scholarly journals Intraoperative contrast-enhanced ultrasound for cerebral glioma resection and the relationship between microvascular perfusion and microvessel density

2019 ◽  
Vol 186 ◽  
pp. 105512
Author(s):  
Jia Wang ◽  
Yilin Yang ◽  
Xi Liu ◽  
Yunyou Duan
Keyword(s):  
Microvessel Density ◽  
Microvascular Perfusion ◽  
Cerebral Glioma ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Glioma Resection ◽  
The Relationship

scholarly journals Intraoperative contrast-enhanced ultrasound for cerebral glioma resection and the relationship with microvessel density

2019 ◽  
Author(s):  
Jia Wang ◽  
Xi Liu ◽  
Yilin Yang ◽  
Yunyou Duan
Keyword(s):  
Real Time ◽  
Microvessel Density ◽  
Color Doppler ◽  
Tumor Resection ◽  
Low Grade ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Cerebral Gliomas ◽  
Before And After ◽  
The Relationship

ABSTRACTPurposeWe studied the value of intraoperative contrast-enhanced ultrasound (iCEUS) for real-time monitoring of resection of cerebral gliomas, and analyzed the relationship between CEUS parameters and microvessel density (MVD) of different pathologic grades of cerebral gliomas.Materials and MethodsICEUS was performed in 49 patients with cerebral gliomas. The enhancement characteristics of cerebral gliomas were observed before and after tumor resection. The number of microvessels was counted by immunostaining with anti-CD34. Differences in these quantitative parameters in cerebral gliomas were compared and subjected to a correlation analysis with MVD.ResultsThe color Doppler flow classification within lesions were significantly different before and after iCEUS (p<0.05). The assessment of iCEUS parameters and tumor MVD showed that cerebral gliomas of different pathological grades had different characteristics. The time-to-peak (Tmax) was significantly shorter, the peak intensity (PI) and MVD were significantly higher in high-grade cerebral gliomas than in low-grade cerebral gliomas (p<0.05). According to the immunostaining, PI was positively (r=0.637) correlated with MVD and Tmax was negatively (r=–0.845) correlated with MVD.ConclusionICEUS may determine the borders of lesions more clearly, indicate the microvascular perfusion in real time, and be helpful in understanding the cerebral gliomas grade.

scholarly journals P16.28 * INTRAOPERATIVE CEREBRAL GLIOMA CHARACTERIZATION WITH CONTRAST ENHANCED ULTRASOUND (CEUS)

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii84-ii84
Author(s):  
F. Prada ◽  
L. Mattei ◽  
M. Del Bene ◽  
C. Casali ◽  
A. Filippini ◽  
...  
Keyword(s):  
Cerebral Glioma ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

scholarly journals Contrast-enhanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage

2012 ◽  
Vol 27 (7) ◽  
pp. 2891-2898 ◽  
Author(s):  
Fang Ma ◽  
Yanqin Cang ◽  
Baozhen Zhao ◽  
Yuanyuan Liu ◽  
Chaoqing Wang ◽  
...  
Keyword(s):  
Kidney Damage ◽  
Microvascular Perfusion ◽  
Contrast Enhanced Ultrasound ◽  
Diabetic Kidney ◽  
Contrast Enhanced

scholarly journals The Value of Peripheral Enhancement Pattern for Diagnosing Thyroid Cancer Using Contrast-Enhanced Ultrasound

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Yan Zhang ◽  
Ming-bo Zhang ◽  
Yu-kun Luo ◽  
Jie Li ◽  
Zhi-li Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Diagnostic Value ◽  
Contrast Enhanced Ultrasound ◽  
Enhancement Pattern ◽  
Contrast Enhanced ◽  
Peripheral Ring ◽  
Conventional Ultrasound ◽  
Relationship Of ◽  
Peripheral Enhancement ◽  
The Relationship

