Cumulative incidence, risk factors and prognostic impact of venous thromboembolism in Japanese patients with advanced gastric cancer

446 Background: Renal cell ca (RCC) is one of solid tumor with relatively highest incidence of venous thromboembolism (VTE). But, there have been to no large-scale studies that focused on VTE in RCC. The aim of this study was to investigate the incidence, time course of VTE, risk factors, and prognosis associated with VTE in RCC patients in Korea. Methods: The medical records of RCC patients (n=1248) histologically diagnosed at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea from Jan 2005 to Mar 2011 were retrospectively reviewed. Results: Among 1248 RCC patients, 69.6% were men, median age was 56years (range: 4∼89), and stage distribution was stage I 65.1%, stage II 9.2%, stage III 10.4%, stage IV 12.5%. The 2-year cumulative incidences of tumor induced VTE (tVTE) was detected in 78 patients (6.3%), while 1-month, 6-months and 1-year cumulative incidence of tVTE were 5.3%, 5.7% and 6.0%, retrospectively. Two-year cumulative incidence of tVTE seemed to increase with stage (0.6%, 3.5%, 22.3% and 24.3% in stages I, II, III and IV, retrospectively). Almost tVTE events developed in the first few months after diagnosis. Stage and metastatic disease were independent risk factors for developing tVTE. In multivariate analysis, the development of tVTE was a significant predictor of survival (P=0.004) and stage, age, ECOG PS was also independent predictor of survival. Conclusions: This is the first study that specially focused on tVTE in RCC. The 2-year cumulative incidence of tVTE in Korean patients with RCC was 6.3%, which is similar to other ethnic group. As tVTE related to poorer survival, RCC patients with advanced stage and metastasis with higher risk of tVTE, close follow-up is recommended and proactive prophylaxis of VTE might be needed.

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6573 The incidence, risk factors and prognostic implications of venous thromboembolism in patients with gastric cancer

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(09)71294-7 ◽

2009 ◽

Vol 7 (2) ◽

pp. 382

Author(s):

K.W. Lee ◽

S.M. Bang ◽

Y.J. Kim ◽

J.H. Kim ◽

D.J. Park ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Venous Thromboembolism ◽

Incidence Risk ◽

Prognostic Implications

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Reappraisal of the incidence, various types and risk factors of malignancies in patients with dermatomyositis and polymyositis in Taiwan

Scientific Reports ◽

10.1038/s41598-021-83729-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jung-Lung Hsu ◽

Ming-Feng Liao ◽

Chun-Che Chu ◽

Hung-Chou Kuo ◽

Rong-Kuo Lyu ◽

...

Keyword(s):

Risk Factors ◽

Cumulative Incidence ◽

Nasopharyngeal Cancer ◽

Serum Levels ◽

Breast Cancers ◽

Cell Dysfunction ◽

Low Degree ◽

Incidence Risk ◽

T Cell Dysfunction ◽

Low Serum

AbstractOur study aimed to investigate the incidence, risk factors and time to occurrence of malignancy in patients with dermatomyositis (DM) and polymyositis (PM). The electronic medical records of 1100 patients with DM and 1164 patients with PM were studied between January 2001 and May 2019. Malignancies after myositis were diagnosed in 61 (5.55%) patients with DM and 38 (3.26%) patients with PM. The cumulative incidence of malignancies in patients with DM were significantly higher than patients with PM (hazard ratio = 1.78, log-rank p = 0.004). Patients with DM had a greater risk of developing malignancy than those with PM at 40–59 years old (p = 0.01). Most malignancies occurred within 1 year after the initial diagnosis of DM (n = 35; 57.38%). Nasopharyngeal cancer (NPC) was the most common type of malignancy in patients with DM (22.95%), followed by lung, and breast cancers. In patients with PM, colorectal, lung and hepatic malignancies were the top three types of malignancy. The risk factors for malignancy included old age (≥ 45 years old) and low serum levels of creatine phosphokinase (CPK) for patients with DM and male sex and low serum levels of CPK for patients with PM. Low serum levels of CPK in patients with myositis with malignancy represented a low degree of muscle destruction/inflammation, which might be attributed to activation of the PD-L1 pathway by tumor cells, thus inducing T-cell dysfunction mediating immune responses in myofibers. A treatment and follow-up algorithm should explore the occurrence of malignancy in different tissues and organs and suggested annual follow-ups for at least 5.5 years to cover the 80% cumulative incidence of malignancy in patients with DM and PM.

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Tu1327 – Risk Factors of Early and Advanced Gastric Cancer: A 8 Years Population Study in Northern Italy

Gastroenterology ◽

10.1016/s0016-5085(19)39523-x ◽

2019 ◽

Vol 156 (6) ◽

pp. S-1027

Author(s):

Chiara Miraglia ◽

Ottavia Cavatorta ◽

Marilisa Franceschi ◽

Pellegrino Crafa ◽

Gianluca Baldassarre ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Advanced Gastric Cancer ◽

Population Study ◽

Northern Italy

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Implications of cytogenetics for venous thromboembolism in acute myeloid leukaemia

Thrombosis and Haemostasis ◽

10.1160/th13-12-1020 ◽

2015 ◽

Vol 113 (01) ◽

pp. 201-208 ◽

Cited By ~ 4

Author(s):

Ji-hyun Kwon ◽

Sung Yoon ◽

Leo Song ◽

Jae-Ho Yoon ◽

Seung-Hwan Shin ◽

...

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Advanced Age ◽

Leukemia Diagnosis ◽

Incidence Risk ◽

Thrombotic Complications ◽

Predictive Role ◽

Independent Risk Factors ◽

One Year ◽

Acute Myeloid

SummaryDue to the high risk of thrombocytopenia and haemorrhage, thrombotic complications have received little attention in patients with acute myeloid leukemia (AML). Furthermore, the predictive role of cytogenetics on venous thromboembolism (VTE) has largely been ignored. This study aimed to evaluate the incidence, risk factors, and prognostic aspects of VTE in AML. A total of 811 consecutive patients with AML were enrolled and analysed retrospectively. Cox time-dependent covariate regression analysis was used to identify the significant predictors of VTE development. To minimise potential confounding factors, we used propensity-score matching to compare overall survival between patients with and without VTE. The six-month and one-year cumulative incidences of VTE were 3.1 % (95 % confidence interval [CI], 2.0–4.7) and 3.9 % (95 % CI, 2.6–5.7), respectively. Of the 26 cases of VTE, 22 (85 %) developed within 6 months of leukemia diagnosis and 13 (50 %) were catheter-related. In multivariate analysis, advanced age (≥ 65 years) (hazard ratio [HR], 2.70; p = 0.03) and increasing cytogenetic risk (common HR, 1.84; p = 0.05) were independent predictors of VTE. There was no significant association between VTE development and decreased survival (p = 0.32 for matched analysis). Advanced age and increasing cytogenetic risk, well-known predictors for clinical outcome in AML, were also independent risk factors of VTE development. Our results suggest that VTE does not hold prognostic implications for AML.

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