Chronic Protein Restriction Does Not Alter Energetic Efficiency or Brown Adipose Tissue Thermogenic Capacity in Genetically Obese (fa/fa) Zucker Rats

1995 ◽  
Vol 125 (8) ◽  
pp. 2183-2193 ◽  
Author(s):  
S. E. Specter ◽  
J. S. Hamilton ◽  
J. S. Stern ◽  
B. A. Horwitz
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Protein Restriction ◽  
Zucker Rats ◽  
Energetic Efficiency ◽  
Brown Adipose ◽  
Thermogenic Capacity

Brown adipose tissue metabolism in ob/ob mice: effects of a high-fat diet and adrenalectomy

1987 ◽  
Vol 253 (2) ◽  
pp. E149-E157
Author(s):  
H. K. Kim ◽  
D. R. Romsos
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
High Fat Diet ◽  
High Fat ◽  
Adipose Tissue Metabolism ◽  
High Carbohydrate ◽  
Bat Mitochondria ◽  
Norepinephrine Turnover ◽  
Brown Adipose ◽  
Thermogenic Capacity

Adrenalectomy prevents development of obesity in ob/ob mice fed high-carbohydrate stock diets partly by stimulating the low thermogenic capacity of their brown adipose tissue (BAT). Adrenalectomy, however, fails to prevent development of obesity in ob/ob mice fed a high-fat diet. Effects of adrenalectomy on BAT metabolism in ob/ob mice fed a high-fat diet were thus examined. ob/ob mice fed the high-fat diet developed gross obesity despite normal BAT metabolism, as assessed by rates of norepinephrine turnover in BAT, GDP binding to BAT mitochondria, and GDP-inhibitable, chloride-induced mitochondrial swelling. Adrenalectomy failed to arrest the development of obesity or to influence BAT metabolism in ob/ob mice fed the high-fat diet. Development of obesity in ob/ob mice fed a high-fat diet is not associated with low thermogenic capacity of BAT or with adrenal secretions, as it is in ob/ob mice fed high-carbohydrate stock diets.

Early weaning alters the thermogenic capacity of brown adipose tissue in adult male and female rats

2019 ◽  
Vol 59 (5) ◽  
pp. 2207-2218 ◽  
Author(s):  
T. C. Peixoto ◽  
C. B. Pietrobon ◽  
I. M. Bertasso ◽  
F. A. H. Caramez ◽  
C. Calvino ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Adult Male ◽  
Female Rats ◽  
Early Weaning ◽  
Male And Female ◽  
Male And Female Rats ◽  
Brown Adipose ◽  
Thermogenic Capacity

Brown adipose tissue in cafeteria-fed hamsters

1985 ◽  
Vol 248 (2) ◽  
pp. E230-E235
Author(s):  
R. J. Schimmel ◽  
L. McCarthy
Keyword(s):  
Adipose Tissue ◽  
Weight Gain ◽  
Brown Adipose Tissue ◽  
Brown Fat ◽  
Cafeteria Diet ◽  
Tissue Protein ◽  
Dietary Regulation ◽  
Isolated Mitochondria ◽  
Brown Adipose ◽  
Thermogenic Capacity

Hamsters consuming a “cafeteria diet” had more brown adipose tissue than did chow-fed hamsters. The growth of the brown fat depots in cafeteria-fed hamsters was accompanied by increases in tissue protein and cytochrome oxidase. To assess the thermogenic capacity of brown fat mitochondria, the binding of GDP to isolated mitochondria was measured. Mitochondrial GDP binding was not affected by feeding the cafeteria diet for 4 wk, but more prolonged cafeteria feeding for 8 wk did, however, increase the binding of GDP to isolated mitochondria. The morphology of brown adipose tissue was altered during cafeteria feeding. The brown adipose tissue of cafeteria-fed hamsters had more large unilocular cells than did the brown adipose tissue of chow-fed hamsters. In addition, the average adipocyte diameter was greater in brown adipose tissue of cafeteria-fed hamsters. These data support the presence of a dietary regulation of brown adipose tissue growth in hamsters. The growth of brown adipose tissue in hamsters eating the cafeteria diet appears to result largely from proliferation of adipocytes, as evidenced by the increases in tissue protein and cytochrome oxidase during cafeteria feeding, but some hypertrophy of the adipocytes also occurs. A dietary regulation of brown fat thermogenic capacity is also apparent but this regulation is evident only after more prolonged periods of cafeteria feeding. Hamsters eating a cafeteria diet increase their caloric intake but have the same or greater body weight gain efficiency as do chow-fed animals. The absence of dietary stimulation of thermogenesis may underlie the similar efficiencies of weight gain in chow- and cafeteria-fed hamsters.

scholarly journals Evidence for the presence of several phosphodiesterase isoforms in brown adipose tissue of Zucker rats: modulation of PDE2 by the fa gene expression

FEBS Letters ◽  
1999 ◽  
Vol 456 (1) ◽  
pp. 207-210 ◽  
Author(s):  
Carole Coudray ◽  
Christine Charon ◽  
Narcisse Komas ◽  
Gérard Mory ◽  
Francine Diot-Dupuy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Zucker Rats ◽  
Brown Adipose
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