Erratum to: “How cost effective are nutrition care interventions delivered in primary care? A systematic review of trial-based economic evaluations.” Nutrition Reviews, nuab082, https://doi.org/10.1093/nutrit/nuab082

Background and Objectives: Prostate cancer is an ever-increasing global incidence and has become the fifth leading cause of cancer-related mortality in men. A significant number of patients with prostate cancer develop metastatic castration-resistant prostate cancer (mCRPC). There are a few second-line treatment options for patients with post-docetaxel mCRPC. This systematic review aimed to assess the cost-effectiveness of cabazitaxel for the treatment of mCRPC. Materials and Methods: Electronic bibliographic databases including: PubMed/Medline, NICE, CRD, and Scopus were searched in January 2018 for identifying full economic evaluations published in English and Persian. The risk of assessment bias and descriptive analyses of individual studies’ findings were presented. Results: Three articles that fulfilled the inclusion criteria were included in the current study. All the included records had a reasonable quality. Cabazitaxel was not recommended as the most cost-effective option for the treatment of docetaxel-refractory mCRPC. Abiraterone acetate and radium-223 were the recommended cost-effective treatments for mCRPC treatment. Conclusion: We found that, in general, while cabazitaxel had equal or slightly higher improvement in Quality-adjusted Life Year (QALY) as compared to the alternatives, it incurred a high cost. Despite the inclusion of a few studies in this review, cabazitaxel was not found to be a cost-effective option. Therefore, we recommend full economic evaluations to be conducted in this area.

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A Systematic Review of Methods, Study Quality, and Results of Economic Evaluation for Childhood and Adolescent Obesity Intervention

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16030485 ◽

2019 ◽

Vol 16 (3) ◽

pp. 485 ◽

Cited By ~ 3

Author(s):

Mandana Zanganeh ◽

Peymane Adab ◽

Bai Li ◽

Emma Frew

Keyword(s):

Systematic Review ◽

Economic Evaluation ◽

Cost Effectiveness ◽

Evidence Synthesis ◽

Evaluation Studies ◽

Cost Effective ◽

Adolescent Obesity ◽

Economic Evaluations ◽

Full Economic Evaluation ◽

Childhood And Adolescent Obesity

Many suggested policy interventions for childhood and adolescent obesity have costs and effects that fall outside the health care sector. These cross-sectorial costs and consequences have implications for how economic evaluation is applied and although previous systematic reviews have provided a summary of cost-effectiveness, very few have conducted a review of methods applied. We undertook this comprehensive review of economic evaluations, appraising the methods used, assessing the quality of the economic evaluations, and summarising cost-effectiveness. Nine electronic databases were searched for full-economic evaluation studies published between January 2001 and April 2017 with no language or country restrictions. 39 economic evaluation studies were reviewed and quality assessed. Almost all the studies were from Western countries and methods were found to vary by country, setting and type of intervention. The majority, particularly “behavioural and policy” preventive interventions, were cost-effective, even cost-saving. Only four interventions were not cost effective. This systematic review suggests that economic evaluation of obesity interventions is an expanding area of research. However, methodological heterogeneity makes evidence synthesis challenging. Whilst upstream interventions show promise, an expanded and consistent approach to evaluate cost-effectiveness is needed to capture health and non-health costs and consequences.

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Dosage for cost-effective exercise-based falls prevention programs for older people: A systematic review of economic evaluations

Annals of Physical and Rehabilitation Medicine ◽

10.1016/j.rehab.2019.06.012 ◽

2020 ◽

Vol 63 (1) ◽

pp. 69-80 ◽

Cited By ~ 1

Author(s):

Stanley John Winser ◽

Hei Tung Fion Chan ◽

Lam Ho ◽

Lau Sze Chung ◽

Lau Tsz Ching ◽

...

Keyword(s):

Systematic Review ◽

Older People ◽

Cost Effective ◽

Prevention Programs ◽

Falls Prevention ◽

Economic Evaluations

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TECHNIQUES FOR DIAGNOSING OSTEOPOROSIS: A SYSTEMATIC REVIEW OF COST-EFFECTIVENESS STUDIES

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462314000257 ◽

2014 ◽

Vol 30 (3) ◽

pp. 273-281 ◽

Cited By ~ 2

Author(s):

Davide Minniti ◽

Ottavio Davini ◽

Maria Rosaria Gualano ◽

Maria Michela Gianino

Keyword(s):

