scholarly journals P0938HEALTH-RELATED QUALITY OF LIFE IN A CHILEAN POPULATION OF DIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Caterina Tiscornia ◽  
Francisca Peña ◽  
Lucia Del vecchio ◽  
Samuel Duran ◽  
Hugo Poblete ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Nutritional Status ◽  
Functional Impairment ◽  
The Other ◽  
Diabetic Patients ◽  
Dialysis Modality ◽  
Dialysis Patients ◽  
The Mean

Abstract Background and Aims A growing number of patients treated with maintenance dialysis are older, frail and have functional impairment. In many instances, functional impairment is a more powerful predictor of adverse outcomes than traditional disease-based measures. The Kidney Disease Quality of Life 36-item short form survey (KDQOL-36) is widely used in dialysis patients; its scores are important predictor of outcome. Aim of the study is to evaluate the associations of KDQOL-36 scores with diabetes, dialysis modality, nutritional status and age in a cohort of dialysis patients from Chile. Method observational, multicenter, cross-sectional study performed in the region of Valparaiso, Chile. 207 adult patients on dialysis from more than 3 months (140 in HD, 67 in PD: mean age 58.9 ± 14.5 years with 37% >= 65 years, M/F 119/88) were asked to fill in the Spanish translation of the KDQOL-36 questionnaire (administered by a trained caregiver). The responses to the SF-36 questions were used to determine scores for the mental component summary (MCS), physical component summary (PCS), burden of kidney disease (BKD), symptoms and problems of kidney disease (SPKD), effects of kidney disease (EKD). The scores went from 0 to 100; the higher scores the better the quality of life. 50 was set as a cut-off level. Nutritional parameters were collected (BMI; mean 27.16 ± 4.7 kg/m2, brachial muscular or fat areas (< 25th percentile for age and sex defined as malnourished). All the patients signed an informed consent. Results Overall, mean scores and percentage of patients with values <50 on the PCS, MCS, BKD, SPKD, and EKD subscales were 45.54 ± 18.82 (60.9%), 57.38 ± 19.41 (36.2%), 73.43 ±18.33 (65.2%), 79.03 ±11.59 (1.9%), and 36.02 ± 34.74 (11.6%), respectively. The mean score of the combination of MCS and PCS was 51.46 ± 16.77 (52.2%). Compared to younger patients, those who were 65 or more years old had significantly higher score of EKD (79.91 ± 16.63 vs 69.59 ± 18.26, p<0.0001), with only 12% of older patients having a score below 50 (Χ2 7.79, p=0.005); the other subscales did not differ significantly. Ninety-one (43.5%) patients were diabetics. They were more likely of being older, having a higher BMI and lower signs of malnutrition (borderline significance). In comparison to non-diabetics, they had lower mean scores on BKD scale (30.42 ± 35.12 vs 40.4 ± 33.87, p=0.04) with a higher number having BKD scores < 50 (66/91 vs 69/116, Χ2 3.82, p=0.035). Moreover, they were more likely of having scores < 50 for the SPKD and EKD subscales. A significant reduction of the muscular and fat brachial areas (<25th percentile) were found in 88 (42.1%) and 49 (23.4%) of the patients, respectively. Mean scores of all subscales did not differ significantly between the groups of muscular and fat brachial areas. The dialysis modality had a significant impact on some subscales. in comparison to PD, a higher number of HD patients had scores < 50 for BKD (Χ2 18.24, p < 0.0001). On the other hand, PD patients were more likely of having lower MNS scores (Χ2 5.69, p < 0.013) and of the combination of PCS and MCS subscales (Χ2 12.82, p < 0.0001). Similar findings were obtained when analysing the scores as continuous variables. Conclusion This is the first formal evaluation of the performances of the KDQOL-36 questionnaire in a cohort of dialysis patients in Chile. Overall, the mean scores of PCS and EKD were well below the reference value of 50. General and kidney-related subscales were affected differently by age, dialysis modality and diabetes. In particular diabetic patients were more likely to perform poorly at kidney-related subscales, with no significant difference for general ones. Interestingly, dialysis modality had an impact on both BKD and MCS with opposite trends. The nutritional status seems to little affect patient quality of life.

MO822POLYPHARMACY NEGATIVELY AFFECTS HEALTH-RELATED QUALITY OF LIFE IN DIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Julia Colombijn ◽  
Anna Bonenkamp ◽  
Anita Van Eck van der Sluijs ◽  
Alferso C Abrahams ◽  
Joost Bijlsma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Dialysis Patients ◽  
Self Rated Health ◽  
Therapeutic Benefits ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related ◽  
The Mean

