Influence of Cyclopropenoid Fatty Acids on the Cholesterol Metabolism of Cockerels

1967 ◽  
Vol 91 (2) ◽  
pp. 174-178 ◽  
Author(s):  
K. C. Goodnight ◽  
A. R. Kemmerer
Keyword(s):  
Fatty Acids ◽  
Cholesterol Metabolism ◽  
Cyclopropenoid Fatty Acids

Relationships between Serum Saturated Fatty Acids and Serum Total Cholesterol and HDL-Cholesterol in Humans

1994 ◽  
Vol 31 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Teruo Nagaya ◽  
Ken-Ichi Nakaya ◽  
Akemi Takahashi ◽  
Izumi Yoshida ◽  
Yoshinari Okamoto
Keyword(s):  
Body Mass Index ◽  
Fatty Acids ◽  
Multivariate Analysis ◽  
Total Cholesterol ◽  
Cholesterol Metabolism ◽  
Saturated Fatty Acids ◽  
Hdl Cholesterol ◽  
Significant Relation ◽  
Men And Women ◽  
Fa Composition

To investigate the effects of serum saturated fatty acids (FAs) on human cholesterol metabolism, total-cholesterol (T-C), HDL-cholesterol (HDL-C), T-C/HDL-C ratio, and FA composition [myristic acid (MA, 14:0), palmitic acid (PA, 16:0) and stearic acid (SA, 18:0)] were determined in serum from 115 men and 120 women (20–70 years old). MA, PA and SA were expressed as percentages of serum total FAs. Using multivariate analysis to account for the confounding effects of age, body mass index, drinking, and smoking it was found that SA was negatively correlated with T-C and T-C/HDL-C ratio in both men and women. In men MA was negatively correlated with HDL-C, and in women SA was positively correlated with HDL-C. Although PA was the major component of serum saturated FAs, PA had no significant relation to any cholesterol indices in either sex. These results suggest that serum MA may aggravate and serum SA may improve cholesterol metabolism, thereby influencing the risk for ischaemic heart disease.

Effects of diets enriched in n−6 or n−3 fatty acids on cholesterol metabolism in older rats chronically fed a cholesterol-enriched diet

Lipids ◽  
2001 ◽  
Vol 36 (3) ◽  
pp. 261-266 ◽  
Author(s):  
Michihiro Fukushima ◽  
Tetsu Ohhashi ◽  
Syugo Ohno ◽  
Hidetoshi Saitoh ◽  
Kei Sonoyama ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cholesterol Metabolism

scholarly journals Pinto Beans (Phaseolus vulgaris L.) Lower Non-HDL Cholesterol in Hamsters Fed a Diet Rich in Saturated Fat and Act on Genes Involved in Cholesterol Homeostasis

2019 ◽  
Vol 149 (6) ◽  
pp. 996-1003 ◽  
Author(s):  
An Tien Nguyen ◽  
Sami Althwab ◽  
Haowen Qiu ◽  
Richard Zbasnik ◽  
Carlos Urrea ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Molecular Mechanisms ◽  
Cholesterol Metabolism ◽  
Saturated Fatty Acids ◽  
Saturated Fat ◽  
Density Lipoprotein ◽  
Cholesterol Homeostasis ◽  
Liver Cholesterol ◽  
Intestinal Cholesterol Absorption ◽  
Pinto Beans

ABSTRACT Background Pinto beans contain multiple active agents such as polyphenols, flavonoids, and saponins, and have been shown to lower cholesterol, but the mechanisms involved in this effect have not been explored. Objective This study was to investigate the changes in cholesterol metabolism in response to whole pinto beans (wPB) and their hulls (hPB) supplemented into a diet rich in saturated fat and the molecular mechanisms potentially responsible for these effects in hamsters. Methods Forty-four 9-wk-old male Golden Syrian hamsters were randomly assigned to 4 diet groups (n = 11), including a 5% (wt:wt) fat diet [normal-fat diet (NF)], a 15% (wt:wt) fat diet [diet rich in saturated fat (HSF), saturated fatty acids accounted for 70% of total fatty acids], or HSF supplemented with 5% (wt:wt) wPB or 0.5% (wt:wt) hPB for 4 wk. Plasma, liver, intestinal, and fecal samples were collected to evaluate multiple cholesterol markers and gene targets. Results The plasma non-high-density lipoprotein (non-HDL) concentration was significantly reduced in the wPB- and hPB-supplemented groups by 31.9 ± 3.5% and 53.6 ± 3.2%, respectively, compared with the HSF group (P < 0.01), to concentrations comparable with the NF group. The wPB-supplemented hamsters had significantly lower liver cholesterol (45.1%, P < 0.001) and higher fecal cholesterol concentrations (94.8%, P = 0.001) than those fed the HSF. The expressions of hepatic 3-hydroxy-3-methylglutaryl CoA reductase (Hmgcr) and small intestinal acyl-coenzyme A: cholesterol acyltransferase 2 (Acat2) were significantly decreased in animals administered wPB (by 89.1% and 63.8%, respectively) and hPB (by 72.9% and 47.7%, respectively) compared with their HSF-fed counterparts (P < 0.05). The wPB normalized the expression of Acat2 to the level of the NF group. Conclusion Pinto beans remediated high cholesterol induced by HSF in male hamsters by decreasing hepatic cholesterol synthesis and intestinal cholesterol absorption, effects which were partially exerted by the hulls.

