Leukemia Induction in Mice by Moloney Virus From Long- and Short-Term Tissue Cultures, and Attempts to Detect a Leukemogenic Virus in Cultures From X-Ray-lnduced Leukemia2

1962 ◽  
Keyword(s):  
Tissue Cultures ◽  
Short Term ◽  
X Ray

scholarly journals GCT-08. PROTON BEAM RADIOTHERAPY FOR PEDIATRIC AND YOUNG-ADULT PATIENTS WITH INTRACRANIAL GERM CELL TUMOR

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii329-iii329
Author(s):  
Minako Sugiyama ◽  
Takayuki Hashimoto ◽  
Takashi Mori ◽  
Kazuya Hara ◽  
Yukayo Terashita ◽  
...  
Keyword(s):  
Young Adult ◽  
Adverse Events ◽  
Germ Cell ◽  
Cell Count ◽  
Proton Beam ◽  
Adult Patients ◽  
Short Term ◽  
Intracranial Germ Cell Tumor ◽  
X Ray ◽  
Proton Beam Radiotherapy

Abstract BACKGROUND To reduce treatment-related adverse events in pediatric and young-adult patients with brain tumors, proton beam radiotherapy (PBT) has recently been performed instead of conventional X-ray radiotherapy. However, whether PBT is as effective as X-ray radiotherapy has not been sufficiently investigated, especially in patients receiving whole-ventricular irradiation. METHODS We report a retrospective observation of 15 patients with intracranial germ cell tumors (GCT), who received PBT at our institution from April 2014 to September 2019. We evaluated their clinical course, short-term adverse events, and prognosis. RESULTS/ CONCLUSION Fifteen patients (9 males and 6 females; median age 13 years) who received PBT following induction chemotherapy were analyzed. Nine patients received 23.4–27.0 GyE of whole-ventricular irradiation due to GCT in the pituitary gland, pineal body, or hypothalamic area. Three patients received 23.4 GyE of whole-brain irradiation: one of them had boost irradiation for basal ganglia. Three patients received 30.6 GyE of craniospinal irradiation (CSI). Six of the 15 patients experienced nausea (grade 2, according to the CTCAE version 4.0). Four patients, including two who received CSI, showed myelosuppression: decrease in white blood cell count, lymphocyte cell count, and neutrophil count (grade 3). No other severe short-term adverse events of >grade 2 was observed in any of the patients. At a median follow-up of 21 months (2-62 months) after irradiation. all patients are alive without recurrence. Our results may be encouraging and further investigations with a larger scale is warranted.

The calcium antagonist diltiazem inhibits calcification enhanced by calcitonin in growth cartilage of rats in ethane-1-hydroxy-1,1-diphosphonate (EHDP)-induced rickets

1986 ◽  
Vol 113 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Masao Eguchi ◽  
Kenichiro Shibata ◽  
Fumio Wada ◽  
Hideya Kawamura ◽  
Takashi Shimauchi ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
Calcium Ion ◽  
Concomitant Administration ◽  
Proximal Region ◽  
Dependent Manner ◽  
Short Term ◽  
X Ray ◽  
Growth Cartilage ◽  
Term Administration ◽  
Dose Dependent

Abstract. In an animal model of human rickets developed by giving a short-term administration of large doses of EHDP to young rats, concomitant administration of [Asu1,7]eel calcitonin (CT) with EHDP resulted in the promotion of calcification in growth cartilage. In an attempt to clarify the mechanisms related to the accelerated calcification due to CT, the effects of diltiazem, a calcium antagonist, were studied. Diltiazem suppressed, in a dose-dependent manner, the accelerated calcification due to CT in the growth cartilage, as determined by findings on the soft X-ray photos, contact microradiograph and light microscopic histology of the proximal region of the tibia. This suppression was only evident when diltiazem and CT were given concomitantly. If it is assumed that diltiazem inhibits the entry of calcium ion into the cells of growth cartilage, in the same manner as seen in case of smooth muscle and myocardial cells, then our results indicate that intracellular concentrations of calcium might play an important role in the occurrence of accelerated calcification due to CT.

