scholarly journals Contrast-enhanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage

2012 ◽  
Vol 27 (7) ◽  
pp. 2891-2898 ◽  
Author(s):  
Fang Ma ◽  
Yanqin Cang ◽  
Baozhen Zhao ◽  
Yuanyuan Liu ◽  
Chaoqing Wang ◽  
...  
Keyword(s):  
Kidney Damage ◽  
Microvascular Perfusion ◽  
Contrast Enhanced Ultrasound ◽  
Diabetic Kidney ◽  
Contrast Enhanced

scholarly journals Use of Contrast-Enhanced Ultrasound to Study Relationship between Serum Uric Acid and Renal Microvascular Perfusion in Diabetic Kidney Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Ling Wang ◽  
Jia-Fen Cheng ◽  
Li-Ping Sun ◽  
Ya-Xiang Song ◽  
Le-Hang Guo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Diabetic Kidney Disease ◽  
Microvascular Perfusion ◽  
Renal Ultrasound ◽  
Contrast Enhanced Ultrasound ◽  
Protein Markers ◽  
Diabetic Kidney ◽  
Contrast Enhanced

Purpose.To investigate the relationship between uric acid and renal microvascular perfusion in diabetic kidney disease (DKD) using contrast-enhanced ultrasound (CEUS) method.Materials and Methods.79 DKD patients and 26 healthy volunteers were enrolled. Renal function and urine protein markers were tested. DKD patients were subdivided into two groups including a normal serum uric acid (SUA) group and a high SUA group. Contrast-enhanced ultrasound (CEUS) was performed, and low acoustic power contrast-specific imaging was used for quantitative analysis.Results.Normal controls (NCs) had the highest levels of AUC, AUC1, and AUC2. Compared to the normal SUA DKD group, high SUA DKD patients had significantly higher IMAX, AUC, and AUC1 (P<0.05). DKD patients with low urinary uric acid (UUA) excretion had significantly higher AUC2 compared to DKD patients with normal UUA (P<0.05).Conclusion.Hyperuricemia in DKD patients was associated with a renal ultrasound image suggestive of microvascular hyperperfusion. The CEUS parameter AUC1 holds promise as an indicator for renal microvascular hyperperfusion, while AUC2 might be a useful indicator of declining glomerular filtration rate in DKD patients with decreased excretion of uric acid.

Contrast-enhanced ultrasound measurement of microvascular perfusion relevant to nutrient and hormone delivery in skeletal muscle: A model study in vitro

2008 ◽  
Vol 75 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Renee M. Ross ◽  
Kathleen Downey ◽  
John M.B. Newman ◽  
Stephen M. Richards ◽  
Michael G. Clark ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Microvascular Perfusion ◽  
Ultrasound Measurement ◽  
Contrast Enhanced Ultrasound ◽  
Model Study ◽  
Contrast Enhanced

scholarly journals Contrast-enhanced ultrasound: A promising method for renal microvascular perfusion evaluation

2016 ◽  
Vol 4 (3) ◽  
pp. 104-108 ◽  
Author(s):  
Ling Wang ◽  
Chandra Mohan
Keyword(s):  
Quantitative Imaging ◽  
Kidney Injury ◽  
Renal Perfusion ◽  
Microvascular Perfusion ◽  
Systematic Evaluation ◽  
Renal Diseases ◽  
Contrast Enhanced Ultrasound ◽  
Traditional Use ◽  
Contrast Enhanced ◽  
Unique Nature

Abstract This article reviews the application of contrast-enhanced ultrasound (CEUS) in gauging renal microvascular perfusion in diverse renal diseases. The unique nature of the contrast agents used in CEUS provides real-time and quantitative imaging of the vasculature. In addition to the traditional use of CEUS for evaluation of kidney masses, it also emerges as a safe and effective imaging approach to assess microvascular perfusion in diffuse renal lesions, non-invasively. Although the precise CEUS parameters that may best predict disease still warrant systematic evaluation, animal models and limited clinical trials in humans raise hopes that CEUS could outcompete competing modalities as a first-line tool for assessing renal perfusion non-invasively, even in ailments such as acute kidney injury and chronic kidney disease.

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