Cancer Conspicuity on Low-energy Images of Contrast-enhanced Mammography Compared With 2D Mammography

2021 ◽  
Author(s):  
Christina Konstantopoulos ◽  
Tejas S Mehta ◽  
Alexander Brook ◽  
Vandana Dialani ◽  
Rashmi Mehta ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Analysis Of Variance ◽  
Digital Mammography ◽  
Regions Of Interest ◽  
Low Energy ◽  
Wilcoxon Test ◽  
Digital Mammogram ◽  
Contrast Enhanced ◽  
Improved Performance ◽  
2D Images

Abstract Objective Low-energy (LE) images of contrast-enhanced mammography (CEM) have been shown to be noninferior to digital mammography. However, our experience is that LE images are superior to 2D mammography. Our purpose was to compare cancer appearance on LE to 2D images. Methods In this IRB-approved retrospective study, seven breast radiologists evaluated 40 biopsy-proven cancer cases on craniocaudal (CC) and mediolateral oblique (MLO) LE images and recent 2D images for cancer visibility, confidence in margins, and conspicuity of findings using a Likert scale. Objective measurements were performed using contrast-to-noise ratio (CNR) estimated from regions of interest placed on tumor and background parenchyma. Reader agreement was evaluated using Fleiss kappa. Per-reader comparisons were performed using Wilcoxon test and overall comparisons used three-way analysis of variance. Results Low-energy images showed improved performance for visibility (CC LE 4.0 vs 2D 3.5, P < 0.001 and MLO LE 3.7 vs 2D 3.5, P = 0.01), confidence in margins (CC LE 3.2 vs 2D 2.8, P < 0.001 and MLO LE 3.1 vs 2D 2.9, P < 0.008), and conspicuity compared to tissue density compared to 2D mammography (CC LE 3.6 vs 2D 3.2, P < 0.001 and MLO LE 3.5 vs 2D 3.2, P < 0.001). The average CNR was significantly higher for LE than for digital mammography (CC 2.1 vs 3.2, P < 0.001 and MLO 2.1 vs 3.4, P < 0.001). Conclusion Our results suggest that cancers may be better visualized on the LE CEM images compared with the 2D digital mammogram.

Low energy mammogram obtained in contrast-enhanced digital mammography (CEDM) is comparable to routine full-field digital mammography (FFDM)

2014 ◽  
Vol 83 (8) ◽  
pp. 1350-1355 ◽  
Author(s):  
Mark A. Francescone ◽  
Maxine S. Jochelson ◽  
D. David Dershaw ◽  
Janice S. Sung ◽  
Mary C. Hughes ◽  
...  
Keyword(s):  
Digital Mammography ◽  
Low Energy ◽  
Full Field ◽  
Full Field Digital Mammography ◽  
Contrast Enhanced

scholarly journals Quantitative breast density in Contrast-Enhanced Mammography

2021 ◽  
Author(s):  
Gisella Gennaro ◽  
Melissa L. Hill ◽  
Elisabetta Bezzon ◽  
Francesca Caumo
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Breast Imaging ◽  
High Energy ◽  
Multiple Correlation Coefficient ◽  
Low Energy ◽  
Wilcoxon Test ◽  
Coefficient Of Determination ◽  
Contrast Enhanced ◽  
Significant Difference

Abstract Background: Breast density is an independent risk factor for breast cancer, and cancer detection in mammography is reduced in dense breasts. Quantitative tools are available to measure breast density from digital mammography (DM) or tomosynthesis (DBT). Contrast-enhanced mammography (CEM) is an emerging breast imaging technique, consisting of the acquisition of an image pair (low-energy, LE, and high-energy, HE) for each mammography view. LE-CEM images have been demonstrated to be visually equivalent to a standard mammogram, thereby, CEM examinations do not require additional mammography to complete the clinical information. In this study, volumetric breast density (VBD) measured in LE-CEM was compared with VBD obtained from DM/DBT images.Methods: Between Mar 2019 and Dec 2020 222 women were enrolled in a prospective clinical trial aiming to compare clinical performance of CEM with breast MRI in a population of women at intermediate and high risk for breast cancer. In this observational cohort study, 150 women enrolled in this trial having at least a DM/DBT study performed before/after CEM were selected. CEM and previous/subsequent DM/DBT images were processed by an automatic algorithm to calculate VBD for each view. VBD from LE-CEM and DM/DBT views were compared using a paired Wilcoxon test. P < 0.05 was considered indicative of a statistically significant difference. A multivariate regression model was applied to analyze the relationship between paired VBD differences and multiple independent variables certainly or potentially affecting VBD.Results: Mean age of women included in this study was 51.0±8.4 years. Median VBD was comparable for LE-CEM and previous/subsequent DM/DBT (12.73% vs. 12.39%), not evidencing any statistically significant difference (P = 0.5855). VBD differences between LE-CEM and DM were associated to significant differences of glandular volume, breast thickness, compression force and pressure, contact area, and nipple-to-posterior-edge distance i.e. variables reflecting differences in breast positioning (coefficient of determination 0.6023; multiple correlation coefficient 0.7761).Conclusions: Volumetric breast density can be obtained from low-energy contrast-enhanced spectral mammography and is not significantly different from volumetric breast density measured from standard mammograms.

scholarly journals Evaluation of low-energy contrast-enhanced spectral mammography images by comparing them to full-field digital mammography using EUREF image quality criteria

