Substance Use Relapse Among Veterans at Termination of Treatment for Substance Use Disorders

2021 ◽  
Author(s):  
Christian A Betancourt ◽  
Panagiota Kitsantas ◽  
Deborah G Goldberg ◽  
Beth A Hawks

ABSTRACT Introduction Military veterans continue to struggle with addiction even after receiving treatment for substance use disorders (SUDs). Identifying factors that may influence SUD relapse upon receiving treatment in veteran populations is crucial for intervention and prevention efforts. The purpose of this study was to examine risk factors that contribute to SUD relapse upon treatment completion in a sample of U.S. veterans using logistic regression and classification tree analysis. Materials and Methods Data from the 2017 Treatment Episode Data Set—Discharge (TEDS-D) included 40,909 veteran episode observations. Descriptive statistics and multivariable logistic regression analysis were conducted to determine factors associated with SUD relapse after treatment discharge. Classification trees were constructed to identify high-risk subgroups for substance use after discharge from treatment for SUDs. Results Approximately 94% of the veterans relapsed upon discharge from outpatient or residential SUD treatment. Veterans aged 18-34 years old were significantly less likely to relapse than the 35-64 age group (odds ratio [OR] 0.73, 95% confidence interval [CI]: 0.66, 0.82), while males were more likely than females to relapse (OR 1.55, 95% CI: 1.34, 1.79). Unemployed veterans (OR 1.92, 95% CI: 1.67, 2.22) or veterans not in the labor force (OR 1.29, 95% CI: 1.13, 1.47) were more likely to relapse than employed veterans. Homeless vs. independently housed veterans had 3.26 (95% CI: 2.55, 4.17) higher odds of relapse after treatment. Veterans with one arrest vs. none were more likely to relapse (OR 1.52, 95% CI: 1.19, 1.95). Treatment completion was critical to maintain sobriety, as every other type of discharge led to more than double the odds of relapse. Veterans who received care at 24-hour detox facilities were 1.49 (95% CI: 1.23, 1.80) times more likely to relapse than those at rehabilitative/residential treatment facilities. Classification tree analysis indicated that homelessness upon discharge was the most important predictor in SUD relapse among veterans. Conclusion Aside from numerous challenges that veterans face after leaving military service, SUD relapse is intensified by risk factors such as homelessness, unemployment, and insufficient SUD treatment. As treatment and preventive care for SUD relapse is an active field of study, further research on SUD relapse among homeless veterans is necessary to better understand the epidemiology of substance addiction among this vulnerable population. The findings of this study can inform healthcare policy and practices targeting veteran-tailored treatment programs to improve SUD treatment completion and lower substance use after treatment.

2020 ◽  
Author(s):  
Mengqian Zhang ◽  
Hongxian Zhang ◽  
Rui Yang ◽  
Guoshuang Feng ◽  
Huiyu Xu ◽  
...  

Abstract Background This study aims to investigate the effects of various factors on treatment outcomes in women undergoing in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) with embryo transfer (ET). Methods Of the 8993 eligible women who underwent their first IVF/ICSI–ET cycles, and met our inclusion and exclusion criteria, 2742(30.5%) achieved clinical pregnancy while 6251(69.5%) did not. Multivariable Cox regression analysis, multiple logistic regression analysis, and classification tree analysis were used sequentially to screen key predictors among predictors of various infertility causes and ovarian stimulation protocols through the best subset technique. Results Multivariate Cox regression analysis showed that the main factor affecting fertility in first attempts at IVF/ICSI–ET is diminished ovarian reserve (DOR), with a hazard ratio (HR) of 0.406 and 95% confidence interval (CI) of 0.353–0.466. Multiple forward logistic regression with 5-fold cross-validation also found that, with an odds ratio (OR) of 2.522 (95% CI = 2.167–2.937), DOR affects fertility. The classification tree analysis was further used to better visualize the model. Conclusions DOR is the major factor affecting success rates in couples undergoing their first attempt at IVF/ICSI-ET. The selection of the most appropriate pairs for IVF/ICSI treatment can not only increase the success rates but also the cumulative cost-effectiveness.


2012 ◽  
Vol 9 (3) ◽  
pp. 235-258 ◽  
Author(s):  
Matthew Tonkin ◽  
Jessica Woodhams ◽  
Ray Bull ◽  
John W. Bond ◽  
Pekka Santtila

2015 ◽  
Vol 8 (2) ◽  
pp. 119-133 ◽  
Author(s):  
Slobodin Ortal ◽  
van de Glind Geurt ◽  
Franck Johan ◽  
Berger Itai ◽  
Yachin Nir ◽  
...  

2015 ◽  
Vol 26 (3) ◽  
pp. 443-454 ◽  
Author(s):  
Gregory M. Dominick ◽  
Mia A. Papas ◽  
Michelle L. Rogers ◽  
William Rakowski

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Nina P Paynter ◽  
Raji Balasubramanian ◽  
Shuba Gopal ◽  
Franco Giulianini ◽  
Leslie Tinker ◽  
...  

Background: Prior studies of metabolomic profiles and coronary heart disease (CHD) have been limited by relatively small case numbers and scant data in women. Methods: The discovery set examined 371 metabolites in 400 confirmed, incident CHD cases and 400 controls (frequency matched on age, race/ethnicity, hysterectomy status and time of enrollment) in the Women’s Health Initiative Observational Study (WHI-OS). All selected metabolites were validated in a separate set of 394 cases and 397 matched controls drawn from the placebo arms of the WHI Hormone Therapy trials and the WHI-OS. Discovery used 4 methods: false-discovery rate (FDR) adjusted logistic regression for individual metabolites, permutation corrected least absolute shrinkage and selection operator (LASSO) algorithms, sparse partial least squares discriminant analysis (PLS-DA) algorithms, and random forest algorithms. Each method was performed with matching factors only and with matching plus both medication use (aspirin, statins, anti-diabetics and anti-hypertensives) and traditional CHD risk factors (smoking, systolic blood pressure, diabetes, total and HDL cholesterol). Replication in the validation set was defined as a logistic regression coefficient of p<0.05 for the metabolites selected by 3 or 4 methods (tier 1), or a FDR adjusted p<0.05 for metabolites selected by only 1 or 2 methods (tier 2). Results: Sixty-seven metabolites were selected in the discovery data set (30 tier 1 and 37 tier 2). Twenty-six successfully replicated in the validation data set (21 tier 1 and 5 tier 2), with 25 significant with adjusting for matching factors only and 11 significant after additionally adjusting for medications and CHD risk factors. Validated metabolites included amino acids, sugars, nucleosides, eicosanoids, plasmologens, polyunsaturated phospholipids and highly saturated triglycerides. These include novel metabolites as well as metabolites such as glutamate/glutamine, which have been shown in other populations. Conclusions: Multiple metabolites in important physiological pathways with robust associations for risk of CHD in women were identified and replicated. These results may offer insights into biological mechanisms of CHD as well as identify potential markers of risk.


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