scholarly journals 699Long Term Outcome of Pyogenic Vertebral Osteomyelitis: A Cohort Study of 260 Patients

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S198-S198
Author(s):  
Arjun Gupta ◽  
Todd Kowalski ◽  
Douglas Osmon ◽  
Mark Enzler ◽  
James Steckelberg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Vertebral Osteomyelitis ◽  
Term Outcome ◽  
Pyogenic Vertebral Osteomyelitis

scholarly journals Long-Term Outcome of Pyogenic Vertebral Osteomyelitis: A Cohort Study of 260 Patients

2014 ◽  
Vol 1 (3) ◽  
Author(s):  
Arjun Gupta ◽  
Todd J. Kowalski ◽  
Douglas R. Osmon ◽  
Mark Enzler ◽  
James M. Steckelberg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Back Pain ◽  
Treatment Failure ◽  
Vertebral Osteomyelitis ◽  
Term Outcome ◽  
Duration Of Symptoms ◽  
Long Term Outcome ◽  
Increased Risk ◽  
Pyogenic Vertebral Osteomyelitis

Abstract Background.  The long-term outcome of patients with pyogenic vertebral osteomyelitis (PVO) has not been fully assessed. Methods.  We conducted a retrospective cohort study to describe the long-term outcome of PVO and to assess risk factors for treatment failure in patients evaluated at our institution between 1994 and 2002. Patients were observed until July 1, 2013. Results.  Two hundred sixty patients with PVO were included in this study. Twenty-seven percent (70) of patients developed their infection after an invasive spinal procedure. Staphylococcus aureus accounted for 40% (103) of infections. Forty-nine percent (128) of patients underwent spinal surgery as part of their initial therapy. The median duration of parenteral antimicrobial therapy was 42 days (interquartile range, 38–53). The estimated 2-, 5-, and 10-year cumulative probability of treatment failure-free survival was 72%, 69%, and 69%, respectively. Seventy-five percent of patients who developed treatment failure did so within 4.7 months of diagnosis. Residual neurological defects and persistent back pain were seen in 16% and 32% of patients, respectively. In a multivariate analysis, longer duration of symptoms before diagnosis and having an infection with S. aureus were associated with increased risk of treatment failure. Conclusions.  Increasing duration of symptoms and infection with S. aureus were associated with treatment failure in patients with PVO. Most treatment failures occurred early after initiation of treatment. Pyogenic vertebral osteomyelitis is associated with a high 2-year failure rate. Persistent neurological deficits and back pain are common after therapy.

scholarly journals Epidemiology, Microbiological Diagnosis, and Clinical Outcomes in Pyogenic Vertebral Osteomyelitis: A 10-year Retrospective Cohort Study

2018 ◽  
Vol 5 (3) ◽  
Author(s):  
Brian S W Chong ◽  
Christopher J Brereton ◽  
Alexander Gordon ◽  
Joshua S Davis
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Vertebral Osteomyelitis ◽  
Index Admission ◽  
Causative Organism ◽  
Microbiological Diagnosis ◽  
Treatment Pathways ◽  
Pyogenic Vertebral Osteomyelitis

Abstract Background Pyogenic vertebral osteomyelitis (PVO) is rising in incidence, but optimal methods of investigation and duration of antibiotic therapy remain controversial. Methods We conducted a single-center retrospective cohort study of PVO at an Australian teaching hospital. We included all adults with a first episode of PVO between 2006 and 2015. PVO was defined based on the presence of prespecified clinical and radiological criteria. The main exposures of interest were investigation strategy and antibiotic treatment. The main outcome measures were duration of hospital admission, mortality during index admission, symptom resolution during index admission, and attributable readmission within 2 years. Results Of 129 included patients, 101 (78%) had a causative organism identified. Patients with an identified pathogen were more likely to be febrile (75% compared with 29%, P < .001) and had a higher mean admission C-reactive protein (207 vs 54, P < .001) compared with patients without an identified pathogen. However, they were less likely to experience an adverse outcome (death or attributable readmission within 2 years; adjusted odds ratio, 0.36; 95% confidence interval, 0.13–0.99; P = .04). Open biopsy of vertebral tissue had a higher diagnostic yield (70%) than fine needle aspirate (41%) or core biopsy (30%). Despite receiving a median of 6 weeks of intravenous antibiotics, only 15% of patients had a full recovery on discharge from index admission. Conclusions Clinical outcomes for patients with PVO were poor. Obtaining a microbiological diagnosis is associated with a better outcome. However, prospective and randomized studies are essential to establishing optimal investigation and treatment pathways.

