scholarly journals PRIMARY HYPERPARATHYROIDISM IN A FIRST-TRIMESTER WOMAN WITH HYPEREMESIS GRAVIDARUM AND PANCREATITIS

2017 ◽  
Vol 3 (1) ◽  
pp. e31-e34 ◽  
Author(s):  
Margaret L. Burks ◽  
Shimon Harary ◽  
Carmen C. Solorzano ◽  
Shichun Bao
Keyword(s):  
Primary Hyperparathyroidism ◽  
Hyperemesis Gravidarum ◽  
First Trimester

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

scholarly journals EFEKTIFITAS PEMBERIAN PERMEN JAHE TERHADAP MUAL MUNTAH PADA IBU HAMIL DI KLINIK KHAIRUNIDA SUNGGAL TAHUN 2018

2019 ◽  
Vol 1 (1) ◽  
pp. 36-44
Author(s):  
Ani Nurdiana ◽  
Betty Mangkuji ◽  
Rismahara Lubis
Keyword(s):  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Sampling Technique ◽  
First Trimester ◽  
Statistical Test ◽  
Nausea And Vomiting ◽  
P Value ◽  
Nutritional Disorder ◽  
Average Decrease ◽  
Pharmacy Department

Pregnancy causes a lot of change in the mother’s body, so there are various kinds of physiological discomfort in the mother such as nause and vomiting, usually mild and controlable. This condition sometimes stops in the first trimester, but its effect may lead to nutritional disorder, dehydration, weakness, weight loss, and electrolyte imbalances. If not treated, it will worsen into Hyperemesis Gravidarum This study aimed to determine the effectiveness og ginger candy in reducing the frecuency of nause and vomiting in first trimester pregnant women in the Khairunida clinik with experimental Quasy design and tested by One Group Pretest Postest. About 15 samples were obtained through purposive sampling technique and the data were taken using the T-dependent test. Through the study, it was found that the frequency of nausea and vomiting before being given intervation was 10,93 and after being given intervation was 3,33 with an average decrease by 7,60. Through the statistical test, it was obtained the p value <(0.05) so that this study concluded that administration of ginger candy was effective in reduring nausea and vomiting in first trimester pregnant women. Further researchers are expected toreduce the use of non-pharmacological drugs to overcome nausea and vomiting in first trimester pregnant women and collaborate with the pharmacy department to facilitate the process of making good qualityy ginger candy.

Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy

2003 ◽  
Vol 79 (3) ◽  
pp. 498-502 ◽  
Author(s):  
Petek Balkanli Kaplan ◽  
Fatih Gücer ◽  
N.Cenk Sayin ◽  
Mahmut Yüksel ◽  
M.Ali Yüce ◽  
...  
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Maternal Serum ◽  
Serum Cytokine ◽  
Cytokine Levels ◽  
First Trimester Of Pregnancy

scholarly journals A rare case of hypercalcemia-induced pancreatitis in a first trimester pregnant woman

2018 ◽  
Vol 2018 ◽  
Author(s):  
Carine Ghassan Richa ◽  
Khadija Jamal Saad ◽  
Ali Khaled Chaaban ◽  
Mohamad Souheil El Rawas
Keyword(s):  
Acute Pancreatitis ◽  
Pregnant Woman ◽  
Primary Hyperparathyroidism ◽  
Rare Case ◽  
First Trimester ◽  
List Type ◽  
Second Trimester ◽  
Adequate Treatment ◽  
Severe Hypercalcemia ◽  
First Trimester Of Pregnancy

Summary The objective of the study is to report a case of acute pancreatitis secondary to hypercalcemia induced by primary hyperparathyroidism in a pregnant woman at the end of the first trimester. The case included a 32-year-old woman who was diagnosed with acute pancreatitis and severe hypercalcemia refractory to many regimens of medical therapy in the first trimester of pregnancy. She was successfully treated with parathyroidectomy in the early second trimester with complete resolution of hypercalcemia and pancreatitis. Neonatal course was unremarkable. To our best knowledge, this is a rare case when primary hyperparathyroidism and its complications are diagnosed in the first trimester of pregnancy. In conclusion, primary hyperparathyroidism is a rare life-threatening condition to the fetus and mother especially when associated with complications such as pancreatitis. Early therapeutic intervention is important to reduce the morbidity and mortality. Parathyroidectomy performed in the second trimester can be the only solution. Learning points: Learning how to make diagnosis of primary hyperparathyroidism in a woman during the first trimester of pregnancy. Understanding the complications of hypercalcemia and be aware of the high mortality and sequelae in both fetus and mother. Providing the adequate treatment in such complicated cases with coordinated care between endocrinologists and obstetricians to ensure optimal outcomes.