2015 ◽  
Vol 25 (10) ◽  
pp. 2813-2820 ◽  
Author(s):  
U. C. Lalji ◽  
C. R. L. P. N. Jeukens ◽  
I. Houben ◽  
P. J. Nelemans ◽  
R. E. van Engen ◽  
...  
Keyword(s):  
Image Quality ◽  
Digital Mammography ◽  
Quality Criteria ◽  
Low Energy ◽  
Full Field ◽  
Full Field Digital Mammography ◽  
Contrast Enhanced

scholarly journals Role of MSCT in the diagnosis of perforated gall bladder (a retrospective study)

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Mohamed M. Harraz ◽  
Ahmed H. Abouissa
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Gall Bladder ◽  
Acute Cholecystitis ◽  
Acute Diverticulitis ◽  
Wall Thickening ◽  
Free Fluid ◽  
Iodinated Contrast ◽  
Contrast Enhanced

Abstract Background Although gall bladder perforation (GBP) is not common, it is considered a life-threating condition, and the possibility of occurrence in cases of acute cholecystitis must be considered. The aim of this study was to assess the role of multi-slice computed tomography (MSCT) in the assessment of GBP. Results It is a retrospective study including 19 patients that had GBP out of 147, there were 11 females (57.8%) and 8 males (42.1%), aged 42 to 79 year (mean age 60) presented with acute abdomen or acute cholecystitis. All patients were examined with abdominal ultrasonography and contrast-enhanced abdominal MSCT after written informed consent was obtained from the patients. This study was between January and December 2018. Patients with contraindications to contrast-enhanced computed tomography (CT) (pregnancy, acute kidney failure, or allergy to iodinated contrast agents) who underwent US only were excluded. Patients with other diagnoses, such as acute diverticulitis of the right-sided colon or acute appendicitis, were excluded. The radiological findings were evaluated such as GB distention; stones; wall thickening, enhancement, and defect; pericholecystic free fluid or collection; enhancement of liver parenchyma; and air in the wall or lumen. All CT findings are compared with the surgical results. Our results revealed that the most important and diagnostic MSCT finding in GBP is a mural defect. Nineteen patients were proved surgically to have GBP. Conclusion GBP is a rare but very serious condition and should be diagnosed and treated as soon as possible to decrease morbidity and mortality. The most accurate diagnostic tool is the CT, MSCT findings most specific and sensitive for the detection of GBP and its complications.

scholarly journals Quantitative Breast Density in Contrast-Enhanced Mammography

2021 ◽  
Vol 10 (15) ◽  
pp. 3309
Author(s):  
Gisella Gennaro ◽  
Melissa L. Hill ◽  
Elisabetta Bezzon ◽  
Francesca Caumo
Keyword(s):  
Breast Density ◽  
Potential Role ◽  
Multiple Correlation Coefficient ◽  
Low Energy ◽  
Coefficient Of Determination ◽  
Contrast Enhanced ◽  
Increased Risk ◽  
Significant Difference ◽  
Automatic Software ◽  
The Relationship

Contrast-enhanced mammography (CEM) demonstrates a potential role in personalized screening models, in particular for women at increased risk and women with dense breasts. In this study, volumetric breast density (VBD) measured in CEM images was compared with VBD obtained from digital mammography (DM) or tomosynthesis (DBT) images. A total of 150 women who underwent CEM between March 2019 and December 2020, having at least a DM/DBT study performed before/after CEM, were included. Low-energy CEM (LE-CEM) and DM/DBT images were processed with automatic software to obtain the VBD. VBDs from the paired datasets were compared by Wilcoxon tests. A multivariate regression model was applied to analyze the relationship between VBD differences and multiple independent variables certainly or potentially affecting VBD. Median VBD was comparable for LE-CEM and DM/DBT (12.73% vs. 12.39%), not evidencing any statistically significant difference (p = 0.5855). VBD differences between LE-CEM and DM were associated with significant differences of glandular volume, breast thickness, compression force and pressure, contact area, and nipple-to-posterior-edge distance, i.e., variables reflecting differences in breast positioning (coefficient of determination 0.6023; multiple correlation coefficient 0.7761). Volumetric breast density was obtained from low-energy contrast-enhanced spectral mammography and was not significantly different from volumetric breast density measured from standard mammograms.

scholarly journals Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 486
Author(s):  
Akihiro Funaoka ◽  
Kazushi Numata ◽  
Atsuya Takeda ◽  
Yusuke Saigusa ◽  
Yuichirou Tsurugai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Local Recurrence ◽  
Tumor Size ◽  
Size Reduction ◽  
Contrast Enhanced Ultrasound ◽  
Tumor Vascularity ◽  
Contrast Enhanced

Radiotherapy is one of the available curative therapies for hepatocellular carcinoma (HCC). We investigate the use of contrast-enhanced ultrasound using Sonazoid (SCEUS) in evaluating the efficacy of radiotherapy for HCC. We enrolled 59 patients with 59 HCCs in this retrospective study. Tumor size and tumor vascularity were evaluated using SCEUS before and 1, 3, 7, 10, and 13 months after radiotherapy. The median follow-up period was 44.5 months (range: 16–82 months). Of the HCCs, 95% (56/59) had no local recurrence, while 5% (3/59) did. At 13 months after radiotherapy, in cases with no local recurrence, SCEUS showed a reduction in tumor vascularity in all cases, while tumor size reduction (>30% reduction, compared with pre-radiotherapy) was observed in 82.1% (46/56). In all three cases of local recurrence, vascularity and tumor size reduction were not observed during the follow-up period and residual HCCs were demonstrated pathologically. Compared with cases with local recurrence, tumor size reduction and reduction in tumor vascularity (p < 0.001) were significantly greater in cases with no local recurrence at 13 months after radiotherapy. SCEUS may be useful in evaluating radiotherapy efficacy for HCC.

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