Systematic Review ◽

Cost Effectiveness ◽

Postmenopausal Women ◽

Cost Effective ◽

Economic Evaluations ◽

Clear Cut ◽

Step Procedure ◽

Database Research ◽

The Cost ◽

Effectiveness Studies

Objectives:The study question was whether dual-energy X-ray absorptiometry (DXA) alone is more cost-effective for identifying postmenopausal women with osteoporosis than a two-step procedure with quantitative ultrasound sonography (QUS) plus DXA. To answer this question, a systematic review was performed.Methods:Electronic databases (PubMed, INAHTA, Health Evidence Network, NIHR, the Health Technology Assessment program, the NHS Economic Evaluation Database, Research Papers in Economics, Web of Science, Scopus, and EconLit) were searched for cost-effectiveness publications. Two independent reviewers selected eligible publications based on the inclusion/exclusion criteria. Quality assessment of economic evaluations was undertaken using the Drummond checklist.Results:Seven journal articles and four reports were reviewed. The cost per true positive case diagnosed by DXA was found to be higher than that for diagnosis by QUS+DXA in two articles. In one article it was found to be lower. In three studies, the results were not conclusive. These articles were characterized by the differences in the types of devices, parameters and thresholds on the QUS and DXA tests and the unit costs of the DXA and QUS tests as well as by variability in the sensitivity and specificity of the techniques and the prevalence of osteoporosis.Conclusions:The publications reviewed did not provide clear-cut evidence for drawing conclusions about which screening test may be more cost-effective for identifying postmenopausal women with osteoporosis.

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Systematic Review: Cost-effective Strategies of Optimizing Anti-tumor Necrosis and Immunomodulators in Inflammatory Bowel Disease

Inflammatory Bowel Diseases ◽

10.1093/ibd/izy399 ◽

2019 ◽

Vol 25 (9) ◽

pp. 1462-1473 ◽

Cited By ~ 8

Author(s):

Abhinav Vasudevan ◽

Peter R Gibson ◽

Daniel R Van Langenberg

Keyword(s):

Systematic Review ◽

Inflammatory Bowel Disease ◽

Willingness To Pay ◽

Bowel Disease ◽

Tumor Necrosis ◽

Cost Effective ◽

Economic Evaluations ◽

Effective Strategies ◽

Medication Costs ◽

Inflammatory Bowel

Abstract Background Medication costs in inflammatory bowel disease (IBD) are now the principal driver of health care costs. Cost-effective strategies to optimize and rationalize treatment are therefore necessary. Methods A systematic review until April 30, 2018, was performed to identify economic evaluations of strategies to optimize infliximab, adalimumab, and immunomodulators for the treatment of IBD in adults. A qualitative synthesis of the identified studies was performed. Results Seventy articles were identified that met the inclusion criteria. Adalimumab seems cost-effective compared with infliximab as maintenance therapy for moderate to severe Crohn’s disease (CD). Infusion costs are a significant additional treatment cost with infliximab. However, other studies found biosimilar infliximab more cost-effective than alternative biologics in fistulizing and moderate-severe luminal CD—although the latter did not reach a willingness-to-pay threshold of <$50,000. In moderate-severe ulcerative colitis, infliximab seems more cost-effective than adalimumab. Multiple tailored approaches to treatment based on objective markers of disease activity or efficacy have been shown to be cost-effective in CD, including following secondary loss of response to anti-TNF therapy for postoperative recurrence and in escalating treatment. For immunomodulator treatment, both thiopurine methyltransferase (TPMT) testing before commencing thiopurines and thiopurine metabolite testing for dose optimization seem cost-effective. Conclusion In a win-win for patients and payers, several potential avenues to achieve cost-effectiveness—but also therapeutic optimization of anti-TNF therapies—were elucidated in this review with comparatively sparse data for immunomodulators. Optimizing immunomodulator and anti-tumor necrosis factor alpha therapy to achieve objective disease control seems to be cost-effective at conventional willingness-to-pay thresholds in a number of clinical settings.

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Economic Evaluations of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Antiplatelets in Patients With Acute Coronary Syndrome: A Systematic Review

Journal of Cardiovascular Pharmacology and Therapeutics ◽

10.1177/1074248420902298 ◽

2020 ◽

Vol 25 (3) ◽

pp. 201-211

Author(s):

Sawsan AlMukdad ◽

Hazem Elewa ◽

Daoud Al-Badriyeh

Keyword(s):

Systematic Review ◽

Acute Coronary Syndrome ◽

Antiplatelet Therapy ◽

Cost Effective ◽

Economic Evaluations ◽

Cyp2c19 Genotype ◽

Coronary Syndrome ◽

Increased Risk ◽

Selection Of ◽

Guided Therapy

Background and Objectives: Clopidogrel is widely used after the percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and requires activation by cytochrome P450 (CYP), primarily CYP2C19. Patients with CYP2C19 loss-of-function alleles are at increased risk of major adverse cardiovascular events, while more expensive novel antiplatelet agents (ticagrelor and prasugrel) are unaffected by the CYP2C19 mutations. This systematic review aims to answer the question about whether overall evidence supports the genotype-guided selection of antiplatelet therapy as a cost-effective strategy in post-PCI ACS. Methods: A systematic literature search of PubMed, EMBASE, EconLit, and PharmGKB was done to identify all the economic evaluations related to genotype-guided therapy compared to the universal use of antiplatelets in ACS patients. Quality of Health Economic Studies tool was used for quality assessment. Results: The search identified 13 articles, where genotype-guided treatment was compared to universal clopidogrel, ticagrelor, and/or prasugrel. Six studies showed that genotype-guided therapy was cost-effective compared to universal clopidogrel, while 5 studies showed that it was dominant. One study specified that genotype-guided with ticagrelor is cost-effective only in both CYP2C19 intermediate and poor metabolizers. Genotype-guided therapy was dominant when compared to universal prasugrel, ticagrelor, or both in 5, 1, and 3 studies, respectively. Only 2 studies reported that universal ticagrelor was cost-effective compared to genotype-guided treatment. All the included articles had good quality. Conclusion: Based on current economic evaluations in the literature, implementing CYP2C19 genotype-guided therapy is a cost-effective approach in guiding the selection of medication in patients with ACS undergoing PCI.