scholarly journals A survey of short-term and long-term stability of tube parameters in a mammography unit

2014 ◽  
Vol 29 (4) ◽  
pp. 321-325
Author(s):  
Jovica Praskalo ◽  
Jasna Davidovic ◽  
Biljana Kocic ◽  
Monika Zivkovic ◽  
Svetlana Pejovic
Keyword(s):  
Screening Program ◽  
Short Term ◽  
X Ray ◽  
Term Stability ◽  
Long Term Stability ◽  
Mammography Screening Program ◽  
The Republic ◽  
Set Up ◽  
The Given

In order to set up a successful mammography screening program in the Republic of Srpska, a Siemens Mammomat 1000 X-ray machine was selected for analysis as the said mammography system is widely used in clinical practice. The variations in tube parameters (specific air kerma, high-voltage accuracy and reproducibility, linearity between exposure and dose exposure time) were monitored over a five-year period, from 2008 to 2012. In addition, due to observed daily fluctuations for chosen parameters, a series of measurements were performed three times a day within a single-month period (mainly October 2012). The goal of such an experimental set up is to assess short-term and long-term stability of tube parameters in the given mammography unit and to make a comparison between them. The present paper shows how an early detection of significant parameter fluctuations can help eliminate irregularities and optimize the performance of mammography systems.

scholarly journals Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS-CoV-2

2020 ◽  
Author(s):  
Jamie A. Kelly ◽  
Alexandra N. Olson ◽  
Krishna Neupane ◽  
Sneha Munshi ◽  
Josue San Emeterio ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Small Molecule ◽  
Ribosomal Frameshift ◽  
Short Term ◽  
X Ray ◽  
Functional Conservation ◽  
Lead Compounds ◽  
X Ray Scattering ◽  
The World ◽  
Functional Analyses

Abstract17 years after the SARS-CoV epidemic, the world is facing the COVID-19 pandemic. COVID-19 is caused by a coronavirus named SARS-CoV-2. Given the most optimistic projections estimating that it will take over a year to develop a vaccine, the best short-term strategy may lie in identifying virus-specific targets for small molecule interventions. All coronaviruses utilize a molecular mechanism called −1 PRF to control the relative expression of their proteins. Prior analyses of SARS-CoV revealed that it employs a structurally unique three-stemmed mRNA pseudoknot to stimulate high rates of −1 PRF, and that it also harbors a −1 PRF attenuation element. Altering −1 PRF activity negatively impacts virus replication, suggesting that this molecular mechanism may be therapeutically targeted. Here we present a comparative analysis of the original SARS-CoV and SARS-CoV-2 frameshift signals. Structural and functional analyses revealed that both elements promote similar rates of −1 PRF and that silent coding mutations in the slippery sites and in all three stems of the pseudoknot strongly ablated −1 PRF activity. The upstream attenuator hairpin activity has also been functionally retained. Small-angle x-ray scattering indicated that the pseudoknots in SARS-CoV and SARS-CoV-2 had the same conformation. Finally, a small molecule previously shown to bind the SARS-CoV pseudoknot and inhibit −1 PRF was similarly effective against −1 PRF in SARS-CoV-2, suggesting that such frameshift inhibitors may provide promising lead compounds to counter the current pandemic.

scholarly journals Enhancing Short-Term Plasticity by Inserting a Thin TiO2 Layer in WOx-Based Resistive Switching Memory

Coatings ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 908 ◽  
Author(s):  
Hyojong Cho ◽  
Sungjun Kim
Keyword(s):  
Photoelectron Spectroscopy ◽  
Oxygen Vacancies ◽  
Short Term Memory ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
X Ray ◽  
Short Term Plasticity ◽  
Good Retention

