scholarly journals Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis

2016 ◽  
Vol 140 (2) ◽  
pp. 322-328 ◽  
Author(s):  
Amy E. Taylor ◽  
Richard M. Martin ◽  
Milan S. Geybels ◽  
Janet L. Stanford ◽  
Irene Shui ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Coffee Consumption ◽  
Causal Role ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis

2018 ◽  
Vol 110 (9) ◽  
pp. 1035-1038 ◽  
Author(s):  
James Yarmolinsky ◽  
Carolina Bonilla ◽  
Philip C Haycock ◽  
Ryan J Q Langdon ◽  
Luca A Lotta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

Abstract 1270: Vitamin E related genetic variants and prostate cancer risk: A Mendelian randomization analysis

2017 ◽  
Author(s):  
Tracy M. Layne ◽  
Shakira M. Nelson ◽  
Stephanie J. Weinstein ◽  
Eric Karlins ◽  
Stephen J. Chanock ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Circulating selenium and prostate cancer risk: a Mendelian randomization analysis

2017 ◽  
Author(s):  
James Yarmolinsky ◽  
Carolina Bonilla ◽  
Philip C Haycock ◽  
Ryan JQ Langdon ◽  
Luca A Lotta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Type 2 Diabetes ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Selenium Supplementation ◽  
High Grade ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

AbstractIn the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade prostate cancer and type 2 diabetes. Mendelian randomization analysis uses genetic variants to proxy modifiable risk factors and can strengthen causal inference in observational studies. We constructed a genetic risk score comprising eleven single-nucleotide polymorphisms robustly (P<5x10−8) associated with circulating selenium in genome-wide association studies. In a Mendelian randomization analysis of 72,729 men in the PRACTICAL Consortium (44,825 cases, 27,904 controls), 114 μg/L higher genetically-elevated circulating selenium was not associated with prostate cancer (OR: 1.01; 95% CI: 0.89-1.13). Concordant with findings from SELECT, selenium was weakly associated with advanced (including high-grade) prostate cancer (OR: 1.21; 95% CI: 0.98-1.49) and type 2 diabetes (OR: 1.18; 95% CI: 0.97-1.43; in a type 2 diabetes GWAS meta-analysis with up to 49,266 cases, 249,906 controls). Mendelian randomization mirrored the outcome of selenium supplementation in SELECT and may offer an approach for the prioritization of interventions for follow-up in large-scale randomized controlled trials.

scholarly journals Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis

PLoS Medicine ◽  
2019 ◽  
Vol 16 (8) ◽  
pp. e1002893 ◽  
Author(s):  
James Yarmolinsky ◽  
Caroline L. Relton ◽  
Artitaya Lophatananon ◽  
Kenneth Muir ◽  
Usha Menon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Epithelial Ovarian Cancer ◽  
Mendelian Randomization ◽  
Ovarian Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals CD28 Genetic Variants Increase Susceptibility to Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Case Control Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yangyang Li ◽  
Li Jin ◽  
Jing Yan ◽  
Hong Zhang ◽  
Rong Zhang ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Mendelian Randomization ◽  
Costimulatory Molecule ◽  
Causal Role ◽  
Chinese Patients ◽  
Diabetic Kidney ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

Few studies have illuminated the genetic role of T cell costimulatory molecule CD28/CD80/CTLA4 variants in diabetic kidney disease (DKD) susceptibility. We aimed to investigate the causal role of genetic polymorphisms in CD28/CD80/CTLA4 with DKD susceptibility in patients with T2DM. A total of 3253 patients with T2DM were recruited for genotyping: including 204 DKD patients and 371 controls in stage 1 and 819 DKD patients and 563 controls in stage 2; besides, 1296 T2DM patients were selected for the analysis of association between loci and DKD-related traits. A subset of 227 T2DM patients (118 patients with DKD and 109 patients without DKD) from the total population above were selected to assess serum soluble CD28 (sCD28) levels. Then, we performed a candidate gene association study to identify single-nucleotide polymorphisms (SNPs) associated with DKD susceptibility and further used those SNPs to perform Mendelian randomization analyses of serum sCD28 level and DKD susceptibility. Under additive genetic models, CD28-rs3116494 ( OR = 1.29 [95% CI 1.11, 1.51], P = 0.0011 ) and CD80-rs3850890 ( OR = 1.16 [95% CI 1.02, 1.31], P = 0.0283 ) were associated with DKD susceptibility adjusted for age, gender, body mass index (BMI), duration of diabetes, and HbA1c. CD28-rs3116494 was associated with serum sCD28 level ( β = 0.26 [95% CI 0.08, 0.44], P = 0.0043 ). The Mendelian randomization analysis showed that CD28-rs3116494 played a causal role in DKD by influencing serum sCD28 levels ( β = 1.15 [95% CI 0.46, 1.83], P = 0.0010 ). In conclusion, we identified that two novel SNPs, CD28-rs3116494 and CD80-rs3850890, were associated with DKD susceptibility. Using the Mendelian randomization analysis, our study provided evidence for a causal relationship between serum CD28 levels and DKD with T2DM in the Chinese population.

scholarly journals The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis. a mendelian randomization analysis of the nord-trØndelag health study

2017 ◽  
Vol 25 ◽  
pp. S181-S182 ◽  
Author(s):  
M.B. Johnsen ◽  
G.Å. Vie ◽  
B.S. Winsvold ◽  
J.H. Bjørngaard ◽  
B.O. Åsvold ◽  
...  
Keyword(s):  
Knee Replacement ◽  
Mendelian Randomization ◽  
Causal Role ◽  
Health Study ◽  
Primary Osteoarthritis ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers

2016 ◽  
Vol 254 ◽  
pp. 242-248 ◽  
Author(s):  
Yasuharu Tabara ◽  
Hirotsugu Ueshima ◽  
Naoyuki Takashima ◽  
Takashi Hisamatsu ◽  
Akira Fujiyoshi ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Mendelian Randomization ◽  
Causal Role ◽  
Low Density ◽  
Cholesterol Levels ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease

2015 ◽  
Vol 36 (23) ◽  
pp. 1454-1462 ◽  
Author(s):  
Stephanie Ross ◽  
Hertzel C. Gerstein ◽  
John Eikelboom ◽  
Sonia S. Anand ◽  
Salim Yusuf ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Mendelian Randomization ◽  
Causal Role ◽  
Mendelian Randomization Analysis ◽  
Artery Disease ◽  
Randomization Analysis
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