scholarly journals Gestational Thyrotoxicosis in a Patient With Hyperemesis Gravidarum

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A929-A929
Author(s):  
Hind Alameddine ◽  
Gurunanthan Palani ◽  
Kidmealem Zekarias
Keyword(s):  
Hyperemesis Gravidarum ◽  
Clinical Signs ◽  
Supportive Therapy ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Antithyroid Drugs ◽  
Significant Elevation ◽  
Free T4 ◽  
Overt Hyperthyroidism ◽  
In Pregnancy

Abstract Untreated or inadequately treated overt hyperthyroidism in pregnancy can have devastating consequences for both mother and fetus. At the same time antithyroid drugs (ATDs) are known for their teratogenic effect and should be avoid when possible; once the diagnosis of hyperthyroidism is made in a pregnant woman, attention should be focused on determining the etiology of the disorder and whether it warrants treatment. Here, we report a case of hyperemesis gravidarum patient presenting with significant elevation of thyroid hormones and a review on diagnosis and management of gestational transient thyrotoxicosis. A 33-year-old female, G4P3 at 8 weeks pregnant admitted for nausea and vomiting. Thyroid labs showed TSH &lt; 0.01 (Reference: 0.4-4.0mU/L) and free T4 is 3.53 (Reference: 0.76-1.46ng/dl). Patient was discharged on antiemetics with a diagnosis of hyperemesis gravidarum. She was re-admitted at 9 weeks pregnant with ongoing nausea and vomiting. She had palpitations, fatigue and reported 15 pound weight loss in 2 weeks. Past medical history included thyroid hormone abnormality noted during pregnancies of 2011 and 2017. Physical exam was significant for tachycardia and diffusely enlarged thyroid gland. Repeat labs showed TSH &lt;0.01, free T4 5.81, total T3 of 317 (Reference: 60-181ng/dl). Thyroid ultrasound showed multiple nodules. Considering significant elevation in free T4 and total T3; empiric therapy with propylthiouracil was recommended. Patient declined anti-thyroid therapy. TSI and TRH antibodies came back later as negative. Patient was treated with enteral feeding for hyperemesis gravidarum. Thyroid labs 3 weeks later improved; FT4 down to 1.63 and TT3 down to 250. Patient delivered healthy baby at 40 weeks of gestation. Although the differential diagnosis of thyrotoxicosis in pregnancy includes any cause that can be seen in a nonpregnant patient, the most likely causes for hyperthyroidism in pregnancy are gestational thyrotoxicosis (GTT) with or without hyperemesis gravidarum or Graves’ disease. GTT is described as an hCG-mediated hyperthyroidism that occurs in the first trimester of pregnancy; it is generally asymptomatic with mild biochemical hyperthyroidism. Distinguishing true overt hyperthyroidism from GTT in a setting of hyperemesis gravidarum is challenging. The absence of clinical signs of hyperthyroidism and negative thyroid antibodies supports the diagnosis of GTT. T3 tends to be disproportionately elevated more than T4 in patients with overt hyperthyroidism. HCG level has not been found to be useful in distinguishing between GTT and GD. Overt hyperthyroidism is treated using anti-thyroid drugs (ATD) whereas supportive therapy without ATD is the accepted standard of treatment of patients with hyperemesis gravidarum and GTT. More studies addressing the best management of these group of patients is needed.

scholarly journals The Effects of Hyperemesis Gravidarum on the Oral Glucose Tolerance Test Values and Gestational Diabetes

2021 ◽  
Vol 122 (4) ◽  
pp. 285-293
Author(s):  
Burak Bayraktar ◽  
Meric Balikoglu ◽  
Miyase Gizem Bayraktar ◽  
Ahkam Goksel Kanmaz
Keyword(s):  
Blood Glucose ◽  
Gestational Diabetes ◽  
Glucose Tolerance Test ◽  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Tolerance Test ◽  
Control Group ◽  
Oral Glucose ◽  
Second Trimester ◽  
Oral Glucose Tolerance