Abstract Background and Aims Dialysis patients are often prescribed a large number of medications to improve metabolic control and manage co-existing comorbidities. However, several studies suggest that a large number of medications can also detrimentally affect their health-related quality of life (HRQoL). Therefore, this study aims to provide insight in the association between the number of medications and various aspects of HRQoL in dialysis patients. Method A multicentre study was conducted among dialysis patients from Dutch dialysis centres three months after initiation of dialysis as part of the ongoing prospective DOMESTICO study. The number of medications, defined as the number of concomitantly prescribed types of drugs, was obtained from electronic patient records. Primary outcome was HRQoL measured with the Physical Component Summary (PCS) score and Mental Component Summary (MCS) score (range 0-100) of the Short Form 12. Secondary outcomes were number of symptoms (range 0-30) measured with the Dialysis Symptoms Index and self-rated health (range 0-100) measured with the visual analogue scale of the EuroQol-5D-5L. Data were analysed using linear regression and adjusted for possible confounders, including age, sex, dialysis modality, and comorbidity. Analyses for MCS and number of symptoms were performed after categorising patients in tertiles according to their number of medications because assumptions of linearity were violated for these outcomes. Results A total of 162 patients were included. Mean age of patients was 58 ± 17 years, 35% were female, and 80% underwent haemodialysis. The mean number of medications was 12.2 ± 4.5. Mean PCS and MCS were 36.6 ± 10.2 and 46.8 ± 10.0, respectively. The mean number of symptoms was 12.3 ± 6.9 and mean self-rated health 60.1 ± 20.6. In adjusted analyses, PCS was 0.6 point lower for each additional medication (95%CI -0.9 – -0.2; p=0.002). MCS was 4.9 point lower (95%CI -8.8 – -1.0; p=0.01) and 1.0 point lower (95%CI -5.1 – 3.1; p=0.63) for the highest and middle tertiles of medications, respectively, compared to the lowest tertile. Patients in the highest tertile of medications reported 4.1 more symptoms compared to the lowest tertile (95%CI 1.5 – 6.6; p=0.002) but no significant difference in the number of symptoms was observed between the middle and lowest tertile. Self-rated health was 1.5 point lower for each medication (95%CI -2.2 – -0.7; p<0.001). Conclusion After adjustment for comorbidity and other confounders, a higher number of medications was associated with a lower PCS, MCS, and self-rated health in dialysis patients and with more symptoms. This suggests that it may be relevant to weigh expected therapeutic benefits of medication against their possible harmful effects on HRQoL. An unfavourable balance between expected benefits and impact on HRQoL might be ground to deviate from clinical guidelines, especially for patients with a limited life-expectancy and for whom a kidney transplant is unattainable.

Quality of Life and Nutritional Status in diabetic patients on hemodialysis

2019 ◽  
Vol 13 (1) ◽  
pp. 576-580 ◽  
Author(s):  
Jenny L. Cepeda Marte ◽  
Adriana Javier ◽  
Carlos Ruiz-Matuk ◽  
Robert Paulino-Ramirez
Keyword(s):  
Quality Of Life ◽  
Nutritional Status ◽  
Diabetic Patients

scholarly journals Assessment of quality of life in type 2 diabetes mellitus patients using World Health Organization quality of life-BREF questionnaire and appraisal of diabetes scale - a cross-sectional study

2021 ◽  
Vol 15 (3) ◽  
Author(s):  
Supriya Patil ◽  
Yamini Patil ◽  
Sanjay Kumar Patil
Keyword(s):  
Quality Of Life ◽  
Cross Sectional Study ◽  
World Health ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
Health Organization

Diabetes is a chronic metabolic disorder that disturbs the quality of life (QOL) of patients. Therefore, evaluation of diabetes- related QOL could be a key outcome measure for its management. This study assessed the QOL in type 2 diabetes mellitus (T2DM) patients using the World Health Organization (WHO) quality of life (QOL)˗BREF questionnaire and disease-specific appraisal of diabetes scale (ADS). In this cross-sectional study, 520 T2DM patients were included. Patients’ demographic data, clinical information was collected through interviews, and the WHOQOL-BREF instrument and ADS were used for the QOL of patients. Statistical analysis was performed by using R software (Version 3.6.0). The mean ADS scores were lower in controlled diabetic subjects (18.50±3.08) and higher in uncontrolled diabetic subjects (19.29±2.73) (P<0.05). For WHOQOL-BREF, the mean scores for all the domains (overall general health, physical, psychological, social, and environmental) were significantly higher in controlled diabetic subjects (P<0.001). In addition, the age, duration of diabetes, associated comorbidities, treatment, and HbA1c level of patients showed a highly significant correlation with WHOQOL-BREF (P<0.001). Diabetic patients had poor-to-average QOL. Therefore, public health measures and education of diabetic patients are essential to create more awareness for improving the QOL of T2DM.