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OAO1.01. Are complementary therapies and integrative care cost-effective? A comprehensive systematic review of economic evaluations

BMC Complementary and Alternative Medicine ◽

10.1186/1472-6882-12-s1-o1 ◽

2012 ◽

Vol 12 (S1) ◽

Cited By ~ 1

Author(s):

P Herman ◽

B Poindexter ◽

C Witt ◽

D Eisenberg

Keyword(s):

Systematic Review ◽

Complementary Therapies ◽

Cost Effective ◽

Economic Evaluations ◽

Integrative Care

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Lifestyle Interventions to Prevent Type 2 Diabetes: A Systematic Review of Economic Evaluation Studies

Journal of Diabetes Research ◽

10.1155/2016/2159890 ◽

2016 ◽

Vol 2016 ◽

pp. 1-14 ◽

Cited By ~ 23

Author(s):

Koffi Alouki ◽

Hélène Delisle ◽

Clara Bermúdez-Tamayo ◽

Mira Johri

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Economic Evaluation ◽

Primary Prevention ◽

Latin American ◽

Cost Effective ◽

Economic Evaluations ◽

Lifestyle Interventions ◽

Obesity Control

Objective. To summarize key findings of economic evaluations of lifestyle interventions for the primary prevention of type 2 diabetes (T2D) in high-risk subjects.Methods. We conducted a systematic review of peer-reviewed original studies published since January 2009 in English, French, and Spanish. Eligible studies were identified through relevant databases including PubMed, Medline, National Health Services Economic Evaluation, CINHAL, EconLit, Web of sciences, EMBASE, and the Latin American and Caribbean Health Sciences Literature. Studies targeting obesity were also included. Data were extracted using a standardized method. The BMJ checklist was used to assess study quality. The heterogeneity of lifestyle interventions precluded a meta-analysis.Results. Overall, 20 studies were retained, including six focusing on obesity control. Seven were conducted within trials and 13 using modeling techniques. T2D prevention by physical activity or diet or both proved cost-effective according to accepted thresholds, except for five inconclusive studies, three on diabetes prevention and two on obesity control. Most studies exhibited limitations in reporting results, primarily with regard to generalizability and justification of selected sensitivity parameters.Conclusion. This confirms that lifestyle interventions for the primary prevention of diabetes are cost-effective. Such interventions should be further promoted as sound investment in the fight against diabetes.

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Economic evaluation of laparoscopic surgery for colorectal cancer

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462307070559 ◽

2007 ◽

Vol 23 (4) ◽

pp. 464-472 ◽

Cited By ~ 7

Author(s):

Robyn M. de Verteuil ◽

Rodolfo A. Hernández ◽

Luke Vale ◽

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Laparoscopic Surgery ◽

Cost Effectiveness ◽

Incremental Cost ◽

Open Surgery ◽

Disease Free Survival ◽

Cost Effective ◽

Economic Evaluations ◽

Short Term

Objectives: The aim of this study was to assess the cost-effectiveness of laparoscopic surgery compared with open surgery for the treatment of colorectal cancer.Methods: A Markov model was developed to model cost-effectiveness over 25 years. Data on the clinical effectiveness of laparoscopic and open surgery for colorectal cancer were obtained from a systematic review of the literature. Data on costs came from a systematic review of economic evaluations and from published sources. The outcomes of the model were presented as the incremental cost per life-year gained and using cost-effectiveness acceptability curves to illustrate the likelihood that a treatment was cost-effective at various threshold values for society's willingness to pay for an additional life-year.Results: Laparoscopic surgery was on average £300 more costly and slightly less effective than open surgery and had a 30 percent chance of being cost-effective if society is willing to pay £30,000 for a life-year. One interpretation of the available data suggests equal survival and disease-free survival. Making this assumption, laparoscopic surgery had a greater chance of being considered cost-effective. Presenting the results as incremental cost per quality-adjusted life-year (QALY) made no difference to the results, as utility data were poor. Evidence suggests short-term benefits after laparoscopic repair. This benefit would have to be at least 0.01 of a QALY for laparoscopic surgery to be considered cost-effective.Conclusions: Laparoscopic surgery is likely to be associated with short-term quality of life benefits, similar long-term outcomes, and an additional £300 per patient. A judgment is required as to whether the short-term benefits are worth this extra cost.

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