Teratogenic Agents

Genetic Consultations in the Newborn ◽

10.1093/med/9780199990993.003.0006 ◽

2019 ◽

pp. 37-46

Author(s):

Robin D. Clark ◽

Cynthia J. Curry

Keyword(s):

Clinical Case ◽

Hyperemesis Gravidarum ◽

Gastric Bypass Surgery ◽

First Trimester ◽

Background Information ◽

Prescription Medications ◽

Congenital Infections ◽

Mendelian Disorders ◽

Folic Acid Antagonists ◽

Trimester Exposure

This chapter reviews background information about the incidence and epidemiology of common teratogenic agents, including prescription medications and congenital infections such as LCMV, parvovirus, TORCH, syphilis, and Zika. The characteristic fetal effects of in utero exposure to ACE inhibitors, anticoagulants, anticonvulsants, folic acid antagonists, immunosuppresants, and Vitamin A derivatives are reviewed. The teratogenic effects associated with chronic maternal disorders, such as gastric bypass surgery, hyperemesis gravidarum, hypertension, hyperthyroidism, and maternal phenylketonuria are discussed. The differential diagnosis includes Mendelian disorders with similar phenotypes. The chapter includes recommendations for evaluation and management. A clinical case presentation features an infant with first-trimester exposure to misoprostol (Cytotec).

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Craniosynostoses

Genetic Consultations in the Newborn ◽

10.1093/med/9780199990993.003.0013 ◽

2019 ◽

pp. 91-100

Author(s):

Robin D. Clark ◽

Cynthia J. Curry

Keyword(s):

Clinical Case ◽

Recurrence Risk ◽

Background Information ◽

Case Presentation ◽

Mendelian Disorders ◽

Common Causes ◽

Incidence Risk ◽

Maternal Thyroid ◽

The Relationship ◽

Single Suture

This chapter reviews background information about the incidence, risk factors, genetics, recurrence risk, and epidemiology of single suture and multiple suture craniosynostosis including isolated and syndromic varieties. The discussion on the differential diagnosis of craniosynostosis summarizes its common causes, including teratogenic agents (fluconazole, maternal thyroid disorders, methotrexate, valproic acid), chromosome anomalies, and Mendelian disorders that involve extracranial malformations. The relationship between premature closure of cranial sutures of postnatal onset and positional plagiocephaly, prematurity, and microcephaly are examined. This chapter provides recommendations for testing, evaluation and management. A clinical case presentation features an infant with Saethre–Chotzen syndrome, whose mildly affected relatives had not been diagnosed.

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Neural Tube Defects

Genetic Consultations in the Newborn ◽

10.1093/med/9780199990993.003.0019 ◽

2019 ◽

pp. 133-138

Author(s):

Robin D. Clark ◽

Cynthia J. Curry

Keyword(s):

Neural Tube ◽

Neural Tube Defects ◽

Clinical Case ◽

Recurrence Risk ◽

Background Information ◽

Case Presentation ◽

Mendelian Disorders ◽

Organ Systems ◽

Common Causes ◽

Incidence Risk

This chapter reviews background information about the incidence, risk factors, genetics, family history, recurrence risk, and epidemiology of isolated and syndromic neural tube defects. The various subtypes of NTD are described including common, lethal and rare presentations such as sacral agenesis and anterior meningomyelocele. Prenatal therapy with in utero surgery is addressed. The discussion on the differential diagnosis of neural tube defects summarizes its common causes, including teratogenic agents, chromosome anomalies (trisomy 18), and Mendelian disorders that cause isolated NTDs and syndromic NTDs that are associated with malformations in other organ systems. The chapter gives recommendations for evaluation and management. A clinical case presentation features an infant with a lumbosacral meningomyelocele caused by valproic acid embryopathy.

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FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

Acta Endocrinologica ◽

10.1530/acta.0.0410123 ◽

1962 ◽

Vol 41 (1) ◽

pp. 123-128 ◽

Cited By ~ 6

Author(s):

Pentti A. Järvinen ◽

Sykkö Pesonen ◽

Pirkko Väänänen

Keyword(s):

Hyperemesis Gravidarum ◽

First Trimester ◽

Control Group ◽

Before And After ◽

Daily Urine ◽

First Trimester Of Pregnancy ◽

The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

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Breast cancer associated with pregnancy: a clinical case

GYNECOLOGY ◽

10.26442/2079-5696_20.1.102-108 ◽

2018 ◽

Vol 20 (1) ◽

pp. 102-108

Author(s):

Yu E Dobrokhotova ◽

S E Arakelov ◽

S Zh Danelyan ◽

E I Borovkova ◽

A E Zykov ◽

...