This study is aimed at determination whether pregnant women who develop hyperemesis gravidarum in the first trimester have a tendency to develop gestational diabetes mellitus (GDM). It is also aimed at identification of effects of hyperemesis gravidarum and GDM on prenatal and neonatal status in case they were detected together. Hyperemesis gravidarum diagnose was based on the following signs and symptoms. To diagnose GDM, first trimester fasting blood glucose measurement and subsequent blood glucose monitoring and 75-g oral glucose tolerance test (OGTT) were performed in the second trimester. A total of 949 singleton pregnant women (95 with and 852 without hyperemesis gravidarum) who met our criteria were included in the study. In the first trimester, plasma blood glucose and positive GDM screening were found to be significantly higher in the hyperemesis gravidarum group compared to the control group (p=0.042 and p<0.001, respectively). However, actual GDM cases were similar between both groups. The positive predictive value was significantly lower in the hyperemesis gravidarum group (28.5% vs. 72.7%, p=0.003). In the second trimester, the prevalence of GDM was 6.6% in the hyperemesis gravidarum group and 7.3% in the control group, with no significant difference (p=0.218) between-groups. In this study, hyperemesis gravidarum was found to cause changes in maternal metabolism in the first trimester of pregnancy due to limited calorie intake and fasting; in the presence of hyperemesis gravidarum, it should be known that the positive predictive value of first trimester gestational diabetes screening may decrease and the diagnosis of pseudo-GDM may increase.

scholarly journals EFEKTIFITAS PEMBERIAN WEDANG JAHE TERHADAP FREKUENSI MUAL DAN MUNTAH PADA IBU HAMIL TRIMESTER I DI KABUPATEN BENGKULU UTARA TAHUN 2017

2018 ◽  
Vol 5 (2) ◽  
pp. 201-211
Author(s):  
Iluh Meta Indrayani ◽  
Rialike Burhan ◽  
Desi Widiyanti
Keyword(s):  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Sampling Technique ◽  
First Trimester ◽  
Average Frequency ◽  
Bivariate Analysis ◽  
Work Area ◽  
Antiemetic Drugs ◽  
Before And After ◽  
Post Test

Emesis gravidarum is a usual complaint that is often experienced by the first trimester pregnant women, and coul develop become hyperemesis gravidarum thus increasing the risk of pregnancy. Ginger is kind of herbs which has been known to prevent nausea vomiting. The purpose of this study is the effectiveness of giving wedang ginger to the frequency of nausea and vomiting in pregnant women trimester I. The design of this research is Quasi experiment with One Group Pre test-Post test design. The sampling technique used purposive sampling with the sample of 10 first trimester pregnant women who experience emesis gravidarum. This research was conducted at Work Area of ​​Air Lais Puskesmas of North Bengkulu Regency on January 5, 2018 until February 6, 2018. Analysis of difference of frequency of nausea vomiting before and after intervention using Paired Sample T-Test. The results of this study indicate the average frequency of nausea vomiting pregnant women trimester I before given wedang ginger of 9.30. While the average frequency of nausea vomiting trimester pregnant women I after given ginger wedang of 4.50. The result of bivariate analysis showed that there was difference of mean of nausea vomiting frequency before and after intervention of wedang ginger equal to 4,80 with p = 0.000. Expected for the community can take advantage of ginger wedang as an alternative treatment before using antiemetic drugs, and can process other variants of ginger plants that can be used to lower the emesis gravidarum frequency.

scholarly journals FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN HIPEREMESIS GRAVIDARUM PADA IBU HAMIL TRIMESTER PERTAMA DI WILAYAH PUSKESMAS TANJUNG PASIR 2020

2021 ◽  
Vol 3 (2) ◽  
pp. 123-130
Author(s):  
Basyariah Lubis ◽  
Latifah Hanim ◽  
Srimelda Br Bangun ◽  
Ronny Ajartha
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Psychological Factors ◽  
Hyperemesis Gravidarum ◽  
Unwanted Pregnancy ◽  
First Trimester ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Center Area

The incidence of hyperemesis gravidarum in Indonesia ranges from 1% to 3% of all pregnancies. Hyperemesis gravidarum can cause problems in pregnancy such as anemia, while anemia itself can result in shock due to lack of nutritional intake, all of which are eaten and drunk. This study aims to determine the relationship between adaptation and psychological factors with the incidence of hyperemesis gravidarum in pregnant women in the first trimester in the Tanjung Pasir Health Center area. This research is an analytical survey with a cross sectional approach. The study was conducted in the Tanjung Pasir 2020 Public Health Center area from March to August 2020. The population in this study were 108 pregnant women in the first trimester at the Hamidah Clinic and a sample of 52 people. Data were obtained using a questionnaire, data analysis consisted of univariate and bivariate analysis. Bivariate analysis using the Chi Square statistical test at α = 5%. The results showed that there was no relationship between adaftation factors (anemia and primigravida) with hyperemesis gravidarum, while psychological factors (unwanted pregnancy, work pressure, income and family harmony) had a relationship with hyperemesis gravidarum. The conclusion of this study is there is a relationship between psychological factors and the incidence of hyperemesis gravidarum in pregnant women in the first trimester in the Tanjung Pasir Puskesmas area. It is suggested that the respondents should increase their knowledge about how to prevent and overcome hyperemesis gravidarum.

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