The long‐term outcome of MOGAD: An observational national cohort study of 61 patients

2021 ◽  
Vol 28 (5) ◽  
pp. 1659-1664
Author(s):  
Romain Deschamps ◽  
Julie Pique ◽  
Xavier Ayrignac ◽  
Nicolas Collongues ◽  
Bertrand Audoin ◽  
...  
Keyword(s):  
Cohort Study ◽  
Term Outcome ◽  
Long Term Outcome ◽  
National Cohort

scholarly journals Long-Term Outcome of Cardiac Surgery in 1,040 Liver Cirrhosis Patient　― Nationwide Population-Based Cohort Study ―

2017 ◽  
Vol 81 (4) ◽  
pp. 476-484 ◽  
Author(s):  
An-Hsun Chou ◽  
Tien-Hsing Chen ◽  
Chun-Yu Chen ◽  
Shao-Wei Chen ◽  
Chao-Wei Lee ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Liver Cirrhosis ◽  
Cohort Study ◽  
Population Based ◽  
Cirrhosis Patient ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Liver Cirrhosis Patient

Long-term outcome 19 years after childhood IgA nephritis: a retrospective cohort study

2006 ◽  
Vol 21 (9) ◽  
pp. 1266-1273 ◽  
Author(s):  
Jaana Ronkainen ◽  
Marja Ala-Houhala ◽  
Helena Autio-Harmainen ◽  
Timo Jahnukainen ◽  
Olli Koskimies ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Iga Nephritis

scholarly journals Long-term Outcome After Survival of a Cardiac Arrest: A Prospective Longitudinal Cohort Study

2017 ◽  
Vol 31 (6) ◽  
pp. 530-539 ◽  
Author(s):  
Véronique R. M. Moulaert ◽  
Caroline M. van Heugten ◽  
Ton P. M. Gorgels ◽  
Derick T. Wade ◽  
Jeanine A. Verbunt
Keyword(s):  
Quality Of Life ◽  
Cardiac Arrest ◽  
Cohort Study ◽  
Anxiety And Depression ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Prospective Longitudinal ◽  
Prospective Longitudinal Cohort

Background. A cardiac arrest can lead to hypoxic brain injury, which can affect all levels of functioning. Objective. To investigate 1-year outcome and the pattern of recovery after surviving a cardiac arrest. Methods. This was a multicenter, prospective longitudinal cohort study with 1 year of follow-up (measurements 2 weeks, 3 months, 1 year). On function level, physical/cardiac function (New York Heart Association Classification), cognition (Cognitive Log [Cog-log], Cognitive Failures Questionnaire), emotional functioning (Hospital Anxiety and Depression Scale, Impact of Event Scale), and fatigue (Fatigue Severity Scale) were assessed. In addition, level of activities (Frenchay Activities Index, FAI), participation (Community Integration Questionnaire [CIQ] and return to work), and quality of life (EuroQol 5D, EuroQol Visual Analogue Scale, SF-36, Quality of Life after Brain Injury) were measured. Results. In this cohort, 141 cardiac arrest survivors were included. At 1 year, 14 (13%) survivors scored below cutoff on the Cog-log. Both anxiety and depression were present in 16 (15%) survivors, 29 (28%) experienced posttraumatic stress symptoms and 55 (52%), severe fatigue. Scores on the FAI and the CIQ were, on average, respectively 96% and 92% of the prearrest scores. Of those previously working, 41 (72%) had returned to work. Most recovery of cognitive function and quality of life occurred within the first 3 months, with further improvement on some domains of quality of life up to 12 months. Conclusions. Overall, long-term outcome in terms of activities, participation, and quality of life after cardiac arrest is reassuring. Nevertheless, fatigue is common; problems with cognition and emotions occur; and return to work can be at risk.

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