neurotoxic potential of two commonly abused SCs, THJ-2201 and 5F-PB22, particularly focusing on how they affect neuronal differentiation in vitro. Differentiation ratios, total neurite length, and neuronal marker expression were assessed in NG108-15 neuroblastoma x glioma cells exposed to the SCs at non-toxic, biologically relevant concentrations (≤1 μM), either in acute or repeated exposure settings. Both SCs enhanced differentiation ratios and total neurite length of NG108-15 cells near two-fold compared to vehicle-treated cells, in a CB1R activation-dependent way, as the CB1R blockade with a specific antagonist (SR141718) abrogated SC-induced effects. Interestingly, repeated 5F-PB22 exposure was required to reach effects similar to a single THJ-2201 dose. Cell viability and proliferation, mitochondrial membrane potential, and intracellular ATP levels were also determined. The tested SCs increased mitochondrial tetramethyl rhodamine ethyl ester (TMRE) accumulation after 24 h at biologically relevant concentrations but did not affect any of the other toxicological parameters. Overall, we report firsthand the CB1R-mediated enhancement of neurodifferentiation by 5F-PB22 and THJ-2201 at biologically relevant concentrations.

scholarly journals Recreational use of synthetic cannabinoids: prevalence, intoxication, side effects, addictive potential

2020 ◽  
pp. 27-35
Author(s):  
А.В. Анцыборов ◽  
О.В. Камплицкая ◽  
М.В. Овсянников ◽  
К.В. Стадник ◽  
Л.Ф. Панченко
Keyword(s):  
Adverse Effects ◽  
Synthetic Cannabinoids ◽  
Drug Market ◽  
Scientific Data ◽  
Google Scholar ◽  
Novel Psychoactive Substances ◽  
Psychoactive Substances ◽  
Urgent Task ◽  
Addictive Potential ◽  
Recreational Use

С появлением на нелегальном рынке наркотиков новых психоактивных веществ, одно из первых в данном классе стали занимать синтетические каннабиноиды (СК). СК в основном распространяются через сеть Интернет, с помощью онлайн мессенджеров, и VPN-сетей. Токсическое влияние СК на организм человека оказывается достаточно мощным и нередко заканчивается летальным исходом. Однако аддиктивный потенциал СК достаточно высок, и нуждается в дальнейшем изучении, особенно с появлением новых классов СК. Разработка дифференциально-диагностических критериев и терапевтических подходов при лечении острых психотических состояний, вызванных употреблением СК, представляется актуальной задачей для практического здравоохранения. Цель: обзор накопленных научных данных о последствиях рекреационного употребления СК на организм человека. Материалы: при написании обзора использовали следующие репрезентативные базы данных: PubMed, Google Scholar, Embase, Cochrane, платформы SciFinder, и Scopus. Методы: в качестве поисковых запросов использовались следующие ключевые слова: Spice, K2, synthetic cannabis, new psychoactive sub-stances (NPS), adverse effects, cannabinoid’s receptor, psychosis due to the use NPS, fatalities. Реферируемые статьи были отфильтрованы по тезисам, с целью определения релевантности для настоящего обзора. With the emergence of novel psychoactive substances in the illegal drug market, synthetic cannabinoids (SCs) became one of the first in this class. SCs are mainly distributed through the Internet, by online messengers and VPN networks. The toxic effect of SCs on the human body is quite powerful and often results in death. The addictive potential of SCs is rather high and needs further study, especially with the emergence of new SC classes. Development of differential diagnostic criteria and therapeutic approaches in the treatment of acute psychotic conditions caused by the use of SCs is an urgent task for practical health care. Objective: to review scientific data on consequences of the recreational use of SCs in humans. Materials: data from six representative databases, PubMed, Google Scholar, Embase, Cochrane, the SciFinder platform, and Scopus, were used for this review. Methods: the following combinations and keywords were used as search queries: Spice, K2, synthetic cannabis, novel psychoactive substances (NPS), adverse effects, cannabinoid’s receptor, psychosis due to the use of NPS, fatalities. Peer-reviewed articles were filtered by abstracts to determine their relevance for the present review.

Medical Risks of Marijuana

2017 ◽  
Author(s):  
Keyword(s):  
Synthetic Cannabinoids ◽  
Accidental Ingestion ◽  
Secondary Exposure ◽  
Recreational Use ◽  
Medical Risks

In recent years, exposure to marijuana and other cannabinoids has become an increasing challenge. Legalization of marijuana for both medical and recreational use has already happened in some states, and more states are considering this. What is the risk of use or secondary exposure, including accidental ingestion, to marijuana or synthetic cannabinoids? https://shop.aap.org/pediatric-collections-medical-risks-of-marijuana-paperback/

scholarly journals Overview of Synthetic Cannabinoids ADB-FUBINACA and AMB-FUBINACA: Clinical, Analytical, and Forensic Implications

2021 ◽  
Vol 14 (3) ◽  
pp. 186
Author(s):  
Carolina Lobato-Freitas ◽  
Andreia Machado Brito-da-Costa ◽  
Ricardo Jorge Dinis-Oliveira ◽  
Helena Carmo ◽  
Félix Carvalho ◽  
...  
Keyword(s):  
Scientific Literature ◽  
Cannabinoid Receptor ◽  
Biological Effects ◽  
Synthetic Cannabinoids ◽  
Detection Methods ◽  
Drug Candidate ◽  
Assessment And Treatment ◽  
Neurological Effects ◽  
Recreational Use ◽  
Harmful Effects

