scholarly journals Ultradeep Sequencing Analysis of Population Dynamics of Virus Escape Mutants in RNAi-Mediated Resistant Plants

2012 ◽  
Vol 29 (11) ◽  
pp. 3297-3307 ◽  
Author(s):  
Fernando Martínez ◽  
Guillaume Lafforgue ◽  
Marco J. Morelli ◽  
Fernando González-Candelas ◽  
Nam-Hai Chua ◽  
...  
Keyword(s):  
Population Dynamics ◽  
Sequencing Analysis ◽  
Virus Escape ◽  
Escape Mutants

scholarly journals Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Science ◽  
2020 ◽  
Vol 369 (6506) ◽  
pp. 1010-1014 ◽  
Author(s):  
Johanna Hansen ◽  
Alina Baum ◽  
Kristen E. Pascal ◽  
Vincenzo Russo ◽  
Stephanie Giordano ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Selective Pressure ◽  
Three Dimensional ◽  
Spike Protein ◽  
Humanized Mice ◽  
Dimensional Structure ◽  
Antibody Treatment ◽  
Virus Escape ◽  
Escape Mutants ◽  
Antibody Cocktail

Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments for Ebola—one from genetically humanized mice and the other from a human survivor. Here, we describe parallel efforts using both humanized mice and convalescent patients to generate antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, which yielded a large collection of fully human antibodies that were characterized for binding, neutralization, and three-dimensional structure. On the basis of these criteria, we selected pairs of highly potent individual antibodies that simultaneously bind the receptor binding domain of the spike protein, thereby providing ideal partners for a therapeutic antibody cocktail that aims to decrease the potential for virus escape mutants that might arise in response to selective pressure from a single-antibody treatment.

scholarly journals Hepatitis B virus "escape" mutants.

BMJ ◽  
1990 ◽  
Vol 301 (6760) ◽  
pp. 1058-1059
Author(s):  
D H Crawford
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Escape ◽  
B Virus ◽  
Escape Mutants

scholarly journals Hepatitis B virus escape mutants induced by antiviral therapy

2008 ◽  
Vol 61 (4) ◽  
pp. 766-768 ◽  
Author(s):  
J. Sheldon ◽  
V. Soriano
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Therapy ◽  
Virus Escape ◽  
B Virus ◽  
Escape Mutants

scholarly journals Primary motor cortex activity traces distinct trajectories of population dynamics during spontaneous facial motor sequences in mice

2021 ◽  
Author(s):  
Juan Carlos Boffi ◽  
Tristan Wiessalla ◽  
Robert Prevedel
Keyword(s):  
Population Dynamics ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Neuronal Population ◽  
Future Research ◽  
Sequencing Analysis ◽  
Population Activity ◽  
Neuronal Populations ◽  
Custom Made ◽  
Facial Area

AbstractWe explore the link between on-going neuronal activity at primary motor cortex (M1) and face movement in awake mice. By combining custom-made behavioral sequencing analysis and fast volumetric Ca2+-imaging, we simultaneously tracked M1 population activity during many different facial motor sequences. We show that a facial area of M1 displays distinct trajectories of neuronal population dynamics across different spontaneous facial motor sequences, suggesting an underlying population dynamics code.Significance statementHow our brain controls a seemingly limitless diversity of body movements remains largely unknown. Recent research brings new light into this subject by showing that neuronal populations at the primary motor cortex display different dynamics during forelimb reaching movements versus grasping, which suggests that different motor sequences could be associated with distinct motor cortex population dynamics. To explore this possibility, we designed an experimental paradigm for simultaneously tracking the activity of neuronal populations in motor cortex across many different motor sequences. Our results support the concept that distinct population dynamics encode different motor sequences, bringing new insight into the role of motor cortex in sculpting behavior while opening new avenues for future research.

scholarly journals Emergence of virus escape mutants after immunization with epitope vaccine.

1995 ◽  
Vol 69 (11) ◽  
pp. 7147-7151 ◽  
Author(s):  
G Weidt ◽  
W Deppert ◽  
O Utermöhlen ◽  
J Heukeshoven ◽  
F Lehmann-Grube
Keyword(s):  
Epitope Vaccine ◽  
Virus Escape ◽  
Escape Mutants

Influenza H5 virus escape mutants: immune protection and antibody production in mice

2004 ◽  
Vol 99 (2) ◽  
pp. 205-208 ◽  
Author(s):  
Yuri A Smirnov ◽  
Asya K Gitelman ◽  
Elena A Govorkova ◽  
Aleksandr S Lipatov ◽  
Nikolai V Kaverin
Keyword(s):  
Antibody Production ◽  
Immune Protection ◽  
Virus Escape ◽  
Escape Mutants
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