Metallothionein Gene Expression in Rats: Tissue-Specific Regulation by Dietary Copper and Zinc

1988 ◽  
Vol 118 (2) ◽  
pp. 222-228 ◽  
Author(s):  
T. Lynn Blalock ◽  
Michael A. Dunn ◽  
Robert J. Cousins
Keyword(s):  
Gene Expression ◽  
Dietary Copper ◽  
Tissue Specific ◽  
Metallothionein Gene ◽  
Copper And Zinc ◽  
Specific Regulation

Tissue-Specific Regulation of Renin-Binding Protein Gene Expression in Rats1

1992 ◽  
Vol 112 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Masazumi Tada ◽  
Saori Takahashi ◽  
Motoshige Miyano ◽  
Yoshihiro Miyake
Keyword(s):  
Gene Expression ◽  
Protein Gene ◽  
Binding Protein ◽  
Tissue Specific ◽  
Binding Protein Gene ◽  
Specific Regulation

The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression

2013 ◽  
Vol 40 (12) ◽  
pp. 6685-6690 ◽  
Author(s):  
Lyudmila V. Dergunova ◽  
Alexandra V. Rozhkova ◽  
Olga Yu. Sudarkina ◽  
Svetlana A. Limborska
Keyword(s):  
Gene Expression ◽  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Regulation

TISSUE-SPECIFIC REGULATION OF KIBRA GENE EXPRESSION IN NEUROBLASTOMA AND KIDNEY CELLS

2011 ◽  
Vol 29 ◽  
pp. e144
Author(s):  
K. Guske ◽  
M. Herrmann ◽  
M. Schelleckes ◽  
B. Schmitz ◽  
K. Duning ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kidney Cells ◽  
Tissue Specific ◽  
Specific Regulation

Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression

2004 ◽  
Vol 286 (6) ◽  
pp. R977-R988 ◽  
Author(s):  
Joachim Fandrey
Keyword(s):  
Gene Expression ◽  
Reproductive Tract ◽  
Fetal Liver ◽  
Hypoxia Inducible Factor ◽  
The Body ◽  
Glycoprotein Hormone ◽  
Tissue Specific ◽  
Specific Regulation ◽  
Main Regulator ◽  
Regulated Gene Expression

Hypoxia-inducible expression of the gene encoding for the glycoprotein hormone erythropoietin (EPO) is the paradigm of oxygen-regulated gene expression. EPO is the main regulator of red blood cell production and more than 100 years of research on the regulation of EPO production have led to the identification of a widespread cellular oxygen sensing mechanism. Central to this signaling cascade is the transcription factor complex hypoxia-inducible factor-1 (HIF-1). Meanwhile, it is known that HIF-1 controls more than 50 oxygen-dependent genes and is now recognized as the main regulator of oxygen homoeostasis in the body. In addition to hypoxic induction, expression of the EPO gene is tightly regulated in a tissue-specific manner. During ontogeny, production of EPO required for erythropoiesis is switched from the fetal liver to the kidneys. Here EPO is mainly synthesized in adulthood. Production of EPO has also been found in organs where it has nonerythropoietic functions: EPO is important for development of the brain and is neuroprotective, whereas it stimulates angiogenesis in the reproductive tract and possibly in other organs. Understanding oxygen and tissue-specific regulation of EPO production is of high relevance for physiology. Moreover, this knowledge might be useful for new therapies to treat human diseases.

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