ADB-FUBINACA and AMB-FUBINACA are two synthetic indazole-derived cannabinoid receptor agonists, up to 140- and 85-fold more potent, respectively, than trans-∆9-tetrahydrocannabinol (∆9-THC), the main psychoactive compound of cannabis. Synthesised in 2009 as a pharmaceutical drug candidate, the recreational use of ADB-FUBINACA was first reported in 2013 in Japan, with fatal cases being described in 2015. ADB-FUBINACA is one of the most apprehended and consumed synthetic cannabinoid (SC), following AMB-FUBINACA, which emerged in 2014 as a drug of abuse and has since been responsible for several intoxication and death outbreaks. Here, we critically review the physicochemical properties, detection methods, prevalence, biological effects, pharmacodynamics and pharmacokinetics of both drugs. When smoked, these SCs produce almost immediate effects (about 10 to 15 s after use) that last up to 60 min. They are rapidly and extensively metabolised, being the O-demethylated metabolite of AMB-FUBINACA, 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamide)-3-methylbutanoic acid, the main excreted in urine, while for ADB-FUBINACA the main biomarkers are the hydroxdimethylpropyl ADB-FUBINACA, hydroxydehydrodimethylpropyl ADB-FUBINACA and hydroxylindazole ADB-FUBINACA. ADB-FUBINACA and AMB-FUBINACA display full agonism of the CB1 receptor, this being responsible for their cardiovascular and neurological effects (e.g., altered perception, agitation, anxiety, paranoia, hallucinations, loss of consciousness and memory, chest pain, hypertension, tachycardia, seizures). This review highlights the urgent requirement for additional studies on the toxicokinetic properties of AMB-FUBINACA and ADB-FUBINACA, as this is imperative to improve the methods for detecting and quantifying these drugs and to determine the best exposure markers in the various biological matrices. Furthermore, it stresses the need for clinicians and pathologists involved in the management of these intoxications to describe their findings in the scientific literature, thus assisting in the risk assessment and treatment of the harmful effects of these drugs in future medical and forensic investigations.

Association of staphylococcal skin infections and swimming

1995 ◽  
Vol 31 (5-6) ◽  
pp. 11-17 ◽  
Author(s):  
N. Charoenca ◽  
R. S. Fujioka
Keyword(s):  
Coastal Waters ◽  
Skin Infection ◽  
Antibiotic Sensitivity ◽  
Control Group ◽  
Skin Infections ◽  
Telephone Interviews ◽  
Phage Types ◽  
History Of ◽  
Staphylococcal Skin Infections ◽  
Recreational Use

An association between using coastal waters for recreation and staphylococcal skin infections has been reported by canoe paddlers and several physicians in Hawaii. A retrospective epidemiological/microbiological monitoring study was undertaken to determine the association between S aureus skin infections in youngsters (4 months to 16 years of age) and their exposure to recreational use of coastal waters. Telephone interviews were conducted of 53 patients with such skin infections and 53 similar (controlled for age and sex) patients with no infection. A significant association between skin infection and water exposure was found, the odds showing that those developing skin infection caused by S aureus were 4 times more likely to have had a history of seawater contact than the control group. Moreover, the antibiotic sensitivity patterns and phage types of S aureus isolated from patients were similar to those isolated from seawater at bathing beaches.

Hallucinogen Use in College Students: Current Trends and Consequences of Use

2020 ◽  
Vol 9 (2) ◽  
pp. 115-127
Author(s):  
Lena S. Jia ◽  
Jessica A. Gold
Keyword(s):  
College Students ◽  
Drug Class ◽  
Positive Effects ◽  
Current Trends ◽  
College Population ◽  
Therapy Studies ◽  
Recreational Use ◽  
Perception Disorder ◽  
Review Current

Hallucinogens are a drug class that is growing in popularity with college students. Recent experimental trends, such as microdosing, have helped promote the use of hallucinogens on campus, and students may be tempted to use these substances due to their beliefs about the drugs’ positive effects on mood. Although hallucinogens are not currently an established form of medical therapy, studies have shown that they have significant benefits as adjunctive treatments for psychological disorders. However, the recreational use of these drugs in college students often occurs in uncontrolled doses or with drug mixing, which is often dangerous. Furthermore, students with mental health disorders may have their symptoms masked by hallucinogenic drug use, which could delay treatment and have serious consequences. Long-term use of these drugs may also result in tolerance or hallucinogen persisting perception disorder. This article attempts to review current information regarding hallucinogen use and how it applies to the college population.

Assessment of recreational use of specially protected natural territories of Tatishchevsky district of Saratov region

2019 ◽  
Vol 27 (2) ◽  
pp. 117-127
Author(s):  
Yulia M Andriyanova ◽  
Irina V Sergeeva ◽  
Yulia M Mokhonko ◽  
Natalia N Gusakova
Keyword(s):  
Natural Resources ◽  
Protected Areas ◽  
Saratov Region ◽  
Future State ◽  
Forest Phytocenoses ◽  
Long Time ◽  
Main Components ◽  
First Time ◽  
Recreational Use ◽  
Specially Protected Natural Territories

The influence of recreation being a set of measures to restore health and recreation, on the main components of forest phytocenoses in specially protected natural territories of the Tatishchevsky district of the Saratov region has been studied for the first time. These phytocenoses have been intensively used for tourism for a long time. The intensity and visits activity of protected areas has been determined; the recreational capacity of territorial objects has been studied. The degree of forest landscapes has been revealed in specially protected natural territories. The findings allow predicting the future state of the natural resources of the Saratov region and can be taken into account when assessing their optimal use.

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