Visual Outcomes, Quality of Life and Satisfaction After Phacoemulsification in Patients With Type 2 Diabetes Mellitus and Patients Without Diabetes

2020 ◽  
Author(s):  
Joao Beato ◽  
Sonia Torres-Costa ◽  
Joao Esteves-Leandro ◽  
Manuel Falcão ◽  
Vitor Rosas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Visual Acuity ◽  
Patient Reported Outcomes ◽  
Diabetic Patients ◽  
Patient Reported ◽  
Visual Function Questionnaire ◽  
The Mean ◽  
Type 2 Diabetic

Abstract BackgroundDiabetic retinopathy (DR) and cataract are major complications that lead to significant visual impairment of diabetic patients. This study aims to compare the changes in visual acuity, quality of life and satisfaction after phacoemulsification between type 2 diabetic and nondiabetic patients.MethodsFifty-seven diabetic patients (37 with no diabetic retinopathy [DR], 11 with mild/moderate nonproliferative DR and 9 with severe nonproliferative/proliferative DR) and 45 controls were submitted to first-eye cataract surgery by phacoemulsification alone or with co-adjuvant intravitreal injection of bevacizumab or triamcinolone. National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was recorded preoperatively and 6 months after surgery; and satisfaction evaluated at 1-month. ResultsCorrected distance visual acuity (CDVA) of the operated eye at 1 and 6-months (p<0.001) was significantly higher than preoperative value in the controls and all diabetic subgroups. The final CDVA in the severe nonproliferative/proliferative DR subgroup was significantly lower compared to the controls and the remaining diabetic subgroups (p<0.05). The mean NEI VFQ-25 composite score significantly improved in both control (15.413.2 points) and diabetic (15.413.0 points) groups, without differences among the diabetic subgroups (p>0.05). Overall patient satisfaction was 93% in both control and diabetic groups. ConclusionThis study provides vision-related patient-reported outcomes that support the benefit from phacoemulsification in all stages of DR, as long as there is adequate monitoring and treatment of retinopathy.

scholarly journals Quality of Life and Symptom Burden among Chronic Kidney Disease of Uncertain Etiology (CKDu) Patients in Girandurukotte, Sri Lanka

2020 ◽  
Vol 17 (11) ◽  
pp. 4041 ◽  
Author(s):  
Hansani Madushika Abeywickrama ◽  
Swarna Wimalasiri ◽  
Yu Koyama ◽  
Mieko Uchiyama ◽  
Utako Shimizu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Short Form ◽  
Symptom Burden ◽  
Symptom Index ◽  
The Mean ◽  
Uncertain Etiology

Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients’ lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. The instruments applied were the Kidney Disease Quality of Life—Short Form (KDQOL-SFTM) version 1.3 and CKD Symptom Index—Sri Lanka. Socio-demographic, disease-related, and anthropometric variables were also investigated. The mean age of patients was 61.87 (SD 11.31), while 69.2% were male. The mean glomerular filtration rate was 28.17 (SD 14.03) mL/min/1.73 min2, and 70.8% were anemic. Bone/joint pain was the most experienced symptom while the median number of symptoms reported by patients was 5 (IQR 3–7). The mean symptom burden, physical component summary, mental component summary, and kidney-disease-specific component scores were 12.71 (SD 10.45), 68.63 (SD 19.58), 78.53 (SD 18.78), and 81.57 (SD 5.86), respectively. Age was found to be a significant predictor of HRQOL, while hemoglobin level and being a farmer were significant predictors of symptom burden. Our data indicate that CKDu patients in all stages experience at least one symptom affecting all aspects of HRQOL.

scholarly journals Perceived health and quality of life in chronic and end-stage kidney disease

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
K Legrand ◽  
E Speyer ◽  
B Stengel ◽  
L Frimat ◽  
W NGUEYON SIME ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
General Population ◽  
Physical Health ◽  
Perceived Health ◽  
Physical And Mental Health ◽  
Dialysis Patients ◽  
Obesity And Diabetes ◽  
End Stage

Abstract Background and objectives Health-related quality of life (HRQoL) is increasingly considered a major outcome in patients with chronic kidney disease (CKD), but the size of its effect on physical and mental health at different disease stages, compared with the general population, is unclear. Design, setting, participants, and measurements We compared HRQoL measures in four groups: 2,687 outpatients with moderate (stage 3, estimated glomerular filtration rate [eGFR] 30-60 mL/min/1.73 m2) or advanced (stage 4-5, eGFR &lt; 30 mL/min/1.73 m2) CKD under nephrology care from 40 nationally representative facilities, 1,658 patients with a functioning graft, 1,251 dialysis patients randomly selected from the national REIN registry, and 20,574 participants in the French Decennial Health Survey, representative of the general population. Results Mean age (years) was 67, 69, and 55 in patients with non-end-stage CKD, on dialysis, or with transplants, respectively; 60% were men. Age- and gender-standardized health status was perceived as fair or poor in 27% of those with moderate CKD and more than 40% of those with advanced CKD and those on dialysis, compared with 12% in transplant patients and 3% in the general population. Compared with the general population, HRQoL physical scores adjusted for age, gender, education, obesity, and diabetes, were significantly lower, by a factor of 2.2 among patients with moderate CKD, 4.1 among those with advanced CKD, 10.2 among those on dialysis, and 4.1 among those with transplants. The effect was stronger for those younger than 65 years. The mental score was lower only for dialysis patients. Conclusions This study highlights the importance of the physical health effects beginning at the moderate stage of CKD. More attention to patients’ CKD-related perceived health is needed. Key messages Physical health declined significantly from moderate through end-stage CKD, with impact greatest among the youngest patients. More attention to CKD’s impact on quality of life is needed.

Sign in / Sign up

Export Citation Format

Share Document