In this work, we emulate biological synaptic properties such as long-term plasticity (LTP) and short-term plasticity (STP) in an artificial synaptic device with a TiN/TiO2/WOx/Pt structure. The graded WOx layer with oxygen vacancies is confirmed via X-ray photoelectron spectroscopy (XPS) analysis. The control TiN/WOx/Pt device shows filamentary switching with abrupt set and gradual reset processes in DC sweep mode. The TiN/WOx/Pt device is vulnerable to set stuck because of negative set behavior, as verified by both DC sweep and pulse modes. The TiN/WOx/Pt device has good retention and can mimic long-term memory (LTM), including potentiation and depression, given repeated pulses. On the other hand, TiN/TiO2/WOx/Pt devices show non-filamentary type switching that is suitable for fine conductance modulation. Potentiation and depression are demonstrated in the TiN/TiO2 (2 nm)/WOx/Pt device with moderate conductance decay by application of identical repeated pulses. Short-term memory (STM) is demonstrated by varying the interval time of pulse inputs for the TiN/TiO2 (6 nm)/WOx/Pt device with a quick decay in conductance.

scholarly journals Physics of Relativistic Jets on Sub-Milliarcsecond Scales

1984 ◽  
Vol 110 ◽  
pp. 207-214
Author(s):  
Martin J. Rees
Keyword(s):  
Energy Production ◽  
Galactic Nuclei ◽  
Primary Energy ◽  
Relativistic Jets ◽  
Short Term ◽  
X Ray ◽  
Long Term Stability ◽  
Extended Sources ◽  
Vlbi Data

The observed superluminal components have (deprojected) lengths of ~ 1020 cm, and imply relativistic bulk motions on these scales. There are, however, persuasive reasons for attributing the primary energy production to scales 1014–1015 cm. Moreover, the initial bifurcation and collimation must also be imposed on these small scales if the long-term stability of the jet axis in extended sources is due to the gyroscopic effect of a spinning black hole (Rees 1978). The issues I shall address in this talk are: how the jet gets from ~ 1015cm to ~ 1019 cm; and what VLBI data can tell us about the properties of galactic nuclei on scales below ~ 1019 cm — scales where optical and X-ray studies provide some evidence, but where there is no short-term hope of achieving spatial resolution.

scholarly journals Optical Short-Term Variability in the X-Ray-Selected BL Lac Object IE 0317+186 and the Radio-Selected BL Lac Object ON231

1989 ◽  
Vol 134 ◽  
pp. 108-109
Author(s):  
F.Z. Cheng ◽  
J.F. Lu ◽  
G.Z. Xie ◽  
K.H. Li ◽  
Z.L. Li ◽  
...  
Keyword(s):  
Light Curves ◽  
Optical Monitoring ◽  
National Observatory ◽  
Image System ◽  
Short Term ◽  
Bl Lac Objects ◽  
X Ray ◽  
Bl Lac ◽  
Ccd Image ◽  
Short Term Variability

In order to compare X-ray-selected BL Lac objects with radio-selected BL Lac objects, we have carried out optical monitoring of some of these objects for about three years at Yunnan Observatory in China. All observations have been made with a CCD-image system at the f/13.3 Cassegrain focus of the 102-cm RCC telescope. The CCD-image system was developed by Ye et al. in Kitt Peak National Observatory of USA (Ye et al., 1985). The filters used were as follows: B-GG385(2mm)+BG12(1mm)+BG18(1mm), V-GG495(2mm)+BG18(2mm). After observing many times, more complete light curves have obtained for the X-ray-selected BL Lac object IE 0317+186 and the radio-selected BL Lac object ON 231, respectively(Fig 1 and Fig 2). Fig 1 shows that IE 0317+186 has a characteristic timescale of about 4.5hours with an amplitudes of ΔV≃0.65 mag. Fig 2 indicates that a timescale of short-term variability in ON 231 is about 70 min with an amplitudes of ΔB≃0.8 mag.

Uncorrelated soft and hard X-ray short-term variations from AM Herculis

1986 ◽  
Vol 306 ◽  
pp. 225 ◽  
Author(s):  
L. Stella ◽  
K. Beuermann ◽  
J. Patterson
Keyword(s):  
Short Term ◽  
X Ray
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