Loss of Tissues in Female Rats Subjected to Food Restriction during Lactation or during Both Gestation and Lactation

The present study investigated whether male offspring (F2 generation) from female rats (F1 generation) whose mothers (F0 generation) were food restricted during gestation inherit a phenotypic transgenerational tendency towards being overweight and obese in the juvenile period, in the absence of food restriction in the F1/F2 generations. Dams of the F0 generation were 40% food restricted during pregnancy. Bodyweight, the number and size of larger and small hypodermal adipocytes (HAs), total retroperitoneal fat (RPF) weight and the expression of glial fibrillary acidic protein (GFAP) in periventricular hypothalamic astrocytes (PHAs), as determined by immunohistochemistry, were evaluated in both generations. In the female F1 generation, there was low bodyweight gain only during the juvenile period (30–65 days of age), a decrease in the size of small adipocytes, an increase in the number of small adipocytes, an increase in RPF weight and an increase in GFAP expression in PHAs at 90–95 days of age. In males of the F2 generation at 50 days of age, there was increased bodyweight and RPF weight, and a small number of adipocytes and GFAP expression in PHAs. These data indicate that the phenotypic transgenerational tendency towards being overweight and obese was observed in females (F1) from mothers (F0) that were prenatally food restricted was transmitted to their male offspring.

Download Full-text

Anti-Osteoporotic Effect of Soy Isoflavones Intake on Low Bone Mineral Density Caused by Voluntary Exercise and Food Restriction in Mature Female Rats

Journal of Nutritional Science and Vitaminology ◽

10.3177/jnsv.65.335 ◽

2019 ◽

Vol 65 (4) ◽

pp. 335-342 ◽

Cited By ~ 2

Author(s):

Kaoru YANAKA ◽

Mitsuru HIGUCHI ◽

Yoshiko ISHIMI

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Food Restriction ◽

Mature Female ◽

Soy Isoflavones ◽

Voluntary Exercise ◽

Female Rats ◽

Mineral Density ◽

Low Bone Mineral Density

Download Full-text

Cyclic Food Restriction Alters Substrate Utilization and Abolishes Protection from Mammary Carcinogenesis in Female Rats

Journal of Nutrition ◽

10.1093/jn/126.5.1398 ◽

1996 ◽

Vol 126 (5) ◽

pp. 1398-1405 ◽

Cited By ~ 20

Author(s):

Anthony R. Tagliaferro ◽

Anne M. Ronan ◽

Loren D. Meeker ◽

Henry J. Thompson ◽

Amy L. Scott ◽

...

Keyword(s):

Food Restriction ◽

Mammary Carcinogenesis ◽

Substrate Utilization ◽

Female Rats

Download Full-text

Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1980.239.6.e422 ◽

1980 ◽

Vol 239 (6) ◽

pp. E422-E429 ◽

Cited By ~ 9

Author(s):

L. Bukowiecki ◽

J. Lupien ◽

N. Follea ◽

A. Paradis ◽

D. Richard ◽

...

Keyword(s):

Adipose Tissue ◽

Exercise Training ◽

Food Restriction ◽

Female Rats ◽

Epididymal Adipose Tissue ◽

Adipocyte Size ◽

Fat Depots ◽

Male And Female Rats ◽

Receptor Sites ◽

Stimulus Recognition

The effects of exercise training and food restriction on the regulation of lipolysis were studied comparatively in adipocytes isolated from male and female rats. Exercise training inhibited cell proliferation in parametrial, but not in epididymal adipose tissue, whereas it significantly reduced adipocyte size in both fat depots. Adipocyte capacity for responding lipolytically to epinephrine (10 microns) or to ACTH (1 micron) was markedly increased by exercise training. Enhanced lipolysis was also observed when cells isolated from exercise-trained animals were stimulated by bypassing with dibutyryl cyclic AMP (5 mM) or theophylline (5 mM) the early metabolic steps associated with hormonal activation of the adenylate cyclase complex. Significantly, binding of (-)-[3H]dihydroalprenolol to cellular receptor sites was not affected by exercise training. It is therefore concluded that exercise training increases adipocyte responsiveness to lipolytic hormones at a metabolic step distal to stimulus recognition by adrenoreceptors, possibly at the level of protein kinases or lipases. Food restriction markedly reduced adipocyte size and partially mimicked the effects of exercise training on adipocyte proliferation and lipolysis.

Download Full-text