Background. Contrast-enhanced ultrasound (CEUS) scanning can detect differences between thyroid tumors and surrounding tissues. However, enhancement patterns within nodules are insufficient for the diagnosis of thyroid carcinomas. The peripheral enhancement patterns of nodules may provide useful diagnostic information. The objective of this study was to investigate the diagnostic accuracy of the peripheral enhancement patterns during CEUS scanning of thyroid nodules. Material and Methods. 120 nodules with peripheral rings during CEUS and definite pathology confirmed by surgery were included in this study. The internal and peripheral CEUS enhancement patterns of these nodules were assessed, and the diagnostic value of CEUS was compared with the conventional ultrasound. The relationship of types of peripheral rings and sizes of nodules was analyzed, respectively. Results. There were 78 benign and 42 malignant nodules. Peripheral irregular ring performs well in detecting malignancy. It improves the diagnostic performance of CEUS by combining with internal enhancement patterns (diagnostic sensitivity of 97.6%, specificity of 98.7%, and accuracy of 98.3%) and adds value to conventional ultrasound (95.2%, 70.5%, and 79.2%). The sizes of the nodules with regular high-enhanced rings (2.34 ± 1.33 cm) were larger than the other three types of peripheral rings (P<0.05). Conclusions. Features of peripheral ring on CEUS are important for the diagnosis of thyroid cancer; they can further contribute to the accuracy combining with the internal enhancement pattern, which could avoid the unnecessary biopsy.

scholarly journals Correlation between Contrast-Enhanced Ultrasound and Microvessel Density via CD31 and CD34 in a rabbit VX2 lung peripheral tumor model

2018 ◽  
Vol 1 (1) ◽  
pp. 37 ◽  
Author(s):  
Jin Xing ◽  
Wen He ◽  
Yi-Wen Ding ◽  
Yang Li ◽  
Yan-Dong Li
Keyword(s):  
Tumor Angiogenesis ◽  
Microvessel Density ◽  
Vascular Endothelial Cells ◽  
Tumor Model ◽  
Imaging Method ◽  
Contrast Enhanced Ultrasound ◽  
Rabbit Lung ◽  
Contrast Enhanced ◽  
Vx2 Tumor ◽  
The Right

Aim: To evaluate the tumor angiogenesis in lung peripheral VX2 tumor model by contrast-enhanced ultrasound (CEUS) and to determine the correlation between CEUS parameters and microvessel density (MVD) calculated via CD31 and CD34 expression.Material and methods: VX2 pulmonary tumors were created in eight Japanese white rabbits by implanting a VX2 sarcoma into the lower portion of the right lung through ultrasound guidance. Tumors were allowed to grow for 14-21 days to achieve a diameter of 7-15 mm, and were examined by CEUS using a SonoVue contrast agent. The results were recorded as digital video images, and the time-intensity curves and hemodynamic parameters were analyzed. Pathological tumor specimens were immediately obtained after the ultrasound examinations. Tumor specimens were stained with hematoxylin and eosin (H&E) and expressed as CD31 and CD34. The different endothelial cell markers were determined by immunohistochemical staining. MVD was calculated via CD 31 and CD34, and the relationship between CEUS parameters and MVD was analyzed.Results: Two distinct types of microvessels were identified in lung peripheral VX2 tumors: differentiated (CD34+) and undifferentiated (CD31+) vessels. A significant correlation was found between CEUS parameters and undifferentiated MVD (CD31+ vessels) in lung peripheral VX2 tumors (p<0.05). A reverse correlation was observed between different MVDs.Conclusions: Two different degrees of differentiation of vascular endothelial cells (CD31 and CD34) exist in the rabbit lung peripheral VX2 tumor model. CD31 MVD can more effectively evaluate tumor angiogenesis compared with CD34 MVD. CEUS, as a non-invasive imaging method, can effectively evaluate tumor angiogenesis in rabbit peripheral lung cancer.

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