A PROPOSED MECHANISM FOR THE EFFECT OF DIFFERENT DIETARY FATS ON SOME ASPECTS OF CHOLESTEROL METABOLISM

1962 ◽  
Vol 40 (1) ◽  
pp. 1091-1100 ◽  
Author(s):  
J. A. Wilkens ◽  
H. de Wit ◽  
B. Bronte-Stewart
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Cholesterol Metabolism ◽  
Dietary Cholesterol ◽  
Serum Levels ◽  
High Serum ◽  
Dietary Fats ◽  
Cholesterol Concentration ◽  
Serum Cholesterol Concentration ◽  
Endogenous Cholesterol

To explain the effect of dietary cholesterol and different fats on serum cholesterol concentration a hypothesis is proposed according to which the condition for the absorption of dietary cholesterol is its state of solution in dietary or endogenous fats. Dietary fats, free from cholesterol, exert their effect on serum cholesterol concentration by causing reabsorption of biliary or endogenous cholesterol. To test this hypothesis the solubility of cholesterol in a number of natural and modified triglyceride fats at 37 °C was determined and found to correlate with the effects of these fats on the serum cholesterol concentration of rats and man. Relatively high solubilities were associated with high serum levels and vice versa. Artificial modification of both unsaponifiable matter and fatty acids of triglyceride oils was found to alter the solubility of cholesterol in these oils. The solubility concept is discussed as a possible mechanism underlying the effect of different dietary fats on serum cholesterol concentration and other aspects of cholesterol metabolism such as absorption, excretion, and liver synthesis.

Cyclopropenoid Fatty Acids in Malagasy baobab: Adansonia grandidieri (Bombacaceae) Seed Oil

1982 ◽  
Vol 84 (12) ◽  
pp. 468-472 ◽  
Author(s):  
E. M. Gaydou ◽  
Dr. J.-P. Bianchini ◽  
A. Ralaimanarivo
Keyword(s):  
Fatty Acids ◽  
Seed Oil ◽  
Cyclopropenoid Fatty Acids

EFFECT OF ERUCIC ACID ON INCORPORATION OF ACETATE-1-C14 INTO CHOLESTEROL AND FATTY ACIDS

1959 ◽  
Vol 37 (7) ◽  
pp. 803-810 ◽  
Author(s):  
K. K. Carroll
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Erucic Acid ◽  
Cholesterol Metabolism ◽  
Young Male ◽  
Male Rats ◽  
Acetate Incorporation ◽  
Acid Incorporation ◽  
Liver Slices ◽  
Fatty Acid Incorporation

Young male rats were fed synthetic diets containing either no fat or various individual fatty acids for 3 to 4 weeks. They were then killed and the incorporation of acetate-1-C14 into cholesterol and fatty acids was measured in liver slices and in scrapings of intestinal mucosa. Acetate incorporation into cholesterol by liver slices was much greater in animals fed erucic acid than in those fed no fat, palmitic, stearic, oleic, or linoleic acids. A marked differential was not observed in fatty acid incorporation but values tended to be higher on the fat-free and erucic acid diets. Erucic acid did not stimulate acetate incorporation into cholesterol by mucosa and in general mucosa seemed to be less sensitive to changes in diet. The results are discussed in relation to previously observed effects of erucic acid on cholesterol metabolism.

Dietary fatty acids and CD36-mediated cholesterol homeostasis: potential mechanisms

2020 ◽  
pp. 1-14 ◽  
Author(s):  
Elif Ulug ◽  
Reyhan Nergiz-Unal
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cholesterol Metabolism ◽  
Fatty Acid Pattern ◽  
Dietary Fatty Acids ◽  
Cholesterol Homeostasis ◽  
Acid Uptake ◽  
Pufa Ratio ◽  
Mortality And Morbidity ◽  
Cd36 Receptor

Abstract Currently, the prevention and treatment of CVD have been a global focus since CVD is the number one cause of mortality and morbidity. In the pathogenesis of CVD, it was generally thought that impaired cholesterol homeostasis might be a risk factor. Cholesterol homeostasis is affected by exogenous factors (i.e. diet) and endogenous factors (i.e. certain receptors, enzymes and transcription factors). In this context, the number of studies investigating the potential mechanisms of dietary fatty acids on cholesterol homeostasis have increased in recent years. As well, the cluster of differentiation 36 (CD36) receptor is a multifunctional membrane receptor involved in fatty acid uptake, lipid metabolism, atherothrombosis and inflammation. CD36 is proposed to be a crucial molecule for cholesterol homeostasis in various mechanisms including absorption/reabsorption, synthesis, and transport of cholesterol and bile acids. Moreover, it has been reported that the amount of fatty acids and fatty acid pattern of the diet influence the CD36 level and CD36-mediated cholesterol metabolism principally in the liver, intestine and macrophages. In these processes, CD36-mediated cholesterol and lipoprotein homeostasis might be impaired by dietary SFA and trans-fatty acids, whereas ameliorated by MUFA in the diet. The effects of PUFA on CD36-mediated cholesterol homeostasis are controversial depending on the amount of n-3 PUFA and n-6 PUFA, and the n-3:n-6 PUFA ratio. Thus, since the CD36 receptor is suggested to be a novel nutrient-sensitive biomarker, the role of CD36 and dietary fatty acids in cholesterol metabolism might be considered in medical nutrition therapy in the near future. Therefore, the novel nutritional target of CD36 and interventions that focus on dietary fatty acids and potential mechanisms underlying cholesterol homeostasis are discussed in this review.

Sign in / Sign up

Export Citation Format

Share Document