Keyword(s):

Breast Cancer ◽

Radiation Therapy ◽

Clinical Case ◽

First Trimester ◽

First Year ◽

Total Mastectomy ◽

First Time

Associated with pregnancy is breast cancer, which was first detected during pregnancy, during the first year after childbirth or at any time against lactation. Diagnosis of the disease in the first trimester is an indication for abortion. The detection of the disease after 20 weeks and the desire of the woman to maintain pregnancy is the basis for conducting a total mastectomy followed by polychemotherapy with doxorubicin with cyclophosphamide or with fluorouracil. Radiation therapy during pregnancy is not applied. The timing and method of delivery are determined individually and depend on the stage of the process and the period of pregnancy, when it was identified. A clinical case of a patient with edematous-infiltrative form of breast cancer of the IV stage, diagnosed for the first time in 22 weeks of pregnancy, is presented.

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Faculty Opinions recommendation of Major congenital malformations after first-trimester exposure to ACE inhibitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14201.501141 ◽

2006 ◽

Author(s):

Laura Magee

Keyword(s):

Ace Inhibitors ◽

Congenital Malformations ◽

First Trimester ◽

Trimester Exposure ◽

Major Congenital Malformations

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PRIMARY HYPERPARATHYROIDISM IN A FIRST-TRIMESTER WOMAN WITH HYPEREMESIS GRAVIDARUM AND PANCREATITIS

AACE Clinical Case Reports ◽

10.4158/ep151136.cr ◽

2017 ◽

Vol 3 (1) ◽

pp. e31-e34 ◽

Cited By ~ 1

Author(s):

Margaret L. Burks ◽

Shimon Harary ◽

Carmen C. Solorzano ◽

Shichun Bao

Keyword(s):

Primary Hyperparathyroidism ◽

Hyperemesis Gravidarum ◽

First Trimester

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Is first trimester exposure to the combination of antiretroviral therapy and folate antagonists a risk factor for congenital abnormalities?

Sexually Transmitted Infections ◽

10.1136/sti.77.6.441 ◽

2001 ◽

Vol 77 (6) ◽

pp. 441-443 ◽

Cited By ~ 32

Author(s):

E. M Jungmann

Keyword(s):

Risk Factor ◽

Antiretroviral Therapy ◽

Congenital Abnormalities ◽

First Trimester ◽

Trimester Exposure

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Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine

Teratology ◽

10.1002/tera.10023 ◽

2002 ◽

Vol 65 (3) ◽

pp. 125-130 ◽

Cited By ~ 19

Author(s):

Kenneth Lyons Jones ◽

Kathleen A. Johnson ◽

Lyn M. Dick ◽

Robert J. Felix ◽

Kelly K. Kao ◽

...

Keyword(s):

Pregnancy Outcomes ◽

First Trimester ◽

Trimester Exposure

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EFEKTIFITAS PEMBERIAN PERMEN JAHE TERHADAP MUAL MUNTAH PADA IBU HAMIL DI KLINIK KHAIRUNIDA SUNGGAL TAHUN 2018

COLOSTRUM : Jurnal Kebidanan ◽

10.36911/colostrum.v1i1.605 ◽

2019 ◽

Vol 1 (1) ◽

pp. 36-44

Author(s):

Ani Nurdiana ◽

Betty Mangkuji ◽

Rismahara Lubis

Keyword(s):

Pregnant Women ◽

Hyperemesis Gravidarum ◽

Sampling Technique ◽

First Trimester ◽

Statistical Test ◽

Nausea And Vomiting ◽

P Value ◽

Nutritional Disorder ◽

Average Decrease ◽

Pharmacy Department

Pregnancy causes a lot of change in the mother’s body, so there are various kinds of physiological discomfort in the mother such as nause and vomiting, usually mild and controlable. This condition sometimes stops in the first trimester, but its effect may lead to nutritional disorder, dehydration, weakness, weight loss, and electrolyte imbalances. If not treated, it will worsen into Hyperemesis Gravidarum This study aimed to determine the effectiveness og ginger candy in reducing the frecuency of nause and vomiting in first trimester pregnant women in the Khairunida clinik with experimental Quasy design and tested by One Group Pretest Postest. About 15 samples were obtained through purposive sampling technique and the data were taken using the T-dependent test. Through the study, it was found that the frequency of nausea and vomiting before being given intervation was 10,93 and after being given intervation was 3,33 with an average decrease by 7,60. Through the statistical test, it was obtained the p value <(0.05) so that this study concluded that administration of ginger candy was effective in reduring nausea and vomiting in first trimester pregnant women. Further researchers are expected toreduce the use of non-pharmacological drugs to overcome nausea and vomiting in first trimester pregnant women and collaborate with the pharmacy department to facilitate the process of making good qualityy ginger candy.

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