Vitamins C and E and other antioxidants in pregnancy and breastfeeding

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Oxidative Stress ◽  
Pregnancy Outcomes ◽  
Food Sources ◽  
High Dose ◽  
Maternal Supplementation ◽  
Oxygen Requirements ◽  
General Studies ◽  
Positive Effect ◽  
High Dose Vitamin ◽  
In Pregnancy

Pregnancy is characterized by oxidative stress, wherein high metabolic demands are accompanied by heightened oxygen requirements in tissues. Additionally, a number of disorders of pregnancy are characterized by a reduction in antioxidant activity. Consequently, it has been hypothesized that maternal supplementation with antioxidants, particularly vitamins C and E, may be beneficial in preventing the occurrence of these disorders. Other important dietary antioxidants include carotenoids, and polyphenols (flavonoids). In general, studies of the effect of providing supplementary vitamin C and E to improve pregnancy outcomes have been inconsistent or have shown no positive effect; some evidence suggests high-dose vitamin E may be harmful. These and other antioxidants are necessary in pregnancy but should ideally be obtained from food sources.

scholarly journals Hemoperitoneu Espontâneo na Gravidez

2019 ◽  
Vol 32 (11) ◽  
pp. 730 ◽  
Author(s):  
Daniela Gonçalves ◽  
Marcília Teixeira ◽  
Rosa Rodrigues ◽  
Jorge Braga
Keyword(s):  
Pregnancy Outcomes ◽  
Clinical Symptoms ◽  
Uterine Wall ◽  
Fetal Bradycardia ◽  
Chronic Disorder ◽  
Spontaneous Hemoperitoneum ◽  
Positive Effect ◽  
Previous Medical History ◽  
In Pregnancy

Endometriosis is a benign, estrogen-dependent chronic disorder. Pregnancy is considered to have a positive effect on endometriosis due to blockage of ovulation; however, evidence is emerging on the role of endometriosis not only in infertility but also in poor pregnancy outcomes. We present the case of a pregnant woman admitted for sudden and severe abdominal pain at 34 weeks gestation. Her previous medical history included endometriosis suspected by clinical symptoms and ultrasound. During cesarean section, performed by sustained fetal bradycardia, a large volume hemoperitoneum and multiple hemorrhagic foci in the posterior uterine wall were detected. Although rare, spontaneous hemoperitoneum may occur in pregnancy, especially in women with endometriosis. Thus, a prompt suspicion and expedite intervention are needed to improve maternal and fetal outcomes.

scholarly journals High-Dose Vitamin D Supplementation in Pregnancy and Neurodevelopment in Childhood

2020 ◽  
Vol 3 (12) ◽  
pp. e2026018
Author(s):  
Laerke Sass ◽  
Rebecca Kofod Vinding ◽  
Jakob Stokholm ◽  
Elín Bjarnadóttir ◽  
Sarah Noergaard ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
High Dose Vitamin ◽  
In Pregnancy

Lower dietary n-6 : n-3 ratio and high-dose vitamin E supplementation improve sperm morphology and oxidative stress in boars

2017 ◽  
Vol 29 (5) ◽  
pp. 940 ◽  
Author(s):  
Qing Liu ◽  
Yuanfei Zhou ◽  
Runjia Duan ◽  
Hongkui Wei ◽  
Siwen Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Antioxidant Capacity ◽  
Sperm Morphology ◽  
Tocopherol Content ◽  
High Dose ◽  
Beneficial Effects ◽  
And Oxidative Stress ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

A 2 × 2 factorial experiment (10 boars per treatment) was conducted for 16 weeks to evaluate the effects of the dietary n-6 : n-3 ratio (14 : 1 vs 6 : 1) and vitamin E (200 vs 400 mg kg–1) on boar sperm morphology and oxidative stress. Sperm mitochondrial membrane potential (MMP), reactive oxygen species (ROS), DNA damage (8-hydroxydeoxyguanosine; 8-OHdG), seminal lipoperoxidation (malondialdehyde; MDA) and antioxidant capacity in the serum, spermatozoa and seminal plasma were assessed as indicators of oxidative stress. Sperm production was similar among groups but increased (P < 0.05) throughout the 16 weeks of the study. Although sperm α-tocopherol content, ROS and seminal MDA did not differ between the two dietary n-6 : n-3 ratio treatments, enhanced antioxidant enzyme activity and MMP, but decreased 8-OHdG, were found in spermatozoa from boars consuming the 6 : 1 diet. The diet with the 6 : 1 ratio positively affected sperm morphology at Weeks 12 and 16 (P < 0.05). The α-tocopherol content and antioxidant capacity increased in boars with increasing levels of vitamin E supplementation. Compared with low-dose vitamin E, high-dose vitamin E supplementation improved sperm morphology. Overall, the results indicate that an n-6 : n-3 ratio of 6 : 1 and 400 mg/kg vitamin E have beneficial effects on sperm morphology by improving antioxidative stress.

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